Nature Reviews Urology - Table of Contents alert Volume 11 Issue 8

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TABLE OF CONTENTS
August 2014 Volume 11 Number 8
Impact Factor 4.522 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers Eric C. Kauffman, Christopher J. Ricketts, Soroush Rais-Bahrami, Youfeng Yang, Maria J. Merino, Donald P. Bottaro, Ramaprasad Srinivasan & W. Marston Linehan
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RESEARCH HIGHLIGHTS Top Male factor infertility: In vitro spermatogenesis and fertilization from cryopreserved murine testicular tissue Published online: 15 July 2014 p421 | doi:10.1038/nrurol.2014.174 PDF Kidney cancer: Diabetes and low serum cholesterol are risk factors for RCC Published online: 01 July 2014 p422 | doi:10.1038/nrurol.2014.157 PDF Prostate cancer: GTx-758 reduces testosterone Published online: 08 July 2014 p422 | doi:10.1038/nrurol.2014.165 PDF Prostate cancer: Phasing in new treatment Published online: 15 July 2014 p423 | doi:10.1038/nrurol.2014.173 PDF Prostate cancer: Niclosamide jumps the hurdle of enzalutamide resistance Published online: 01 July 2014 p424 | doi:10.1038/nrurol.2014.160 PDF Kidney cancer: Androgen receptor—a new target in renal cell carcinoma? Published online: 01 July 2014 p425 | doi:10.1038/nrurol.2014.159 PDF Prostate cancer: Unravelling bias in vasectomy associations Published online: 22 July 2014 p425 | doi:10.1038/nrurol.2014.182 PDF Prostate cancer: Multiparametric MRI is better than a nomogram for predicting high-risk disease Published online: 01 July 2014 p426 | doi:10.1038/nrurol.2014.161 PDF Incontinence: Long-term durability of autologous fascial slings Published online: 08 July 2014 p426 | doi:10.1038/nrurol.2014.166 PDF Infectious disease: New Trichs: screening and therapy Published online: 01 July 2014 p427 | doi:10.1038/nrurol.2014.158 PDF Kidney cancer: A model for the masses—3D printing of kidney tumours Published online: 08 July 2014 p428 | doi:10.1038/nrurol.2014.167 PDF Incontinence: Artificial urinary sphincter more likely to fail in compromised urethras Published online: 22 July 2014 p428 | doi:10.1038/nrurol.2014.183 PDF IN BRIEF Andrology: Low risk of prostate cancer after testosterone therapy | Prostate cancer: Linked brachytherapy seeds to prevent migration | Testicular cancer: Circulating tumour cells predictive of stage | Stones: Thiazide prophylaxis does not increase diabetes risk | Prostate cancer: Targeted GRPR photoacoustic imaging shows promise | Kidney cancer: Renal pelvic score predicts urine leak after nephrectomy | Prostate cancer: Fixed sling is superior for postprostatectomy incontinence | Male factor infertility: Effects of ejaculatory abstinence on sperm parameters PDF
NEWS AND VIEWS		Top
Prostate cancer: Rescreening policies and risk calculators Monique J. Roobol Published online: 01 July 2014 p429 | doi:10.1038/nrurol.2014.142 PSA-based screening is common in the western world. However, rescreening policies are ambiguous, resulting in unnecessary testing. Recent data suggest that rescreening intervals should be decided on the basis of a baseline PSA level, but how is this recommendation likely to be received by the clinical community? Full Text | PDF
Bladder cancer: Defining intermediate-risk non-muscle-invasive bladder cancer S. Bruce Malkowicz Published online: 22 July 2014 p430 | doi:10.1038/nrurol.2014.172 The pathology of intermediate-risk non-muscle-invasive bladder cancer is less well-defined than both high-risk and low-risk presentations of this disease. Recently reported guidelines seek to aid clinicians in classification of intermediate-risk patients, and also provide treatment recommendations for this subgroup. Full Text | PDF
Paediatrics: New cryptorchidism guidelines reach a consensus Jorma Toppari Published online: 29 July 2014 p432 | doi:10.1038/nrurol.2014.180 The American Urological Association has released a new guideline on the evaluation and treatment of cryptorchidism, recommending early orchiopexy as the first-line treatment for both the congenital and acquired forms of the disease; hormonal therapy is not recommended. Given similarities with current European recommendations, transatlantic consensus has been achieved. Full Text | PDF
Prostate cancer: Predicting response to androgen receptor signalling inhibition Christopher P. Evans & Primo N. Lara Jr Published online: 22 July 2014 p433 | doi:10.1038/nrurol.2014.179 Although the androgen receptor remains active in metastatic castration-resistant prostate cancer, the heterogeneity of this disease means that response to treatment in individual patients is uncertain. Analysis of relevant tissue before and after therapy can help identify markers of response and resistance to androgen receptor signalling inhibitors. Full Text | PDF
REVIEWS		Top
Enhanced recovery programmes for patients undergoing radical cystectomy Julian Smith, Raj S. Pruthi & John McGrath Published online: 15 July 2014 p437 | doi:10.1038/nrurol.2014.164 In this Review, Smith and colleagues discuss the use of enhanced recovery programmes, which are multimodal approaches to minimize the psychological and physiological disruption—and expedite the return of normal function—after radical cystectomy. They consider the preoperative, perioperative and postoperative factors that should be incorporated into clinical care to improve patient outcomes. Abstract | Full Text | PDF
Sexual dysfunction after cystectomy and urinary diversion Rishi A. Modh, John P. Mulhall & Scott M. Gilbert Published online: 01 July 2014 p445 | doi:10.1038/nrurol.2014.151 Cystectomy with urinary diversion is a key approach to the management of bladder cancer. This Review provides an overview of a complication that is common among the men and women who undergo such surgical treatment: sexual dysfunction. In particular, the tools that can be used to assess sexual function in this context and its effect on quality of life, the various contributory aetiological factors underlying sexual dysfunction, as well as approaches to treating sexual issues are discussed. Abstract | Full Text | PDF
Voiding dysfunction due to detrusor underactivity: an overview Marcus J. Drake, Jonathan Williams & Dominika A. Bijos Published online: 08 July 2014 p454 | doi:10.1038/nrurol.2014.156 Detrusor underactivity (DUA) results in prolonged urinary voiding or failure to completely empty the bladder and is associated with lower urinary tract symptoms. Drake and colleagues provide an overview of the pathophysiology and management of DUA, highlighting the aetiological, diagnostic, and therapeutic challenges of this condition. Abstract | Full Text | PDF
Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers Eric C. Kauffman, Christopher J. Ricketts, Soroush Rais-Bahrami, Youfeng Yang, Maria J. Merino, Donald P. Bottaro, Ramaprasad Srinivasan & W. Marston Linehan Published online: 22 July 2014 p465 | doi:10.1038/nrurol.2014.162 In this Review, Kauffman and colleagues summarize contemporary understanding of the molecular biology underlying TFE3 and TFEB gene-fusion-associated (translocation) renal cell carcinomas. They discuss the candidate mechanisms and signalling pathways thought to contribute to the oncogenesis of these tumours, and describe TFE3 and TFEB fusion genetic organization. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE Landmarks in non-muscle-invasive bladder cancer Laura S. Mertens, Yann Neuzillet, Simon Horenblas & Bas W. G. van Rhijn Published online: 01 July 2014 p476 | doi:10.1038/nrurol.2014.130 Non-muscle-invasive bladder cancer represents 75% of primary diagnoses and is characterized by frequent recurrence but a low risk of mortality. In this Timeline article, Mertens and colleagues discuss landmark events in the detection, diagnosis, and treatment of non-muscle-invasive bladder cancer. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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