The EMBO Journal Table of Contents for 17 December 2014; Vol. 33, No. 24

17 December 2014 | Volume 33, Number 24 Submit Table of Contents Have you seen? Articles Retraction Volume 33, Number 24 Have you seen? Orphan enzyme cuts down on sugar The presenilin‐like protease SPPL3 cleaves Golgi‐resident glycosyltransferases and glycosidases to regulate global protein N‐glycosylation. Siniša Urban Published online 20.11.2014 Burning down the house: IRF7 makes the difference for microglia Tissue‐specific environmental factors determine the fate of resident myeloid‐derived cells, affecting the resolution of tissue injury in the brain. Nora Hagemeyer and Marco Prinz Published online 13.11.2014 Making ends meet: a role of RNA ligase RTCB in unfolded protein response Recent studies show that RTCB not only processes intron‐containing tRNAs, but also splices XBP1, a key regulator of UPR that is also important for priming specific cells for high secretory activity such as plasma cells. Witold Filipowicz Published online 17.11.2014 Articles Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation The intramembrane‐cleaving GxGD‐type aspartyl protease, SPPL3, controls the proteolytic release of the ectodomain of glycosyltransferases and glycosidases to regulate cellular N‐glycosylation. Matthias Voss, Ulrike Künzel, Fabian Higel, Peer‐Hendrik Kuhn, Alessio Colombo, Akio Fukumori, Martina Haug‐Kröper, Bärbel Klier, Gudula Grammer, Andreas Seidl, Bernd Schröder, Reinhard Obst, Harald Steiner, Stefan F Lichtenthaler, Christian Haass, and Regina Fluhrer Published online 29.10.2014 Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7‐dependent manner TGFβ1 regulates the ability of microglia to acquire an inflammation resolving phenotype under pathological conditions by down‐regulating the expression of the transcription factor IRF7. Merav Cohen, Orit Matcovitch, Eyal David, Zohar Barnett‐Itzhaki, Hadas Keren‐Shaul, Ronnie Blecher‐Gonen, Diego Adhemar Jaitin, Antonio Sica, Ido Amit, and Michal Schwartz Published online 10.11.2014 The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells The capacity of B cells to differentiate into plasma cells and secrete antibodies upon activation relies on the efficient splicing of the XBP1 mRNA, catalyzed by the tRNA ligase complex and its co‐factor archease during the unfolded protein response. Jennifer Jurkin, Theresa Henkel, Anne Færch Nielsen, Martina Minnich, Johannes Popow, Therese Kaufmann, Katrin Heindl, Thomas Hoffmann, Meinrad Busslinger, and Javier Martinez Published online 06.11.2014 Cytosolic RNA:DNA hybrids activate the cGAS–STING axis RNA:DNA hybrids are a novel class of intracellular PAMP molecules that can directly stimulate cGAS to produce cGAMP leading to the induction of antiviral response genes. Arun K Mankan, Tobias Schmidt, Dhruv Chauhan, Marion Goldeck, Klara Höning, Moritz Gaidt, Andrew V Kubarenko, Liudmila Andreeva, Karl‐Peter Hopfner, and Veit Hornung Published online 25.11.2014 TDP‐1, the Caenorhabditis elegans ortholog of TDP‐43, limits the accumulation of double‐stranded RNA Mutations in RNA‐binding protein TDP‐43 are linked to ALS. This study reports that the worm homolog of TDP‐43, TDP‐1, limits the accumulation of double‐stranded RNAs, offering insight on the potential contribution of TDP‐43/TDP‐1 to disease onset. Tassa K Saldi, Peter EA Ash, Gavin Wilson, Patrick Gonzales, Alfonso Garrido‐Lecca, Christine M Roberts, Vishantie Dostal, Tania F Gendron, Lincoln D Stein, Thomas Blumenthal, Leonard Petrucelli, and Christopher D Link Published online 12.11.2014 Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells This paper unravels the functionality of Escargot, so far described as marker for progenitors cells in Drosophila, in intestinal stem cell maintenance and suppressor of differentiation. Jerome Korzelius, Svenja K Naumann, Mariano A Loza‐Coll, Jessica SK Chan, Devanjali Dutta, Jessica Oberheim, Christine Gläßer, Tony D Southall, Andrea H Brand, D Leanne Jones, and Bruce A Edgar Published online 08.10.2014 Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot These authors uncover a dual role of Escargot (Esg) in Drosophila intestinal stem cell homeostasis: While regulating stem cell maintenance, Esg also controls Notch‐dependent enteroblast differentiation via its direct target gene Amun. Mariano A Loza‐Coll, Tony D Southall, Sharsti L Sandall, Andrea H Brand, and D Leanne Jones Published online 27.11.2014 Arhgef7 promotes activation of the Hippo pathway core kinase Lats βPix (Arhgef7) is required for cytoplasmic accumulation of Yap/Taz induced by either high cell density or cytoskeletal remodelling and acts by scaffolding the hippo kinase component Lats to Yap/Taz. Emad Heidary Arash, Ki Myung Song, Siyuan Song, Ahmed Shiban, and Liliana Attisano Published online 25.11.2014 Retraction Retraction: ‘Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity’ Jens C Schwamborn, Myriam Müller, Annemarie HM Becker, and Andreas W Püschel Published online 17.12.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.