Leukemia - Table of Contents alert Volume 28 Issue 8

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Before you buy, VISIT MARKETPLACE    Review Top Expert panel consensus statement on the optimal use of pomalidomide in relapsed and refractory multiple myeloma OPEN M A Dimopoulos, X Leleu, A Palumbo, P Moreau, M Delforge, M Cavo, H Ludwig, G J Morgan, F E Davies, P Sonneveld, S A Schey, S Zweegman, M Hansson, K Weisel, M V Mateos, T Facon and J F S Miguel Leukemia 2014 28: 1573-1585; advance online publication, February 5, 2014; 10.1038/leu.2014.60 Abstract | Full Text Original Articles Top ACUTE LEUKEMIAS Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients R Kihara, Y Nagata, H Kiyoi, T Kato, E Yamamoto, K Suzuki, F Chen, N Asou, S Ohtake, S Miyawaki, Y Miyazaki, T Sakura, Y Ozawa, N Usui, H Kanamori, T Kiguchi, K Imai, N Uike, F Kimura, K Kitamura, C Nakaseko, M Onizuka, A Takeshita, F Ishida, H Suzushima, Y Kato, H Miwa, Y Shiraishi, K Chiba, H Tanaka, S Miyano, S Ogawa and T Naoe Leukemia 2014 28: 1586-1595; advance online publication, February 3, 2014; 10.1038/leu.2014.55 Abstract | Full Text Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo I Pizzitola, F Anjos-Afonso, K Rouault-Pierre, F Lassailly, S Tettamanti, O Spinelli, A Biondi, E Biagi and D Bonnet Leukemia 2014 28: 1596-1605; advance online publication, February 7, 2014; 10.1038/leu.2014.62 Abstract | Full Text Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition M R Sapienza, F Fuligni, C Agostinelli, C Tripodo, S Righi, M A Laginestra, A Pileri, Jr, M Mancini, M Rossi, F Ricci, A Gazzola, F Melle, C Mannu, F Ulbar, M Arpinati, M Paulli, T Maeda, D Gibellini, L Pagano, N Pimpinelli, M Santucci, L Cerroni, C M Croce, F Facchetti, P P Piccaluga and S A Pileri for the AIRC 5xMille consortium ‘Genetics-driven targeted management of lymphoid malignancies’ and the Italian Registry on Blastic Plasmacytoid Dendritic Cell Neoplasm Leukemia 2014 28: 1606-1616; advance online publication, February 7, 2014; 10.1038/leu.2014.64 Abstract | Full Text Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia M Celton, A Forest, G Gosse, S Lemieux, J Hebert, G Sauvageau and B T Wilhelm Leukemia 2014 28: 1617-1626; advance online publication, February 11, 2014; 10.1038/leu.2014.67 Abstract | Full Text CHRONIC MYELOPROLIFERATIVE NEOPLASIAS Loss of wild-type Jak2 allele enhances myeloid cell expansion and accelerates myelofibrosis in Jak2V617F knock-in mice H Akada, S Akada, R E Hutchison and G Mohi Leukemia 2014 28: 1627-1635; advance online publication, January 31, 2014; 10.1038/leu.2014.52 Abstract | Full Text CHRONIC LYMPHOCYTIC LEUKEMIA Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia OPEN V El-Khoury, S Pierson, E Szwarcbart, N H C Brons, O Roland, S Cherrier-De Wilde, L Plawny, E Van Dyck and G Berchem Leukemia 2014 28: 1636-1646; advance online publication, January 14, 2014; 10.1038/leu.2014.19 Abstract | Full Text IMMUNOLOGY IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors M Jourdan, M Cren, N Robert, K Bolloré, T Fest, C Duperray, F Guilloton, D Hose, K Tarte and B Klein Leukemia 2014 28: 1647-1656; advance online publication, February 7, 2014; 10.1038/leu.2014.61 Abstract | Full Text SENSITIVITY AND RESISTANCE TO THERAPY BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies OPEN J M Bogenberger, S M Kornblau, W E Pierceall, R Lena, D Chow, C-X Shi, J Mantei, G Ahmann, I M Gonzales, A Choudhary, R Valdez, J Camoriano, V Fauble, R E Tiedemann, Y H Qiu, K R Coombes, M Cardone, E Braggio, H Yin, D O Azorsa, R A Mesa, A K Stewart and R Tibes Leukemia 2014 28: 1657-1665; advance online publication, January 23, 2014; 10.1038/leu.2014.44 Abstract | Full Text ONCOGENES, FUSION GENES AND TUMOR SUPPRESSOR GENES BCR-ABL1–positive microvesicles transform normal hematopoietic transplants through genomic instability: implications for donor cell leukemia X Zhu, Y You, Q Li, C Zeng, F Fu, A Guo, H Zhang, P Zou, Z Zhong, H Wang, Y Wu, Q Li, F Kong and Z Chen Leukemia 2014 28: 1666-1675; advance online publication, January 31, 2014; 10.1038/leu.2014.51 Abstract | Full Text DIFFERENTIATION Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes G Jego, D Lanneau, A De Thonel, K Berthenet, A Hazoumé, N Droin, A Hamman, F Girodon, P-S Bellaye, G Wettstein, A Jacquel, L Duplomb, A Le Mouël, C Papanayotou, E Christians, P Bonniaud, V Lallemand-Mezger, E Solary and C Garrido Leukemia 2014 28: 1676-1686; advance online publication, February 7, 2014; 10.1038/leu.2014.63 Abstract | Full Text LYMPHOMA Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway P P Piccaluga, M Rossi, C Agostinelli, F Ricci, A Gazzola, S Righi, F Fuligni, M A Laginestra, M Mancini, M R Sapienza, A De Renzo, P L Tazzari, D Gibellini, P Went, F Alviano, P L Zinzani, G P Bagnara, G Inghirami, C Tripodo and S A Pileri on behalf of the AIRC 5xMille consortium ‘Genetics-driven targeted management of lymphoid malignancies’ and the European T-cell Lymphoma Study Group Leukemia 2014 28: 1687-1697; advance online publication, January 31, 2014; 10.1038/leu.2014.50 Abstract | Full Text Detection of MYD88 L265P in peripheral blood of patients with Waldenström’s Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance L Xu, Z R Hunter, G Yang, Y Cao, X Liu, R Manning, C Tripsas, J Chen, C J Patterson, M Kluk, S Kanan, J Castillo, N Lindeman and S P Treon Leukemia 2014 28: 1698-1704; advance online publication, February 10, 2014; 10.1038/leu.2014.65 Abstract | Full Text MYELOMA Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma L Melchor, A Brioli, C P Wardell, A Murison, N E Potter, M F Kaiser, R A Fryer, D C Johnson, D B Begum, S Hulkki Wilson, G Vijayaraghavan, I Titley, M Cavo, F E Davies, B A Walker and G J Morgan Leukemia 2014 28: 1705-1715; advance online publication, January 13, 2014; 10.1038/leu.2014.13 Abstract | Full Text A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib A Ray, Z Tian, D S Das, R L Coffman, P Richardson, D Chauhan and K C Anderson Leukemia 2014 28: 1716-1724; advance online publication, January 30, 2014; 10.1038/leu.2014.46 Abstract | Full Text Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma M Affer, M Chesi, W D Chen, J J Keats, Y N Demchenko, K Tamizhmani, V M Garbitt, D L Riggs, L A Brents, A V Roschke, S Van Wier, R Fonseca, P L Bergsagel and W M Kuehl Leukemia 2014 28: 1725-1735; advance online publication, February 12, 2014; 10.1038/leu.2014.70 Abstract | Full Text Letters To The Editor Top JAK inhibition with ruxolitinib as pretreatment for allogeneic stem cell transplantation in primary or post-ET/PV myelofibrosis T Stübig, H Alchalby, M Ditschkowski, D Wolf, G Wulf, T Zabelina, C Wolschke, F Ayuk and N Kröger Leukemia 2014 28: 1736-1738; advance online publication, February 26, 2014; 10.1038/leu.2014.86 Full Text Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia M Kontro, H Kuusanmäki, S Eldfors, T Burmeister, E I Andersson, Ø Bruserud, T H Brümmendorf, H Edgren, B T Gjertsen, M Itälä-Remes, S Lagström, O Lohi, T Lundán, J M L Martí, M M Majumder, A Parsons, T Pemovska, H Rajala, K Vettenranta, O Kallioniemi, S Mustjoki, K Porkka and C A Heckman Leukemia 2014 28: 1738-1742; advance online publication, February 27, 2014; 10.1038/leu.2014.89 Full Text Functional and genetic aberrations of in vitro-cultured marrow-derived mesenchymal stromal cells of patients with classical Philadelphia-negative myeloproliferative neoplasms M A Avanzini, M E Bernardo, F Novara, M Mantelli, V Poletto, L Villani, E Lenta, D M Ingo, V Achille, E Bonetti, M Massa, R Campanelli, G Fois, P Catarsi, R P Gale, A Moretta, A Aronica, R Maccario, G Acquafredda, D Lisini, M Zecca, O Zuffardi, F Locatelli, G Barosi and V Rosti on behalf of the AGIMM Investigators Leukemia 2014 28: 1742-1745; advance online publication, March 12, 2014; 10.1038/leu.2014.97 Full Text Ikaros transcripts Ik6/10 and levels of full-length transcript are critical for chronic myeloid leukaemia blast crisis transformation L Wang, A Howarth and R E Clark Leukemia 2014 28: 1745-1747; advance online publication, March 12, 2014; 10.1038/leu.2014.99 Full Text Immunophenotypic alterations of bone marrow myeloid cell compartments in multiple myeloma patients predict for myelodysplasia-associated cytogenetic alterations S Matarraz, B Paiva, M Díez-Campelo, S Bárrena, M Jara-Acevedo, M L Gutiérrez, J M Sayagués, M-L Sánchez, P Bárcena, M P Garrastazul, M J Berruezo, J M Duran, C Cerveró, J A García-Erce, L Florensa, G D Méndez, O Gutierrez, M C del Cañizo, J J M van Dongen, J F San Miguel and A Orfao Leukemia 2014 28: 1747-1750; advance online publication, March 14, 2014; 10.1038/leu.2014.103 Full Text Disseminated tuberculosis associated with ruxolitinib R K Hopman, S J Lawrence and S T Oh Leukemia 2014 28: 1750-1751; advance online publication, March 13, 2014; 10.1038/leu.2014.104 Full Text Genomic analysis of the clonal origin and evolution of acute promyelocytic leukemia in a unique patient with a very late (17 years) relapse X Zhang, Q Zhang, J Dahlström, A N Tran, B Yang, Z Gu, M Ghaderi, A Porwit, J Jia, Å Derolf, D Xu and M Björkholm Leukemia 2014 28: 1751-1754; advance online publication, March 21, 2014; 10.1038/leu.2014.113 Full Text Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8 H Becker, K Maharry, K Mrózek, S Volinia, A-K Eisfeld, M D Radmacher, J Kohlschmidt, K H Metzeler, S Schwind, S P Whitman, J H Mendler, Y-Z Wu, D Nicolet, P Paschka, B L Powell, T H Carter, M Wetzler, J E Kolitz, A J Carroll, M R Baer, M A Caligiuri, R M Stone, G Marcucci and C D Bloomfield for the Alliance for Clinical Trials in Oncology Leukemia 2014 28: 1754-1758; advance online publication, March 21, 2014; 10.1038/leu.2014.114 Full Text Leukemic stem cells of acute myeloid leukemia patients carrying NPM1 mutation are candidates for targeted immunotherapy V Schneider, L Zhang, L Bullinger, M Rojewski, S Hofmann, M Wiesneth, H Schrezenmeier, M Götz, U Botzenhardt, T F E Barth, K Döhner, H Döhner and J Greiner Leukemia 2014 28: 1759-1762; advance online publication, March 28, 2014; 10.1038/leu.2014.116 Full Text Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms T L Lasho, A Pardanani, A Tefferi and D I Smith Leukemia 2014 28: 1762-1764; advance online publication, March 28, 2014; 10.1038/leu.2014.117 Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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