Nature Reviews Nephrology - Table of Contents alert Volume 10 Issue 8

TABLE OF CONTENTS
August 2014 Volume 10 Number 8
Impact Factor 7.943 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Next-generation sequencing for research and diagnostics in kidney disease Kirsten Y. Renkema, Marijn F. Stokman, Rachel H. Giles & Nine V. A. M. Knoers
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RESEARCH HIGHLIGHTS Top Nephrotic syndrome: Rituximab is safe and effective in FRNS and SDNS—but where to go from here? Published online: 08 July 2014 p421 | doi:10.1038/nrneph.2014.119 PDF Paediatrics: CARPEDIEM—continuous renal replacement therapy for infants Published online: 10 June 2014 p422 | doi:10.1038/nrneph.2014.100 PDF Clinical Trials: Off-pump coronary artery bypass graft surgery reduces postoperative AKI risk Published online: 17 June 2014 p423 | doi:10.1038/nrneph.2014.107 PDF Genetics: Mapping pathways of CKD Published online: 01 July 2014 p423 | doi:10.1038/nrneph.2014.117 PDF Transplantation: IgG reactivity to apoptotic cells—role in presensitization revealed Published online: 01 July 2014 p423 | doi:10.1038/nrneph.2014.118 PDF Chronic kidney disease: Targeting connexin-43 reduces progression of CKD in mice Published online: 10 June 2014 p424 | doi:10.1038/nrneph.2014.101 PDF Glomerular disease: To the rescue—migrating renin lineage cells heal the injured glomerular mesangium Published online: 24 June 2014 p424 | doi:10.1038/nrneph.2014.115 PDF IN BRIEF From ERA-EDTA—Anaemia: Treating iron deficiency and elevated phosphate—new data | From ERA-EDTA—Transplantation: Calcification propensity associated with renal graft failure | From ERA-EDTA—Diabetic nephropathy: Bardoxolone methyl promotes sodium and fluid retention | From ERA-EDTA—Chronic Kidney Disease: CCL2 inhibition is renoprotective in diabetic nephropathy PDF Nephrology JOBS of the week Thesis position in bioinformatics Laboratory of Immnology Pathology and Immunotherapy More Science jobs from Nephrology EVENT ISN World Congress of Nephrology 2015 13.03.15 Cape Town, South Africa More science events from
NEWS AND VIEWS		Top
Transplantation: CNIs to mTOR inhibitors—effects on allosensitization? Aditi Gupta & Bruce Kaplan Published online: 27 May 2014 p425 | doi:10.1038/nrneph.2014.94 Pre-existing HLA antibodies negatively impact long-term graft survival and might be a major risk factor for the formation of new HLA antibodies. Whether conversion of transplant recipients from calcineurin inhibitors to mammalian target of rapamycin inhibitors increases the risk of allosensitization remains to be determined. Full Text | PDF
Clinical trials: ISN-ACCTS: global initiatives to improve clinical research Adeera Levin & Giuseppe Remuzzi Published online: 10 June 2014 p426 | doi:10.1038/nrneph.2014.98 The International Society of Nephrology-Advisory Committee of Clinical Trials and Studies aims to ensure access to timely and unbiased expert advice for all investigators, and to facilitate the development and execution of clinical trials within a highly ethical framework. The initiative will foster high-quality, cost-effective research in a sustainable network. Full Text | PDF
Chronic kidney disease: Prenatal risk factors for kidney and urinary tract anomalies Robert H. Mak & Franz Schaefer Published online: 17 June 2014 p428 | doi:10.1038/nrneph.2014.105 Childhood-onset chronic kidney disease is the result of congenital anomalies of the kidneys and urinary tract in approximately two-thirds of all patients. An area of intense research in recent years, however, is the potential impact of maternal obesity on renal ontogenesis or postnatal renal function in the offspring. Full Text | PDF
Transplantation: Molecular diagnosis of kidney transplant rejection Christian Morath & Martin Zeier Published online: 17 June 2014 p429 | doi:10.1038/nrneph.2014.106 Acute or chronic antibody-mediated rejection (ABMR) of kidney allografts is currently diagnosed by the presence of donor-specific alloantibodies and distinct pathological findings in biopsy samples. A new study highlights the potential of molecular diagnostics incorporated into standard criteria for acute ABMR to help identify patients at risk of graft loss. Full Text | PDF
Glomerular disease: The search goes on: suPAR is not the elusive FSGS factor Jeroen K. Deegens & Jack F. Wetzels Published online: 24 June 2014 p431 | doi:10.1038/nrneph.2014.113 New research indicates that intact soluble urokinase plasminogen activator receptor (suPAR) does not induce albuminuria in mice. These data corroborate the most recent clinical findings, showing that intact suPAR is not the plasma permeability factor responsible for recurrence of focal segmental glomerulosclerosis after renal transplantation. Full Text | PDF
REVIEWS		Top
Next-generation sequencing for research and diagnostics in kidney disease Kirsten Y. Renkema, Marijn F. Stokman, Rachel H. Giles & Nine V. A. M. Knoers Published online: 10 June 2014 p433 | doi:10.1038/nrneph.2014.95 The introduction of next-generation sequencing has provided revolutionary opportunities for comprehensive genetic testing in research and diagnostics. Here, the authors discuss approaches used for novel gene identification, the potential of these techniques to improve the management of patients with inherited kidney diseases—focusing on nephronophthisis and congenital anomalies of the kidney and urinary tract—and the remaining challenges for implementation of next-generation sequencing in clinical practice. Abstract | Full Text | PDF
Pathology of IgA nephropathy Ian S. D. Roberts Published online: 27 May 2014 p445 | doi:10.1038/nrneph.2014.92 In this Review, Ian Roberts provides a detailed description of the immunohistology and light microscopical features of IgA nephropathy, and highlights the importance of accurate recognition of the various histological lesions for reproducible classification of the disease. The different schemas used for classifying IgA nephropathy are compared, with particular focus on the Oxford classification. Abstract | Full Text | PDF
Renal transplantation in autosomal dominant polycystic kidney disease Nada Kanaan, Olivier Devuyst & Yves Pirson Published online: 17 June 2014 p455 | doi:10.1038/nrneph.2014.104 Renal transplantation is the preferred treatment option for patients with autosomal dominant polycystic kidney disease (ADPKD) and end-stage renal disease. Here, the authors discuss special considerations for pretransplant screening and living-related kidney donation in patients with ADPKD, as well as post-transplant outcomes and complications in these patients. Abstract | Full Text | PDF
Pre-eclampsia part 1: current understanding of its pathophysiology Tinnakorn Chaiworapongsa, Piya Chaemsaithong, Lami Yeo & Roberto Romero Published online: 08 July 2014 p466 | doi:10.1038/nrneph.2014.102 Several genetic and environmental factors have been implicated in pre-eclampsia, a rare but serious condition leading to maternal and perinatal morbidity and mortality. In the first of this two-part Review, Chaiworapongsa and colleagues discuss the pathophysiology of pre-eclampsia, including imbalance between angiogenic and antiangiogenic factors, which has emerged as the central pathogenetic mechanism. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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