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| July 2014 Volume 15 Number 7 | |||||||||||||||||||||||||||||||||||||||||||||||
In this issue
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| REVIEWS | Top | ||||||||||||||||||||||||||||||||||||||||||||||
| Müller glial cell reprogramming and retina regeneration Daniel Goldman p431 | doi:10.1038/nrn3723 Müller glia in the fish retina respond to injury by reprogramming to a stem-cell-like state that enables them to regenerate all of the major retinal cell types. Goldman reviews our current understanding of the mechanisms that regulate this regenerative response and considers how this knowledge might be applied to improve repair in the mammalian retina. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||||||||||
| Light as a central modulator of circadian rhythms, sleep and affect Tara A. LeGates, Diego C. Fernandez & Samer Hattar p443 | doi:10.1038/nrn3743 Alterations in normal patterns of exposure to light disrupt circadian rhythms and sleep, and have a profound effect on health and mood. Hattar and colleagues describe the role of intrinsically photosensitive retinal ganglion cells in mediating the direct and indirect effects of light on mood and cognition. Abstract | Full Text | PDF | Supplementary information | |||||||||||||||||||||||||||||||||||||||||||||||
| A neurocentric perspective on glioma invasion Vishnu Anand Cuddapah, Stefanie Robel, Stacey Watkins & Harald Sontheimer p455 | doi:10.1038/nrn3765 Malignant gliomas are notoriously difficult cancers to treat. The majority of current therapeutics target the traditional oncological traits of glioma cells. In this Review, Cuddapah et al. explore the unique biology of glioma cells and propose novel, brain-specific therapeutic targets. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||||||||||
| Grid cells and cortical representation Edvard I. Moser, Yasser Roudi, Menno P. Witter, Clifford Kentros, Tobias Bonhoeffer & May-Britt Moser p466 | doi:10.1038/nrn3766 Nervous systems recreate properties of the environment in activity patterns referred to as neural representations. In this Review, Moser and colleagues examine how grid cells in the medial entorhinal cortex contribute to the neural representation of external space. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||||||||||
| PERSPECTIVES | Top | ||||||||||||||||||||||||||||||||||||||||||||||
| OPINION Is the din really harmless? Long-term effects of non-traumatic noise on the adult auditory system Boris Gourévitch, Jean-Marc Edeline, Florian Occelli & Jos J. Eggermont p483 | doi:10.1038/nrn3744 Environmental noise is thought to have a negligible influence on the auditory system, but recent data casts doubt on this assumption. In this Opinion article, Gourévitch and colleagues provide their view on how long-term exposure to environmental noise alters the way sound is represented in the adult brain. Abstract | Full Text | PDF | Supplementary information | |||||||||||||||||||||||||||||||||||||||||||||||
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| *2012 Journal Citation Report (Thomson Reuters, 2013) |
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