EMBO reports Table of Contents for December 2014; Vol. 15, No. 12

December 2014 | Volume 15, Number 12 Submit Table of Contents Editorial Hot off the Press Science & Society Review Scientific Reports Addendum Retraction Volume 15, Number 12 Editorial The winning of the Western Howy laments the lack of a simple tool for specific protein analysis, akin to PCR for nucleic acids. Howy Jacobs Published online 30.11.2014 Hot off the Press Micro‐RNAs meet epigenetics to make for better brains A study in this issue shows that miR‐15b directly targets TET3 to epigenetically repress cyclin D1 expression and neural progenitor cell proliferation, which promotes neurogenesis in the mouse neocortex. Florian Noack and Federico Calegari Published online 03.11.2014 Closing the MCM cycle at replication termination sites The termination of eukaryotic DNA replication is a poorly understood process. Two recent papers show that the CMG replicative helicase is unloaded at replication termination sites after Mcm7 ubiquitylation by Cdc48/p97‐mediated extraction. Armelle Lengronne and Philippe Pasero Published online 12.11.2014 Science & Society Scientometrics in a changing research landscape: Bibliometrics has become an integral part of research quality evaluation and has been changing the practice of research Bibliometrics has become an integral component of quality assessment for science and funding decisions. The next challenge for scientometrics is to develop similarly reliable indicators for the social impact of research. Lutz Bornmann and Loet Leydesdorff Published online 11.11.2014 Lifestyle in the sperm: There is growing evidence that epigenetic marks can be inherited. But what is the nature of the information they store and over how many generations do they prevail? Observations of epigenetic inheritance challenge classical genetics and imply that Lamarck might have been right—sort of. The jury is still out, as the mechanisms and scope of epigenetic inheritance are not yet fully understood. Katrin Weigmann Published online 08.11.2014 Brown is the new green: Brownfield sites often harbour a surprisingly large amount of biodiversity Crumbling industrial areas on the edges of cities are a common eyesore but often support a wide variety of species. Conservationists are trying to discover why brownfield sites are such havens of biodiversity so as to better protect and manage them. Philip Hunter Published online 05.11.2014 Review The extracellular matrix modulates the hallmarks of cancer This review discusses how the biochemical and biophysical properties of the extracellular matrix evolve during tumor progression and how they critically impact the behavior of tumor and stromal cells. Michael W Pickup, Janna K Mouw, and Valerie M Weaver Published online 08.11.2014 Scientific Reports Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β‐catenin signalling Tyr phosphorylation of LRP6 by Src and Fer is reported as a new mode of negative regulation of Wnt/β‐catenin signalling. LRP6 phosphorylation is stimulated by Wnt and leads to the disruption of LRP6 signalosome formation and removal of LRP6 from the cell surface. Qing Chen, Yi Su, Janine Wesslowski, Anja I Hagemann, Mirana Ramialison, Joachim Wittbrodt, Steffen Scholpp, and Gary Davidson Published online 12.11.2014 Cezanne (OTUD7B) regulates HIF‐1α homeostasis in a proteasome‐independent manner The Lys11 linkage‐specific deubiquitinase Cezanne is shown to regulate HIF‐1α protein stability. Intriguingly, Cezanne‐mediated stabilization depends on pVHL, but not hydroxylation, and is proteasome‐independent. Anja Bremm, Sonia Moniz, Julia Mader, Sonia Rocha, and David Komander Published online 29.10.2014 The RtcB RNA ligase is an essential component of the metazoan unfolded protein response Work in C. elegans shows that RtcB is the RNA ligase for xbp‐1 splicing in the IRE‐1 branch of the UPR. RtcB also ligates endogenous tRNA substrates and promotes lifespan and development. Sara Guckian Kosmaczewski, Tyson James Edwards, Sung Min Han, Matthew J Eckwahl, Benjamin Isaiah Meyer, Sally Peach, Jay R Hesselberth, Sandra L Wolin, and Marc Hammarlund Published online 03.11.2014 Foxd3 suppresses NFAT‐mediated differentiation to maintain self‐renewal of embryonic stem cells This study shows that Foxd3, a pluripotency‐associated transcription factor, interacts with and represses NFAT transcriptional activities by recruiting the co‐repressor Tle4. Thus, Foxd3 represses, while NFATc3 activates, a set of differentiation‐associated genes to maintain the balance between self‐renewal and differentiation in mouse embryonic stem cells. Lili Zhu, Shiyue Zhang, and Ying Jin Published online 06.11.2014 Epithelial–stromal interaction via Notch signaling is essential for the full maturation of gut‐associated lymphoid tissues This study shows that for the full development of gut‐associated lymphoid tissues, stromal cells must induce Notch signaling in the adjacent intestinal epithelium to prevent goblet cell differentiation. Yuuki Obata, Shunsuke Kimura, Gaku Nakato, Keito Iizuka, Yurika Miyagawa, Yutaka Nakamura, Yukihiro Furusawa, Machiko Sugiyama, Keiichiro Suzuki, Masashi Ebisawa, Yumiko Fujimura, Hisahiro Yoshida, Toshihiko Iwanaga, Koji Hase, and Hiroshi Ohno Published online 05.11.2014 MicroRNA‐15b promotes neurogenesis and inhibits neural progenitor proliferation by directly repressing TET3 during early neocortical development This study shows that miR‐15b targets TET3 and that miR‐15b and TET3 contribute to maintain the NPC pool during early neocortical development. Xiaohui Lv, Huihui Jiang, Yanli Liu, Xuepei Lei, and Jianwei Jiao Published online 24.10.2014 E2F1 induces miR‐224/452 expression to drive EMT through TXNIP downregulation The E2F1‐miR‐244/452‐TXNIP pathway is shown to be crucial for melanoma invasion and metastasis in vivo. By activating the expression of miR‐224/452, E2F1 leads to the downregulation of its inhibitor, TXNIP, and induces EMT. Susanne Knoll, Katharina Fürst, Bhavani Kowtharapu, Ulf Schmitz, Stephan Marquardt, Olaf Wolkenhauer, Hubert Martin, and Brigitte M Pützer Published online 23.10.2014 Addendum UBL5 is essential for pre‐mRNA splicing and sister chromatid cohesion in human cells Yasuyoshi Oka, Hanne Varmark, Kristoffer Vitting‐Seerup, Petra Beli, Johannes Waage, Anna Hakobyan, Martin Mistrik, Chunaram Choudhary, Mikkel Rohde, Simon Bekker‐Jensen, and Niels Mailand Published online 30.11.2014 Retraction Retraction: ‘Switching of chromatin‐remodelling complexes for oestrogen receptor‐α’ Maiko Okada, Shin‐ichiro Takezawa, Yoshihiro Mezaki, Ikuko Yamaoka, Ichiro Takada, Hirochika Kitagawa, and Shigeaki Kato Published online 30.11.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.