Nature Reviews Genetics Contents July 2014 Volume 15 Number 7 pp 439-512

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TABLE OF CONTENTS
July 2014 Volume 15 Number 7		Advertisement
Impact Factor 41.063 *	In this issue Research Highlights Progress Reviews Perspectives Also this month Article series: Modes of transcriptional regulation Regulatory elements  Featured article: Insights into RNA structure and function from genome-wide studies Stefanie A. Mortimer, Mary Anne Kidwell & Jennifer A. Doudna	An Atlas of Genetic Influences on Human Blood Metabolites   "Metabolomics...an excellent way of understanding individual uniqueness and . . ." - Craig Venter A new publication in Nature Genetics reveals how metabolomic profiling coupled with genomics data yields new insight into diseases, potential biomarkers and drug treatments.  Freely available here.
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RESEARCH HIGHLIGHTS Top Transposable elements: ERE and there for pluripotency p439 | doi:10.1038/nrg3756 PDF Disease genetics: Mitochondrial variation affects disease risk p440 | doi:10.1038/nrg3760 PDF Gene regulation: Chanzyme in action — divide and conquer? p440 | doi:10.1038/nrg3761 PDF Chromosomes: Dynamically in the loop p440 | doi:10.1038/nrg3762 PDF Genome evolution: Evolutionary insights from comparative bear genomics p442 | doi:10.1038/nrg3757 PDF Translational genomics: A network of the human metabolome p442 | doi:10.1038/nrg3758 PDF Synthetic biology: In vivo replication of semi-synthetic DNA p443 | doi:10.1038/nrg3759 PDF IN BRIEF Non-coding RNA: Small RNA determines silkworm sex | Pathogen genetics: Single-cell analysis of intra-host variation | Disease genetics: Incidental medical findings in genetic research | Gene therapy: Genome editing in haematopoietic stem cells | Plant genomics: Insights into duplicate gene fate in plants | Synthetic biology: Communication from the non-living world | Evolution: How the butterfly changed its spots PDF Genetics JOBS of the week Tenure-Track Faculty Position in Statistical Genetics / Genomics University of Connecticut School of Medicine and the Jackson Laboratory (JAX) Postdoctoral Position, Signaling and Gene Expression in Immune Cells Universitat Pompeu Fabra (UPF) Postdoctoral researchers in regulatory genomics & epigenomics University of Iowa Carver College of Medicine Postdoctoral Researcher, Computational Clinical Genomics Memorial Sloan Kettering Postdoctoral Research Associate Duke University More Science jobs from Genetics EVENT Short Course on the Genetics of Addiction 28.08.14 Bar Harbor, USA More science events from
PROGRESS		Top
Engineering adeno-associated viruses for clinical gene therapy Melissa A. Kotterman & David V. Schaffer p445 | doi:10.1038/nrg3742 Although gene delivery vectors based on adeno-associated viruses (AAVs) have emerged as safe and effective for numerous clinical gene therapy applications, many challenges remain. Recent advances in AAV vector development through rational design and directed evolution, as well as in the design of novel genetic cargoes, promise to extend clinical successes of AAV-mediated gene therapy. Abstract | Full Text | PDF | Supplementary information
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REVIEWS		Top
Article series: Modes of transcriptional regulation In pursuit of design principles of regulatory sequences Michal Levo & Eran Segal p453 | doi:10.1038/nrg3684 Gene-regulatory DNA elements control complex spatiotemporal patterns of gene expression, and alterations to these sequences are commonly associated with inter-individual phenotypic variation and human disease. This Review discusses our latest understanding of how different layers of information in these sequences control the binding of regulators and influence gene expression outcomes. Abstract | Full Text | PDF
Insights into RNA structure and function from genome-wide studies Stefanie A. Mortimer, Mary Anne Kidwell & Jennifer A. Doudna p469 | doi:10.1038/nrg3681 Recent technological advances have enabled the probing of RNA structure across the transcriptomes of various species in vitro and in vivo. This Review discusses our latest understanding of how RNA structure influences various steps of gene expression, including translation, mRNA localization and microRNA-mediated gene regulation. Abstract | Full Text | PDF
Empirical fitness landscapes and the predictability of evolution J. Arjan G.M. de Visser & Joachim Krug p480 | doi:10.1038/nrg3744 A central topic in biology concerns how genotypes determine phenotypes and functions of organisms that affect their evolutionary fitness. This Review discusses recent advances in the development of empirical fitness landscapes and their contribution to theoretical analyses of the predictability of evolution. Abstract | Full Text | PDF
Transcriptional outcome of telomere signalling Jing Ye, Valérie M. Renault, Karine Jamet & Eric Gilson p491 | doi:10.1038/nrg3743 The role of telomeric factors as guardians of chromosome ends from threats to genome integrity (such as degradation and inappropriate DNA damage response activation) has long been appreciated. This Review discusses the extratelomeric activity of these factors and how they can regulate the transcription of genes involved in metabolism, immunity and differentiation. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION The dawn of evolutionary genome engineering Csaba Pál, Balázs Papp & György Pósfai p504 | doi:10.1038/nrg3746 In this Opinion article, the authors highlight the potential of genome engineering for the study of evolution and focus on microbial systems. They discuss the prospects and problems of the emerging field of evolutionary genome engineering, and pinpoint how a combination of genome engineering and laboratory evolution can shed light on evolutionary forces. Abstract | Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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