Nature Reviews Nephrology - Table of Contents alert Volume 11 Issue 2

TABLE OF CONTENTS
February 2015 Volume 11 Number 2
Impact Factor 8.368 *	In this issue Research Highlights Year in Review Reviews Also this month  Featured article: Causes and pathogenesis of focal segmental glomerulosclerosis Agnes B. Fogo
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RESEARCH HIGHLIGHTS Top Glomerular disease: Thrombospondin type-1 domain-containing 7A—a new player in membranous nephropathy Published online: 02 December 2014 p63 | doi:10.1038/nrneph.2014.227 PDF Fibrosis: Dysfunctional fatty acid oxidation in renal fibrosis Published online: 23 December 2014 p64 | doi:10.1038/nrneph.2014.244 PDF Transplantation: Levofloxacin treatment does not prevent BK virus infection Published online: 02 December 2014 p65 | doi:10.1038/nrneph.2014.228 PDF Risk factors: Sickle cell trait increases the risk of chronic kidney disease Published online: 02 December 2014 p65 | doi:10.1038/nrneph.2014.229 PDF Transplantation: Induction of chimerism and immune tolerance using belatacept Published online: 02 December 2014 p66 | doi:10.1038/nrneph.2014.230 PDF Glomerular disease: Autophagy failure and mitochondrial dysfunction in FSGS Published online: 09 December 2014 p66 | doi:10.1038/nrneph.2014.233 PDF IN BRIEF Chronic kidney disease: MicroRNA inhibition in Alport syndrome | Transplantation: Sirolimus: effects on malignancy and survival | Basic research: Role of mTOR in regulation of ENaC activity | Sepsis: β1-adrenoreceptor blockade in sepsis PDF
YEAR IN REVIEW		Top
Glomerular disease in 2014: Advances in basic science and translational medicine Fernando C. Fervenza & Sanjeev Sethi Published online: 13 January 2015 p67 | doi:10.1038/nrneph.2014.248 Knowledge of the pathogenesis of glomerular disease and approaches to therapy continued to advance in 2014. Key studies identified thrombospondin type-1 domain-containing protein 7A as an antigenic target in primary membranous nephropathy, and demonstrated efficacy of rituximab as maintenance therapy in relapsing or steroid-dependent nephrotic syndrome and antineutrophil cytoplasmic antibody-associated vasculitis. Full Text | PDF
Diabetic nephropathy in 2014: Improved cardiorenal prognosis in diabetic nephropathy Hans-Henrik Parving & Peter Rossing Published online: 09 December 2014 p68 | doi:10.1038/nrneph.2014.238 In 2014, key studies in the field of diabetic nephropathy highlighted the importance of albuminuria as a predictor of cardiovascular risk and showed that the incidence of renal and cardiovascular complications is decreasing. Promising efficacy data were obtained with atrasentan, whereas a trial of bardoxolone methyl led to safety concerns. Full Text | PDF
Cardiovascular disease in CKD in 2014: New insights into cardiovascular risk factors and outcomes Pantelis A. Sarafidis & George L. Bakris Published online: 16 December 2014 p70 | doi:10.1038/nrneph.2014.242 Chronic kidney disease (CKD) is an established independent risk factor for increased cardiovascular events and cardiovascular mortality. During 2014, several research efforts focused on clarifying the complex pathophysiology, assessing the prognostic associations and improving the treatment of cardiovascular disease in patients with CKD. Full Text | PDF
Renal transplantation in 2014: Renal transplantation—reducing risk and improving outcome Dennis A. Hesselink & Willem Weimar Published online: 16 December 2014 p72 | doi:10.1038/nrneph.2014.240 Several studies published in 2014 might facilitate improvements in the treatment and long-term care of renal transplant recipients. The potential risks of living kidney donation, the efficacy and safety of alemtuzumab-based induction therapy, and the treatment of chronic hepatitis E virus infection have been addressed. Full Text | PDF
Acute kidney injury in 2014: A step towards understanding mechanisms of renal repair Azra Bihorac & John A. Kellum Published online: 06 January 2015 p74 | doi:10.1038/nrneph.2014.245 In 2014, key articles in the field of acute kidney injury highlighted the importance of tubular homeostasis in renal regeneration. Cell cycle regulators, inflammatory signals and progenitors were identified as important factors that mediate the balance between inflammation and tubular regeneration necessary for renal repair. Full Text | PDF
REVIEWS		Top
Causes and pathogenesis of focal segmental glomerulosclerosis Agnes B. Fogo Published online: 02 December 2014 p76 | doi:10.1038/nrneph.2014.216 Focal segmental glomerulosclerosis is a heterogeneous disease characterized by primary podocyte injury or a lesion that occurs secondarily in any form of chronic kidney disease. In this Review, Agnes Fogo reviews the causes and pathogenesis of primary and non-immunologic adaptive secondary types of FSGS. Abstract | Full Text | PDF
Immune cells in experimental acute kidney injury Hye Ryoun Jang & Hamid Rabb Published online: 21 October 2014 p88 | doi:10.1038/nrneph.2014.180 The immune system has a vital role in the renal response to acute kidney injury (AKI). In this Review, Hye Ryoun Jang and Hamid Rabb describe current understanding of the function of the innate and adaptive immune systems in the early and late injury phases of ischaemic and nephrotoxic AKI, and describe the influence of immune cells on recovery and long-term outcome following AKI. Abstract | Full Text | PDF
HNF1B-associated renal and extra-renal disease—an expanding clinical spectrum Rhian L. Clissold, Alexander J. Hamilton, Andrew T. Hattersley, Sian Ellard & Coralie Bingham Published online: 23 December 2014 p102 | doi:10.1038/nrneph.2014.232 Mutations in hepatocyte nuclear factor 1β (HNF1B) are the most common monogenic cause of developmental kidney disease. Affected patients commonly present with renal cysts; however, this condition is characterized by its diversity of renal and extra-renal phenotypes. Here, the authors analyse the clinical phenotypes, the spectrum of causative heterozygous HNF1B mutations, discuss the molecular pathways by which HNF1B might contribute to renal pathologies, and identify areas for future molecular, genetic and clinical research in HNF1B-associated disease. Abstract | Full Text | PDF | Supplementary information
Urea transporter proteins as targets for small-molecule diuretics Cristina Esteva-Font, Marc O. Anderson & Alan S. Verkman Published online: 09 December 2014 p113 | doi:10.1038/nrneph.2014.219 Conventional diuretics target salt transporters in kidney tubules, but urea transporters have emerged as alternative targets for small-molecule salt-sparing diuretics. This Review summarizes the structure, expression and function of urea transporters and describes the evidence supporting the validity of using small-molecule inhibitors of urea transporters as salt-sparing diuretics. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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