Nature Reviews Neurology - Table of Contents alert Volume 11 Issue 1

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TABLE OF CONTENTS
January 2015 Volume 11 Number 1
Impact Factor 14.103 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Disturbed mitochondrial dynamics and neurodegenerative disorders Florence Burté, Valerio Carelli, Patrick F. Chinnery & Patrick Yu-Wai-Man
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RESEARCH HIGHLIGHTS Top Parkinson disease: Facilitating detection of prodromal Parkinson disease in primary care clinics Published online: 16 December 2014 p1 | doi:10.1038/nrneurol.2014.238 PDF Parkinson disease: Blocking mitochondrial fission—a new treatment approach for Parkinson disease? Published online: 25 November 2014 p2 | doi:10.1038/nrneurol.2014.227 PDF Neural repair and rehabilitation: Implant helps patient with incomplete locked-in syndrome Published online: 25 November 2014 p2 | doi:10.1038/nrneurol.2014.230 PDF Dementia: Vascular comorbidities linked with early-onset dementia Published online: 02 December 2014 p3 | doi:10.1038/nrneurol.2014.233 PDF Stroke: Cortical connectivity predicts success of stroke rehabilitation Published online: 02 December 2014 p4 | doi:10.1038/nrneurol.2014.229 PDF IN BRIEF Spinal cord injury: Modulation of the PTPσ receptor promotes recovery after spinal cord injury in rats | Epilepsy: Vagus nerve stimulation could increase cardiac stability and reduce risk of SUDEP | Stroke: Molecular markers could help predict stroke risk after TIA | Traumatic brain injury: Glymphatic pathway dysfunction after traumatic brain injury might promote tau aggregation | Neurodevelopmental disorders: Symptom acuity can aid selection of genotyping technique | Neuromuscular disease: Patients with refractory myasthenia gravis respond to immunotherapy after cyclophosphamide induction | Parkinson disease: α-Synuclein antibodies might not be a reliable PD biomarker | Dementia: Visual hallucinations in neurodegenerative disease are associated with volume loss in the right anterior insula PDF Neurology JOBS of the week Postdoctoral positiion University of Iowa Post Doctoral Scientist-Parikh Lab Nationwide Children's Hospital Endowed Chair in Spinal Cord Research University of Alberta Concussion clinical / research fellowship University Health Network (Toronto) More Science jobs from Neurology EVENT The Lancet Neurology Autoimmune Disorders Conference 26.03.15 Barcelona, Spain More science events from
NEWS AND VIEWS		Top
Parkinson disease: How reliable are prodromal indicators of Parkinson disease? Laura Silveira-Moriyama & Andrew J. Lees Published online: 16 December 2014 p5 | doi:10.1038/nrneurol.2014.235 The notion that the classic motor features of Parkinson disease (PD) are preceded by a prodrome has received renewed interest in the past decade. A recent study corroborates previous findings that smell loss and constipation are signifiers of nigral degeneration. But can we really predict who is going to get PD? Full Text | PDF
Demyelinating disease: Is TOPIC the last trial for clinically isolated syndrome? Bruce A. C. Cree Published online: 16 December 2014 p6 | doi:10.1038/nrneurol.2014.239 The recent TOPIC trial found that teriflunomide could prevent relapses in patients with clinically isolated syndrome (CIS). Many other multiple sclerosis (MS) therapies are effective for CIS, because CIS is the first clinical manifestation of MS for most patients. Questions remain over the utility of future trials like TOPIC. Full Text | PDF
Stroke: LDL and stroke risk—clinical practice or target practice? Jong-Ho Park & Bruce Ovbiagele Published online: 09 December 2014 p8 | doi:10.1038/nrneurol.2014.234 LDL-lowering drugs are widely recommended for the secondary prevention of vascular events in patients who have experienced a stroke or transient ischaemic attack. As a new study illustrates, however, lipid management among this group remains inadequate, possibly placing patients at unnecessary risk of stroke recurrence. Full Text | PDF
Parkinson disease: Exercise matters in patients with PD—another piece of evidence Georg Ebersbach Published online: 02 December 2014 p9 | doi:10.1038/nrneurol.2014.231 After decades of near neglect, the importance of exercise for patients with Parkinson disease is being increasingly supported by recent studies in experimental animal models and controlled clinical trials. Now, an inverse relationship between physical activity and disease burden has been demonstrated in a large cohort study. Full Text | PDF
REVIEWS		Top
Disturbed mitochondrial dynamics and neurodegenerative disorders Florence Burté, Valerio Carelli, Patrick F. Chinnery & Patrick Yu-Wai-Man Published online: 09 December 2014 p11 | doi:10.1038/nrneurol.2014.228 The network between mitochondia is in a constant state of flux, with organelles fusing and separating in response to cellular metabolic demands. Disturbances to mitochondrial fusion and fission have been observed in several human diseases, and in this Review, Florence Burté and colleagues discuss how the mitochondrial network might play a crucial part in neurodegeneration. The authors focus on major protein mediators of mitochondrial dynamics, including optic atrophy protein and the mitofusins, and trace the involvement of mitochondrial dynamics in autosomal dominant optic atrophy, Charcot-Marie-Tooth disease and other disorders. Abstract | Full Text | PDF
The ongoing pursuit of neuroprotective therapies in Parkinson disease Dilan Athauda & Thomas Foltynie Published online: 02 December 2014 p25 | doi:10.1038/nrneurol.2014.226 Despite the promise that many potential neuroprotective treatments for Parkinson disease (PD) have shown in preclinical studies, the benefits have not been replicated in recent clinical trials. In this Review, Athauda and Foltynie discuss the reasons for this 'failure to translate', and propose strategies to avoid such eventualities in the future, including improved trial design and repositioning of existing drugs. They also review the most promising drugs that are currently in preclinical development or clinical testing for their neuroprotective properties in PD. Abstract | Full Text | PDF
Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases Alberto Lleó, Enrica Cavedo, Lucilla Parnetti, Hugo Vanderstichele, Sanna Kaisa Herukka, Niels Andreasen, Roberta Ghidoni, Piotr Lewczuk, Andreas Jeromin, Bengt Winblad, Magda Tsolaki, Barbara Mroczko, Pieter Jelle Visser, Isabel Santana, Per Svenningsson, Kaj Blennow, Dag Aarsland, José Luis Molinuevo, Henrik Zetterberg & Brit Mollenhauer. Published online: 16 December 2014 p41 | doi:10.1038/nrneurol.2014.232 Despite a growing emphasis on biomarkers in research into Alzheimer disease (AD) and Parkinson disease (PD), there is little consensus as to which biomarkers are most effective. In this Review, Lleó and colleagues discuss cerebrospinal fluid (CSF) biomarkers for AD and PD, with a particular emphasis on applicability to clinical trials. Compared with AD, less is known about CSF biomarkers in PD, and the authors highlight several areas for further research. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Microglial and macrophage polarization—new prospects for brain repair Xiaoming Hu, Rehana K. Leak, Yejie Shi, Jun Suenaga, Yanqin Gao, Ping Zheng & Jun Chen. Published online: 11 November 2014 p56 | doi:10.1038/nrneurol.2014.207 After brain injuries, microglia and macrophages can aid or hinder tissue repair depending on polarization toward specific cell phenotypes. This Perspectives article describes the phenotypic dynamics and different functions of these cells after acute CNS injury and argues that therapeutic approaches should focus on subtle adjustment of the balance between their phenotypes. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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