The EMBO Journal Table of Contents for 17 June 2014; Vol. 33, No. 12

17 June 2014 | Volume 33, Number 12 Submit Table of Contents Editorial Have you seen? Review Articles Volume 33, Number 12 Editorial STAP dance Systematic image screening at EMBO Press uncovers many irregularities, which are thereby prevented from entering the scientific literature. Such mechanisms may have helped thwart publication of manipulated images in recent high‐profile papers. Bernd Pulverer Published online 05.06.2014 Have you seen? SIRT2 controls the pentose phosphate switch G6PD, the rate‐limiting enzyme of the pentose phosphate pathway, is activated by SIRT2 deacetylation to maintain cellular NADPH homeostasis during oxidative stress. Lindsay E Wu and David A Sinclair Published online 13.05.2014 NAD+ controls neural stem cell fate in the aging brain Age‐associated loss of NAD+ or Nampt, the rate‐limiting biosynthetic step for this coenzyme, accounts for the loss of neural stem/progenitor cells self‐renewal and differentiation. Christopher Wiley and Judith Campisi Published online 03.06.2014 Synapse reorganization—a new partnership revealed New findings reveal that calcium and calmodulin affect the stability of the postsynaptic scaffold by regulating palmitoylation and synaptic membrane localization of PSD‐95. Takeo Saneyoshi and Yasunori Hayashi Published online 24.04.2014 Review Focus: Molecular Memory: Immunological memory within the innate immune system As part of our review series on Molecular Memory, Joseph Sun and colleagues focus on “unconventional” immunological memory, memory responses in natural killer (NK) cells that are traditionally considered part of the innate immune system. Joseph C Sun, Sophie Ugolini, and Eric Vivier Published online 27.03.2014 Articles Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress Following oxidative stress, production of the reductant NADPH via the pentose phosphate pathway is stimulated by SIRT2‐mediated deacetylation and activation of G6PD. Yi‐Ping Wang, Li‐Sha Zhou, Yu‐Zheng Zhao, Shi‐Wen Wang, Lei‐Lei Chen, Li‐Xia Liu, Zhi‐Qiang Ling, Fu‐Jun Hu, Yi‐Ping Sun, Jing‐Ye Zhang, Chen Yang, Yi Yang, Yue Xiong, Kun‐Liang Guan, and Dan Ye Published online 25.04.2014 Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging NAD+ and the NAD+ biosynthetic enzyme Nampt decline in the aging hippocampus. Nampt ablation in adult neural stem cells in vivo reduces cell numbers, proliferation, and oligodendrogenesis. Decreases in the stem cell pool are reversed by enhancing hippocampal NAD+. Liana R Stein and Shin‐ichiro Imai Published online 08.05.2014 Capping of the N‐terminus of PSD‐95 by calmodulin triggers its postsynaptic release Ca2+ influx promotes Ca2+/calmodulin binding to the N‐terminus of PSD‐95, which blocks PSD‐95 palmitoylation leading to reduced retention of PSD‐95 at synapses. Yonghong Zhang, Lucas Matt, Tommaso Patriarchi, Zulfiqar A Malik, Dhrubajyoti Chowdhury, Deborah K Park, Alessandra Renieri, James B Ames, and Johannes W Hell Published online 04.04.2014 Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells ATP released by activated T cells induces P2X4/P2X7‐mediated calcium waves in neighboring lymphocytes leading to reduced lymphocytes motility that promotes more effective antigen scanning. Chiuhui Mary Wang, Cristina Ploia, Fabio Anselmi, Adelaida Sarukhan, and Antonella Viola Published online 19.05.2014 Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer Global chromatin occupancy‐ and gene expression data, together with ‘pseudohypoxic’ regulation of HIF1alpha stability establish a predominantly metabolic function of nuclear ARRB1 in prostate cancer. Vincent Zecchini, Basetti Madhu, Roslin Russell, Nelma Pértega‐Gomes, Anne Warren, Edoardo Gaude, Joana Borlido, Rory Stark, Heather Ireland‐Zecchini, Roheet Rao, Helen Scott, Joan Boren, Charlie Massie, Mohammad Asim, Kevin Brindle, John Griffiths, Christian Frezza, David E Neal, and Ian G Mills Published online 16.05.2014 Lysophosphatidic acid acts as a nutrient‐derived developmental cue to regulate early hematopoiesis Yolk sac phosphatidylcholines serve not only nutrient roles for the developing embryo, but can also give rise to signaling molecules that are here shown to regulate hemangioblast formation and primitive hematopoiesis in vertebrates. Haisen Li, Rui Yue, Bin Wei, Ge Gao, Jiulin Du, and Gang Pei Published online 14.05.2014 Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II‐coupled nucleosome recycling Dissection of the essential multisubunit NuA4 acetyltransferase reveals a trimeric subcomplex that interacts with elongating RNA polymerase II and functions independently to control transcription‐coupled histone exchange. Dorine Rossetto, Myriam Cramet, Alice Y Wang, Anne‐Lise Steunou, Nicolas Lacoste, Julia M Schulze, Valérie Côté, Julie Monnet‐Saksouk, Sandra Piquet, Amine Nourani, Michael S Kobor, and Jacques Côté Published online 19.05.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.