Scientific Reports Table of Contents e-alert: 24 June 2014

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24 June 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports             Jump to the content that matters to you ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Health Sciences               Biological Sciences ▲ top               Differential responses to thermal variation between fitness metrics ▶     Sabrina Clavijo-Baquet, Francisca Boher, Lucia Ziegler et al.     Temperature is a major factor affecting population abundance and individual performance. Net reproductive rate (R0) and intrinsic rate of increase (r) differ in their response to …             Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma ▶     Bingli Wu, Chunquan Li, Zepeng Du et al.     LCN2 (lipocalin 2) is a member of the lipocalin family of proteins that transport small, hydrophobic ligands. LCN2 is elevated in various cancers including esophageal squamous …             Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells ▶     Yilan Zhang, Xianglian Ge, Fayu Yang et al.     CRISPR/Cas9 -mediated DNA cleavage (CCMDC) is becoming increasingly used for efficient genome engineering. Proto-spacer adjacent motif (PAM) adjacent to target sequence is one of …             3′UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network ▶     Li Li, Duolin Wang, Mengzhu Xue et al.     Competing endogenous RNA (ceRNA) interactions form a multilayered network that regulates gene expression in various biological pathways. Recent studies have demonstrated novel …             Differential requirement of GRP94 and GRP78 in mammary gland development ▶     Genyuan Zhu, Miao Wang, Benjamin Spike et al.     Glucose Regulated Protein (GRP) 94 and GRP78 are critical molecular chaperones and regulators of signaling. Conditional knockout mouse models have revealed tissue specific …             Green strategy from waste to value-added-chemical production: efficient biosynthesis of 6-hydroxy-3-succinoyl-pyridine by an engineered biocatalyst ▶     Hao Yu, Hongzhi Tang, Ping Xu     Value-added intermediates produced by microorganisms during the catabolism of N-heterocycles are potential building blocks for agrochemical synthesis and pharmaceutical …             Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system ▶     Tetsushi Sakuma, Ayami Nishikawa, Satoshi Kume et al.     CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications, not only for single gene targeting, but also for multiple targeted mutagenesis. To …             Professional diversity and the productivity of cities ▶     Luís M. A. Bettencourt, Horacio Samaniego, Hyejin Youn     Attempts to understand the relationship between diversity, productivity and scale have remained limited due to the scheme-dependent nature of the taxonomies describing complex …             Three-dimensional super-resolution and localization of dense clusters of single molecules ▶     Anthony Barsic, Ginni Grover, Rafael Piestun     When a single molecule is detected in a wide-field microscope, the image approximates the point spread function of the system. However, as the distribution of molecules becomes …             Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems ▶     Takashi Nakano, Catherine Chin, David Mo Aung Myint et al.     Existing nanoscale chemical delivery systems target diseased cells over long, sustained periods of time, typically through one-time, destructive triggering. Future directions lie …             Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique ▶     Wanjuan Chen, Jingxin Liu, Longmei Zhang et al.     Human induced pluripotent stem cells (iPSC) can be used to understand the pathological mechanisms of human disease. These cells are a promising source for cell-replacement …             Rational design and validation of a Tip60 histone acetyltransferase inhibitor ▶     Chunxia Gao, Emer Bourke, Martin Scobie et al.     Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including …             Tyrosinase-catalyzed site-specific immobilization of engineered C-phycocyanin to surface ▶     Greta Faccio, Michael M. Kämpf, Chiara Piatti et al.     Enzymatic crosslinking of proteins is often limited by the steric availability of the target residues, as of tyrosyl side chains in the case of tyrosinase. Carrying an N-terminal …             Visual tracking combined with hand-tracking improves time perception of moving stimuli ▶     Alessandro Carlini, Robert French     A number of studies have shown that performing a secondary task while executing a time-judgment task impairs performance on the latter task. However, this turns out not to be the …             Epigenetic Regulation by Chromatin Activation Mark H3K4me3 in Primate Progenitor Cells within Adult Neurogenic Niche ▶     Richard S. Sandstrom, Michael R. Foret, Douglas A. Grow et al.     Histone 3 lysine 4 trimethylation (H3K4me3) is known to be associated with transcriptionally active or poised genes and required for postnatal neurogenesis within the …             Analysis of phytoplasma-responsive sRNAs provide insight into the pathogenic mechanisms of mulberry yellow dwarf disease ▶     Ying-Ping Gai, Yi-Qun Li, Fang-Yue Guo et al.     The yellow dwarf disease associated with phytoplasmas is one of the most devastating diseases of mulberry and the pathogenesis involved in the disease is poorly understood. To …             Atomic force microscopy based nanoassay: a new method to study α-Synuclein-dopamine bioaffinity interactions ▶     Stefania Corvaglia, Barbara Sanavio, Rolando P. Hong Enriquez et al.     Intrinsically Disordered Proteins (IDPs) are characterized by the lack of well-defined 3-D structure and show high conformational plasticity. For this reason, they are a strong …             Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells ▶     Yan Zhou, Kai Sun, Yi Ma et al.     The tumor microenvironment, including ischemia, has been increasingly recognized as a critical factor in the process of tumor development. Hypoxia and nutrient deficiency …             Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy, and Mammary Gland Fibroma ▶     Changsong Wang, Bo Sun, Lei Guo et al.     The association between cancer and volatile organic metabolites in exhaled breaths has attracted increasing attention from researchers. The present study reports on a systematic …             Quantifying the impact of exogenous abscisic acid and gibberellins on pre-maturity α-amylase formation in developing wheat grains ▶     Kirtikumar R. Kondhare, Peter Hedden, Peter S. Kettlewell et al.     To study the role of abscisic acid (ABA) and gibberellins (GA) in pre-maturity α-amylase (PMA) formation in developing wheat grain, two glasshouse experiments were conducted under …             Light-induced rapid Ca2+ response and MAPK phosphorylation in the cells heterologously expressing human OPN5 ▶     Takashi Sugiyama, Hirobumi Suzuki, Takeo Takahashi     Molecular imaging is a powerful tool for investigating intracellular signalling, but it is difficult to acquire conventional fluorescence imaging from photoreceptive cells. Here …             Luminescent threat: toxicity of light stick attractors used in pelagic fishery ▶     Tiago Franco de Oliveira, Amanda Lucila Medeiros da Silva, Rafaela Alves de Moura et al.     Light sticks (LS) are sources of chemiluminescence commonly used in pelagic fishery, where hundreds are discarded and reach the shores. Residents from fishing villages report an …             Brain signatures of moral sensitivity in adolescents with early social deprivation ▶     María Josefina Escobar, David Huepe, Jean Decety et al.     The present study examined neural responses associated with moral sensitivity in adolescents with a background of early social deprivation. Using high-density …             Survey of the Japanese Coast Reveals Abundant Placozoan Populations in the Northern Pacific Ocean ▶     Hiroaki Nakano     Placozoans are the simplest extant free-living animals consisting of only five cell types and lacking neurons and muscle cells. Their phylogenetic position implies they are …             Analysis of interactions between SNARE proteins using imaging ellipsometer coupled with microfluidic array ▶     Cai Qi, Hong Zhang, Li Liu et al.     The soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins are small and abundant membrane-bound proteins, whose specific interactions mediate membrane …             Elevated O3 enhances the attraction of whitefly-infested tomato plants to Encarsia formosa ▶     Hongying Cui, Jianwei Su, Jianing Wei et al.     We experimentally examined the effects of elevated O3 and whitefly herbivory on tomato volatiles, feeding and oviposition preferences of whiteflies and behavioural responses of …             Evolution of eukaryotic single-stranded DNA viruses of the Bidnaviridae family from genes of four other groups of widely different viruses ▶     Mart Krupovic, Eugene V. Koonin     Single-stranded (ss)DNA viruses are extremely widespread, infect diverse hosts from all three domains of life and include important pathogens. Most ssDNA viruses possess small …             Phase-contrast X-ray CT Imaging of Esophagus and Esophageal Carcinoma ▶     Jianfa Zhang, Dongping Tian, Runhua Lin et al.     The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which …             Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus ▶     Mya Myat Ngwe Tun, Kotaro Aoki, Masachika Senba et al.     Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of the TNF-α, IL-10 and other cytokines in appropriate KO mice …             All-optical regulation of gene expression in targeted cells ▶     Yisen Wang, Hao He, Shiyang Li et al.     Controllable gene expression is always a challenge and of great significance to biomedical research and clinical applications. Recently, various approaches based on …             Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis ▶     Amiq Gazdhar, Dirk Lebrecht, Michael Roth et al.     Reactive oxygen species (ROS) have been implemented in the etiology of pulmonary fibrosis (PF) in systemic sclerosis. In the bleomycin model, we evaluated the role of acquired …             Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins ▶     Hiroaki Miyashita, Miho Chikazawa, Natsuki Otaki et al.     Covalent modification of proteins exerts significant effects on their chemical properties and has important functional and regulatory consequences. We now report the …             Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population ▶     Masakazu Nakano, Yoko Ikeda, Yuichi Tokuda et al.     The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk …             Multifunctional Photosensitizer-Based Contrast Agents for Photoacoustic Imaging ▶     Chris Jun Hui Ho, Ghayathri Balasundaram, Wouter Driessen et al.     Photoacoustic imaging is a novel hybrid imaging modality combining the high spatial resolution of optical imaging with the high penetration depth of ultrasound imaging. Here, for …             Lp(a) is not associated with diabetes but affects fibrinolysis and clot structure ex vivo ▶     Marianne Månsson, Inge Kalies, Göran Bergström et al.     Lipoprotein (a) [Lp(a)] is a low density lipoprotein (LDL) with one apolipoprotein (a) molecule bound to the apolipoprotein B-100 of LDL. Lp(a) is an independent risk factor for …             Short-term effects of different genetically modified maize varieties on arthropod food web properties: an experimental field assessment ▶     Ágnes Szénási, Zoltán Pálinkás, Mihály Zalai et al.     There is concern that genetically modified (GM) plants may have adverse affects on the arthropod biodiversity comprising agricultural landscapes. The present study report on a two …             Chromosome Instability in mouse Embryonic Stem Cells ▶     Nerea Gaztelumendi, Carme Nogués     Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell …             Prioritising in situ conservation of crop resources: A case study of African cowpea (Vigna unguiculata) ▶     C. Moray, E. T. Game, N. Maxted     Conserving crop wild relatives (CWR) is critical for maintaining food security. However, CWR-focused conservation plans are lacking, and are often based on the entire genus, even …             Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology ▶     Feng Li, Dale O. Cowley, Debra Banner et al.     Humanized mouse models have become increasingly important and widely used in modeling human diseases in biomedical research. Immunodeficient mice such as NOD-Rag1-/-IL2RgammaC-null…             Multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors ▶     Robert J. Paproski, Andrew Heinmiller, Keith Wachowicz et al.     Photoacoustic imaging is an emerging hybrid imaging technology capable of breaking through resolution limits of pure optical imaging technologies imposed by optical-scattering to …             Parity and pancreatic cancer risk: evidence from a meta-analysis of twenty epidemiologic studies ▶     Beibei Zhu, Li Zou, Juan Han et al.     Multiple studies have hypothesized parity is associated with pancreatic cancer risk but obtained conflicting results. We conducted a meta-analysis (including a dose-response …                 Nature Reviews Neurology  Focus on Epilepsy    In this special focus issue, cutting-edge investigators from around the world highlight the important challenges and progress in epilepsy research and clinical practice.   Produced with financial support from UCB         Chemical Sciences ▲ top               Convenient, Sensitive and High-Throughput Method for Screening Botanic Origin ▶     Yuan Yuan, Chao Jiang, Libing Liu et al.     In this work, a rapid (within 4–5 h), sensitive and visible new method for assessing botanic origin is developed by combining loop-mediated isothermal amplification with cationic …             Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique ▶     Wanjuan Chen, Jingxin Liu, Longmei Zhang et al.     Human induced pluripotent stem cells (iPSC) can be used to understand the pathological mechanisms of human disease. These cells are a promising source for cell-replacement …             Facile strain analysis of largely bending films by a surface-labelled grating method ▶     Norihisa Akamatsu, Wataru Tashiro, Keisuke Saito et al.     Mechanical properties of flexible films, for example surface strain of largely bending films, are key to design of stretchable electronic devices, wearable biointegrated devices, …             New Vanadium Compounds in Venezuela Heavy Crude Oil Detected by Positive-ion Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry ▶     Xu Zhao, Quan Shi, Murray R. Gray et al.     Metalloporphyrins are ubiquitous in nature, particularly iron porphyrins (hemes) and magnesium dihydroporphyrins or chlorophylls. Oxovanadium (IV) complexes of alkyl porphyrins …             Electrochemical response of metal complexes in homogeneous solution under photoirradiation ▶     Arisa Fukatsu, Mio Kondo, Masaya Okamura et al.     The electrochemical detection of metal complexes in the photoexcited state is important for understanding photoinduced electron transfer (PET) processes, which play a central role …             A label-free fluorescent probe for Hg2+ and biothiols based on graphene oxide and Ru-complex ▶     Linlin Wang, Tianming Yao, Shuo Shi et al.     A novel, selective and sensitive switch-on fluorescent sensor for Hg2 and switch-off fluorescent probe for biothiols was developed by using [Ru(bpy)2(pip)]2 as the signal reporter …             An Extended Phenacene-type Molecule, [8]Phenacene: Synthesis and Transistor Application ▶     Hideki Okamoto, Ritsuko Eguchi, Shino Hamao et al.     A new phenacene-type molecule, [8]phenacene, which is an extended zigzag chain of coplanar fused benzene rings, has been synthesised for use in an organic field-effect transistor …             A new silver nanorod SPR probe for detection of trace benzoyl peroxide ▶     Zhiliang Jiang, Guiqing Wen, Yanghe Luo et al.     The stable silver nanorod (AgNR) sol in red was prepared by the two-step procedure of NaBH4-H2O2 and citrate heating reduction. The AgNR had a transverse and a longitudinal …                     Physical Sciences ▲ top               Structural and electronic analysis of the atomic scale nucleation of Ag on α-Ag2WO4 induced by electron irradiation ▶     Juan Andrés, Lourdes Gracia, Patricio Gonzalez-Navarrete et al.     In this work, we utilise a combination of theory, computation and experiments to understand the early events related to the nucleation of Ag filaments on α-Ag2WO4 crystals, which …             The Italian primary school-size distribution and the city-size: a complex nexus ▶     Alessandro Belmonte, Riccardo Di Clemente, Sergey V. Buldyrev     We characterize the statistical law according to which Italian primary school-size distributes. We find that the school-size can be approximated by a log-normal distribution, with …             Fabrication of full-color InGaN-based light-emitting diodes on amorphous substrates by pulsed sputtering ▶     Jeong Woo Shon, Jitsuo Ohta, Kohei Ueno et al.     InGaN-based light-emitting diodes (LEDs) have been widely accepted as highly efficient light sources capable of replacing incandescent bulbs. However, applications of InGaN LEDs …             Lithographically Defined Three-dimensional Pore-patterned Carbon with Nitrogen Doping for High-Performance Ultrathin Supercapacitor Applications ▶     Da-Young Kang, Jun Hyuk Moon     Supercapacitors that exhibit long cycle lives and fast charge/discharge rates are a promising energy-storage technology for next-generation mobile or wearable electronic systems. …             Transfer Entropy and Transient Limits of Computation ▶     Mikhail Prokopenko, Joseph T. Lizier     Transfer entropy is a recently introduced information-theoretic measure quantifying directed statistical coherence between spatiotemporal processes, and is widely used in diverse …             Three-dimensional super-resolution and localization of dense clusters of single molecules ▶     Anthony Barsic, Ginni Grover, Rafael Piestun     When a single molecule is detected in a wide-field microscope, the image approximates the point spread function of the system. However, as the distribution of molecules becomes …             Triggered dynamics in a model of different fault creep regimes ▶     Srđan Kostić, Igor Franović, Matjaž Perc et al.     The study is focused on the effect of transient external force induced by a passing seismic wave on fault motion in different creep regimes. Displacement along the fault is …             Fully Roll-to-Roll Gravure Printable Wireless (13.56 MHz) Sensor-Signage Tags for Smart Packaging ▶     Hwiwon Kang, Hyejin Park, Yongsu Park et al.     Integration of sensing capabilities with an interactive signage through wireless communication is enabling the development of smart packaging wherein wireless (13.56 MHz) power …             Controllability and observability analysis for vertex domination centrality in directed networks ▶     Bingbo Wang, Lin Gao, Yong Gao et al.     Topological centrality is a significant measure for characterising the relative importance of a node in a complex network. For directed networks that model dynamic processes, …             Convenient, Sensitive and High-Throughput Method for Screening Botanic Origin ▶     Yuan Yuan, Chao Jiang, Libing Liu et al.     In this work, a rapid (within 4–5 h), sensitive and visible new method for assessing botanic origin is developed by combining loop-mediated isothermal amplification with cationic …             Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems ▶     Takashi Nakano, Catherine Chin, David Mo Aung Myint et al.     Existing nanoscale chemical delivery systems target diseased cells over long, sustained periods of time, typically through one-time, destructive triggering. Future directions lie …             Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique ▶     Wanjuan Chen, Jingxin Liu, Longmei Zhang et al.     Human induced pluripotent stem cells (iPSC) can be used to understand the pathological mechanisms of human disease. These cells are a promising source for cell-replacement …             Professional diversity and the productivity of cities ▶     Luís M. A. Bettencourt, Horacio Samaniego, Hyejin Youn     Attempts to understand the relationship between diversity, productivity and scale have remained limited due to the scheme-dependent nature of the taxonomies describing complex …             Facile strain analysis of largely bending films by a surface-labelled grating method ▶     Norihisa Akamatsu, Wataru Tashiro, Keisuke Saito et al.     Mechanical properties of flexible films, for example surface strain of largely bending films, are key to design of stretchable electronic devices, wearable biointegrated devices, …             Connecting Core Percolation and Controllability of Complex Networks ▶     Tao Jia, Márton Pósfai     Core percolation is a fundamental structural transition in complex networks related to a wide range of important problems. Recent advances have provided us an analytical framework …             Graphene/Si-nanowire heterostructure molecular sensors ▶     Jungkil Kim, Si Duk Oh, Ju Hwan Kim et al.     Wafer-scale graphene/Si-nanowire (Si-NW) array heterostructures for molecular sensing have been fabricated by vertically contacting single-layer graphene with high-density Si NWs. …             Mean first-passage time for maximal-entropy random walks in complex networks ▶     Yuan Lin, Zhongzhi Zhang     We perform an in-depth study for mean first-passage time (MFPT)—a primary quantity for random walks with numerous applications—of maximal-entropy random walks (MERW) performed in …             The Strength of the Strongest Ties in Collaborative Problem Solving ▶     Yves-Alexandre de Montjoye, Arkadiusz Stopczynski, Erez Shmueli et al.     Complex problem solving in science, engineering, and business has become a highly collaborative endeavor. Teams of scientists or engineers collaborate on projects using their …             Wetting failure of hydrophilic surfaces promoted by surface roughness ▶     Meng-Hua Zhao, Xiao-Peng Chen, Qing Wang     Wetting failure is of vital importance to many physical phenomena, such as industrial coating and drop emission. Here we show when and how the surface roughness promotes the …             New Vanadium Compounds in Venezuela Heavy Crude Oil Detected by Positive-ion Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry ▶     Xu Zhao, Quan Shi, Murray R. Gray et al.     Metalloporphyrins are ubiquitous in nature, particularly iron porphyrins (hemes) and magnesium dihydroporphyrins or chlorophylls. Oxovanadium (IV) complexes of alkyl porphyrins …             Layer Anti-Ferromagnetism on Bilayer Honeycomb Lattice ▶     Hong-Shuai Tao, Yao-Hua Chen, Heng-Fu Lin et al.     Bilayer honeycomb lattice, with inter-layer tunneling energy, has a parabolic dispersion relation, and the inter-layer hopping can cause the charge imbalance between two …             Strong Anisotropy of Dirac Cones in SrMnBi2 and CaMnBi2 Revealed by Angle-Resolved Photoemission Spectroscopy ▶     Ya Feng, Zhijun Wang, Chaoyu Chen et al.     The Dirac materials, such as graphene and three-dimensional topological insulators, have attracted much attention because they exhibit novel quantum phenomena with their low …             Metal Oxide Induced Charge Transfer Doping and Band Alignment of Graphene Electrodes for Efficient Organic Light Emitting Diodes ▶     Jens Meyer, Piran R. Kidambi, Bernhard C. Bayer et al.     The interface structure of graphene with thermally evaporated metal oxide layers, in particular molybdenum trioxide (MoO3), is studied combining photoemission spectroscopy, sheet …             Induced Ferromagnetism at BiFeO3/YBa2Cu3O7 Interfaces ▶     Jian-Xin Zhu, Xiao-Dong Wen, J. T. Haraldsen et al.     Transition metal oxides (TMOs) exhibit many emergent phenomena ranging from high-temperature superconductivity and giant magnetoresistance to magnetism and ferroelectricity. In …             Hybrid architecture for encoded measurement-based quantum computation ▶     M. Zwerger, H. J. Briegel, W. Dür     We present a hybrid scheme for quantum computation that combines the modular structure of elementary building blocks used in the circuit model with the advantages of a …             Spatial correlation analysis of cascading failures: Congestions and Blackouts ▶     Li Daqing, Jiang Yinan, Kang Rui et al.     Cascading failures have become major threats to network robustness due to their potential catastrophic consequences, where local perturbations can induce global propagation of …             Atomic force microscopy based nanoassay: a new method to study α-Synuclein-dopamine bioaffinity interactions ▶     Stefania Corvaglia, Barbara Sanavio, Rolando P. Hong Enriquez et al.     Intrinsically Disordered Proteins (IDPs) are characterized by the lack of well-defined 3-D structure and show high conformational plasticity. For this reason, they are a strong …             Tyrosinase-catalyzed site-specific immobilization of engineered C-phycocyanin to surface ▶     Greta Faccio, Michael M. Kämpf, Chiara Piatti et al.     Enzymatic crosslinking of proteins is often limited by the steric availability of the target residues, as of tyrosyl side chains in the case of tyrosinase. Carrying an N-terminal …             Surface Nanostructures in Manganite Films ▶     A. Gambardella, P. Graziosi, I. Bergenti et al.     Ultrathin manganite films are widely used as active electrodes in organic spintronic devices. In this study, a scanning tunnelling microscopy (STM) investigation with atomic …             A High-yield Two-step Transfer Printing Method for Large-scale Fabrication of Organic Single-crystal Devices on Arbitrary Substrates ▶     Wei Deng, Xiujuan Zhang, Huanhuan Pan et al.     Single-crystal organic nanostructures show promising applications in flexible and stretchable electronics, while their applications are impeded by the large incompatibility with …             Developing Gradient Metal Alloys through Radial Deposition Additive Manufacturing ▶     Douglas C. Hofmann, Scott Roberts, Richard Otis et al.     Interest in additive manufacturing (AM) has dramatically expanded in the last several years, owing to the paradigm shift that the process provides over conventional manufacturing. …             Ultrafast and versatile spectroscopy by temporal Fourier transform ▶     Chi Zhang, Xiaoming Wei, Michel E. Marhic et al.     One of the most remarkable and useful properties of a spatially converging lens system is its inherent ability to perform the Fourier transform; the same applies for the time-lens …             High Energy Product Developed from Cobalt Nanowires ▶     Kinjal Gandha, Kevin Elkins, Narayan Poudyal et al.     Cobalt nanowires with high aspect ratio have been synthesized via a solvothermal chemical process. Based on the shape anisotropy and orientation of the nanowire assemblies, a …             Measuring spatial correlations of photon pairs by automated raster scanning with spatial light modulators ▶     E. C. Paul, M. Hor-Meyll, P. H. Souto Ribeiro et al.     We demonstrate the use of a phase-only spatial light modulator for the measurement of transverse spatial distributions of coincidence counts between twin photon beams, in a fully …             Formation mechanism and optimization of highly luminescent N-doped graphene quantum dots ▶     Dan Qu, Min Zheng, Ligong Zhang et al.     Photoluminescent graphene quantum dots (GQDs) have received enormous attention because of their unique chemical, electronic and optical properties. Here a series of GQDs were …             Effect of Mechanical Loads on Stability of Nanodomains in Ferroelectric Ultrathin Films: Towards Flexible Erasing of the Non-Volatile Memories ▶     W. J. Chen, Yue Zheng, W. M. Xiong et al.     Intensive investigations have been drawn on nanoscale ferroelectrics for their prospective applications such as developing memory devices. In contrast with the commonly used …             Novel synaptic memory device for neuromorphic computing ▶     Saptarshi Mandal, Ammaarah El-Amin, Kaitlyn Alexander et al.     This report discusses the electrical characteristics of two-terminal synaptic memory devices capable of demonstrating an analog change in conductance in response to the varying …             Long-range electronic reconstruction to a dxz,yz-dominated Fermi surface below the LaAlO3/SrTiO3 interface ▶     A. P. Petrović, A. Paré, T. R. Paudel et al.     Low dimensionality, broken symmetry and easily-modulated carrier concentrations provoke novel electronic phase emergence at oxide interfaces. However, the spatial extent of such …             Temporal scaling in information propagation ▶     Junming Huang, Chao Li, Wen-Qiang Wang et al.     For the study of information propagation, one fundamental problem is uncovering universal laws governing the dynamics of information propagation. This problem, from the …             All-optical regulation of gene expression in targeted cells ▶     Yisen Wang, Hao He, Shiyang Li et al.     Controllable gene expression is always a challenge and of great significance to biomedical research and clinical applications. Recently, various approaches based on …             Multifunctional Photosensitizer-Based Contrast Agents for Photoacoustic Imaging ▶     Chris Jun Hui Ho, Ghayathri Balasundaram, Wouter Driessen et al.     Photoacoustic imaging is a novel hybrid imaging modality combining the high spatial resolution of optical imaging with the high penetration depth of ultrasound imaging. Here, for …             Electrochemical response of metal complexes in homogeneous solution under photoirradiation ▶     Arisa Fukatsu, Mio Kondo, Masaya Okamura et al.     The electrochemical detection of metal complexes in the photoexcited state is important for understanding photoinduced electron transfer (PET) processes, which play a central role …             A label-free fluorescent probe for Hg2+ and biothiols based on graphene oxide and Ru-complex ▶     Linlin Wang, Tianming Yao, Shuo Shi et al.     A novel, selective and sensitive switch-on fluorescent sensor for Hg2 and switch-off fluorescent probe for biothiols was developed by using [Ru(bpy)2(pip)]2 as the signal reporter …             A new silver nanorod SPR probe for detection of trace benzoyl peroxide ▶     Zhiliang Jiang, Guiqing Wen, Yanghe Luo et al.     The stable silver nanorod (AgNR) sol in red was prepared by the two-step procedure of NaBH4-H2O2 and citrate heating reduction. The AgNR had a transverse and a longitudinal …             PIN architecture for ultrasensitive organic thin film photoconductors ▶     Zhiwen Jin, Jizheng Wang     Organic thin film photoconductors (OTFPs) are expected to have wide applications in the field of optical communications, artificial vision and biomedical sensing due to their …             An Extended Phenacene-type Molecule, [8]Phenacene: Synthesis and Transistor Application ▶     Hideki Okamoto, Ritsuko Eguchi, Shino Hamao et al.     A new phenacene-type molecule, [8]phenacene, which is an extended zigzag chain of coplanar fused benzene rings, has been synthesised for use in an organic field-effect transistor …             Spin excitations of ferronematic order in underdoped cuprate superconductors ▶     G. Seibold, C. Di Castro, M. Grilli et al.     High-temperature superconductors exhibit a characteristic hourglass-shaped spectrum of magnetic fluctuations which most likely contribute to the pairing glue in the cuprates. …             Anomalous enhancement in interfacial perpendicular magnetic anisotropy through uphill diffusion ▶     Tanmay Das, Prabhanjan D. Kulkarni, S. C. Purandare et al.     We observed interfacial chemical sharpening due to uphill diffusion in post annealed ultrathin multilayer stack of Co and Pt, which leads to enhanced interfacial perpendicular …             Structure of local interactions in complex financial dynamics ▶     X. F. Jiang, T. T. Chen, B. Zheng     With the network methods and random matrix theory, we investigate the interaction structure of communities in financial markets. In particular, based on the random matrix …             Adsorption of tetracycline from aqueous solutions onto multi-walled carbon nanotubes with different oxygen contents ▶     Fei Yu, Jie Ma, Sheng Han     Oxidized multi-walled carbon nanotubes (MWCNTs) with different oxygen contents were investigated for the adsorption of tetracycline (TC) from aqueous solutions. As the surface …               Earth & Environmental Sciences ▲ top               Professional diversity and the productivity of cities ▶     Luís M. A. Bettencourt, Horacio Samaniego, Hyejin Youn     Attempts to understand the relationship between diversity, productivity and scale have remained limited due to the scheme-dependent nature of the taxonomies describing complex …             Contrasting biogeochemical characteristics of the Oubangui River and tributaries (Congo River basin) ▶     Steven Bouillon, Athanase Yambélé, David P. Gillikin et al.     The Oubangui is a major tributary of the Congo River. We describe the biogeochemistry of contrasting tributaries within its central catchment, with watershed vegetation ranging …             Triggered dynamics in a model of different fault creep regimes ▶     Srđan Kostić, Igor Franović, Matjaž Perc et al.     The study is focused on the effect of transient external force induced by a passing seismic wave on fault motion in different creep regimes. Displacement along the fault is …             Seismic, satellite, and site observations of internal solitary waves in the NE South China Sea ▶     Qunshu Tang, Caixia Wang, Dongxiao Wang et al.     Internal solitary waves (ISWs) in the NE South China Sea (SCS) are tidally generated at the Luzon Strait. Their propagation, evolution, and dissipation processes involve numerous …             Analysis of phytoplasma-responsive sRNAs provide insight into the pathogenic mechanisms of mulberry yellow dwarf disease ▶     Ying-Ping Gai, Yi-Qun Li, Fang-Yue Guo et al.     The yellow dwarf disease associated with phytoplasmas is one of the most devastating diseases of mulberry and the pathogenesis involved in the disease is poorly understood. To …             Horizontal eddy energy flux in the world oceans diagnosed from altimetry data ▶     Chi Xu, Xiao-Dong Shang, Rui Xin Huang     During the propagation of coherent mesoscale eddies, they directly or indirectly induce many effects and interactions at different scales, implying eddies are actually serving as …             Adsorption of tetracycline from aqueous solutions onto multi-walled carbon nanotubes with different oxygen contents ▶     Fei Yu, Jie Ma, Sheng Han     Oxidized multi-walled carbon nanotubes (MWCNTs) with different oxygen contents were investigated for the adsorption of tetracycline (TC) from aqueous solutions. As the surface …             Missing Lead and High 3He/4He in Ancient Sulfides Associated with Continental Crust Formation ▶     Shichun Huang, Cin-Ty A. Lee, Qing-Zhu Yin     Major terrestrial reservoirs have Pb isotopes more radiogenic than the bulk silicate Earth. This requires a missing unradiogenic Pb reservoir, which has been argued to reside in …             Cyclone-induced rapid creation of extreme Antarctic sea ice conditions ▶     Zhaomin Wang, John Turner, Bo Sun et al.     Two polar vessels, Akademik Shokalskiy and Xuelong, were trapped by thick sea ice in the Antarctic coastal region just to the west of 144°E and between 66.5°S and 67°S in late …               Health Sciences ▲ top               Assessment of the temperature effect on childhood diarrhea using satellite imagery ▶     Zhiwei Xu, Yang Liu, Zongwei Ma et al.     A quasi-Poisson generalized linear model combined with a distributed lag non-linear model was used to quantify the main effect of temperature on emergency department visits (EDVs) …             Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique ▶     Wanjuan Chen, Jingxin Liu, Longmei Zhang et al.     Human induced pluripotent stem cells (iPSC) can be used to understand the pathological mechanisms of human disease. These cells are a promising source for cell-replacement …             Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system ▶     Masafumi Inui, Mami Miyado, Maki Igarashi et al.     Introducing a point mutation is a fundamental method used to demonstrate the roles of particular nucleotides or amino acids in the genetic elements or proteins, and is widely used …             Convenient, Sensitive and High-Throughput Method for Screening Botanic Origin ▶     Yuan Yuan, Chao Jiang, Libing Liu et al.     In this work, a rapid (within 4–5 h), sensitive and visible new method for assessing botanic origin is developed by combining loop-mediated isothermal amplification with cationic …             Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells ▶     Yan Zhou, Kai Sun, Yi Ma et al.     The tumor microenvironment, including ischemia, has been increasingly recognized as a critical factor in the process of tumor development. Hypoxia and nutrient deficiency …             Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy, and Mammary Gland Fibroma ▶     Changsong Wang, Bo Sun, Lei Guo et al.     The association between cancer and volatile organic metabolites in exhaled breaths has attracted increasing attention from researchers. The present study reports on a systematic …             Clinicopathological features and prognostic factors of young breast cancers in Eastern Guangdong of China ▶     Jin-Tao Wei, Wen-He Huang, Cai-Wen Du et al.     Breast cancer in young women is typically with higher proportion of adverse pathological features. Breast cancer with BRCA1 mutation is often early-onset, and is usually …             Luminescent threat: toxicity of light stick attractors used in pelagic fishery ▶     Tiago Franco de Oliveira, Amanda Lucila Medeiros da Silva, Rafaela Alves de Moura et al.     Light sticks (LS) are sources of chemiluminescence commonly used in pelagic fishery, where hundreds are discarded and reach the shores. Residents from fishing villages report an …             Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus ▶     Mya Myat Ngwe Tun, Kotaro Aoki, Masachika Senba et al.     Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of the TNF-α, IL-10 and other cytokines in appropriate KO mice …             Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population ▶     Masakazu Nakano, Yoko Ikeda, Yuichi Tokuda et al.     The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk …             Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis ▶     Amiq Gazdhar, Dirk Lebrecht, Michael Roth et al.     Reactive oxygen species (ROS) have been implemented in the etiology of pulmonary fibrosis (PF) in systemic sclerosis. In the bleomycin model, we evaluated the role of acquired …             Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins ▶     Hiroaki Miyashita, Miho Chikazawa, Natsuki Otaki et al.     Covalent modification of proteins exerts significant effects on their chemical properties and has important functional and regulatory consequences. We now report the …             Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology ▶     Feng Li, Dale O. Cowley, Debra Banner et al.     Humanized mouse models have become increasingly important and widely used in modeling human diseases in biomedical research. Immunodeficient mice such as NOD-Rag1-/-IL2RgammaC-null…             Lp(a) is not associated with diabetes but affects fibrinolysis and clot structure ex vivo ▶     Marianne Månsson, Inge Kalies, Göran Bergström et al.     Lipoprotein (a) [Lp(a)] is a low density lipoprotein (LDL) with one apolipoprotein (a) molecule bound to the apolipoprotein B-100 of LDL. Lp(a) is an independent risk factor for …             Parity and pancreatic cancer risk: evidence from a meta-analysis of twenty epidemiologic studies ▶     Beibei Zhu, Li Zou, Juan Han et al.     Multiple studies have hypothesized parity is associated with pancreatic cancer risk but obtained conflicting results. 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