Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 11 Issue 8

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TABLE OF CONTENTS
August 2014 Volume 11 Number 8
Impact Factor 10.807*	In this issue Research Highlights News and Views Reviews Consensus Statement Also this month  Featured article: Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic OPEN Colin Hill, Francisco Guarner, Gregor Reid, Glenn R. Gibson, Daniel J. Merenstein, Bruno Pot, Lorenzo Morelli, Roberto Berni Canani, Harry J. Flint, Seppo Salminen, Philip C. Calder & Mary Ellen Sanders
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RESEARCH HIGHLIGHTS Top Genetics: Driver genes are mutated early in the course of oesophageal adenocarcinoma Published online: 15 July 2014 p453 | doi:10.1038/nrgastro.2014.117 PDF Liver transplantation: Immune responses to HCV infection linked to liver transplant tolerance Published online: 15 July 2014 p454 | doi:10.1038/nrgastro.2014.124 PDF IBD: TH9 cells might have a role in the pathogenesis of ulcerative colitis Published online: 24 June 2014 p455 | doi:10.1038/nrgastro.2014.108 PDF NAFLD: PNPLA3 variant and hepatic steatosis Published online: 01 July 2014 p455 | doi:10.1038/nrgastro.2014.115 PDF Motility: CO2-releasing suppository quickly and effectively relieves constipation Published online: 01 July 2014 p455 | doi:10.1038/nrgastro.2014.116 PDF Biliary tract: IL-33, innate lymphoid cells and IL-13 are required for cholangiocyte proliferation Published online: 17 June 2014 p456 | doi:10.1038/nrgastro.2014.101 PDF Gut microbiota: Tackling the effects of diet and exercise on the gut microbiota Published online: 24 June 2014 p456 | doi:10.1038/nrgastro.2014.109 PDF IN BRIEF Hepatitis: Simeprevir inclusion in PEG-IFN plus ribavirin regimen for hepatitis C is safe and effective | Liver: MicroRNAs in acute liver failure—a role in recovery? | Infection: FMT: a safe treatment for Clostridium difficile infection in immunocompromised patients | Liver cancer: New mutations involved in hepatoblastoma identified PDF Gastroenterology & Hepatology JOBS of the week Gastroenterologist Marshfield Clinic Transplant Hepatologist The Queen's Medical Center General Gastroenterology / Advanced Endoscopy / Hepatology Assistant Professor Texas Tech University Health Sciences Center Tenure Track Assistant Professor of Gastroenterology Universität Basel More Science jobs from Gastroenterology & Hepatology EVENT Liver Metabolism and Nonalcoholic Fatty Liver Disease (NAFLD) 22.03.15 Whistler, Canada More science events from
NEWS AND VIEWS		Top
Coeliac disease: The debate on coeliac disease screening—are we there yet? Carlo Catassi & Alessio Fasano Published online: 08 July 2014 p457 | doi:10.1038/nrgastro.2014.119 The majority of patients with coeliac disease are undiagnosed, leading to debate about the utility of screening. The heterogeneous clinical presentation, which includes asymptomatic forms, can partially explain the difficulties faced when identifying coeliac disease. Now, Kurppa and colleagues add another element to the debate by strengthening the arguments for general screening. Full Text | PDF
PPI therapy: The small bowel, low-dose aspirin and PPIs—should we be concerned? Angel Lanas & Carlos Sostres Published online: 08 July 2014 p458 | doi:10.1038/nrgastro.2014.120 A new study suggests that co-prescription of low-dose aspirin and PPIs increases the incidence of small-bowel mucosal breaks. Should we be concerned about the potential negative interactions of these drugs? Or is the balance of evidence still substantially tipped towards the need for PPIs to protect against aspirin-induced upper gastrointestinal damage? Full Text | PDF
Neurogastroenterology: Neuronal correlates of placebo in chronic FGIDs QiQi Zhou & G. Nicholas Verne Published online: 08 July 2014 p460 | doi:10.1038/nrgastro.2014.118 Placebo analgesia is increasingly appreciated in many difficult to treat chronic functional gastrointestinal disorders such as IBS. However, investigations of interactions between psychological and biological placebo factors are still in early stages. Now, technologies have been developed that enable neural mechanisms of placebo analgesia to be studied more directly in humans. Full Text | PDF
REVIEWS		Top
Treatment options for acute pancreatitis Olaf J. Bakker, Yama Issa, Hjalmar C. van Santvoort, Marc G. Besselink, Nicolien J. Schepers, Marco J. Bruno, Marja A. Boermeester & Hein G. Gooszen Published online: 25 March 2014 p462 | doi:10.1038/nrgastro.2014.39 Several important changes in disease classification and improvements in the management of patients with acute pancreatitis have been achieved in the past few years. This Review provides an overview of these changes, the effect on patient management and outcome, and outlines their scientific basis. Abstract | Full Text | PDF
Radiation enteropathy—pathogenesis, treatment and prevention Martin Hauer-Jensen, James W. Denham & H. Jervoise N. Andreyev Published online: 01 April 2014 p470 | doi:10.1038/nrgastro.2014.46 Radiation enteropathy remains an important obstacle to uncomplicated cancer cures after radiation therapy of pelvic and abdominal malignancies. Moreover, the prevalence of radiation enteropathy in the population exceeds that of IBD. This Review introduces the clinical problem of radiation enteropathy, discusses contemporary concepts in pathogenesis, current therapeutic options and strategies for development of new radioprotective agents. Abstract | Full Text | PDF
MRI for assessing and predicting response to neoadjuvant treatment in rectal cancer Regina G. H. Beets-Tan & Geerard L. Beets Published online: 25 March 2014 p480 | doi:10.1038/nrgastro.2014.41 In this Review, the authors highlight the strengths and weaknesses of MRI for response assessment after chemoradiotherapy in patients with rectal cancer, and on its ability to predict tumour response at the time of primary diagnosis. New functional magnetic resonance technology is also outlined. Abstract | Full Text | PDF
Advances in the management of the explanted donor liver Maxim Nebrig, Peter Neuhaus & Andreas Pascher Published online: 22 April 2014 p489 | doi:10.1038/nrgastro.2014.58 In this Review, various aspects of pretransplant donor liver management are discussed, including donor preconditioning, conventional and dynamic preservation techniques and ex vivo organ viability monitoring and graft pretreatment. The technique and clinical outcomes of split-liver transplantation are evaluated. Furthermore, the literature on rare liver donor conditions with non-standard ethical or technical issues is assessed with respect to clinical relevance. Abstract | Full Text | PDF
A role for the gut microbiota in IBS Stephen M. Collins Published online: 22 April 2014 p497 | doi:10.1038/nrgastro.2014.40 The gut microbiota is now acknowledged to have a profound effect on human health and disease. Here, Stephen Collins explores the role of the gut microbiota in the development of IBS, describing experimental evidence and clinical observational and trial data that implicates the gut microbiota in the manifestation of IBS. Abstract | Full Text | PDF
CONSENSUS STATEMENT		Top
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic Colin Hill, Francisco Guarner, Gregor Reid, Glenn R. Gibson, Daniel J. Merenstein, Bruno Pot, Lorenzo Morelli, Roberto Berni Canani, Harry J. Flint, Seppo Salminen, Philip C. Calder & Mary Ellen Sanders Published online: 10 June 2014 p506 | doi:10.1038/nrgastro.2014.66 Probiotics are widely regarded as live microorganisms that, when administered in sufficient amounts, confer a health benefit, but guidance is needed on the most appropriate use of the term. This Consensus Statement outlines recommendations for the scope and definition of the term 'probiotic' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in October 2013. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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