Nature Reviews Urology - Table of Contents alert Volume 11 Issue 6

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TABLE OF CONTENTS
June 2014 Volume 11 Number 6
Impact Factor 4.793*	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Prostate cancer in young men: an important clinical entity Claudia A. Salinas, Alex Tsodikov, Miriam Ishak-Howard & Kathleen A. Cooney
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RESEARCH HIGHLIGHTS Top Paediatrics: Antimicrobial prophylaxis for vesicoureteral reflux—where will the RIVUR study lead us? Published online: 20 May 2014 p301 | doi:10.1038/nrurol.2014.112 PDF Bladder cancer: Root cause of bladder cancer revealed Published online: 13 May 2014 p302 | doi:10.1038/nrurol.2014.108 PDF Prostate cancer: Novel targeting of androgen signalling in CRPC Published online: 13 May 2014 p303 | doi:10.1038/nrurol.2014.107 PDF Imaging: fMRI developments promise understanding of voiding dysfunction Published online: 13 May 2014 p303 | doi:10.1038/nrurol.2014.113 PDF Sexual dysfunction: Premature ejaculation and female sexual satisfaction Published online: 13 May 2014 p304 | doi:10.1038/nrurol.2014.114 PDF Pathology: Clinical benefit of scrotal specimen analysis questioned Published online: 20 May 2014 p304 | doi:10.1038/nrurol.2014.115 PDF Paediatrics: Dipstick adequate for febrile UTI test Published online: 20 May 2014 p304 | doi:10.1038/nrurol.2014.116 PDF Prostate cancer: Mixed responses to ipilimumab Published online: 27 May 2014 p305 | doi:10.1038/nrurol.2014.121 PDF Prostate cancer: Combined FEC-PET/MRI improves diagnostic accuracy Published online: 13 May 2014 p306 | doi:10.1038/nrurol.2014.111 PDF Testicular cancer: Identifying occult metastatic seminoma using two small RNAs Published online: 27 May 2014 p306 | doi:10.1038/nrurol.2014.117 PDF Prostate cancer: European urologists prefer surgery for high-risk prostate cancer Published online: 27 May 2014 p307 | doi:10.1038/nrurol.2014.122 PDF Imaging: Routine imaging unnecessary after blunt renal trauma Published online: 27 May 2014 p307 | doi:10.1038/nrurol.2014.123 PDF Bladder cancer: Accelerating MVAC Published online: 27 May 2014 p307 | doi:10.1038/nrurol.2014.128 PDF IN BRIEF Prostate cancer: Assay to predict negative repeat biopsies validated | Bladder cancer: Long-term oncological outcomes similar for RARC and ORC | Prostate cancer: High prevalence of screen-detected disease in Ghana | Prostate cancer: Validated tool for predicting docetaxel response in CRPC | Prostate cancer: Laparoscopic radical prostatectomy for high-risk disease | Bladder cancer: Solifenacin relieves irritative symptoms after TURBT | Stones: Kidney stones linked to increased cardiovascular risk | Incontinence: Leak point pressure predicts successful male sling surgery PDF
NEWS AND VIEWS		Top
Prostate cancer: Primary ADT monotherapy not suitable for localized disease Oliver Sartor & Jonathan Silberstein Published online: 27 May 2014 p309 | doi:10.1038/nrurol.2014.119 Although current guidelines do not endorse the use of primary androgen deprivation therapy (PADT) as monotherapy for localized prostate cancer, many patients continue to receive this treatment. New outcomes research confirms that there is no clear reason for use of PADT in men with localized prostate cancer. Full Text | PDF
Bladder cancer: Bladder preservation—learning what we don't know Maha Hussain & Dan Theodorescu Published online: 20 May 2014 p310 | doi:10.1038/nrurol.2014.102 Bladder preservation for patients with muscle-invasive bladder cancer has the potential to offer a quality-of-life advantage, but owing to the lack of randomized trials oncological equivalence to surgery has not been demonstrated. A new article provides a comprehensive overview of the current status of this procedure, but raises timely and important questions. Full Text | PDF
Prostate cancer: Surgery versus observation for localized prostate cancer Roderick C. N. van den Bergh & Gianluca Giannarini Published online: 13 May 2014 p312 | doi:10.1038/nrurol.2014.109 A key study comparing radical prostatectomy and watchful waiting for prostate cancer has been updated with extended follow-up observation, demonstrating substantial benefits of surgery for reduced mortality mainly in younger men, but also reduced requirement for palliative treatment in older men. These findings should be interpreted within the current scenario of prostate cancer diagnosis and treatment. Full Text | PDF
Incontinence: A novel, psychometrically validated bladder diary for LUTS Stefano Salvatore & Umberto Leone Roberti Maggiore Published online: 20 May 2014 p314 | doi:10.1038/nrurol.2014.110 The recently developed International Consultation on Incontinence Questionnaire Bladder Diary is the first psychometrically validated urinary diary. It provides clinicians and researchers with an invaluable diagnostic tool that will contribute to improved management of patients with lower urinary tract symptoms, and can now be considered the gold standard of bladder diaries. Full Text | PDF
Kidney cancer: Bisphosphonates in the era of antiangiogenic targeted therapy Frederik C. Roos Published online: 03 June 2014 p315 | doi:10.1038/nrurol.2014.120 Bone is the second most common metastatic site in patients presenting with metastatic renal cell carcinoma. Bisphosphonates have been approved to reduce bone pain and the risk of skeletal-related events (SREs) in such patients; however, new research suggests bisphosphonates do not improve survival or prevent development of SREs. Full Text | PDF
REVIEWS		Top
Prostate cancer in young men: an important clinical entity Claudia A. Salinas, Alex Tsodikov, Miriam Ishak-Howard & Kathleen A. Cooney Published online: 13 May 2014 p317 | doi:10.1038/nrurol.2014.91 Current data suggest that early-onset prostate cancer is a distinct clinicopathological subtype of prostate cancer, with more rapid progression to disease-specific death than late-onset prostate cancer of similar stage and grade. Here, the authors discuss the epidemiology of early-onset prostate cancer and the unique challenges it poses. Abstract | Full Text | PDF
Urological applications of natural orifice transluminal endoscopic surgery (NOTES) Mark D. Tyson & Mitchell R. Humphreys Published online: 13 May 2014 p324 | doi:10.1038/nrurol.2014.96 Natural orifice transluminal endoscopic surgery (NOTES) can reduce or eliminate altogether the need for external incisions and might, therefore, improve the outcomes of surgery compared with open and even laparoscopic methodologies. Herein, the historical development, the current status and the future of NOTES nephrectomy, radical prostatectomy and cystectomy are discussed. Abstract | Full Text | PDF
Renal struvite stones—pathogenesis, microbiology, and management strategies Ryan Flannigan, Wai Ho Choy, Ben Chew & Dirk Lange Published online: 13 May 2014 p333 | doi:10.1038/nrurol.2014.99 Struvite stones are a subset of kidney stones that form as a result of UTI with urease-producing pathogens, and can cause significant morbidity and mortality if left untreated or treated inadequately. Here, we provide an overview of our current understanding of the microbiology, pathogenesis, treatment, and prevention of struvite stones. Abstract | Full Text | PDF
The status of surgery in the management of high-risk prostate cancer Christian Bach, Sailaja Pisipati, Datesh Daneshwar, Mark Wright, Edward Rowe, David Gillatt, Raj Persad & Anthony Koupparis Published online: 13 May 2014 p342 | doi:10.1038/nrurol.2014.100 Radiation therapy combined with androgen-deprivation therapy has become the standard-of-care treatment for patients with high-risk prostate cancer; however, superiority of this approach over other therapeutic options, such as surgery, has not been clearly demonstrated. This Review provides a comprehensive overview of the current status of surgery in the treatment of high-risk prostate cancer and highlights the findings that might underlie the increasing use of radical prostatectomy as the first-line treatment among patients with this disease. Abstract | Full Text | PDF
Quality-of-life assessment tools for men with prostate cancer Jonathan Bergman & Aaron Laviana Published online: 20 May 2014 p352 | doi:10.1038/nrurol.2014.101 Quality-of-life assessment tools give patients and health-care providers a nuanced understanding not only of how long patients will survive, but also how well they will live. Bergman and Laviana describe the range of tools used to assess quality of life in men with prostate cancer. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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