Frontiers in Cell and Developmental Biology – read our selection of open access articles

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What's an RT?   Information   Fees & Waivers   Peer Review System Dear Indiana Jones, Frontiers in Cell and Developmental Biology is thrilled to present a selection of highly viewed articles from across our specialty sections, that we feel best represent the broad scope and high-quality of the journal. We hope you enjoy reading them! Adult stem cell and mesenchymal progenitor theories of aging So-ichiro Fukada et al. In this review, the authors discuss how stem cell and other theories connect to explain the progress of aging. In addition, we consider the mesenchymal progenitor theory of aging to describing the process of aging. Human bone marrow mesenchymal progenitors: perspectives on an optimized in vitro manipulation Alex Balduino et al. In this review article, the authors propose and recommend a few procedures to be followed to facilitate the establishment of quality control standards when working with mesenchymal progenitors isolation and expansion. Grand challenges in the field of stem cell research Atsushi Asakura In this Specialty Grand Challenge article, the authors explains the current challenge of understanding the molecular mechanisms of how adult stem cells maintain their stem cell qualities: specific differentiation capability, self-renewal activity, and response to the microenvironments of the stem cell niche. Deciphering cancer heterogeneity: the biological space Xin Wei Wang et al. In this article, the authors hypothesize that specific sets of cancer hallmarks collectively occupy different tumor biological space representing the misregulation of different biological processes. In principle, a combination of different cancer hallmarks can result in new convergent molecular networks that are unique to each tumor subgroup and represent ideal druggable targets. With over 500 editors on our editorial boards, we bring all relevant areas within cell and developmental biology together on an open access platform . If you are interested in joining us, we would be delighted to hear from you! To find out more about our unique approach to scholarly publishing, or if you have any quesions for us, please visit our website or send us an email. Sincerely, The Frontiers Editorial Office cellbiology.editorial.office@frontiersin.org As a registered user of Nature Publishing Group's Web sites, our database indicates that you have opted-in to receive product information and special offers. If you no longer wish to receive these e-mails or to discontinue all e-mail services from Nature Publishing Group please update your online account. Modify My Account (Log in to be recognised as a Nature.com registrant). For further information on technical assistance | print subscriptions | other enquiries. Nature Publishing Group | Principal offices: London | New York and Tokyo, and offices in cities worldwide including Boston | Buenos Aires | Cairo | Delhi | Mumbai | Hong Kong | Madrid | Barcelona | Munich | Heidelberg | Basingstoke | Melbourne | Paris | San Francisco | Seoul and Washington DC. Macmillan Publishers Limited is a company incorporated in England & Wales under company number 785998 & whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. Nature Publishing Group | 75 Varick St Fl 9 | New York | NY 10013-1917 | USA © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All rights reserved.