Nature Reviews Genetics Contents February 2015 Volume 16 Number 2 pp 67-126

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TABLE OF CONTENTS
February 2015 Volume 16 Number 2
Impact Factor 39.794 *	In this issue Research Highlights Reviews Analysis Also this month Article series: Modes of transcriptional regulation Non-coding RNA Modelling  Featured article: Methods of integrating data to uncover genotype-phenotype interactions Marylyn D. Ritchie, Emily R. Holzinger, Ruowang Li, Sarah A. Pendergrass & Dokyoon Kim
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RESEARCH HIGHLIGHTS Top Stem cells: Multiple routes to pluripotency p67 | doi:10.1038/nrg3892 PDF Population genetics: The African Genome Variation Project p68 | doi:10.1038/nrg3886 PDF Gene expression: You are not alone — cis and trans factors both contribute to ASE p68 | doi:10.1038/nrg3887 PDF Human genetics: Somatic mutations linked to future disease risk p69 | doi:10.1038/nrg3889 PDF Technology: Multi-tasking CRISPR RNA scaffolds p70 | doi:10.1038/nrg3898 PDF Gene regulation: Multiple mechanisms of small RNAs p70 | doi:10.1038/nrg3902 PDF IN BRIEF Genome evolution: To have or have not — recurrent intron loss in plants | Chromatin: High-resolution 3D mapping of loops | Technology: Nanopore sequencing for clinical diagnostics | Evolution: Gene age begets constraint PDF Genetics JOBS of the week Postdoctoral Fellow in Translational Cancer Research Vanderbilt Univeristy Postdoctoral Associate -Therapeutic Microbiology Baylor College of Medicine (BCM) Postdoctoral Associates in Neurodegenerative Diseases University of Minnesota PhD Position in Plant-Microbe Interactions, Small Regulatory RNAs Ludwig-Maximilians-Universität (LMU) in Munich Post-Doctoral Position Centre National de la Recherche Scientifique (CNRS) More Science jobs from Genetics EVENT More science events from
REVIEWS		Top
Article series: Modes of transcriptional regulation RNA-mediated epigenetic regulation of gene expression Daniel Holoch & Danesh Moazed p71 | doi:10.1038/nrg3863 Small and long non-coding RNAs have emerged as key regulators of gene expression through their direct and indirect actions on chromatin. This Review describes how RNAs form powerful surveillance systems that detect and silence inappropriate transcription events, and how such systems provide a memory of these events via self-reinforcing epigenetic loops. Abstract | Full Text | PDF | Supplementary information
Methods of integrating data to uncover genotype-phenotype interactions Marylyn D. Ritchie, Emily R. Holzinger, Ruowang Li, Sarah A. Pendergrass & Dokyoon Kim p85 | doi:10.1038/nrg3868 Integrating multiple data types can be substantially more informative than analysing data sets separately, and methods to combine data sets are now emerging. This Review outlines the current approaches for data integration and the various strengths and weaknesses of these strategies. The analytical challenges that emerge with data sets of this magnitude are also described, and the authors provide their perspective on how such systems genomic analyses might develop in the future. Abstract | Full Text | PDF
Article series: Non-coding RNA Emerging roles of tRNA in adaptive translation, signalling dynamics and disease Sebastian Kirchner & Zoya Ignatova p98 | doi:10.1038/nrg3861 This Review describes our latest understanding of the range of functions of tRNAs. Emerging roles include the tight regulation of tRNA biogenesis to meet the translational needs of different cell types, cleavage and covalent modification of tRNAs in stress signalling, and diverse mechanistic links to various diseases. Abstract | Full Text | PDF
ANALYSIS		Top
Article series: Modelling Competition between target sites of regulators shapes post-transcriptional gene regulation Marvin Jens & Nikolaus Rajewsky p113 | doi:10.1038/nrg3853 Increasing evidence suggests that competition between transcripts for binding of microRNAs and RNA-binding proteins might be a fundamental principle of post-transcriptional gene regulation. The authors use a simple steady-state model to quantitatively assess competition effects under physiological conditions and review the role of endogenous 'sponges' in light of the key features that emerge. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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