Nature Reviews Molecular Cell Biology contents August 2014 Volume 15 Number 8 pp 497-558

If you are unable to see the message below, click here to view.

Advertisement
Impress Yourself - The new Eppendorf Cell Culture Consumables  Experience a new dimension in cell culture with Eppendorf Cell Culture Consumables. Your needs for excellent cell performance and reliability as well as for advanced protection against contamination set our focus in development. Premium in all aspects: Product, Performance and Packaging.
TABLE OF CONTENTS
August 2014 Volume 15 Number 8
Impact Factor 37.162 *	In this issue Research Highlights Progress Reviews Perspectives Also this month Article Series: Post-translational modifications Technologies and techniques  Featured article: Regulation of microRNA biogenesis Minju Ha & V. Narry Kim
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
The 2014 IMB Conference on Nuclear RNA in Gene Regulation & Chromatin Structure will focus on the emerging roles of RNA molecules in regulating gene expression and in affecting chromatin structure in the nucleus. The meeting aims on bringing together the latest concepts and findings in the field. Keynote speakers will be Ruth Lehmann and Steven E. Jacobsen.
Advertisement
Call for Papers Nature Plants: From Bench to Biosphere Nature Plants is now open for submissions and welcomes manuscripts from all areas of plant research. Submit your research online today!  View the complete Guide to Authors
RESEARCH HIGHLIGHTS Top Stem cells: Ovary surface stem cells repair ovulatory wounds p497 | doi:10.1038/nrm3844 LGR5+ epithelial stem cells that sustain ovary repair and homeostasis are located throughout the ovary surface. PDF Organelle dynamics: KIF7 organizes cilia p498 | doi:10.1038/nrm3839 KIF7 binds to microtubule plus ends at cilia tips to control cilium architecture and to organize a specialized compartment that mediates Hedgehog signalling. PDF Apoptosis: DR5 unfolds ER stress p498 | doi:10.1038/nrm3843 ER stress induces apoptosis through DR5, which is regulated by the UPR factors PERK and IRE1α. PDF Translation: DENR-MCT1 reinitiates translation p498 | doi:10.1038/nrm3845 Translation reinitiation of open reading frames (ORFs) located after upstream ORFs is dependent on the DENR-MCT1 complex, which regulates a specific set of mRNAs. PDF TECHNOLOGY WATCH RNA domain characterization p500 | doi:10.1038/nrm3847 PDF TECHNOLOGY WATCH Multiplexed enzyme activity screening p500 | doi:10.1038/nrm3848 PDF Mechanotransduction: A stiff response p500 | doi:10.1038/nrm3852 Extracellular matrix stiffness-dependent FAK-CAS-RAC1 signalling regulates intracellular stiffness and cell cycling. PDF JOURNAL CLUB Plant biology informs drug discovery p501 | doi:10.1038/nrm3842 Michael Rape provides a striking example of how basic research — in this case in the plant sciences — can be unexpectedly informative for drug development. PDF Development: Mechanical forces linked to organ growth p501 | doi:10.1038/nrm3846 Jub protein couples cytoskeletal tension to growth by modulating Hippo signalling. PDF IN BRIEF DNA replication: DNA Pol θ controls replication timing | RNA: Two classes of mRNA methylation sites | Chromosomes: Epigenetics of kinetochore assembly PDF Molecular Cell Biology JOBS of the week Molecular Biology of Ovarian Cancers Massachusetts General Hospital & Harvard Medical School Postdoctoral Research Position in Molecular Pulmonary Vascular Biology Brigham & Women's Hospital - Harvard Medical School Postdoctoral Research Associate in Plant Molecular Biology The University of York Postdoctoral Position in Pluripotent Stem Cell Biology University of California - Los Angeles Postdoctoral Research Associate Position: Signal Transduction and Cell Biology University of California, San Diego More Science jobs from Molecular Cell Biology EVENT Molecular Switches 24.09.14 Prien, Germany More science events from
PROGRESS		Top
Linear ubiquitin chains: NF-κB signalling, cell death and beyond Kazuhiro Iwai, Hiroaki Fujita & Yoshiteru Sasaki p503 | doi:10.1038/nrm3836 Linear ubiquitylation was initially identified owing to its function in canonical nuclear factor-κB activation. Recent studies have revealed the involvement of linear ubiquitin chains in the regulation of other signalling pathways and cell death, and in several diseases including cancer, which highlights the unexpected importance of this form of ubiquitylation. Abstract | Full Text | PDF
REVIEWS		Top
Regulation of microRNA biogenesis Minju Ha & V. Narry Kim p509 | doi:10.1038/nrm3838 In animals, microRNAs (miRNAs) are ~22 nucleotides in length and are produced by two RNase III proteins — Drosha and Dicer. Their biogenesis is regulated at multiple levels, including at the level of miRNA transcription; by Drosha and Dicer processing; by their modification through RNA editing, RNA methylation, uridylation and adenylation; Argonaute loading; and by RNA decay. Abstract | Full Text | PDF
Small RNAs break out: the molecular cell biology of mobile small RNAs Peter Sarkies & Eric A. Miska p525 | doi:10.1038/nrm3840 Mobile RNAs function in antiviral defence, cell signalling and gene expression regulation, and might also mediate transgenerational epigenetic inheritance. Genetic and molecular studies in plants and nematodes have begun to provide insights into the mechanisms underlying RNA movement, its functions and the nature of mobile RNA molecules. Abstract | Full Text | PDF | Supplementary information
Article series: Post-translational modifications The growing landscape of lysine acetylation links metabolism and cell signalling Chunaram Choudhary, Brian T. Weinert, Yuya Nishida, Eric Verdin & Matthias Mann p536 | doi:10.1038/nrm3841 Recent technical advances are expanding our understanding of how lysine acetylation, as well as other metabolite-sensitive acylations, regulates various cellular processes. Emerging findings point to new functions for different acylations and deacylating enzymes, and clarify the intricate link between lysine acetylation and cellular metabolism. Abstract | Full Text | PDF
PERSPECTIVES		Top
INNOVATION Article series: Technologies and techniques Illuminating cell signalling with optogenetic tools Doug Tischer & Orion D. Weiner p551 | doi:10.1038/nrm3837 The optogenetic toolkit has rapidly expanded to include various proteins and cellular functions, such as cell signalling, that can be controlled by light. The practical considerations in using and deciding between optogenetic systems, such as systems that use light-oxygen-voltage (LOV) domains, phytochrome proteins, CRYPTOCHROME 2 (CRY2) and the fluorescent protein Dronpa, are now well defined. Abstract | Full Text | PDF
Advertisement
With scientific editing from MSC you benefit from Nature-standard editing and advice on your manuscript, giving you the best chance of acceptance by the journal of your choice. Expert editors, fast service. Submit your manuscript today and save 10% with code SE_TOC14!
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2012 Journal Citation Report (Thomson Reuters, 2013)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.