Scientific Reports Table of Contents e-alert: 27 January 2015

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27 January 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports             Jump to the content that matters to you ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Health Sciences               Biological Sciences ▲ top               Reactive short-chain leaf volatiles act as powerful inducers of abiotic stress-related gene expression ▶     Yasuo Yamauchi, Mikiko Kunishima, Masaharu Mizutani et al.     Abiotic stresses cause serious damage to plants; therefore, plants undergo a complicated stress response through signal transduction originating from environmental stimuli. Here …             DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells ▶     Seunghee Lee, Hyung-Sik Kim, Kyoung-Hwan Roh et al.     DNA methyltransferase (DNMT) inhibitors regulate target gene expression through epigenetic modifications, and these compounds have primarily been studied for cancer therapy or …             Transcriptomic analysis reveals the roles of microtubule-related genes and transcription factors in fruit length regulation in cucumber (Cucumis sativus L.) ▶     Li Jiang, Shuangshuang Yan, Wencai Yang et al.     Cucumber (Cucumis sativus L.) fruit is a type of fleshy fruit that is harvested immaturely. Early fruit development directly determines the final fruit length and diameter, and …             Developing genome-wide microsatellite markers of bamboo and their applications on molecular marker assisted taxonomy for accessions in the genus Phyllostachys ▶     Hansheng Zhao, Li Yang, Zhenhua Peng et al.     Morphology-based taxonomy via exiguously reproductive organ has severely limitation on bamboo taxonomy, mainly owing to infrequent and unpredictable flowering events of bamboo. …             Nonuniform gene expression pattern detected along the longitudinal axis in the matured rice leaf ▶     Ning Li, Yun-Ru Chen, Zehong Ding et al.     Rice (Oryza sativa) is a staple crop that supports half the world's population and an important monocot model system. Monocot leaf matures in a basipetal manner, and has a …             Functional Characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells ▶     Frank J. P. Kühn, Cornelia Kühn, Andreas Lückhoff     The human non-selective cation channel TRPM2 represents a mediator of apoptosis triggered by oxidative stress. The principal agonist ADP-ribose binds to the cytosolic domain of …             The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family ▶     Louise Kime, Helen A. Vincent, Deena M. A. Gendoo et al.     The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression. It is …             Aspiration dynamics in structured population acts as if in a well-mixed one ▶     Jinming Du, Bin Wu, Long Wang     Understanding the evolution of human interactive behaviors is important. Recent experimental results suggest that human cooperation in spatial structured population is not …             Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force ▶     Tao Guo, Liqiang Zhang, Anna Konermann et al.     Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as …             Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils ▶     Juliana D. B. Rocha, Michelle T. C. Nascimento, Debora Decote-Ricardo et al.     In the present study, we characterized the in vitro modulation of NETs (neutrophil extracellular traps) induced in human neutrophils by the opportunistic fungus Cryptococcus …             Effects of agricultural intensification on ability of natural enemies to control aphids ▶     Zi-Hua Zhao, Cang Hui, Da-Han He et al.     Agricultural intensification through increasing fertilization input and cropland expansion has caused rapid loss of semi-natural habitats and the subsequent loss of natural …             Embryonic stem cell differentiation requires full length Chd1 ▶     Paolo Piatti, Chin Yan Lim, Roxana Nat et al.     The modulation of chromatin dynamics by ATP-dependent chromatin remodeling factors has been recognized as an important mechanism to regulate the balancing of self-renewal and …             Median Modified Wiener Filter for nonlinear adaptive spatial denoising of protein NMR multidimensional spectra ▶     Carlo Vittorio Cannistraci, Ahmed Abbas, Xin Gao     Denoising multidimensional NMR-spectra is a fundamental step in NMR protein structure determination. The state-of-the-art method uses wavelet-denoising, which may suffer when …             Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells ▶     Javier A. García-Vilas, Ana R. Quesada, Miguel A. Medina     Damnacanthal, an anthraquinone present in noni plants, targets several tyrosine kinases and has antitumoral effects. This study aims at getting additional insight on the …             A novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks ▶     Suyu Mei, Hao Zhu     Protein-protein interaction (PPI) prediction is generally treated as a problem of binary classification wherein negative data sampling is still an open problem to be addressed. …             Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway ▶     Joana Fraga, Ana Maranha, Vitor Mendes et al.     A novel four-step pathway identified recently in mycobacteria channels trehalose to glycogen synthesis and is also likely involved in the biosynthesis of two other crucial …             ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution ▶     Stephen R. Hennigar, Young Ah Seo, Supriya Sharma et al.     Mammary gland involution is the most dramatic example of physiological cell death. It occurs through an initial phase of lysosomal-mediated cell death (LCD) followed by …             Enhanced antitumor effects of the BRBP1 compound peptide BRBP1-TAT-KLA on human brain metastatic breast cancer ▶     Bo Fu, Wei Long, Ying Zhang et al.     Novel molecularly targeted agents that block the development and metastasis of human brain metastatic breast cancer hold great promise for their translational value. In this …             Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning ▶     Lionel Blanchet, Jan A. M. Smeitink, Sjenet E. van Emst - de Vries et al.     In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and …             Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2 ▶     Sung Un Huh, Gil-Je Lee, Ji Hoon Jung et al.     Plants are constantly exposed to pathogens and environmental stresses. To minimize damage caused by these potentially harmful factors, plants respond by massive transcriptional …             Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling ▶     Wang-Chuan Chen, Tien-Sheng Tseng, Nai-Wan Hsiao et al.     Tyrosinase is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments leading to hyperpigmentation disorders that can be treated with depigmenting …             Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia ▶     Insaf Bahrini, Ji-hoon Song, Diego Diez et al.     Selective elimination of synaptic connections is a common phenomenon which occurs during both developmental and pathological conditions. Glial cells have a central role in the …             CORRIGENDUM: Resting-state functional reorganization of the rat limbic system following neuropathic injury ▶     M. N. Baliki, P. C. Chang, A. T. Baria et al.                 CORRIGENDUM: Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway ▶     Connor D. MacMillan, Hon S. Leong, David W. Dales et al.                 Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas ▶     Chunguang Luan, Lingling Xie, Xi Yang et al.     The fungal microbiota is an important component of the human gut microbiome and may be linked to gastrointestinal disease. In this study, the fungal microbiota of biopsy samples …             Glycomic Signatures on Serum IgGs for Prediction of Postvaccination Response ▶     Jing-Rong Wang, Wen-Da Guan, Lee-Fong Yau et al.     Millions of individuals are vaccinated worldwide each year to stimulate their adaptive immune systems to produce protective antibodies and T-cell response against pathogens. …             Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity ▶     Wen-Jie Du, Jing-Jing Guo, Ming-Tao Gao et al.     Soluble amyloid β-protein (Aβ) oligomers, the main neurotoxic species, are predominantly formed from monomers through a fibril-catalyzed secondary nucleation. Herein, we …             Roles of 3,3′,4′,5-tetrachlorosalicylanilide in regulating extracellular electron transfer of Shewanella oneidensis MR-1 ▶     Yong-Peng Wang, Sheng-Song Yu, Hai-Ling Zhang et al.     Microbial extracellular electron transfer (EET) is critically involved in many pollutant conversion processes in both natural environment and engineered bioelectrochemical …             Deconvolution Analysis for Classifying Gastric Adenocarcinoma Patients Based on Differential Scanning Calorimetry Serum Thermograms ▶     Sonia Vega, María Asuncion Garcia-Gonzalez, Angel Lanas et al.     Recently, differential scanning calorimetry (DSC) has been acknowledged as a novel tool for diagnosing and monitoring several diseases. This highly sensitive technique has been …             The putative Na+/Cl−-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis ▶     Zhuo Luan, Caitlin Quigley, Hong-Sheng Li     Most organisms are able to maintain systemic water homeostasis over a wide range of external or dietary osmolarities. The excretory system, composed of the kidneys in mammals and …             MBSTAR: multiple instance learning for predicting specific functional binding sites in microRNA targets ▶     Sanghamitra Bandyopadhyay, Dip Ghosh, Ramkrishna Mitra et al.     MicroRNA (miRNA) regulates gene expression by binding to specific sites in the 3′untranslated regions of its target genes. Machine learning based miRNA target prediction …             Analysis of the age of Panax ginseng based on telomere length and telomerase activity ▶     Jiabei Liang, Chao Jiang, Huasheng Peng et al.     Ginseng, which is the root of Panax ginseng (Araliaceae), has been used in Oriental medicine as a stimulant and dietary supplement for more than 7,000 years. Older ginseng plants …             Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation ▶     Rui-Feng Yang, Li-Hong Sun, Ran Zhang et al.     Precise regulation of mtDNA transcription and oxidative phosphorylation (OXPHOS) is crucial for human health. As a component of mitochondrial contact site and cristae organizing …             Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations ▶     Hong Qi, Linxi Li, Jianwei Shuai     A Ca2 signaling model is proposed to consider the crosstalk of Ca2 ions between endoplasmic reticulum (ER) and mitochondria within microdomains around inositol 1, 4, …             Complex forest dynamics indicate potential for slowing carbon accumulation in the southeastern United States ▶     John W. Coulston, David N. Wear, James M. Vose     Over the past century forest regrowth in Europe and North America expanded forest carbon (C) sinks and offset C emissions but future C accumulation is uncertain. Policy makers …             Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia ▶     Keiko Doi, Takahiko Imai, Christopher Kressler et al.     The Rap G protein signal regulates Notch activation in early thymic progenitor cells, and deregulated Rap activation (Raphigh) results in the development of Notch-dependent …             Evolutionary analysis of rubella viruses in mainland China during 2010–2012: endemic circulation of genotype 1E and introductions of genotype 2B ▶     Zhen Zhu, Pierre Rivailler, Emily Abernathy et al.     Rubella remains a significant burden in mainland China. In this report, 667 viruses collected in 24 of 31 provinces of mainland China during 2010–2012 were sequenced and …             Diminished serum repetin levels in patients with schizophrenia and bipolar disorder ▶     Shuai Wang, Huixun Ren, Jie Xu et al.     Repetin (RPTN) protein is a member of S100 family and is known to be expressed in the normal epidermis. Here we show that RPTN is ubiquitously expressed in both mouse and human …             Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries ▶     Ludovit Paulis, Jeremy Fauconnier, Olivier Cazorla et al.     Sonic hedgehog (SHH) is a conserved protein involved in embryonic tissue patterning and development. SHH signaling has been reported as a cardio-protective pathway via muscle …             N-Glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential ▶     Krystal Teasley Hamorsky, J. Calvin Kouokam, Jessica M. Jurkiewicz et al.     Plant-based transient overexpression systems enable rapid and scalable production of subunit vaccines. Previously, we have shown that cholera toxin B subunit (CTB), an oral …             In Vitro Expansion of Corneal Endothelial Cells on Biomimetic Substrates ▶     Rachelle N. Palchesko, Kira L. Lathrop, James L. Funderburgh et al.     Corneal endothelial (CE) cells do not divide in vivo, leading to edema, corneal clouding and vision loss when the density drops below a critical level. The endothelium can be …             Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector ▶     Stina Bäckman, Jonas Näslund, Mats Forsman et al.     Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the …             Magnetic-activated cell sorting (MACS) can be used as a large-scale method for establishing zebrafish neuronal cell cultures ▶     Georg Welzel, Daniel Seitz, Stefan Schuster     Neuronal cell cultures offer a crucial tool to mechanistically analyse regeneration in the nervous system. Despite the increasing importance of zebrafish (Danio rerio) as an in …             AtNPF5.5, a nitrate transporter affecting nitrogen accumulation in Arabidopsis embryo ▶     Sophie Léran, Bharti Garg, Yann Boursiac et al.     Dipeptide (Leu-Leu) and nitrate transport activities of 26 Arabidopsis NPF (NRT1/PTR Family) proteins were screened in Saccharomyces cerevisiae and Xenopus laevis oocytes, …             Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol ▶     Hyeon Jeong Lee, Wandi Zhang, Delong Zhang et al.     We report a cholesterol imaging method using rationally synthesized phenyl-diyne cholesterol (PhDY-Chol) and stimulated Raman scattering (SRS) microscope. The phenyl-diyne group …             A biliverdin-binding cyanobacteriochrome from the chlorophyll d–bearing cyanobacterium Acaryochloris marina ▶     Rei Narikawa, Takahiro Nakajima, Yuki Aono et al.     Cyanobacteriochromes (CBCRs) are linear tetrapyrrole-binding photoreceptors in cyanobacteria that absorb visible and near-ultraviolet light. CBCRs are divided into two types …             Engineering an in vitro air-blood barrier by 3D bioprinting ▶     Lenke Horváth, Yuki Umehara, Corinne Jud et al.     Intensive efforts in recent years to develop and commercialize in vitro alternatives in the field of risk assessment have yielded new promising two- and three dimensional (3D) …             The Hd, Hj, and Hz66 flagella variants of Salmonellaenterica serovar Typhi modify host responses and cellular interactions ▶     Fernanda Schreiber, Sally Kay, Gad Frankel et al.     Salmonella Typhi, the causative agent of typhoid fever, is a monophyletic, human-restricted bacterium that exhibits limited phenotypic variation. S. Typhi from Indonesia are a …             PACT/RAX Regulates the Migration of Cerebellar Granule Neurons in the Developing Cerebellum ▶     Yue Yong, Ya Meng, Hanqing Ding et al.     PACT and its murine ortholog RAX were originally identified as a protein activator for the dsRNA-dependent, interferon-inducible protein kinase PKR. Recent studies indicated that …             Distinguishing Proteins From Arbitrary Amino Acid Sequences ▶     Stephen S.-T. Yau, Wei-Guang Mao, Max Benson et al.     What kinds of amino acid sequences could possibly be protein sequences? From all existing databases that we can find, known proteins are only a small fraction of all possible …             Cloud computing approaches for prediction of ligand binding poses and pathways ▶     Morgan Lawrenz, Diwakar Shukla, Vijay S. Pande     We describe an innovative protocol for ab initio prediction of ligand crystallographic binding poses and highly effective analysis of large datasets generated for protein-ligand …             3D-DIP-Chip: a microarray-based method to measure genomic DNA damage ▶     James Rees Powell, Mark Richard Bennett, Katie Ellen Evans et al.     Genotoxins cause DNA damage, which can result in genomic instability. The genetic changes induced have far-reaching consequences, often leading to diseases such as cancer. A wide …             An integrated phylogenomic approach toward pinpointing the origin of mitochondria ▶     Zhang Wang, Martin Wu     Overwhelming evidence supports the endosymbiosis theory that mitochondria originated once from the Alphaproteobacteria. However, its exact position in the tree of life remains …             Fossils reject climate change as the cause of extinction of Caribbean bats ▶     J. Angel Soto-Centeno, David W. Steadman     We combined novel radiocarbon dates of bat fossils with time-scaled ecological niche models (ENM) to study bat extinctions in the Caribbean. Radiocarbon-dated fossils show that …             Analysis of Genome-Wide RNA-Sequencing Data Suggests Age of the CEPH/Utah (CEU) Lymphoblastoid Cell Lines Systematically Biases Gene Expression Profiles ▶     Yuan Yuan, Lei Tian, Dongsheng Lu et al.     In human, Lymphoblastoid cell lines (LCLs) from the CEPH/CE (Centre d'Etude du Polymorphisme Humain – Utah) family resource have been extensively used for examining the genetics …             Genomic organization of the crested ibis MHC provides new insight into ancestral avian MHC structure ▶     Li-Cheng Chen, Hong Lan, Li Sun et al.     The major histocompatibility complex (MHC) plays an important role in immune response. Avian MHCs are not well characterized, only reporting highly compact Galliformes MHCs and …             Potent effects of dioscin against obesity in mice ▶     Min Liu, Lina Xu, Lianhong Yin et al.     The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease (NAFLD) are unclear. Thus, the purpose of the present study was to further confirm its …             Intraoperative vascular DIVA surgery reveals angiogenic hotspots in tumor zones of malignant gliomas ▶     Ilker Y. Eyüpoglu, Nirjhar Hore, Zheng Fan et al.     Malignant gliomas belong to the most threatening tumor entities and are hallmarked by rapid proliferation, hypervascularization and an invasive growth pattern. The primary …             Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility ▶     Mingzhi Liao, Guangyu Wang, Baoku Quan et al.     Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been …             CO2 enrichment and N addition increase nutrient loss from decomposing leaf litter in subtropical model forest ecosystems ▶     Juxiu Liu, Xiong Fang, Qi Deng et al.     As atmospheric CO2 concentration increases, many experiments have been carried out to study effects of CO2 enrichment on litter decomposition and nutrient release. However, the …             Phosphate addition enhanced soil inorganic nutrients to a large extent in three tropical forests ▶     Feifei Zhu, Xiankai Lu, Lei Liu et al.     Elevated nitrogen (N) deposition may constrain soil phosphorus (P) and base cation availability in tropical forests, for which limited evidence have yet been available. In this …             Thrombin induces ischemic LTP (iLTP): implications for synaptic plasticity in the acute phase of ischemic stroke ▶     Efrat Shavit Stein, Zeev Itsekson-Hayosh, Anna Aronovich et al.     Acute brain ischemia modifies synaptic plasticity by inducing ischemic long-term potentiation (iLTP) of synaptic transmission through the activation of N-Methyl-D-aspartate …             The PUFA-Enriched Fatty Acid Profiles of some Frozen Bison from the Early Holocene found in the Siberian Permafrost ▶     José L. Guil-Guerrero, Ignacio Rodríguez-García, Irina Kirillova et al.     Knowledge concerning the availability of n-3 fatty acids for humans in prehistoric times is highly relevant in order to draw useful conclusions on the healthy dietary habits for …             Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin ▶     Rita Slaaby     This novel method enables specific measurement of the activation of hybrid receptors formed between the Insulin Receptor (IR) and the Insulin-like Growth Factor 1 Receptor …             Group size effect on cooperation in one-shot social dilemmas ▶     Hélène Barcelo, Valerio Capraro     Social dilemmas are central to human society. Depletion of natural resources, climate protection, security of energy supply, and workplace collaborations are all examples of …             GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing ▶     Huashan Zhao, Jingqiao Qiao, Shoubing Zhang et al.     G protein-coupled receptors (GPCRs) mediate multiple key biological processes in the body. The orphan receptor GPR39 has been reported to be involved in various …             Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2 ▶     Kazuhiro Suzuki, Kosuke Sako, Kazuhiro Akiyama et al.     The cyclin B-dependent protein kinase Cdk1 is a master regulator of mitosis and phosphorylates numerous proteins on the minimal consensus motif Ser/Thr-Pro (S/T-P). At least in …             Angiogenin Secretion From Hepatoma Cells Activates Hepatic Stellate Cells To Amplify A Self-Sustained Cycle Promoting Liver Cancer ▶     Cristina Bárcena, Milica Stefanovic, Anna Tutusaus et al.     Hepatocellular carcinoma (HCC) frequently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs) remodeling the extracellular matrix …             Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying ▶     Susana Camacho, Stephanie Michlig, Carole de Senarclens-Bezençon et al.     Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon …             Comparative computational analysis of pluripotency in human and mouse stem cells ▶     Mathias Ernst, Raed Abu Dawud, Andreas Kurtz et al.     Pluripotent cells can be subdivided into two distinct states, the naïve and the primed state, the latter being further advanced on the path of differentiation. There are …             Image artifacts in Single Molecule Localization Microscopy: why optimization of sample preparation protocols matters ▶     Donna R. Whelan, Toby D. M. Bell     Single molecule localization microscopy (SMLM) techniques allow for sub-diffraction imaging with spatial resolutions better than 10 nm reported. Much has been discussed relating …             Identification of novel viral receptors with cell line expressing viral receptor-binding protein ▶     Mei Mei, Jianqiang Ye, Aijian Qin et al.     The viral cell receptors and infection can be blocked by the expression of the viral receptor-binding protein. Thus, the viral cell receptor is an attractive target for …             A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery ▶     Shayan F. Lahiji, Manita Dangol, Hyungil Jung     Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto …             Transcriptome and Histopathological Changes in Mouse Brain Infected with Neospora caninum ▶     Maki Nishimura, Sachi Tanaka, Fumiaki Ihara et al.     Neospora caninum is a protozoan parasite that causes neurological disorders in dogs and cattle. It can cause nonsuppurative meningoencephalitis and a variety of neuronal symptoms …             Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM ▶     Nidhan K. Biswas, Vikas Chandra, Neeta Sarkar-Roy et al.     Neoplastic cells of Glioblastoma multiforme (GBM) may or may not show sustained response to temozolomide (TMZ) chemotherapy. We hypothesize that TMZ chemotherapy response in GBM …             Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor ▶     Hei-Man Vincent Tang, Kewu Pan, Ka-Yiu Edwin Kong et al.     Ferredoxins are iron-sulfur proteins that play important roles in electron transport and redox homeostasis. Yeast Apd1p is a novel member of the family of thioredoxin-like …             Rice stripe virus affects the viability of its vector offspring by changing developmental gene expression in embryos ▶     Shuo Li, Shijuan Wang, Xi Wang et al.     Plant viruses may affect the viability and development process of their herbivore vectors. Small brown planthopper (SBPH) is main vector of Rice stripe virus (RSV), which causes …             Photoprotection in sequestered plastids of sea slugs and respective algal sources ▶     Sónia Cruz, Paulo Cartaxana, Rebecca Newcomer et al.     Some sea slugs are capable of retaining functional sequestered chloroplasts (kleptoplasts) for variable periods of time. The mechanisms supporting the maintenance of these …             Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan ▶     Dominik Bernhardt, Matthias Müller, Andreas S. Reichert et al.     Aging of biological systems is accompanied by degeneration of mitochondrial functions. Different pathways are active to counteract the processes which lead to mitochondrial …             siRNA induces gelsolin gene transcription activation in human esophageal cancer cell ▶     Guo-Wei Huang, Lian-Di Liao, En-Min Li et al.     Recent studies show that targeting gene promoter or 3′ terminal regions of mRNA with siRNA induces target gene transcription. However, the ability of exon-targeting siRNA to …             Checkpoint-dependent RNR induction promotes fork restart after replicative stress ▶     Esther C. Morafraile, John F. X. Diffley, José Antonio Tercero et al.     The checkpoint kinase Rad53 is crucial to regulate DNA replication in the presence of replicative stress. Under conditions that interfere with the progression of replication …             Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP) ▶     Jigang Wang, Chong-Jing Zhang, Jianbin Zhang et al.     Target-identification and understanding of mechanism-of-action (MOA) are challenging for development of small-molecule probes and their application in biology and drug discovery. …             Equilibrated Atomic Models of Outward-Facing P-glycoprotein and Effect of ATP Binding on Structural Dynamics ▶     Lurong Pan, Stephen G. Aller     P-glycoprotein (Pgp) is an ATP-binding cassette (ABC) transporter that alternates between inward- and outward-facing conformations to capture and force substrates out of cells …             Large number of putative chemoreception and pheromone biosynthesis genes revealed by analyzing transcriptome from ovipositor-pheromone glands of Chilo suppressalis ▶     Yi-Han Xia, Ya-Nan Zhang, Xiao-Qing Hou et al.     The chemoreception role of moth ovipositor has long been suggested, but its molecular mechanism is mostly unknown. By transcriptomic analysis of the female ovipositor-pheromone …             Characterising two-pathogen competition in spatially structured environments ▶     Chiara Poletto, Sandro Meloni, Ashleigh Van Metre et al.     Different pathogens spreading in the same host population often generate complex co-circulation dynamics because of the many possible interactions between the pathogens and the …             A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke ▶     Cheng-long Xie, Wen-Wen Wang, Xiao-Dong Xue et al.     The neuroprotective actions of Ginsenoside-Rg1 (G-Rg1) have been documented for experimental stroke therapy. We used a systematic review and meta-analysis to assess the efficacy …             Functional Loop Dynamics of the Streptavidin-Biotin Complex ▶     Jianing Song, Yongle Li, Changge Ji et al.     Accelerated molecular dynamics (aMD) simulation is employed to study the functional dynamics of the flexible loop3-4 in the strong-binding streptavidin-biotin complex system. …             Semaphorin3A elevates vascular permeability and contributes to cerebral ischemia-induced brain damage ▶     Sheng Tao Hou, Ladan Nilchi, Xuesheng Li et al.     Semaphorin 3A (Sema3A) increased significantly in mouse brain following cerebral ischemia. However, the role of Sema3A in stroke brain remains unknown. Our aim was to determine …             Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma ▶     Jian Guan, Rohit Gupta, Fabian V. Filipp     We characterized the mutational landscape of human skin cutaneous melanoma (SKCM) using data obtained from The Cancer Genome Atlas (TCGA) project. We analyzed next-generation …                     Chemical Sciences ▲ top               Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle ▶     Dmitry Yu Zubarev, Dmitrij Rappoport, Alán Aspuru-Guzik     We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of …             Electrostatic doping as a source for robust ferromagnetism at the interface between antiferromagnetic cobalt oxides ▶     Zi-An Li, N. Fontaíña-Troitiño, A. Kovács et al.     Polar oxide interfaces are an important focus of research due to their novel functionality which is not available in the bulk constituents. So far, research has focused mainly on …             Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol ▶     Hyeon Jeong Lee, Wandi Zhang, Delong Zhang et al.     We report a cholesterol imaging method using rationally synthesized phenyl-diyne cholesterol (PhDY-Chol) and stimulated Raman scattering (SRS) microscope. The phenyl-diyne group …             Surface Enhanced Electrochemiluminescence of Ru(bpy)32+ ▶     Daifang Wang, Longhua Guo, Rong Huang et al.     Surface enhanced spectroscopy such as surface enhanced Raman spectrum (SERS) and surface enhanced fluorescence have been investigated extensively in the past two decades. Herein, …             Cloud computing approaches for prediction of ligand binding poses and pathways ▶     Morgan Lawrenz, Diwakar Shukla, Vijay S. Pande     We describe an innovative protocol for ab initio prediction of ligand crystallographic binding poses and highly effective analysis of large datasets generated for protein-ligand …             Formation of Stoichiometric CsFn Compounds ▶     Qiang Zhu, Artem R. Oganov, Qingfeng Zeng     Alkali halides MX, have been viewed as typical ionic compounds, characterized by 1:1 ratio necessary for charge balance between M and X−. It was proposed that group I elements …             Aqueous Black Colloids of Reticular Nanostructured Gold ▶     S. E. Stanca, W. Fritzsche, J. Dellith et al.     Since ancient times, noble gold has continuously contributed to several aspects of life from medicine to electronics. It perpetually reveals its new features. We report the …             Functional Loop Dynamics of the Streptavidin-Biotin Complex ▶     Jianing Song, Yongle Li, Changge Ji et al.     Accelerated molecular dynamics (aMD) simulation is employed to study the functional dynamics of the flexible loop3-4 in the strong-binding streptavidin-biotin complex system. …             Strain-induced significant increase in metal-insulator transition temperature in oxygen-deficient Fe oxide epitaxial thin films ▶     Kei Hirai, Daisuke Kan, Noriya Ichikawa et al.     Oxygen coordination of transition metals is a key for functional properties of transition-metal oxides, because hybridization of transition-metal d and oxygen p orbitals …             High-temperature supercapacitor with a proton-conducting metal pyrophosphate electrolyte ▶     Takashi Hibino, Kazuyo Kobayashi, Masahiro Nagao et al.     Expanding the range of supercapacitor operation to temperatures above 100°C is important because this would enable capacitors to operate under the severe conditions required for …                 Scientific Editing: MSC Scientific Editing gives your research article a high-quality scientific edit that can help you make an impact on your intended audience.  Nature-standard editing - English language edit included - Specialist editors in your subject area. Find out more today.         Physical Sciences ▲ top               Infrared-induced variation of the magnetic properties of a magnetoplasmonic film with a 3D sub-micron periodic triangular roof-type antireflection structure ▶     Junlong Tian, Wang Zhang, Yiqiao Huang et al.     A carbon-matrix nickel composite magnetoplasmonic film with a 3D sub-micron periodic triangular roof-type antireflection structure (SPTAS) was fabricated via a simple and …             Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle ▶     Dmitry Yu Zubarev, Dmitrij Rappoport, Alán Aspuru-Guzik     We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of …             Spin and field squeezing in a spin-orbit coupled Bose-Einstein condensate ▶     Yixiao Huang, Zheng-Da Hu     Recently, strong spin-orbit coupling with equal Rashba and Dresselhaus strength has been realized in neutral atomic Bose-Einstein condensates via a pair of Raman lasers. In this …             Directional learning and the provisioning of public goods ▶     Heinrich H. Nax, Matjaž Perc     We consider an environment where players are involved in a public goods game and must decide repeatedly whether to make an individual contribution or not. However, players lack …             Fracture mode control: a bio-inspired strategy to combat catastrophic damage ▶     Haimin Yao, Zhaoqian Xie, Chong He et al.     The excellent mechanical properties of natural biomaterials have attracted intense attention from researchers with focus on the strengthening and toughening mechanisms. …             Defects in Silicene: Vacancy Clusters, Extended Line Defects, and Di-adatoms ▶     Shuang Li, Yifeng Wu, Yi Tu et al.     Defects are almost inevitable during the fabrication process, and their existence strongly affects thermodynamic and (opto)electronic properties of two-dimensional materials. …             Electric-field-induced Shift in the Threshold Voltage in LaAlO3/SrTiO3 Heterostructures ▶     Seong Keun Kim, Shin-Ik Kim, Hyungkwang Lim et al.     The two-dimensional electron gas (2DEG) at the interface between insulating LaAlO3 and SrTiO3 is intriguing both as a fundamental science topic and for possible applications in …             A study of room-temperature LixMn1.5Ni0.5O4 solid solutions ▶     Kuppan Saravanan, Angelique Jarry, Robert Kostecki et al.     Understanding the kinetic implication of solid-solution vs. biphasic reaction pathways is critical for the development of advanced intercalation electrode materials. Yet this has …             Aspiration dynamics in structured population acts as if in a well-mixed one ▶     Jinming Du, Bin Wu, Long Wang     Understanding the evolution of human interactive behaviors is important. Recent experimental results suggest that human cooperation in spatial structured population is not …             Electrostatic doping as a source for robust ferromagnetism at the interface between antiferromagnetic cobalt oxides ▶     Zi-An Li, N. Fontaíña-Troitiño, A. Kovács et al.     Polar oxide interfaces are an important focus of research due to their novel functionality which is not available in the bulk constituents. So far, research has focused mainly on …             MBSTAR: multiple instance learning for predicting specific functional binding sites in microRNA targets ▶     Sanghamitra Bandyopadhyay, Dip Ghosh, Ramkrishna Mitra et al.     MicroRNA (miRNA) regulates gene expression by binding to specific sites in the 3′untranslated regions of its target genes. Machine learning based miRNA target prediction …             Quantum Clock Synchronization with a Single Qudit ▶     Armin Tavakoli, Adán Cabello, Marek Żukowski et al.     Clock synchronization for nonfaulty processes in multiprocess networks is indispensable for a variety of technologies. A reliable system must be able to resynchronize the …             Dynamic Phases, Pinning, and Pattern Formation for Driven Dislocation Assemblies ▶     Caizhi Zhou, Charles Reichhardt, Cynthia J. Olson Reichhardt et al.     We examine driven dislocation assemblies and show that they can exhibit a set of dynamical phases remarkably similar to those of driven systems with quenched disorder such as …             Tunable pattern-free graphene nanoplasmonic waveguides on trenched silicon substrate ▶     Jiajiu Zheng, Longhai Yu, Sailing He et al.     Graphene has emerged as a promising material for active plasmonic devices in the mid-infrared (MIR) region owing to its fast tunability, strong mode confinement, and long-lived …             Achieving planar plasmonic subwavelength resolution using alternately arranged insulator-metal and insulator-insulator-metal composite structures ▶     Bo Han Cheng, Kai Jiun Chang, Yung-Chiang Lan et al.     This work develops and analyzes a planar subwavelength device with the ability of one-dimensional resolution at visible frequencies that is based on alternately arranged …             Thermal conductivity of skutterudite CoSb3 from first principles: Substitution and nanoengineering effects ▶     Ruiqiang Guo, Xinjiang Wang, Baoling Huang     CoSb3-based skutterudites are promising intermediate-temperature thermoelectric materials and fundamental understanding of the thermal transport in CoSb3 is crucial for further …             ERRATUM: Shaping complex microwave fields in reverberating media with binary tunable metasurfaces ▶     Nadège Kaina, Matthieu Dupré, Geoffroy Lerosey et al.                 Distinct itinerant spin-density waves and local-moment antiferromagnetism in an intermetallic ErPd2Si2 single crystal ▶     Hai-Feng Li, Chongde Cao, Andrew Wildes et al.     Identifying the nature of magnetism, itinerant or localized, remains a major challenge in condensed-matter science. Purely localized moments appear only in magnetic insulators, …             Te/C nanocomposites for Li-Te Secondary Batteries ▶     Jeong-Uk Seo, Gun-Kyu Seong, Cheol-Min Park     New battery systems having high energy density are actively being researched in order to satisfy the rapidly developing market for longer-lasting mobile electronics and hybrid …             Development of n-type cobaltocene-encapsulated carbon nanotubes with remarkable thermoelectric property ▶     Takahiro Fukumaru, Tsuyohiko Fujigaya, Naotoshi Nakashima     Direct conversion from heat to electricity is one of the important technologies for a sustainable society since large quantities of energy are wasted as heat. We report the …             Determination of the quantized topological magneto-electric effect in topological insulators from Rayleigh scattering ▶     Lixin Ge, Tianrong Zhan, Dezhuan Han et al.     Topological insulators (TIs) exhibit many exotic properties. In particular, a topological magneto-electric (TME) effect, quantized in units of the fine structure constant, exists …             Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol ▶     Hyeon Jeong Lee, Wandi Zhang, Delong Zhang et al.     We report a cholesterol imaging method using rationally synthesized phenyl-diyne cholesterol (PhDY-Chol) and stimulated Raman scattering (SRS) microscope. The phenyl-diyne group …             Surface Enhanced Electrochemiluminescence of Ru(bpy)32+ ▶     Daifang Wang, Longhua Guo, Rong Huang et al.     Surface enhanced spectroscopy such as surface enhanced Raman spectrum (SERS) and surface enhanced fluorescence have been investigated extensively in the past two decades. Herein, …             WS2 mode-locked ultrafast fiber laser ▶     Dong Mao, Yadong Wang, Chaojie Ma et al.     Graphene-like two dimensional materials, such as WS2 and MoS2, are highly anisotropic layered compounds that have attracted growing interest from basic research to practical …             Relativistic Quantum Metrology in Open System Dynamics ▶     Zehua Tian, Jieci Wang, Heng Fan et al.     Quantum metrology studies the ultimate limit of precision in estimating a physical quantity if quantum strategies are exploited. Here we investigate the evolution of a two-level …             Formation of Stoichiometric CsFn Compounds ▶     Qiang Zhu, Artem R. Oganov, Qingfeng Zeng     Alkali halides MX, have been viewed as typical ionic compounds, characterized by 1:1 ratio necessary for charge balance between M and X−. It was proposed that group I elements …             Magnetic Imaging: a New Tool for UK National Nuclear Security ▶     Brendan J. Darrer, Joe C. Watson, Paul Bartlett et al.     Combating illicit trafficking of Special Nuclear Material may require the ability to image through electromagnetic shields. This is the case when the trafficking involves cargo …             Cloud computing approaches for prediction of ligand binding poses and pathways ▶     Morgan Lawrenz, Diwakar Shukla, Vijay S. Pande     We describe an innovative protocol for ab initio prediction of ligand crystallographic binding poses and highly effective analysis of large datasets generated for protein-ligand …             Modulation of microporous/mesoporous structures in self-templated cobalt-silica ▶     Dana L. Martens, David K. Wang, Julius Motuzas et al.     Finite control of pore size distributions is a highly desired attribute when producing porous materials. While many methodologies strive to produce such materials through one-pot …             A “green” strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles ▶     V. Agostoni, P. Horcajada, M. Noiray et al.     Nanoparticles made of metal-organic frameworks (nanoMOFs) attract a growing interest in gas storage, separation, catalysis, sensing and more recently, biomedicine. Achieving …             Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner ▶     Jin Young Kim, Changho Lee, Kyungjin Park et al.     Optical-resolution photoacoustic microscopy (OR-PAM) is a novel label-free microscopic imaging tool to provide in vivo optical absorbing contrasts. Specially, it is crucial to …             Modification of perpendicular magnetic anisotropy and domain wall velocity in Pt/Co/Pt by voltage-induced strain ▶     P. M. Shepley, A. W. Rushforth, M. Wang et al.     The perpendicular magnetic anisotropy Keff, magnetization reversal, and field-driven domain wall velocity in the creep regime are modified in Pt/Co(0.85–1.0 nm)/Pt thin films by …             Unusual ferromagnetic critical behavior owing to short-range antiferromagnetic correlations in antiperovskite Cu1-xNMn3+x (0.1 ≤ x ≤ 0.4) ▶     Jianchao Lin, Peng Tong, Dapeng Cui et al.     For ferromagnets, varying from simple metals to strongly correlated oxides,the critical behaviors near the Curie temperature (TC) can be grouped into several universal classes. …             Intrinsic Topological Insulator Bi1.5Sb0.5Te3-xSex Thin Crystals ▶     Wei Wang, Li Li, Wenqin Zou et al.     The quaternary topological insulator (Bi,Sb)2(Te,Se)3 has demonstrated topological surface states with an insulating bulk. Scientists have identified an optimized composition of …             Photothermoelectric and photovoltaic effects both present in MoS2 ▶     Youwei Zhang, Hui Li, Lu Wang et al.     As a finite-energy-bandgap alternative to graphene, semiconducting molybdenum disulfide (MoS2) has recently attracted extensive interest for energy and sensor applications. In …             Hierarchically porous silicon–carbon–nitrogen hybrid materials towards highly efficient and selective adsorption of organic dyes ▶     Lala Meng, Xiaofei Zhang, Yusheng Tang et al.     The hierarchically macro/micro-porous silicon–carbon–nitrogen (Si–C–N) hybrid material was presented with novel functionalities of totally selective and highly efficient …             Highly Sensitive and Multifunctional Tactile Sensor Using Free-standing ZnO/PVDF Thin Film with Graphene Electrodes for Pressure and Temperature Monitoring ▶     James S. Lee, Keun-Young Shin, Oug Jae Cheong et al.     We demonstrate an 80-μm-thick film (which is around 15% of the thickness of the human epidermis), which is a highly sensitive hybrid functional gauge sensor, and was fabricated …             CORRIGENDUM: Computational Study of In-Plane Phonon Transport in Si Thin Films ▶     Xinjiang Wang, Baoling Huang                 Origin of Degradation Phenomenon under Drain Bias Stress for Oxide Thin Film Transistors using IGZO and IGO Channel Layers ▶     Jun Yong Bak, Youngho Kang, Shinhyuk Yang et al.     Top-gate structured thin film transistors (TFTs) using In-Ga-Zn-O (IGZO) and In-Ga-O (IGO) channel compositions were investigated to reveal a feasible origin for degradation …             Effective medium theory for anisotropic metamaterials ▶     Xiujuan Zhang, Ying Wu     Materials with anisotropic material parameters can be utilized to fabricate many fascinating devices, such as hyperlenses, metasolids, and one-way waveguides. In this study, we …             Dynamic properties of excitons in ZnO/AlGaN/GaN hybrid nanostructures ▶     Mathias Forsberg, Carl Hemmingsson, Hiroshi Amano et al.     Hybrid samples based on ZnO colloidal nanocrystals (NCs) deposited on AlGaN/GaN quantum well (QW) structures with different top barrier thickness d=3, 6 and 9 nm are studied by …             Aqueous Black Colloids of Reticular Nanostructured Gold ▶     S. E. Stanca, W. Fritzsche, J. Dellith et al.     Since ancient times, noble gold has continuously contributed to several aspects of life from medicine to electronics. It perpetually reveals its new features. We report the …             High performance organic-inorganic perovskite-optocoupler based on low-voltage and fast response perovskite compound photodetector ▶     Dong Li, Guifang Dong, Wenzhe Li et al.     Organic-inorganic hybrid photodetectors attract considerable attention because they can combine the advantages of both organic and inorganic systems. Here, a perovskite compound …             Electronic Structure Engineering of Cu2O Film/ZnO Nanorods Array All-Oxide p-n Heterostructure for Enhanced Photoelectrochemical Property and Self-powered Biosensing Application ▶     Zhuo Kang, Xiaoqin Yan, Yunfei Wang et al.     We have engineered the electronic structure at the interface between Cu2O and ZnO nanorods (NRs) array, through adjusting the carrier concentration of Cu2O. The electrodeposition …             High-temperature supercapacitor with a proton-conducting metal pyrophosphate electrolyte ▶     Takashi Hibino, Kazuyo Kobayashi, Masahiro Nagao et al.     Expanding the range of supercapacitor operation to temperatures above 100°C is important because this would enable capacitors to operate under the severe conditions required for …             Magnetization reversal using excitation of collective modes in nanodot matrices ▶     Mehrdad Elyasi, Charanjit S. Bhatia, Hyunsoo Yang     The large arrays of magnetic dots are the building blocks of magnonic crystals and the emerging bit patterned media for future recording technology. In order to fully utilize the …             Spin pumping in Ferromagnet-Topological Insulator-Ferromagnet Heterostructures ▶     A. A. Baker, A. I. Figueroa, L. J. Collins-McIntyre et al.     Topological insulators (TIs) are enticing prospects for the future of spintronics due to their large spin-orbit coupling and dissipationless, counter-propagating conduction …             Control of orbital reconstruction in (LaAlO3)M/(SrTiO3)N(001) quantum wells by strain and confinement ▶     David Doennig, Rossitza Pentcheva     The diverse functionality emerging at oxide interfaces calls for a fundamental understanding of the mechanisms and control parameters of electronic reconstructions. Here, we …             Strain-induced significant increase in metal-insulator transition temperature in oxygen-deficient Fe oxide epitaxial thin films ▶     Kei Hirai, Daisuke Kan, Noriya Ichikawa et al.     Oxygen coordination of transition metals is a key for functional properties of transition-metal oxides, because hybridization of transition-metal d and oxygen p orbitals …             Anisotropic Quantum Confinement Effect and Electric Control of Surface States in Dirac Semimetal Nanostructures ▶     Xianbo Xiao, Shengyuan A. Yang, Zhengfang Liu et al.     The recent discovery of Dirac semimetals represents a new achievement in our fundamental understanding of topological states of matter. Due to their topological surface states, …             The generation of Continuous-Variable Entanglement Frequency Comb ▶     Youbin Yu, Xiaomin Cheng, Huaijun Wang et al.     Continuous-variable (CV) entanglement frequency comb can be produced by enhanced Raman scattering in an above-threshold optical oscillator cavity in which a hexagonally-poled …             Functional Loop Dynamics of the Streptavidin-Biotin Complex ▶     Jianing Song, Yongle Li, Changge Ji et al.     Accelerated molecular dynamics (aMD) simulation is employed to study the functional dynamics of the flexible loop3-4 in the strong-binding streptavidin-biotin complex system. …             Characterising two-pathogen competition in spatially structured environments ▶     Chiara Poletto, Sandro Meloni, Ashleigh Van Metre et al.     Different pathogens spreading in the same host population often generate complex co-circulation dynamics because of the many possible interactions between the pathogens and the …             Interplay of relativistic and nonrelativistic transport in atomically precise segmented graphene nanoribbons ▶     Constantine Yannouleas, Igor Romanovsky, Uzi Landman     Graphene's isolation launched explorations of fundamental relativistic physics originating from the planar honeycomb lattice arrangement of the carbon atoms, and of potential …               Earth & Environmental Sciences ▲ top               Directional learning and the provisioning of public goods ▶     Heinrich H. Nax, Matjaž Perc     We consider an environment where players are involved in a public goods game and must decide repeatedly whether to make an individual contribution or not. However, players lack …             A study of room-temperature LixMn1.5Ni0.5O4 solid solutions ▶     Kuppan Saravanan, Angelique Jarry, Robert Kostecki et al.     Understanding the kinetic implication of solid-solution vs. biphasic reaction pathways is critical for the development of advanced intercalation electrode materials. Yet this has …             Integrated metagenomics and network analysis of soil microbial community of the forest timberline ▶     Junjun Ding, Yuguang Zhang, Ye Deng et al.     The forest timberline responds quickly and markedly to climate changes, rendering it a ready indicator. Climate warming has caused an upshift of the timberline worldwide. …             Complex forest dynamics indicate potential for slowing carbon accumulation in the southeastern United States ▶     John W. Coulston, David N. Wear, James M. Vose     Over the past century forest regrowth in Europe and North America expanded forest carbon (C) sinks and offset C emissions but future C accumulation is uncertain. Policy makers …             Insolation driven biomagnetic response to the Holocene Warm Period in semi-arid East Asia ▶     Suzhen Liu, Chenglong Deng, Jule Xiao et al.     The Holocene Warm Period (HWP) provides valuable insights into the climate system and biotic responses to environmental variability and thus serves as an excellent analogue for …             Nannofossils in 2011 El Hierro eruptive products reinstate plume model for Canary Islands ▶     Kirsten Zaczek, Valentin R. Troll, Mario Cachao et al.     The origin and life cycle of ocean islands have been debated since the early days of Geology. In the case of the Canary archipelago, its proximity to the Atlas orogen led to …             Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector ▶     Stina Bäckman, Jonas Näslund, Mats Forsman et al.     Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the …             CO2 enrichment and N addition increase nutrient loss from decomposing leaf litter in subtropical model forest ecosystems ▶     Juxiu Liu, Xiong Fang, Qi Deng et al.     As atmospheric CO2 concentration increases, many experiments have been carried out to study effects of CO2 enrichment on litter decomposition and nutrient release. However, the …             Hydraulic Experiments for Determination of In-situ Hydraulic Conductivity of Submerged Sediments ▶     Bong-Joo Lee, Ji-Hoon Lee, Heesung Yoon et al.     A new type of in-situ hydraulic permeameter was developed to determine vertical hydraulic conductivity (VHC) of saturated sediments from hydraulic experiments using Darcy's law. …             Hierarchically porous silicon–carbon–nitrogen hybrid materials towards highly efficient and selective adsorption of organic dyes ▶     Lala Meng, Xiaofei Zhang, Yusheng Tang et al.     The hierarchically macro/micro-porous silicon–carbon–nitrogen (Si–C–N) hybrid material was presented with novel functionalities of totally selective and highly efficient …               Health Sciences ▲ top               Association of the immature platelet fraction with sepsis diagnosis and severity ▶     Rodolfo Monteiro Enz Hubert, Melina Veiga Rodrigues, Bruna Dolci Andreguetto et al.     Management of Sepsis would greatly benefit from the incorporation of simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate …             AhR expression and polymorphisms are associated with risk of coronary arterial disease in Chinese population ▶     Shian Huang, Xiaorong Shui, Yuan He et al.     The aryl hydrocarbon receptor (AhR) mediates the control of environmental toxicity, and modulates the development and pathogenesis of the cardiovascular system. However, little …             Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force ▶     Tao Guo, Liqiang Zhang, Anna Konermann et al.     Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as …             Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning ▶     Lionel Blanchet, Jan A. M. Smeitink, Sjenet E. van Emst - de Vries et al.     In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and …             Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis ▶     Wenji Xue, Meiling Zhu, Yiwei Wang et al.     Phospholipase C epsilon 1 (PLCE1) plays an important role in cell growth, differentiation and oncogenesis. An increasing number of individual studies have investigated the …             Glycomic Signatures on Serum IgGs for Prediction of Postvaccination Response ▶     Jing-Rong Wang, Wen-Da Guan, Lee-Fong Yau et al.     Millions of individuals are vaccinated worldwide each year to stimulate their adaptive immune systems to produce protective antibodies and T-cell response against pathogens. …             Photorefraction estimates of refractive power varies with the ethnic origin of human eyes ▶     N. Geetha Sravani, Vinay Kumar Nilagiri, Shrikant R. Bharadwaj     Eccentric infrared photorefraction is an attractive tool for measuring refractive errors of young children and uncooperative subjects, for it allows quick and non-invasive …             Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia ▶     Keiko Doi, Takahiko Imai, Christopher Kressler et al.     The Rap G protein signal regulates Notch activation in early thymic progenitor cells, and deregulated Rap activation (Raphigh) results in the development of Notch-dependent …             Evolutionary analysis of rubella viruses in mainland China during 2010–2012: endemic circulation of genotype 1E and introductions of genotype 2B ▶     Zhen Zhu, Pierre Rivailler, Emily Abernathy et al.     Rubella remains a significant burden in mainland China. In this report, 667 viruses collected in 24 of 31 provinces of mainland China during 2010–2012 were sequenced and …             Diminished serum repetin levels in patients with schizophrenia and bipolar disorder ▶     Shuai Wang, Huixun Ren, Jie Xu et al.     Repetin (RPTN) protein is a member of S100 family and is known to be expressed in the normal epidermis. Here we show that RPTN is ubiquitously expressed in both mouse and human …             Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries ▶     Ludovit Paulis, Jeremy Fauconnier, Olivier Cazorla et al.     Sonic hedgehog (SHH) is a conserved protein involved in embryonic tissue patterning and development. SHH signaling has been reported as a cardio-protective pathway via muscle …             N-Glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential ▶     Krystal Teasley Hamorsky, J. Calvin Kouokam, Jessica M. Jurkiewicz et al.     Plant-based transient overexpression systems enable rapid and scalable production of subunit vaccines. Previously, we have shown that cholera toxin B subunit (CTB), an oral …             Circulating vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D and risk of colorectal cancer ▶     Hou-Qun Ying, Hui-Ling Sun, Bang-Shun He et al.     Epidemiological investigation have suggested that there is a significantly inverse association between circulating 25-hydroxyvitamin D (25(OH)D) and the risk for developing …             Determining the Pathogenicity of Genetic Variants Associated with Cardiac Channelopathies ▶     Oscar Campuzano, Catarina Allegue, Anna Fernandez et al.     Advancements in genetic screening have generated massive amounts of data on genetic variation; however, a lack of clear pathogenic stratification has left most variants …             Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility ▶     Mingzhi Liao, Guangyu Wang, Baoku Quan et al.     Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been …             Potent effects of dioscin against obesity in mice ▶     Min Liu, Lina Xu, Lianhong Yin et al.     The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease (NAFLD) are unclear. Thus, the purpose of the present study was to further confirm its …             Intraoperative vascular DIVA surgery reveals angiogenic hotspots in tumor zones of malignant gliomas ▶     Ilker Y. Eyüpoglu, Nirjhar Hore, Zheng Fan et al.     Malignant gliomas belong to the most threatening tumor entities and are hallmarked by rapid proliferation, hypervascularization and an invasive growth pattern. The primary …             Fecal calprotectin as a biomarker of intestinal graft versus host disease after allogeneic hematopoietic stem cell transplantation ▶     Fryderyk Lorenz, Stefan Marklund, Mårten Werner et al.     The diagnosis of gastrointestinal graft versus host disease (GI-GVHD) is based on clinical symptoms and histological findings. In clinical practice, it is often difficult to …             Angiogenin Secretion From Hepatoma Cells Activates Hepatic Stellate Cells To Amplify A Self-Sustained Cycle Promoting Liver Cancer ▶     Cristina Bárcena, Milica Stefanovic, Anna Tutusaus et al.     Hepatocellular carcinoma (HCC) frequently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs) remodeling the extracellular matrix …             Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA ▶     Benjamin B. Albert, José G. B. Derraik, David Cameron-Smith et al.     We evaluated the quality and content of fish oil supplements in New Zealand. All encapsulated fish oil supplements marketed in New Zealand were eligible for inclusion. Fatty acid …             Identification of novel viral receptors with cell line expressing viral receptor-binding protein ▶     Mei Mei, Jianqiang Ye, Aijian Qin et al.     The viral cell receptors and infection can be blocked by the expression of the viral receptor-binding protein. Thus, the viral cell receptor is an attractive target for …             Thrombin induces ischemic LTP (iLTP): implications for synaptic plasticity in the acute phase of ischemic stroke ▶     Efrat Shavit Stein, Zeev Itsekson-Hayosh, Anna Aronovich et al.     Acute brain ischemia modifies synaptic plasticity by inducing ischemic long-term potentiation (iLTP) of synaptic transmission through the activation of N-Methyl-D-aspartate …             A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery ▶     Shayan F. Lahiji, Manita Dangol, Hyungil Jung     Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto …             Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying ▶     Susana Camacho, Stephanie Michlig, Carole de Senarclens-Bezençon et al.     Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon …             Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM ▶     Nidhan K. Biswas, Vikas Chandra, Neeta Sarkar-Roy et al.     Neoplastic cells of Glioblastoma multiforme (GBM) may or may not show sustained response to temozolomide (TMZ) chemotherapy. We hypothesize that TMZ chemotherapy response in GBM …             Transcriptome and Histopathological Changes in Mouse Brain Infected with Neospora caninum ▶     Maki Nishimura, Sachi Tanaka, Fumiaki Ihara et al.     Neospora caninum is a protozoan parasite that causes neurological disorders in dogs and cattle. It can cause nonsuppurative meningoencephalitis and a variety of neuronal symptoms …             The prevalence of sexual dysfunction in the female health care providers in Jeddah, Saudi Arabia ▶     Abdulrahim A. Rouzi, Nora Sahly, Dana Sawan et al.     The objective of this study was to determine the prevalence of sexual dysfunction in Saudi and non-Saudi female health care providers in Jeddah, Saudi Arabia. One -hundred twenty …             Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis ▶     Benchun Jiang, Ke Zhu, Hua Shao et al.     E-Cadherin (CDH1) plays a key role in cell adhesion, which is vital to the normal development and maintenance of cells. Down regulation of CDH1, may lead to dysfunction of the …             Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma ▶     Jian Guan, Rohit Gupta, Fabian V. Filipp     We characterized the mutational landscape of human skin cutaneous melanoma (SKCM) using data obtained from The Cancer Genome Atlas (TCGA) project. We analyzed next-generation …             A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke ▶     Cheng-long Xie, Wen-Wen Wang, Xiao-Dong Xue et al.     The neuroprotective actions of Ginsenoside-Rg1 (G-Rg1) have been documented for experimental stroke therapy. We used a systematic review and meta-analysis to assess the efficacy …             Characterising two-pathogen competition in spatially structured environments ▶     Chiara Poletto, Sandro Meloni, Ashleigh Van Metre et al.     Different pathogens spreading in the same host population often generate complex co-circulation dynamics because of the many possible interactions between the pathogens and the …                 • Careers & Jobs           naturejobs.com Science jobs of the week       Senior Research Fellow     University of Portsmouth, UK            Postdoctoral Researcher     Lehigh University            PhD studentship     Centre National de la Recherche Scientifique (CNRS)            Postdoc Position     University of Sao Paulo (Brazil)            PhD-student     Georg-August-Universität Göttingen            Clinical Trial Manager     Institute of Cancer Research (ICR)            Postdoctoral Associates     Sanford Bunrham Medical Research Institute            Bioinformatics Specialist II     Massachusetts General Hospital            Associate Research Fellow     University of Exeter            Postdoctoral Fellow     Cleveland Clinic Lerner Research Institute          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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