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2014/07/29

Scientific Reports Table of Contents e-alert: 29 July 2014

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Biological Sciences top
 
 
 
 
 
 
 

Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes

 
 

Chris Grant, Dawid Deszcz, Yu-Chia Wei et al.

 
 

Effective application of whole-cell devices in synthetic biology and biocatalysis will always require consideration of the uptake of molecules of interest into the cell. Here we …

 
 
 
 
 
 

A Longitudinal Study on Children's Music Training Experience and Academic Development

 
 

Hua Yang, Weiyi Ma, Diankun Gong et al.

 
 

This study examined the relation between long-term music training and child development based on 250 Chinese elementary school students' academic development of first language …

 
 
 
 
 
 

Plant Cells Use Auxin Efflux to Explore Geometry

 
 

Beatrix Zaban, Wenwen Liu, Xingyu Jiang et al.

 
 

Cell movement is the central mechanism for animal morphogenesis. Plant cell development rather relies on flexible alignment of cell axis adjusting cellular differentiation to …

 
 
 
 
 
 

Lymphatic endothelial cells support tumor growth in breast cancer

 
 

Esak Lee, Niranjan B. Pandey, Aleksander S. Popel

 
 

Tumor lymphatic vessels (LV) serve as a conduit of tumor cell dissemination, due to their leaky nature and secretion of tumor-recruiting factors. Though lymphatic endothelial …

 
 
 
 
 
 

Protein engineering of selected residues from conserved sequence regions of a novel Anoxybacillus α-amylase

 
 

Velayudhan Ranjani, Štefan Janeček, Kian Piaw Chai et al.

 
 

The α-amylases from Anoxybacillus species (ASKA and ADTA), Bacillus aquimaris (BaqA) and Geobacillus thermoleovorans (GTA, Pizzo and GtamyII) were proposed as a novel group of the …

 
 
 
 
 
 

Comparative metabolomics in primates reveals the effects of diet and gene regulatory variation on metabolic divergence

 
 

Ran Blekhman, George H. Perry, Sevini Shahbaz et al.

 
 

Human diets differ from those of non-human primates. Among few obvious differences, humans consume more meat than most non-human primates and regularly cook their food. It is …

 
 
 
 
 
 

Enhanced cellular preservation by clay minerals in 1 billion-year-old lakes

 
 

David Wacey, Martin Saunders, Malcolm Roberts et al.

 
 

Organic-walled microfossils provide the best insights into the composition and evolution of the biosphere through the first 80 percent of Earth history. The mechanism of …

 
 
 
 
 
 

Combined Application of NMR- and GC-MS-Based Metabonomics Yields a Superior Urinary Biomarker Panel for Bipolar Disorder

 
 

Jian-jun Chen, Zhao Liu, Song-hua Fan et al.

 
 

Bipolar disorder (BD) is a debilitating mental disorder that cannot be diagnosed by objective laboratory-based modalities. Our previous studies have independently used nuclear …

 
 
 
 
 
 

Living biointerfaces based on non-pathogenic bacteria to direct cell differentiation

 
 

Aleixandre Rodrigo-Navarro, Patricia Rico, Anas Saadeddin et al.

 
 

Genetically modified Lactococcus lactis, non-pathogenic bacteria expressing the FNIII7-10 fibronectin fragment as a protein membrane have been used to create a living biointerface …

 
 
 
 
 
 

Controlled Heterogeneous Stem Cell Differentiation on a Shape Memory Hydrogel Surface

 
 

Yanjiao Han, Tao Bai, Wenguang Liu

 
 

The success of stem cell therapies is highly dependent on the ability to control their programmed differentiation. So far, it is commonly believed that the differentiation …

 
 
 
 
 
 

Quantitative Comparison of Tumor Delivery for Multiple Targeted Nanoparticles Simultaneously by Multiplex ICP-MS

 
 

Andrew Elias, Samuel H. Crayton, Robert Warden-Rothman et al.

 
 

Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and …

 
 
 
 
 
 

Serial changes of humor comprehension for four-frame comic Manga: an fMRI study

 
 

Mariko Osaka, Ken Yaoi, Takehiro Minamoto et al.

 
 

Serial changes of humor comprehension evoked by a well organized four-frame comic Manga were investigated by fMRI in each step of humor comprehension. The neural substrates …

 
 
 
 
 
 

TLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis

 
 

Chaoran Yin, Ting Zhang, Liangjun Qiao et al.

 
 

Normal interfollicular epidermis (IFE) homeostasis is maintained throughout the entire life by its own stem cells that self-renew and generate progeny that undergo terminal …

 
 
 
 
 
 

Direct and indirect effects of glomalin, mycorrhizal hyphae, and roots on aggregate stability in rhizosphere of trifoliate orange

 
 

Qiang-Sheng Wu, Ming-Qin Cao, Ying-Ning Zou et al.

 
 

To test direct and indirect effects of glomalin, mycorrhizal hyphae, and roots on aggregate stability, perspex pots separated by 37-μm nylon mesh in the middle were used to form …

 
 
 
 
 
 

Hitchhiking of host biology by beneficial symbionts enhances transmission

 
 

Brittany M. Ott, Michael Cruciger, Andrew M. Dacks et al.

 
 

Transmission plays a key role in the evolution of symbiosis. Mixed mode transmission combines horizontal and vertical mechanisms for symbiont acquisition. However, features that …

 
 
 
 
 
 

Transcranial optical vascular imaging (TOVI) of cortical hemodynamics in mouse brain

 
 

Vyacheslav Kalchenko, David Israeli, Yuri Kuznetsov et al.

 
 

In vivo imaging of cerebral vasculature and blood flow provides highly valuable information for clinicians as well as researchers. Nevertheless, currently available methods are …

 
 
 
 
 
 

Chrysanthemum CmNAR2 interacts with CmNRT2 in the control of nitrate uptake

 
 

Chunsun Gu, Xiaoxue Zhang, Jiafu Jiang et al.

 
 

Nitrate transporters are an important component of plant growth and development. Chrysanthemum morifolium is an important ornamental species, for which a sufficient supply of …

 
 
 
 
 
 

Direct Detection of FoxP3 Expression in Thymic Double-Negative CD4CD8 Cells by Flow Cytometry

 
 

Gang Liu, Zongfang Li, Yang Wei et al.

 
 

Foxp3 expression is a marker of regulatory T cells (Treg), but how early it is expressed in the thymus is still not fully defined. In this study, we examined Foxp3 expression in …

 
 
 
 
 
 

Ameliorating ER-stress attenuates Aeromonas hydrophila-induced mitochondrial dysfunctioning and caspase mediated HKM apoptosis in Clarias batrachus

 
 

Chaitali Banerjee, Ambika Singh, Taposh Kumar Das et al.

 
 

Endoplasmic reticulum (ER)-stress and unfolding protein response (UPR) has not been implied in Aeromonas hydrophila-pathogenicity. We report increased expression of the ER-stress …

 
 
 
 
 
 

Starvation-response may not involve Atg1-dependent autophagy induction in non-unikont parasites

 
 

László Földvári-Nagy, Eszter Ari, Péter Csermely et al.

 
 

Autophagy, the lysosome-mediated self-degradation process, is implicated in survival during starvation in yeast, Dictyostelium and animals. In these eukaryotic taxa (collectively …

 
 
 
 
 
 

Channelrhodopsin2 Current During the Action Potential: “Optical AP Clamp” and Approximation

 
 

Emilia Entcheva, John C. Williams

 
 

The most widely used optogenetic tool, Channelrhodopsin2 (ChR2), is both light- and voltage-sensitive. A light-triggered action potential or light-driven perturbations of ongoing …

 
 
 
 
 
 

Community structure of planktonic methane-oxidizing bacteria in a subtropical reservoir characterized by dominance of phylotype closely related to nitrite reducer

 
 

Hisaya Kojima, Riho Tokizawa, Kouhei Kogure et al.

 
 

Methane-oxidizing bacteria (MOB) gain energy from the oxidation of methane and may play important roles in freshwater ecosystems. In this study, the community structure of …

 
 
 
 
 
 

Social cycling and conditional responses in the Rock-Paper-Scissors game

 
 

Zhijian Wang, Bin Xu, Hai-Jun Zhou

 
 

How humans make decisions in non-cooperative strategic interactions is a big question. For the fundamental Rock-Paper-Scissors (RPS) model game system, classic Nash equilibrium …

 
 
 
 
 
 

Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/β-catenin Signaling Pathway

 
 

Kun Zhang, Jinsong Guo, Zigang Ge et al.

 
 

Nanosecond pulsed electric fields (nsPEFs) characterized by high voltage, low energy and non-thermal effects, have been broadly investigated as a potential tumor therapy; however, …

 
 
 
 
 
 

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

 
 

Juanwen Zhang, Ying Zhao, Chengfu Xu et al.

 
 

High serum free fatty acid (FFA) levels are associated with metabolic syndrome (MS). This study aimed to assess the association of fasting serum FFAs with nonalcoholic fatty liver …

 
 
 
 
 
 

High genetic diversity and absence of founder effects in a worldwide aquatic invader

 
 

Christophe Lejeusne, Alice Saunier, Nicolas Petit et al.

 
 

The introduced oriental shrimp Palaemon macrodactylus has recently become widespread in temperate estuaries worldwide. However, this recent worldwide spread outside of its native …

 
 
 
 
 
 

Succinate production from CO2-grown microalgal biomass as carbon source using engineered Corynebacterium glutamicum through consolidated bioprocessing

 
 

Jungseok Lee, Sang Jun Sim, Michael Bott et al.

 
 

The potential for production of chemicals from microalgal biomass has been considered as an alternative route for CO2 mitigation and establishment of biorefineries. This study …

 
 
 
 
 
 

Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells

 
 

Shaoying Lu, Jihye Seong, Yi Wang et al.

 
 

Focal adhesions (FAs) are dynamic subcellular structures crucial for cell adhesion, migration and differentiation. It remains an enigma how enzymatic activities in these local …

 
 
 
 
 
 

Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation

 
 

Theodore Hu, Young Min Chung, Michelle Guan et al.

 
 

Cancer is a leading cause of death worldwide. Because the cytotoxic effects of conventional chemotherapies often harm normal tissue cells along with cancer cells, conventional …

 
 
 
 
 
 

The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair

 
 

Bert Yu-Hung Chen, Cheng-Hsiang Huang, Ying-Hsi Lin et al.

 
 

BRCA1 is a phosphoprotein involved in many biological processes, including transcription, ubiquitination, checkpoint control, homologous recombination, and DNA repair. We have …

 
 
 
 
 
 

Renaturing Membrane Proteins in the Lipid Cubic Phase, a Nanoporous Membrane Mimetic

 
 

Dianfan Li, Martin Caffrey

 
 

Membrane proteins play vital roles in the life of the cell and are important therapeutic targets. Producing them in large quantities, pure and fully functional is a major …

 
 
 
 
 
 

Deep sequencing extends the diversity of human papillomaviruses in human skin

 
 

Davit Bzhalava, Laila Sara Arroyo Mühr, Camilla Lagheden et al.

 
 

Most viruses in human skin are known to be human papillomaviruses (HPVs). Previous sequencing of skin samples has identified 273 different cutaneous HPV types, including 47 …

 
 
 
 
 
 

Route-dependent switch between hierarchical and egalitarian strategies in pigeon flocks

 
 

Hai-Tao Zhang, Zhiyong Chen, Tamás Vicsek et al.

 
 

The mechanisms that underlie fascinating inter-individual interactions among animal groups have attracted increasing attention from biologists, physicists, and system scientists. …

 
 
 
 
 
 

Dermcidin isoform-2 induced nullification of the effect of acetyl salicylic acid in platelet aggregation in acute myocardial infarction

 
 

Sarbashri Bank, Pradipta Jana, Smarajit Maiti et al.

 
 

The aggregation of platelets on the plaque rupture site on the coronary artery is reported to cause both acute coronary syndromes (ACS) and acute myocardial infarction (AMI). …

 
 
 
 
 
 

ROR1 expression correlated with poor clinical outcome in human ovarian cancer

 
 

Huilin Zhang, Jinrong Qiu, Chunping Ye et al.

 
 

The receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a transmembrane protein belongs to receptor tyrosine kinase (RTK) family. This study aimed to examine the expression …

 
 
 
 
 
 

Smelling directions: Olfaction modulates ambiguous visual motion perception

 
 

Shenbing Kuang, Tao Zhang

 
 

Senses of smells are often accompanied by simultaneous visual sensations. Previous studies have documented enhanced olfactory performance with concurrent presence of congruent …

 
 
 
 
 
 

The influence of emotional facial expressions on gaze-following in grouped and solitary pedestrians

 
 

Andrew C. Gallup, Andrew Chong, Alex Kacelnik et al.

 
 

The mechanisms contributing to collective attention in humans remain unclear. Research indicates that pedestrians utilise the gaze direction of others nearby to acquire …

 
 
 
 
 
 

Incorporation of aurochs into a cattle herd in Neolithic Europe: single event or breeding?

 
 

Jörg Schibler, Julia Elsner, Angela Schlumbaum

 
 

Domestication is an ongoing process continuously changing the lives of animals and humans and the environment. For the majority of European cattle (Bos taurus) genetic and …

 
 
 
 
 
 

Drl.3 governs primitive hematopoiesis in zebrafish

 
 

Wittaya Pimtong, Madhusmita Datta, Allison M. Ulrich et al.

 
 

The molecular program controlling hematopoietic differentiation is not fully understood. Here, we describe a family of zebrafish genes that includes a novel hematopoietic …

 
 
 
 
 
 

Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae

 
 

Richard Marley, Carlo N. G. Giachello, Nigel S. Scrutton et al.

 
 

The mechanisms that facilitate animal magnetoreception have both fascinated and confounded scientists for decades, and its precise biophysical origin remains unclear. Among the …

 
 
 
 
 
 

Accurate Inference of Local Phased Ancestry of Modern Admixed Populations

 
 

Yamin Ma, Jian Zhao, Jian-Syuan Wong et al.

 
 

Population stratification is a growing concern in genetic-association studies. Averaged ancestry at the genome level (global ancestry) is insufficient for detecting the population …

 
 
 
 
 
 

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

 
 

John F. Kellie, Richard E. Higgs, John W. Ryder et al.

 
 

A robust top down proteomics method is presented for profiling alpha-synuclein species from autopsied human frontal cortex brain tissue from Parkinson's cases and controls. The …

 
 
 
 
 
 

The rice endophyte Harpophora oryzae genome reveals evolution from a pathogen to a mutualistic endophyte

 
 

Xi-Hui Xu, Zhen-Zhu Su, Chen Wang et al.

 
 

The fungus Harpophora oryzae is a close relative of the pathogen Magnaporthe oryzae and a beneficial endosymbiont of wild rice. Here, we show that H. oryzae evolved from a …

 
 
 
 
 
 

Timing of circadian genes in mammalian tissues

 
 

Anja Korenčič, Rok Košir, Grigory Bordyugov et al.

 
 

Circadian clocks are endogenous oscillators driving daily rhythms in physiology. The cell-autonomous clock is governed by an interlocked network of transcriptional feedback loops. …

 
 
 
 
 
 

Heterologous expression of Ceratophyllum demersum phytochelatin synthase, CdPCS1, in rice leads to lower arsenic accumulation in grain

 
 

Manju Shri, Richa Dave, Sanjay Diwedi et al.

 
 

Recent studies have identified rice (Oryza sativa) as a major dietary source of inorganic arsenic (As) and poses a significant human health risk. The predominant model for plant …

 
 
 
 
 
 

Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor

 
 

Min Li, Weng Ieong Tou, Hong Zhou et al.

 
 

Urea transporter B (UT-B) is a membrane channel protein that specifically transports urea. UT-B null mouse exhibited urea selective urine concentrating ability deficiency, which …

 
 
 
 
 
 

Nitrogen Deprivation Induces Lipid Droplet Accumulation and Alters Fatty Acid Metabolism in Symbiotic Dinoflagellates Isolated from Aiptasia pulchella

 
 

Li-Chi Weng, Buntora Pasaribu, I. -Ping Lin et al.

 
 

The stability of cnidarian-dinoflagellate (genus Symbiodinium spp.) endosymbioses depends on the regulation of nutrient transport between Symbiodinium populations and their hosts. …

 
 
 
 
 
 
 
 
 
Nature Reviews Neurology 
Focus on Epilepsy 
 
In this special focus issue, cutting-edge investigators from around the world highlight the important challenges and progress in epilepsy research and clinical practice.

Produced with financial support from UCB
 
 
 
 
Chemical Sciences top
 
 
 
 
 
 
 

Controlled Heterogeneous Stem Cell Differentiation on a Shape Memory Hydrogel Surface

 
 

Yanjiao Han, Tao Bai, Wenguang Liu

 
 

The success of stem cell therapies is highly dependent on the ability to control their programmed differentiation. So far, it is commonly believed that the differentiation …

 
 
 
 
 
 

Rotation Motion of Designed Nano-Turbine

 
 

Jingyuan Li, Xiaofeng Wang, Lina Zhao et al.

 
 

Construction of nano-devices that can generate controllable unidirectional rotation is an important part of nanotechnology. Here, we design a nano-turbine composed of carbon …

 
 
 
 
 
 

Anisotropic Charge Distribution and Anisotropic van der Waals Radius Leading to Intriguing Anisotropic Noncovalent Interactions

 
 

Hahn Kim, Van Dung Doan, Woo Jong Cho et al.

 
 

Although group (IV–VII) nonmetallic elements do not favor interacting with anionic species, there are counterexamples including the halogen bond. Such binding is known to be …

 
 
 
 
 
 

Elastic, Conductive, Polymeric Hydrogels and Sponges

 
 

Yun Lu, Weina He, Tai Cao et al.

 
 

As a result of inherent rigidity of the conjugated macromolecular chains resulted from the delocalized π-electron system along the polymer backbone, it has been a huge challenge …

 
 
 
 
 
 

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

 
 

John F. Kellie, Richard E. Higgs, John W. Ryder et al.

 
 

A robust top down proteomics method is presented for profiling alpha-synuclein species from autopsied human frontal cortex brain tissue from Parkinson's cases and controls. The …

 
 
 
 
 
 
   
 
 
Physical Sciences top
 
 
 
 
 
 
 

Design and Development of Potential Tissue Engineering Scaffolds from Structurally Different Longitudinal Parts of a Bovine-Femur

 
 

Sumit Pramanik, Belinda Pingguan-Murphy, Jongman Cho et al.

 
 

The complex architecture of the cortical part of the bovine-femur was examined to develop potential tissue engineering (TE) scaffolds. Weight-change and X-ray diffraction (XRD) …

 
 
 
 
 
 

Rotation Motion of Designed Nano-Turbine

 
 

Jingyuan Li, Xiaofeng Wang, Lina Zhao et al.

 
 

Construction of nano-devices that can generate controllable unidirectional rotation is an important part of nanotechnology. Here, we design a nano-turbine composed of carbon …

 
 
 
 
 
 

Competitive Dynamics on Complex Networks

 
 

Jiuhua Zhao, Qipeng Liu, Xiaofan Wang

 
 

We consider a dynamical network model in which two competitors have fixed and different states, and each normal agent adjusts its state according to a distributed consensus …

 
 
 
 
 
 

Light Management in Flexible Glass by Wood Cellulose Coating

 
 

Zhi-Qiang Fang, Hong-Li Zhu, Yuan-Yuan Li et al.

 
 

Ultra-thin flexible glass with high transparency is attractive for a broad range of display applications; however, substrates with low optical haze are not ideal for thin film …

 
 
 
 
 
 

Kinetics of the coefficient of friction of elastomers

 
 

Qiang Li, Andrey Dimaki, Mikhail Popov et al.

 
 

We study theoretically and numerically the kinetics of the coefficient of friction of an elastomer due to abrupt changes of sliding velocity. Numerical simulations reveal the same …

 
 
 
 
 
 

Controlled Heterogeneous Stem Cell Differentiation on a Shape Memory Hydrogel Surface

 
 

Yanjiao Han, Tao Bai, Wenguang Liu

 
 

The success of stem cell therapies is highly dependent on the ability to control their programmed differentiation. So far, it is commonly believed that the differentiation …

 
 
 
 
 
 

Living biointerfaces based on non-pathogenic bacteria to direct cell differentiation

 
 

Aleixandre Rodrigo-Navarro, Patricia Rico, Anas Saadeddin et al.

 
 

Genetically modified Lactococcus lactis, non-pathogenic bacteria expressing the FNIII7-10 fibronectin fragment as a protein membrane have been used to create a living biointerface …

 
 
 
 
 
 

Quantitative Comparison of Tumor Delivery for Multiple Targeted Nanoparticles Simultaneously by Multiplex ICP-MS

 
 

Andrew Elias, Samuel H. Crayton, Robert Warden-Rothman et al.

 
 

Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and …

 
 
 
 
 
 

Identifying recycled ash in basaltic eruptions

 
 

Claudia D'Oriano, Antonella Bertagnini, Raffaello Cioni et al.

 
 

Deposits of mid-intensity basaltic explosive eruptions are characterized by the coexistence of different types of juvenile clasts, which show a large variability of external …

 
 
 
 
 
 

Complementary compressive imaging for the telescopic system

 
 

Wen-Kai Yu, Xue-Feng Liu, Xu-Ri Yao et al.

 
 

Conventional single-pixel cameras recover images only from the data recorded in one arm of the digital micromirror device, with the light reflected to the other direction not to …

 
 
 
 
 
 

Social cycling and conditional responses in the Rock-Paper-Scissors game

 
 

Zhijian Wang, Bin Xu, Hai-Jun Zhou

 
 

How humans make decisions in non-cooperative strategic interactions is a big question. For the fundamental Rock-Paper-Scissors (RPS) model game system, classic Nash equilibrium …

 
 
 
 
 
 

Highly Uniform and Reproducible Surface Enhanced Raman Scattering on Air-stable Metallic Glassy Nanowire Array

 
 

Xue Liu, Yang Shao, Yao Tang et al.

 
 

Preparation of surface enhanced Raman scattering (SERS) nanostructures with both high sensitivity as well as high reproducibility has always been difficult and costly for routine …

 
 
 
 
 
 

Beyond Cassie equation: Local structure of heterogeneous surfaces determines the contact angles of microdroplets

 
 

Bo Zhang, Jianjun Wang, Zhiping Liu et al.

 
 

The application of Cassie equation to microscopic droplets is recently under intense debate because the microdroplet dimension is often of the same order of magnitude as the …

 
 
 
 
 
 

Anisotropic Charge Distribution and Anisotropic van der Waals Radius Leading to Intriguing Anisotropic Noncovalent Interactions

 
 

Hahn Kim, Van Dung Doan, Woo Jong Cho et al.

 
 

Although group (IV–VII) nonmetallic elements do not favor interacting with anionic species, there are counterexamples including the halogen bond. Such binding is known to be …

 
 
 
 
 
 

Fabrication of wide-bandgap transparent electrodes by using conductive filaments: Performance breakthrough in vertical-type GaN LED

 
 

Su Jin Kim, Hee-Dong Kim, Kyeong Heon Kim et al.

 
 

For realizing next-generation solid-state lighting devices, performance breakthroughs must be accomplished for nitride-based light-emitting diodes (LEDs). Highly transparent …

 
 
 
 
 
 

Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/β-catenin Signaling Pathway

 
 

Kun Zhang, Jinsong Guo, Zigang Ge et al.

 
 

Nanosecond pulsed electric fields (nsPEFs) characterized by high voltage, low energy and non-thermal effects, have been broadly investigated as a potential tumor therapy; however, …

 
 
 
 
 
 

Channelrhodopsin2 Current During the Action Potential: “Optical AP Clamp” and Approximation

 
 

Emilia Entcheva, John C. Williams

 
 

The most widely used optogenetic tool, Channelrhodopsin2 (ChR2), is both light- and voltage-sensitive. A light-triggered action potential or light-driven perturbations of ongoing …

 
 
 
 
 
 

Crossover between Weak Antilocalization and Weak Localization of Bulk States in Ultrathin Bi2Se3 Films

 
 

Huichao Wang, Haiwen Liu, Cui-Zu Chang et al.

 
 

We report transport studies on the 5 nm thick Bi2Se3 topological insulator films which are grown via molecular beam epitaxy technique. The angle-resolved photoemission …

 
 
 
 
 
 

Dual field effects in electrolyte-gated spinel ferrite: electrostatic carrier doping and redox reactions

 
 

Takashi Ichimura, Kohei Fujiwara, Hidekazu Tanaka

 
 

Controlling the electronic properties of functional oxide materials via external electric fields has attracted increasing attention as a key technology for next-generation …

 
 
 
 
 
 

Unification of the family of Garrison-Wright's phases

 
 

Xiao-Dong Cui, Yujun Zheng

 
 

Inspired by Garrison and Wight's seminal work on complex-valued geometric phases, we generalize the concept of Pancharatnam's “in-phase” in interferometry and further develop a …

 
 
 
 
 
 

Route-dependent switch between hierarchical and egalitarian strategies in pigeon flocks

 
 

Hai-Tao Zhang, Zhiyong Chen, Tamás Vicsek et al.

 
 

The mechanisms that underlie fascinating inter-individual interactions among animal groups have attracted increasing attention from biologists, physicists, and system scientists. …

 
 
 
 
 
 

CORRIGENDUM: Extremely high-accuracy correction of air refractive index using two-colour optical frequency combs

 
 

Guanhao Wu, Mayumi Takahashi, Kaoru Arai et al.

 
 

 
 
 
 
 
 

Elastic, Conductive, Polymeric Hydrogels and Sponges

 
 

Yun Lu, Weina He, Tai Cao et al.

 
 

As a result of inherent rigidity of the conjugated macromolecular chains resulted from the delocalized π-electron system along the polymer backbone, it has been a huge challenge …

 
 
 
 
 
 

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

 
 

John F. Kellie, Richard E. Higgs, John W. Ryder et al.

 
 

A robust top down proteomics method is presented for profiling alpha-synuclein species from autopsied human frontal cortex brain tissue from Parkinson's cases and controls. The …

 
 
 
 
 
 

Evidencing the existence of intrinsic half-metallicity and ferromagnetism in zigzag gallium sulfide nanoribbons

 
 

Yungang Zhou, Sean Li, Weilie Zhou et al.

 
 

The achievement of half-metallicity with ferromagnetic (FM) coupling has become a key technology for the development of one-dimensional (1D) nanoribbons for spintronic …

 
 
 
 
 
 

Electrical conductivity of ice VII

 
 

Taku Okada, Toshiaki Iitaka, Takehiko Yagi et al.

 
 

It was discovered that a peak appears near a pressure of Pc=10 GPa in the electrical conductivity of ice VII as measured through impedance spectroscopy in a diamond anvil cell …

 
 
 
 
 
 

Enhanced Thermoelectric Performance of Cu2CdSnSe4 by Mn Doping: Experimental and First Principles Studies

 
 

F. S. Liu, J. X. Zheng, M. J. Huang et al.

 
 

Serials of Mn doping by substituting Cd sites on Cu2CdSnSe4 are prepared by the melting method and the spark plasma sintering (SPS) technique to form Cu2Cd1−xMnxSnSe4. Our …

 
 
 
 
 
 

Coalescence-induced crystallisation wave in Pd nanoparticles

 
 

Panagiotis Grammatikopoulos, Cathal Cassidy, Vidyadhar Singh et al.

 
 

Palladium nanoparticles offer an attractive alternative to bulk palladium for catalysis, hydrogen storage and gas sensing applications. Their performance depends strongly on …

 
 
 
 
 
 

Study of Multi-level Characteristics for 3D Vertical Resistive Switching Memory

 
 

Yue Bai, Huaqiang Wu, Riga Wu et al.

 
 

Three-dimensional (3D) integration and multi-level cell (MLC) are two attractive technologies to achieve ultra-high density for mass storage applications. In this work, a …

 
 
 
 
 
 

The impact of hot charge carrier mobility on photocurrent losses in polymer-based solar cells

 
 

Bronson Philippa, Martin Stolterfoht, Paul L. Burn et al.

 
 

A typical signature of charge extraction in disordered organic systems is dispersive transport, which implies a distribution of charge carrier mobilities that negatively impact on …

 
 
 
 
 
 
 
Earth & Environmental Sciences top
 
 
 
 
 
 
 

Carbonaceous particles reduce marine microgel formation

 
 

Ruei-Feng Shiu, Wei-Chun Chin, Chon-Lin Lee

 
 

An increase in ambient carbonaceous particle (CNP) levels has been found, potentially leading to significant environmental/health hazards. These particles will ultimately enter …

 
 
 
 
 
 

Enhanced cellular preservation by clay minerals in 1 billion-year-old lakes

 
 

David Wacey, Martin Saunders, Malcolm Roberts et al.

 
 

Organic-walled microfossils provide the best insights into the composition and evolution of the biosphere through the first 80 percent of Earth history. The mechanism of …

 
 
 
 
 
 

Antarctic-wide array of high-resolution ice core records reveals pervasive lead pollution began in 1889 and persists today

 
 

J. R. McConnell, O. J. Maselli, M. Sigl et al.

 
 

Interior Antarctica is among the most remote places on Earth and was thought to be beyond the reach of human impacts when Amundsen and Scott raced to the South Pole in 1911. Here …

 
 
 
 
 
 

Identifying recycled ash in basaltic eruptions

 
 

Claudia D'Oriano, Antonella Bertagnini, Raffaello Cioni et al.

 
 

Deposits of mid-intensity basaltic explosive eruptions are characterized by the coexistence of different types of juvenile clasts, which show a large variability of external …

 
 
 
 
 
 

Effects of water stratification and mixing on microbial community structure in a subtropical deep reservoir

 
 

Zheng Yu, Jun Yang, Stefano Amalfitano et al.

 
 

Microorganisms play pivotal roles within aquatic ecosystems, affecting their structure, functioning and services. However, little is known about the effects of water …

 
 
 
 
 
 

Hf-Nd isotopic variability in mineral dust from Chinese and Mongolian deserts: implications for sources and dispersal

 
 

Wancang Zhao, Youbin Sun, William Balsam et al.

 
 

Mineral dust provenances are closely related to the orogenic processes which may have distinct Hf-Nd isotopic signatures. Here we report the clay-sized (<2 μm) Hf-Nd isotope data …

 
 
 
 
 
 

Community structure of planktonic methane-oxidizing bacteria in a subtropical reservoir characterized by dominance of phylotype closely related to nitrite reducer

 
 

Hisaya Kojima, Riho Tokizawa, Kouhei Kogure et al.

 
 

Methane-oxidizing bacteria (MOB) gain energy from the oxidation of methane and may play important roles in freshwater ecosystems. In this study, the community structure of …

 
 
 
 
 
 

Spatial-temporal variation of marginal land suitable for energy plants from 1990 to 2010 in China

 
 

Dong Jiang, Mengmeng Hao, Jingying Fu et al.

 
 

Energy plants are the main source of bioenergy which will play an increasingly important role in future energy supplies. With limited cultivated land resources in China, the …

 
 
 
 
 
 

Low blood cell counts in wild Japanese monkeys after the Fukushima Daiichi nuclear disaster

 
 

Kazuhiko Ochiai, Shin-ichi Hayama, Sachie Nakiri et al.

 
 

In April 2012 we carried out a 1-year hematological study on a population of wild Japanese monkeys inhabiting the forest area of Fukushima City. This area is located 70 km from …

 
 
 
 
 
 

Incorporation of aurochs into a cattle herd in Neolithic Europe: single event or breeding?

 
 

Jörg Schibler, Julia Elsner, Angela Schlumbaum

 
 

Domestication is an ongoing process continuously changing the lives of animals and humans and the environment. For the majority of European cattle (Bos taurus) genetic and …

 
 
 
 
 
 

Late Eocene to early Oligocene quantitative paleotemperature record: Evidence from continental halite fluid inclusions

 
 

Yan-jun Zhao, Hua Zhang, Cheng-lin Liu et al.

 
 

Climate changes within Cenozoic extreme climate events such as the Paleocene–Eocene Thermal Maximum and the First Oligocene Glacial provide good opportunities to estimate the …

 
 
 
 
 
 

Nitrogen Deprivation Induces Lipid Droplet Accumulation and Alters Fatty Acid Metabolism in Symbiotic Dinoflagellates Isolated from Aiptasia pulchella

 
 

Li-Chi Weng, Buntora Pasaribu, I. -Ping Lin et al.

 
 

The stability of cnidarian-dinoflagellate (genus Symbiodinium spp.) endosymbioses depends on the regulation of nutrient transport between Symbiodinium populations and their hosts. …

 
 
 
 
 
 

Electrical conductivity of ice VII

 
 

Taku Okada, Toshiaki Iitaka, Takehiko Yagi et al.

 
 

It was discovered that a peak appears near a pressure of Pc=10 GPa in the electrical conductivity of ice VII as measured through impedance spectroscopy in a diamond anvil cell …

 
 
 
 
 
 
 
Health Sciences top
 
 
 
 
 
 
 

Combined Application of NMR- and GC-MS-Based Metabonomics Yields a Superior Urinary Biomarker Panel for Bipolar Disorder

 
 

Jian-jun Chen, Zhao Liu, Song-hua Fan et al.

 
 

Bipolar disorder (BD) is a debilitating mental disorder that cannot be diagnosed by objective laboratory-based modalities. Our previous studies have independently used nuclear …

 
 
 
 
 
 

Evaluation of transmission risks associated with in vivo replication of several high containment pathogens in a biosafety level 4 laboratory

 
 

Judie Alimonti, Anders Leung, Shane Jones et al.

 
 

Containment level 4 (CL4) laboratories studying biosafety level 4 viruses are under strict regulations to conduct nonhuman primate (NHP) studies in compliance of both animal …

 
 
 
 
 
 

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

 
 

Juanwen Zhang, Ying Zhao, Chengfu Xu et al.

 
 

High serum free fatty acid (FFA) levels are associated with metabolic syndrome (MS). This study aimed to assess the association of fasting serum FFAs with nonalcoholic fatty liver …

 
 
 
 
 
 

Antifibrotic effects of KS370G, a caffeamide derivative, in renal ischemia-reperfusion injured mice and renal tubular epithelial cells

 
 

Sung-Ting Chuang, Yueh-Hsiung Kuo, Ming-Jai Su

 
 

Accumulating evidence suggests that renal tubulointerstitial fibrosis is a main cause of end-stage renal disease. Clinically, there are no beneficial treatments that can …

 
 
 
 
 
 

Inherent insulin sensitivity is a major determinant of multimeric adiponectin responsiveness to short-term weight loss in extreme obesity

 
 

Stefania Mai, Gillian E. Walker, Amelia Brunani et al.

 
 

High molecular weight (HMW-A) adiponectin levels mirror alterations in glucose homeostasis better than medium (MMW-A) and low molecular weight (LMW-A) components. In 25 patients …

 
 
 
 
 
 

Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation

 
 

Theodore Hu, Young Min Chung, Michelle Guan et al.

 
 

Cancer is a leading cause of death worldwide. Because the cytotoxic effects of conventional chemotherapies often harm normal tissue cells along with cancer cells, conventional …

 
 
 
 
 
 

ROR1 expression correlated with poor clinical outcome in human ovarian cancer

 
 

Huilin Zhang, Jinrong Qiu, Chunping Ye et al.

 
 

The receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a transmembrane protein belongs to receptor tyrosine kinase (RTK) family. This study aimed to examine the expression …

 
 
 
 
 
 

Dermcidin isoform-2 induced nullification of the effect of acetyl salicylic acid in platelet aggregation in acute myocardial infarction

 
 

Sarbashri Bank, Pradipta Jana, Smarajit Maiti et al.

 
 

The aggregation of platelets on the plaque rupture site on the coronary artery is reported to cause both acute coronary syndromes (ACS) and acute myocardial infarction (AMI). …

 
 
 
 
 
 

Deep sequencing extends the diversity of human papillomaviruses in human skin

 
 

Davit Bzhalava, Laila Sara Arroyo Mühr, Camilla Lagheden et al.

 
 

Most viruses in human skin are known to be human papillomaviruses (HPVs). Previous sequencing of skin samples has identified 273 different cutaneous HPV types, including 47 …

 
 
 
 
 
 

Low blood cell counts in wild Japanese monkeys after the Fukushima Daiichi nuclear disaster

 
 

Kazuhiko Ochiai, Shin-ichi Hayama, Sachie Nakiri et al.

 
 

In April 2012 we carried out a 1-year hematological study on a population of wild Japanese monkeys inhabiting the forest area of Fukushima City. This area is located 70 km from …

 
 
 
 
 
 

Phosphodiesterase type 5 inhibitors for the treatment of post-nerve sparing radical prostatectomy erectile dysfunction in men

 
 

Jinhong Li, Qingquan Shi, Chunxiao Pu et al.

 
 

Prostate cancer (PCa) is the most common solid neoplasm diagnosed in developed countries. Nerve-sparing radical prostatectomy (NS-RP) has been widely accepted as the best choice …

 
 
 
 
 
 

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

 
 

John F. Kellie, Richard E. Higgs, John W. Ryder et al.

 
 

A robust top down proteomics method is presented for profiling alpha-synuclein species from autopsied human frontal cortex brain tissue from Parkinson's cases and controls. The …

 
 
 
 
 
 

Accurate Inference of Local Phased Ancestry of Modern Admixed Populations

 
 

Yamin Ma, Jian Zhao, Jian-Syuan Wong et al.

 
 

Population stratification is a growing concern in genetic-association studies. Averaged ancestry at the genome level (global ancestry) is insufficient for detecting the population …

 
 
 
 
 
 

Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor

 
 

Min Li, Weng Ieong Tou, Hong Zhou et al.

 
 

Urea transporter B (UT-B) is a membrane channel protein that specifically transports urea. UT-B null mouse exhibited urea selective urine concentrating ability deficiency, which …

 
 
 
 
 
 
 
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