Nature Reviews Microbiology contents July 2014 Volume 12 Number 7 pp 457-528

TABLE OF CONTENTS
July 2014 Volume 12 Number 7
Impact Factor 22.49 *	In this issue Editorial Research Highlights News and Analysis Reviews Analysis Also this month Article Series: Vector-borne diseases  Featured article: Unravelling the structural and mechanistic basis of CRISPR–Cas systems John van der Oost, Edze R. Westra, Ryan N. Jackson & Blake Wiedenheft
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EDITORIAL		Top
A prize purpose p457 | doi:10.1038/nrmicro3306 The Longitude Prize 2014 has stimulated debate over the true purpose of these initiatives and whether the public can rise to the challenge of making such decisions. Full Text | PDF
RESEARCH HIGHLIGHTS Top Fungal biology: ECM fungi and all that JAZz p459 | doi:10.1038/nrmicro3305 A new study provides the first mechanistic insights into the negative regulation of plant jasmonic acid signalling by an ectomycorrhizal fungus, Laccaria bicolor. PDF Bacterial pathogenesis: Bacteria choose to fight and flee p460 | doi:10.1038/nrmicro3294 A new study shows that a bacterial pathogen uses a fight-and-flight response to coexist and synergize with a commensal bacterium in vivo. PDF Bacterial secretion: A trans-kingdom effector p460 | doi:10.1038/nrmicro3296 This study identifies a new Pseudomonas aeruginosa type VI secretion system effector that targets both prokaryotic and eukaryotic cells — the phospholipase D effector PldB. PDF Techniques and applications: Self-like antigens under fire p462 | doi:10.1038/nrmicro3290 This study describes the use of a new microbial glycan microarray to characterize how host immune molecules bind to bacterial cell surface carbohydrates. PDF Parasite biology: Piecing it together p462 | doi:10.1038/nrmicro3303 Torgbor et al. propose a model to explain the involvement of Plasmodium falciparum in the development of endemic Burkitt's lymphoma. PDF Parasite biology: A tripartite virulence complex in Toxoplasma p463 | doi:10.1038/nrmicro3304 ROP5, ROP17 and ROP18 function synergistically to target host immunity-related GTPases, which promotes Toxoplasma gondii evasion of the mouse immune response. PDF IN BRIEF Synthetic biology: Rewriting the code of life | Biofilms: Two kingdoms come together | Bacterial genetics: Bacterial small RNAs scoop up proteins | Metagenomics: Why stop here? | Viral pathogenesis: The pandemic potential of H10N8 | Biofilms: Targeting (p)ppGpp disrupts biofilms PDF Microbiology JOBS of the week Microbiology Professor Nanjing Medical University Aquatic Microbiology University of Waterloo Immune synapse and intracellular signalling Universidad Autonoma de Madrid Postdoc Fellow in Epigenomics and Transcriptomics University of California - Los Angeles Postdoctoral Associate Arizona State University, Biodesign Institute More Science jobs from Microbiology EVENT Microbiology & Infectious Diseases Congress 29.09.14 Oxford, UK More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Split reality for novel tick virus Hayley M. Bennett p464 | doi:10.1038/nrmicro3297 This month's Genome Watch describes the discovery of a segmented RNA virus that provides an evolutionary link between segmented and unsegmented genomes. PDF
REVIEWS		Top
Microbiological effects of sublethal levels of antibiotics Dan I. Andersson & Diarmaid Hughes p465 | doi:10.1038/nrmicro3270 Bacteria are frequently exposed to subinhibitory concentrations of antibiotics, and recent evidence suggests that this is likely to select for resistance. In this Review, Andersson and Hughes discuss the ecology of antibiotics, the ability of subinhibitory concentrations of antibiotics to select for resistance and the effects of low-level drug exposure on bacterial physiology. Abstract | Full Text | PDF
Unravelling the structural and mechanistic basis of CRISPR–Cas systems John van der Oost, Edze R. Westra, Ryan N. Jackson & Blake Wiedenheft p479 | doi:10.1038/nrmicro3279 In this Review, van der Oost et al. summarize the recent structural and biochemical insights into the molecular mechanisms of RNA-guided interference by CRISPR–Cas systems in bacteria and archaea. By comparing the three main types of CRISPR–Cas systems, they highlight the unique and conserved properties of the system and also discuss outstanding questions that require further study. Abstract | Full Text | PDF | Supplementary information
Functional long-range RNA–RNA interactions in positive-strand RNA viruses Beth L. Nicholson & K. Andrew White p493 | doi:10.1038/nrmicro3288 Long-range intragenomic RNA–RNA interactions in the genomes of positive-strand RNA viruses involve direct nucleotide base pairing and can span distances of thousands of nucleotides. In this Review, Nicholson and White discuss recent insights into the structure and function of these genomic features and highlight their diverse roles in the gene expression and genome replication of positive-strand RNA viruses. Abstract | Full Text | PDF
Article series: Vector-borne diseases Motility and more: the flagellum of Trypanosoma brucei Gerasimos Langousis & Kent L. Hill p505 | doi:10.1038/nrmicro3274 The protozoan parasite Trypanosoma brucei has a single flagellum that is present in all of its different developmental stages. In this Review, Langousis and Hill discuss the structural and functional features of the flagellum and highlight its central role in the virulence and transmission of this important human pathogen. Abstract | Full Text | PDF | Supplementary information
ANALYSIS		Top
The elemental composition of virus particles: implications for marine biogeochemical cycles Luis F. Jover, T. Chad Effler, Alison Buchan, Steven W. Wilhelm & Joshua S. Weitz p519 | doi:10.1038/nrmicro3289 Weitz and colleagues use a biophysical scaling model of intact virus particles to quantify differences in the elemental stoichiometry of marine viruses compared with their microbial hosts. They propose that, under certain circumstances, marine virus populations could make a previously unrecognised and important contribution to the reservoir and cycling of oceanic phosphorus. Abstract | Full Text | PDF | Supplementary information
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