Nature Reviews Molecular Cell Biology contents July 2014 Volume 15 Number 7 pp 427-496

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TABLE OF CONTENTS
July 2014 Volume 15 Number 7
Impact Factor 37.162 *	In this issue Research Highlights Reviews Also this month Article series: Technologies and techniques DNA damage  Featured article: Cellular senescence: from physiology to pathology Daniel Muñoz-Espín & Manuel Serrano
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RESEARCH HIGHLIGHTS Top Epigenetics: The TRPM7 ion channel modifies histones p427 | doi:10.1038/nrm3824 The kinase portion of the ion channel TRPM7 binds to components of chromatin-remodelling complexes and phosphorylates histones. PDF Gene Expression: β-globin transcription activation: LDB1 looping it all together p428 | doi:10.1038/nrm3830 Chromatin looping and transcription activation at the β-globin locus are separate processes that are mediated by LDB1. PDF Stem cells: Keeping alert p428 | doi:10.1038/nrm3834 Quiescent muscle stem cells transition from a G0 to a GAlert state in response to injury and mTORC1 signalling. PDF Transcription: Transcript elongation: pause at your peril p430 | doi:10.1038/nrm3818 The DNA helicase RECQL5 has a role in moderating transcription stress levels and consequently in suppressing chromosomal breaks. PDF Endocytosis: Bend it like galectin 3 p430 | doi:10.1038/nrm3820 Galectin 3 binds to glycosylated cargos and glycosphingolipids, which leads to membrane bending and clathrin-independent carrier biogenesis. PDF JOURNAL CLUB A silent revolution in chromosome biology p431 | doi:10.1038/nrm3817 Frank Uhlmann discusses how biophysics and electron microscopy studies have shed light on what lies inside chromosomes. PDF IN BRIEF Metabolism: CDK4 suppresses gluconeogenesis | RNA metabolism: Heat stresses splicing | Technique: Single-cell western blotting | Metabolism: LSD1 tunes adipose tissues | Cell cycle: Making the spindle checkpoint strong | Cell migration: Dynamic junctions during group travel PDF Nature Reviews Molecular Cell Biology JOBS of the week Postdoctoral Research Associate in Molecular Biology, Cell Biology & Virology University of Oxford Postdoctoral Fellow Baylor College of Medicine and Texas Children's Hospital Senior Postdoctoral Fellow Loma Linda University (LLU) Postdoctoral Researcher UT M. D. Anderson Cancer Center More Science jobs from Nature Reviews Molecular Cell Biology EVENT Molecular Switches 24.09.14 Prien, Germany More science events from
Corrigendum: The lipid trade William A. Prinz p430 | doi:10.1038/nrm3825 Full Text | PDF
REVIEWS		Top
Polo-like kinases: structural variations lead to multiple functions Sihem Zitouni et al. p433 | doi:10.1038/nrm3819 Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response. Recent structural and molecular studies have revealed how such processes depend on the tight regulation of PLK abundance, activity, localization and interactions with other proteins, and how dysregulation may be associated with disease. Abstract | Full Text | PDF | Supplementary information
Article series: Technologies and techniques The emergence of proteome-wide technologies: systematic analysis of proteins comes of age Michal Breker & Maya Schuldiner p453 | doi:10.1038/nrm3821 Large-scale methodologies to facilitate the systematic measurement of protein abundance, translation level, turnover rate, post-translational modification, localization and interaction with other proteins are beginning to enable dynamic assessments of proteomes at the single-cell level. Abstract | Full Text | PDF
Article series: DNA damage Understanding nucleotide excision repair and its roles in cancer and ageing Jurgen A. Marteijn, Hannes Lans, Wim Vermeulen & Jan H. J. Hoeijmakers p465 | doi:10.1038/nrm3822 Nucleotide excision repair (NER) eliminates structurally diverse DNA lesions by repairing helix-distorting damage throughout the genome as well as transcription-blocking lesions. NER defects result in a wide range of disease phenotypes and recent findings have led to a mechanistic model that explains the complex genotype-phenotype correlations of transcription-coupled repair disorders. Abstract | Full Text | PDF
Cellular senescence: from physiology to pathology Daniel Muñoz-Espín & Manuel Serrano p482 | doi:10.1038/nrm3823 Classically associated with ageing and cancer, cellular senescence also seems to function in tissue remodelling during embryonic development and tissue repair, in which senescent cells are cleared before regeneration. Senescence is therapeutically relevant, as it can be either beneficial or detrimental in different diseases. Abstract | Full Text | PDF
Corrigendum: The amyloid state and its association with protein misfolding diseases Tuomas P. J. Knowles, Michele Vendruscolo & Christopher M. Dobson p496 | doi:10.1038/nrm3826 Full Text | PDF
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Nature Cell Biology  SERIES ON GENOMIC INSTABILITY  The maintenance of genomic stability is crucial to prevent human diseases such as cancer. This special Series from Nature Cell Biology features Reviews covering key aspects of mechanisms causing failure in genome duplication, segregation and repair.
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