Nature Reviews Endocrinology - Table of Contents alert Volume 10 Issue 8

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TABLE OF CONTENTS
August 2014 Volume 10 Number 8
Impact Factor 11.025 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Beyond intestinal soap—bile acids in metabolic control Folkert Kuipers, Vincent W. Bloks & Albert K. Groen
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RESEARCH HIGHLIGHTS Top Metabolism: Type 2 immunity at the origin of beige adipocytes Published online: 24 June 2014 p443 | doi:10.1038/nrendo.2014.99 PDF Therapy: Statin potency is associated with risk of new-onset diabetes in patients with CVD Published online: 17 June 2014 p444 | doi:10.1038/nrendo.2014.95 PDF Thyroid gland: Human thyroid gland development and function—angiogenesis in the spotlight Published online: 24 June 2014 p444 | doi:10.1038/nrendo.2014.98 PDF Diabetes: Absence of hormone-sensitive lipase associated with risk of T2DM Published online: 10 June 2014 p445 | doi:10.1038/nrendo.2014.92 PDF Reproductive endocrinology: A microRNA prevents cervical embryonic implantation Published online: 10 June 2014 p445 | doi:10.1038/nrendo.2014.93 PDF Genetics: Fracture risk in acromegaly Published online: 17 June 2014 p445 | doi:10.1038/nrendo.2014.96 PDF Obesity: Rethinking inflammation and adipocyte homeostasis Published online: 01 July 2014 p446 | doi:10.1038/nrendo.2014.103 PDF IN BRIEF Nutrition: Obesity causes irreversible loss of olfaction | Diabetes: Physical activity lowers risk of T2DM in women with a history of gestational diabetes mellitus | Therapy: Targeting insulin-degrading enzyme in diabetes mellitus | Metabolism: PDX improves insulin sensitivity via skeletal muscle IL-6 PDF Endocrinology JOBS of the week Senior Scientist Sanofi Research Group Leaders Cochin Institute (Inserm-Cnrs-University Paris Descartes) More Science jobs from
NEWS AND VIEWS		Top
Genetics: Pinpointing a hotspot in adrenal Cushing syndrome Thomas J. Giordano Published online: 10 June 2014 p447 | doi:10.1038/nrendo.2014.89 A gain-of-function point mutation in the gene that encodes one of the catalytic subunits of protein kinase A (PRKACA) in cortisol-producing adrenocortical adenomas has been independently reported by three groups. This hotspot point mutation (c.617T>G PRKACA) drives increased cAMP signalling and expands the pathogenic role of protein kinase A in benign lesions of the adrenal cortex. Full Text | PDF
Diabetes: Glycaemia and insulin after acute myocardial infarction Paresh Dandona & Ajay Chaudhuri Published online: 01 July 2014 p448 | doi:10.1038/nrendo.2014.101 The long-term outcomes of the DIGAMI 1 study indicate that intensive glucose lowering could be beneficial after an acute myocardial infarction in patients with type 2 diabetes mellitus. However, questions have been raised about whether it is acute or long-term glycaemic control or insulin that is beneficial. Full Text | PDF
Therapy: Caloric and fat intake in statin users Vasilios G. Athyros & Dimitri P. Mikhailidis Published online: 03 June 2014 p450 | doi:10.1038/nrendo.2014.82 A new report examines trends in caloric and fat intake—known modifiers of cardiovascular risk—among statin users and non-users. As statins are the most effective hypolipidaemic agents currently used to prevent cardiovascular disease, it is important to understand how statin treatment affects dietary attitude. Full Text | PDF
Diabetes: Progress in reducing vascular complications of diabetes Gillian L. Booth & Bernard Zinman Published online: 10 June 2014 p451 | doi:10.1038/nrendo.2014.90 Reducing or eliminating the clinical burden associated with the debilitating long-term complications of diabetes has long been a goal of management of this disease. A new study, published in the New England Journal of Medicine, suggests that we are closer to achieving this goal than previously thought. Full Text | PDF
Cardiovascular endocrinology: First-time heart failure increases risk of diabetes mellitus Rury R. Holman Published online: 01 July 2014 p453 | doi:10.1038/nrendo.2014.105 Patients with diabetes mellitus have an increased risk of developing heart failure. In a recent study, people hospitalised for first-time heart failure also had an increased risk of developing type 2 diabetes mellitus (T2DM) that was positively associated with loop-diuretic dosage. These findings highlight the need for extra awareness of T2DM in such patients. Full Text | PDF
REVIEWS		Top
Obesity and cancer—mechanisms underlying tumour progression and recurrence Jiyoung Park, Thomas S. Morley, Min Kim, Deborah J. Clegg & Philipp E. Scherer Published online: 17 June 2014 p455 | doi:10.1038/nrendo.2014.94 Obesity is associated with an increased risk of certain cancers, such as breast and colon cancers and hepatocellular carcinoma. In this Review, the authors discuss the mechanisms that underlie the interplay between tumour cells and adipocyte-rich stromal tissues that drives the creation and maintenance of a unique microenvironment that favours tumour growth and metastasis. Abstract | Full Text | PDF
Circadian clock control of endocrine factors Karen L. Gamble, Ryan Berry, Stuart J. Frank & Martin E. Young Published online: 27 May 2014 p466 | doi:10.1038/nrendo.2014.78 Adequate circadian oscillation of endocrine factors is essential in the maintenance of metabolic homeostasis. The authors of this Review explain the influence of extrinsic and intrinsic factors on endocrine circadian rhythms and how dysregulation of these rhythms can lead to disease in animals and humans. They also discuss therapeutic strategies to restore circadian rhythmicity and improve metabolism. Abstract | Full Text | PDF
Malformation syndromes associated with disorders of sex development John M. Hutson, Sonia R. Grover, Michele O'Connell & Samuel D. Pennell Published online: 10 June 2014 p476 | doi:10.1038/nrendo.2014.83 Disruption of the precise timing of gonadal differentiation and the exposure to adequate levels of specific hormones during critical periods that is required for normal genital development leads to disorders of sex development. This Review summarises the malformation syndromes associated with disorders of sex development and discusses the recent research into their aetiology. Abstract | Full Text | PDF
Beyond intestinal soap—bile acids in metabolic control Folkert Kuipers, Vincent W. Bloks & Albert K. Groen Published online: 13 May 2014 p488 | doi:10.1038/nrendo.2014.60 In this article, Kuipers and colleagues review how bile acids modulate glucose and lipid metabolism. The authors discuss the mechanisms by which bile acids, agonists of bile acid signalling pathways and bile acid sequestrants influence glucose levels in animal models and patients with insulin resistance and type 2 diabetes mellitus and how altered bile acid metabolism might contribute to the beneficial effects of bariatric surgery. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Hyperinsulinaemic androgen excess in adolescent girls Lourdes Ibáñez, Ken K. Ong, Abel López-Bermejo, David B. Dunger & Francis de Zegher Published online: 29 April 2014 p499 | doi:10.1038/nrendo.2014.58 Hyperinsulinaemic androgen excess leads to hirsutism, acne, seborrhoea and irregular menstrual cycles in young women. In this Perspectives article, Ibáñez and colleagues hypothesize that hyperinsuliaemic androgen excess arises owing to increased lipid load in adipose tissue, outline potential diagnostic criteria, and discuss the advantages and disadvantages of different treatment options for girls with this disorder. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Endocrinology was previously published as Nature Clinical Practice Endocrinology & Metabolism.

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