Nature Reviews Cardiology - Table of Contents alert Volume 11 Issue 7

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TABLE OF CONTENTS
July 2014 Volume 11 Number 7
Impact Factor 10.400 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Clinical classification of plaque morphology in coronary disease Fumiyuki Otsuka, Michael Joner, Francesco Prati, Renu Virmani & Jagat Narula
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RESEARCH HIGHLIGHTS Top Interventional cardiology: COMFORTABLE biodegradable stents in a new CENTURY? Published online: 10 June 2014 p371 | doi:10.1038/nrcardio.2014.81 PDF Arrhythmias: MINERVA trial results reported Published online: 13 May 2014 p372 | doi:10.1038/nrcardio.2014.68 PDF Coronary artery disease: Long-term superiority of CABG surgery for three-vessel disease confirmed Published online: 10 June 2014 p372 | doi:10.1038/nrcardio.2014.82 PDF Interventional cardiology: Sex-specific outcomes in PVI for PAD Published online: 13 May 2014 p373 | doi:10.1038/nrcardio.2014.69 PDF Prevention: Relating risk factor reduction to disease risk on a global level Published online: 20 May 2014 p373 | doi:10.1038/nrcardio.2014.72 PDF Arrhythmias: New PACES/HRS consensus statements Published online: 27 May 2014 p373 | doi:10.1038/nrcardio.2014.76 PDF Cardiac resuscitation: The 'smoker's paradox' after in-hospital cardiac arrest Published online: 20 May 2014 p374 | doi:10.1038/nrcardio.2014.73 PDF Device therapy: CRT effective in elderly patients with heart failure Published online: 03 June 2014 p374 | doi:10.1038/nrcardio.2014.78 PDF Cardiology JOBS of the week More Science jobs from Cardiology EVENT 2014 Cardiometabolic Health Congress 22.10.14 Boston, USA More science events from
NEWS AND VIEWS		Top
Hypertension: How should data from SYMPLICITY HTN-3 be interpreted? Roland E. Schmieder Published online: 20 May 2014 p375 | doi:10.1038/nrcardio.2014.70 The SYMPLICITY HTN-3 trial demonstrated unexpectedly large and small blood pressure reductions in the control and renal denervation groups, respectively. Although this study was well designed, it had several weaknesses and the results are inconclusive, with the exception of the positive signal for renal denervation in non-African-American individuals. Full Text | PDF
Pharmacotherapy: Colchicine for recurrent pericarditis—what's new in CORP-2? Faisal F. Syed & Bongani M. Mayosi Published online: 27 May 2014 p376 | doi:10.1038/nrcardio.2014.71 In the CORP-2 trial, patients with multiple recurrences of idiopathic or autoimmune pericarditis were randomly assigned to receive colchicine or placebo, in addition to standard anti-inflammatory therapy. After 6 months, colchicine significantly reduced recurrent pericarditis rates. Are we moving closer to a reliable treatment for this common disease? Full Text | PDF
REVIEWS		Top
Clinical classification of plaque morphology in coronary disease Fumiyuki Otsuka, Michael Joner, Francesco Prati, Renu Virmani & Jagat Narula Published online: 29 April 2014 p379 | doi:10.1038/nrcardio.2014.62 In this Review, Otsuka et al. describe how optical coherence tomography (OCT)—an intravascular imaging modality with high resolution—can be used to define various stages of plaque progression. The authors also highlight how OCT might be used in the identification of high-risk plaques vulnerable to rupture in patients with coronary disease, to enable pre-emptive interventional treatment, and how OCT might be used in the management of acute coronary syndromes. Abstract | Full Text | PDF
Comprehensive plaque assessment by coronary CT angiography Pál Maurovich-Horvat, Maros Ferencik, Szilard Voros, Béla Merkely & Udo Hoffmann Published online: 22 April 2014 p390 | doi:10.1038/nrcardio.2014.60 Catastrophic acute coronary events are often the result of ruptured atherosclerotic plaques and subsequent luminal thrombosis. Preventing such an event seems to be the only effective strategy to reduce mortality and morbidity of coronary artery disease. This Review highlights how computed tomography angiography might be combined with fluid dynamic assessment to identify rupture-prone plaques in patients with coronary artery disease. Abstract | Full Text | PDF | Supplementary information
Natriuretic peptides in cardiometabolic regulation and disease Nora E. Zois, Emil D. Bartels, Ingrid Hunter, Birgitte S. Kousholt, Lisbeth H. Olsen & Jens P. Goetze Published online: 13 May 2014 p403 | doi:10.1038/nrcardio.2014.64 Dysregulation of the natriuretic peptide system has been associated with several life-style related metabolic and cardiovascular disorders, including obesity, type 2 diabetes mellitus, hypertension, atherosclerosis, thrombosis, and myocardial ischaemia, implying biological effects beyond pressure-volume homeostasis. In this Review, Zois et al. discuss the role of the various natriuretic peptides in the pathophysiology of these cardiometabolic conditions. Abstract | Full Text | PDF
Angiotensin-converting enzyme 2 and angiotensin 1-7: novel therapeutic targets Fan Jiang, Jianmin Yang, Yongtao Zhang, Mei Dong, Shuangxi Wang, Qunye Zhang, Fang Fang Liu, Kai Zhang & Cheng Zhang Published online: 29 April 2014 p413 | doi:10.1038/nrcardio.2014.59 Angiotensin-converting enzyme 2, and its product angiotensin 1-7, are thought to have counteracting effects against the adverse actions of the better-known members of the renin-angiotensin system and might, therefore, be useful therapeutic targets in patients with cardiovascular disease. Professor Jiang and colleagues review the evidence for the potential roles of these proteins in various cardiovascular conditions, including hypertension, atherosclerosis, myocardial remodelling, heart failure, ischaemic stroke, and diabetes. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION A role for pericytes in coronary no-reflow Fergus M. O'Farrell & David Attwell Published online: 29 April 2014 p427 | doi:10.1038/nrcardio.2014.58 Coronary 'no-reflow' is a substantial clinical problem, even after successful percutaneous coronary intervention for myocardial infarction. In this Perspectives, article, O'Farrell and Attwell describe the similarities between this phenomenon and no-reflow in the brain after ischaemic stroke, and propose that pericytes contribute to the underlying pathophysiology in both situations. Cardiac pericytes might, therefore, be a novel therapeutic target for coronary no-reflow. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Cardiology was previously published as Nature Clinical Practice Cardiovascular Medicine.

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