Nature Reviews Nephrology - Table of Contents alert Volume 10 Issue 11

TABLE OF CONTENTS
November 2014 Volume 10 Number 11
Impact Factor 8.368 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Management of hyperkalaemia in chronic kidney disease Csaba P. Kovesdy
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RESEARCH HIGHLIGHTS Top Stones: Ultrasonography and computed tomography: performance in detection of kidney stones Published online: 30 September 2014 p611 | doi:10.1038/nrneph.2014.182 PDF Diabetic nephropathy: HIF activation in prevention of diabetic nephropathy Published online: 23 September 2014 p612 | doi:10.1038/nrneph.2014.177 PDF Clinical trials: Lifestyle intervention reduces CKD risk associated with type 2 diabetes Published online: 02 September 2014 p613 | doi:10.1038/nrneph.2014.166 PDF Dialysis: Optimal timing of arteriovenous fistula placement in elderly patients Published online: 16 September 2014 p613 | doi:10.1038/nrneph.2014.171 PDF Pre-eclampsia: Low-dose aspirin for pre-eclampsia Published online: 30 September 2014 p613 | doi:10.1038/nrneph.2014.183 PDF Transplantation: The role of platelets in antibody-mediated rejection Published online: 09 September 2014 p614 | doi:10.1038/nrneph.2014.167 PDF Gut microbiota: Post-transplant complications associated with gut flora Published online: 23 September 2014 p614 | doi:10.1038/nrneph.2014.178 PDF IN BRIEF Renal artery stenosis: Routine renal revascularization after stenosis: no benefit | Risk factors: AKI after CABG increases risk of ESRD | Transplantation: Steroid-free immunosuppression reduces 5-year morbidity | Renal fibrosis: Renal interstitial fibrosis predicted by mathematical model PDF Nephrology JOBS of the week More Science jobs from Nephrology EVENT ISN World Congress of Nephrology 2015 13.03.15 Cape Town, South Africa More science events from
NEWS AND VIEWS		Top
Glomerular disease: Pre-eclampsia, podocyturia and the role of parietal epithelial cells Turgay Saritas & Marcus J. Moeller Published online: 09 September 2014 p615 | doi:10.1038/nrneph.2014.163 Podocyturia in patients with pre-eclampsia has been widely documented, but the underlying pathology is unknown. A new study highlights the glomerular histological alterations in a unique Dutch cohort of deceased patients with pre-eclampsia. The results suggest an important, albeit controversial, role of parietal epithelial cells in this context. Full Text | PDF
Therapy: Atenolol versus metoprolol tartrate—conflicting outcomes data Sukhbir K. Randhawa & William J. Elliott Published online: 09 September 2014 p617 | doi:10.1038/nrneph.2014.164 Two recent population-based studies reported higher death rates in patients given metoprolol tartrate than in those given atenolol. These observations contrast with those of a US study in which patients with known cardiovascular disease were excluded, suggesting that indication bias or residual confounding might account for the difference in findings. Full Text | PDF
Dialysis: Is it realistic to compare peritoneal dialysis and haemodialysis? Frederic O. Finkelstein & Nathan W. Levin Published online: 30 September 2014 p618 | doi:10.1038/nrneph.2014.176 A new study suggests that peritoneal dialysis achieves a favourable mortality outcome compared with haemodialysis for the first 2 years of treatment. However, registry-based comparisons of mortality outcomes in patients with end-stage renal disease on either renal replacement modality are often fraught with complications. Full Text | PDF
Hypertension: Is it time to reconsider blood pressure guidelines? Anna Burgner & Julia B. Lewis Published online: 23 September 2014 p620 | doi:10.1038/nrneph.2014.174 The KDIGO recommendation for blood pressure management in patients with chronic kidney disease and proteinuria is based partly on underpowered subgroup and post hoc analyses. New observational data, however, demonstrate that lower blood pressure goals may be harmful in this group of patients. Full Text | PDF
Risk factors: HDL-cholesterol levels and mortality in patients with ESRD Nosratola D. Vaziri Published online: 23 September 2014 p621 | doi:10.1038/nrneph.2014.169 In the general population, risk of cardiovascular disease is inversely associated with HDL-cholesterol levels. However, a new post hoc analysis of data from the German Diabetes Dialysis study reports no correlation between HDL cholesterol and mortality among patients on dialysis—a phenomenon that the authors attribute to HDL dysfunction. Full Text | PDF
Hypertension: Fluid overload and post-dialysis hypertension Francesca Mallamaci & Giovanni Tripepi Published online: 23 September 2014 p623 | doi:10.1038/nrneph.2014.175 Although intradialytic hypertension is associated with all-cause mortality, the mechanisms that underlie this phenomenon are not well understood. Now, Nongnuch et al. report that post-dialysis hypertension is associated with extracellular fluid overload, and suggest that patients with this condition might benefit from increased dialysis session length or frequency. Full Text | PDF
REVIEWS		Top
Dendritic cells and macrophages in the kidney: a spectrum of good and evil Natasha M. Rogers, David A. Ferenbach, Jeffrey S. Isenberg, Angus W. Thomson & Jeremy Hughes Published online: 30 September 2014 p625 | doi:10.1038/nrneph.2014.170 Renal dendritic cells and macrophages are key factors in the initiation and propagation of renal disease and tissue regeneration. In this Review, the authors discuss the common and distinct characteristics of dendritic cells and macrophages as well as current understanding of the renal-specific functions of these important phagocytic, antigen-presenting cell types in potentiating or mitigating intrinsic kidney disease. Abstract | Full Text | PDF
Economic evaluation of dialysis therapies Scott W. Klarenbach, Marcello Tonelli, Betty Chui & Braden J. Manns Published online: 26 August 2014 p644 | doi:10.1038/nrneph.2014.145 The cost and cost-effectiveness of dialysis therapy for patients with end-stage renal disease is a key consideration for health-care providers, particularly given the increasing prevalence of chronic kidney disease worldwide. Here, Klarenbach and colleagues discuss available data comparing the relative cost and cost-effectiveness of various dialysis modalities, including variations in the intrinsic costs of the different modalities and other factors, such as economic differences between high-income and low–middle-income nations. Abstract | Full Text | PDF
Management of hyperkalaemia in chronic kidney disease Csaba P. Kovesdy Published online: 16 September 2014 p653 | doi:10.1038/nrneph.2014.168 Hyperkalaemia is common in patients with chronic kidney disease and is associated with adverse outcomes. Here, Csaba Kovesdy gives an overview of the mechanisms underlying hyperkalaemia and its clinical consequences in this patient population, and discusses current treatment regimens, as well as emerging therapies that might enable the more-liberal use of beneficial therapeutics in specific populations of patients at risk of hyperkalaemia. Abstract | Full Text | PDF
Donor-derived infection—the challenge for transplant safety Jay A. Fishman & Paolo A. Grossi Published online: 02 September 2014 p663 | doi:10.1038/nrneph.2014.159 Each year, over 70,000 organs are transplanted worldwide. The degree of risk of transmission of infection from transplanted organs to the recipient is largely unknown and is difficult to assess for specific organs. Here, Jay A. Fishman and Paolo A. Grossi describe the major risk factors for organ donor-derived transmission of infection and discuss opportunities to reduce the incidence of such events. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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