Nature Reviews Nephrology - Table of Contents alert Volume 10 Issue 10

TABLE OF CONTENTS
October 2014 Volume 10 Number 10
Impact Factor 8.368 *	In this issue Research Highlights News and Views Reviews Perspectives Correspondence Also this month  Featured article: Henoch–Schönlein purpura nephritis in children Jean-Claude Davin & Rosanna Coppo
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RESEARCH HIGHLIGHTS Top Hypertension: Urinary sodium and potassium excretion: association with blood pressure and clinical outcomes Published online: 26 August 2014 p541 | doi:10.1038/nrneph.2014.157 PDF Transplantation: Alemtuzumab induction reduces acute rejection risk Published online: 12 August 2014 p542 | doi:10.1038/nrneph.2014.143 PDF Development: Wnt5a implicated in CAKUT Published online: 19 August 2014 p543 | doi:10.1038/nrneph.2014.155 PDF Glomerular disease: Innate immunity—APOL1 interaction Published online: 26 August 2014 p543 | doi:10.1038/nrneph.2014.158 PDF Transplantation: Prognostic value of C3d-binding DSA Published online: 02 September 2014 p543 | doi:10.1038/nrneph.2014.165 PDF Connective tissue diseases: mTORC is a potential therapeutic target in APS Published online: 05 August 2014 p544 | doi:10.1038/nrneph.2014.141 PDF Cystic kidney disease: Intracellular clusterin implicated in nephropathic cystinosis Published online: 12 August 2014 p544 | doi:10.1038/nrneph.2014.142 PDF IN BRIEF Polycystic kidney disease: High-resolution ultrasonography improves cyst detection | Dialysis: Haemodialysis-associated cardiovascular risks revealed | Diabetic nephropathy: Nlrp3-inflammasome activated in diabetic nephropathy | Genetics: Rare mutations associated with chronic kidney disease PDF Nephrology JOBS of the week Postdoctoral fellow University of Pittsburgh School of Medicine More Science jobs from Nephrology EVENT ISN World Congress of Nephrology 2015 13.03.15 Cape Town, South Africa More science events from
NEWS AND VIEWS		Top
Glomerular disease: Limiting autoimmune tissue injury: ROS and the inflammasome Santhosh V. R. Kumar & Hans-Joachim Anders Published online: 26 August 2014 p545 | doi:10.1038/nrneph.2014.156 Schreiber et al. have identified an unexpected immunoregulatory role of reactive oxygen species in antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis. Here, we discuss these findings in view of other pathways with well-known immunostimulatory roles in kidney disease that have recently been shown to have additional immunosuppressive effects. Full Text | PDF
Diabetic nephropathy: Renoprotective effects of pentoxifylline in the PREDIAN trial Tony He & Mark E. Cooper Published online: 09 September 2014 p547 | doi:10.1038/nrneph.2014.162 The PREDIAN trial investigated the renoprotective effects of pentoxifylline, in addition to renin—angiotensin system blockade, in patients with type 2 diabetes mellitus and chronic kidney disease. This promising approach resulted in a reduction in the rate of decline in estimated glomerular filtration rate and a significant decrease in albuminuria. Full Text | PDF
Transplantation: Recognizing self versus non-self: new territory for monocytes Deepak K. Nayak & Thalachallour Mohanakumar Published online: 19 August 2014 p548 | doi:10.1038/nrneph.2014.144 The role of the innate immune system in mediating allograft rejection is unclear. A new study demonstrates for the first time the ability of allografts to stimulate the differentiation of monocytes into inflammatory dendritic cells, which produce IL-12 and stimulate T cells, leading to graft rejection. Full Text | PDF
Acute kidney injury: Validating the KDIGO definition and staging—one step at a time Vivekanand Jha & Vivek Kumar Published online: 02 September 2014 p550 | doi:10.1038/nrneph.2014.160 Despite uncertainty in the KDIGO guidelines, new research has shown that they can accurately identify acute kidney injury in critically ill patients who have a high risk of mortality. Future refinements to AKI definitions will require biomarkers, and robust assessments in prospective studies. Full Text | PDF
Transplantation: To accept, or not to accept—that is the question Jeremy Robert Chapman & Chi Kwam Lam Published online: 09 September 2014 p551 | doi:10.1038/nrneph.2014.161 Should poor-quality kidneys be allocated to elderly recipients? A new study has determined that kidney recipients aged ≥70 years have similar outcomes regardless of donor-organ quality, with the exception of the lowest-quintile quality organs. These data can help physicians advise their elderly patients to decide whether or not to accept a kidney offer. Full Text | PDF
REVIEWS		Top
Immunization after kidney transplantation—what is necessary and what is safe? Camille N. Kotton Published online: 29 July 2014 p555 | doi:10.1038/nrneph.2014.122 Although vulnerable to infection, substantial numbers of kidney transplant recipients remain unvaccinated. This missed opportunity for protection can result in serious infection, graft loss and mortality. Here, Camille Kotton discusses the safety, efficacy, need for and timing of vaccination in adult transplant recipients, including discussion of specific vaccines and indications. Abstract | Full Text | PDF
Henoch–Schönlein purpura nephritis in children Jean-Claude Davin & Rosanna Coppo Published online: 29 July 2014 p563 | doi:10.1038/nrneph.2014.126 Nephritis is observed in around 30% of children with Henoch–Schönlein purpura (HSP). The treatment of these patients is complicated by similarity to IgA nephropathy. Here, the authors discuss advances in understanding of the pathophysiology, diagnosis and treatment of paediatric HSP nephritis. They suggest that current treatment guidelines based evidence obtained in adults with IgA nephropathy might be inappropriate for children with HSP nephritis. Abstract | Full Text | PDF
Deferasirox nephrotoxicity—the knowns and unknowns Juan Daniel Díaz-García, Angel Gallegos-Villalobos, Liliana Gonzalez-Espinoza, Maria D. Sanchez-Niño, Jesus Villarrubia & Alberto Ortiz Published online: 22 July 2014 p574 | doi:10.1038/nrneph.2014.121 Since the approval of deferasirox for patients with blood-transfusion-related iron overload by the FDA in 2005, >150,000 patient-years of exposure have occurred. However, nephrotoxicity is a common adverse effect of deferasirox therapy and the drug remains a medicine under additional monitoring status. Here, Díaz-García et al. review the clinical features, epidemiology and current understanding of the molecular mechanisms of deferasirox nephrotoxicity. Abstract | Full Text | PDF | Supplementary information
Translational research in ADPKD: lessons from animal models Hester Happé & Dorien J. M. Peters Published online: 19 August 2014 p587 | doi:10.1038/nrneph.2014.137 In the past decade, rodent models have proven critical to study the molecular basis and natural history of polycystic kidney disease. Here, the authors provide an update on the models used to investigate the molecular pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) and test potential therapies. They also highlight progress that has been made in understanding the pathophysiology of ADPKD in humans. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Drug development: how academia, industry and authorities interact Silvio Garattini & Norberto Perico Published online: 05 August 2014 p602 | doi:10.1038/nrneph.2014.133 Drug trial and approval processes are often affected by the conflicting interests of regulatory authorities, academia, and the pharmaceutical industry. In this Perspectives article, Silvio Garattini and Norberto Perico discuss examples of particular relevance to therapeutic interventions in nephrology, to highlight and summarize flaws in the current drug development process. The authors call on academia to develop more-effective relationships with both regulatory authorities and the pharmaceutical industry to balance public needs with commercial aims. Abstract | Full Text | PDF
CORRESPONDENCE		Top
suPAR is the circulating factor in some but not all FSGS Howard Trachtman & Jochen Reiser Published online: 26 August 2014 p610 | doi:10.1038/nrneph.2014.113-c1 Full Text | PDF
Reply: Measurement of serum suPAR is not ready for clinical use Jeroen Deegens & Jack Wetzels Published online: 26 August 2014 p610 | doi:10.1038/nrneph.2014.113-c2 Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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