Nature Cell Biology contents: February 2015 Volume 17 Number 2, pp 107 - 194

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS February 2015 Volume 17, Issue 2 News and Views Articles Subscribe   Facebook   RSS   Recommend to library   Twitter   News and Views Top A niche role for periostin and macrophages in glioblastoma   pp107 - 109 Mario Leonardo Squadrito and Michele De Palma doi:10.1038/ncb3095 Macrophages facilitate tumour progression, but it is unclear whether this capability is influenced by tumour-initiating cells. Glioblastoma stem cells are now shown to secrete periostin, a matrix protein that recruits protumoral macrophages and enhances glioblastoma progression in mice. See also: Article by Zhou et al. Control of ciliation in embryogenesis   pp109 - 111 Anna S. Nikonova and Erica A. Golemis doi:10.1038/ncb3103 The protrusion of cilia into extracellular space provides cells with sensors of localized environmental cues that include fluid flow, mechanical force and important growth factors such as Hedgehog. Live imaging has now captured the initial appearance of cilia during embryogenesis, and defined lineage-specific determinants that restrict extra-embryonal ciliogenesis. See also: Article by Bangs et al. Articles Lineage specificity of primary cilia in the mouse embryo   pp113 - 122 Fiona K. Bangs, Nadine Schrode, Anna-Katerina Hadjantonakis and Kathryn V. Anderson doi:10.1038/ncb3091 Anderson and colleagues report that, although mouse embryonic tissues form primary cilia, in cells destined for extraembryonic lineages, the activities of aurora kinase A and the tubulin deacetylase HDAC6 inhibit ciliogenesis. See also: News and Views by Nikonova & Golemis Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration   pp123 - 136 Shahin Rafii, Zhongwei Cao, Raphael Lis, Ilias I. Siempos, Deebly Chavez et al. doi:10.1038/ncb3096 Ding and colleagues report that blood platelets recruited to the lung by injury release the chemokine SDF-1, which interacts with its receptor CXCR4 on pulmonary capillary endothelial cells and thereby initiates alveolar regeneration. Cell Biology JOBS of the week Postdoctoral Fellow in Cell Biology UCLA Postdoc Position in Live Imaging, Cell and Developmental Biology: A*STAR Agency for Science, Technology and Research (A*STAR) Postdoctoral Fellow in bioinformatics and stem cell biology The University of Texas Medical School At Houston Junior Group Leaders Cell Biology of Cancer and Genomic Instability IFOM (Foundation FIRC Institute of Molecular Oncology) Postdoctoral fellow positions in hematopoiesis and stem cell biology Lund University More Science jobs from Cell Biology EVENT 36th New Phytologist Symposium: Cell biology at the plant?microbe interface 29.12.15 Munich, Germany More science events from Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature   pp137 - 147 Hunter Elliott, Robert S. Fischer, Kenneth A. Myers, Ravi A. Desai, Lin Gao et al. doi:10.1038/ncb3092 Elliott et al. use high-resolution imaging, microfabrication and computational analyses to show that the interplay between cell-surface curvature and activity and cortical recruitment of myosin II, control cell migration in 3D matrices. Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement   pp148 - 159 Subramanian P. Ramanathan, Jonne Helenius, Martin P. Stewart, Cedric J. Cattin, Anthony A. Hyman et al. doi:10.1038/ncb3098 Hyman, Muller and colleagues characterize how mitotic rounding forces relate to the dynamics of the actomyosin cortex. They find that myosin II enables the cell to resist deformation. USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria   pp160 - 169 Christian N. Cunningham, Joshua M. Baughman, Lilian Phu, Joy S. Tea, Christine Yu et al. doi:10.1038/ncb3097 Cunningham et al. characterize the ubiquitin chain linkages regulated by the opposing activities of the E3 ligase parkin and the deubiquitylation enzyme USP30 on mitochondria. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth   pp170 - 182 Wenchao Zhou, Susan Q. Ke, Zhi Huang, William Flavahan, Xiaoguang Fang et al. doi:10.1038/ncb3090 Bao and colleagues report that glioblastoma cancer stem cells produce periostin, which in turn recruits tumour-associated macrophages to the tumour site to foster growth. See also: News and Views by Squadrito & De Palma Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis   pp183 - 194 Miranda Y. Fong, Weiying Zhou, Liang Liu, Aileen Y. Alontaga, Manasa Chandra et al. doi:10.1038/ncb3094 Wang and colleagues report that cancer-cell-derived extracellular vesicles that contain miR-122 reprogram glucose metabolism of premetastatic niche cells to alter nutrient availability and promote metastasis. Top Advertisement Nature Plants - Now launched  The first issue of Nature Plants has now published. Covering all aspects of plant science including genetics, cell and molecular biology, ecology, evolution, agriculture, biotechnology and economics.  Explore the first issue — free access for a limited time.    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.