Nature Reviews Neurology - Table of Contents alert Volume 11 Issue 2

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TABLE OF CONTENTS
February 2015 Volume 11 Number 2
Impact Factor 14.103 *	In this issue Research Highlights Year in Review Reviews Also this month  Featured article: Intravenous immunoglobulin in neurology—mode of action and clinical efficacy Jan D. Lünemann, Falk Nimmerjahn & Marinos C. Dalakas
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Nature Collections  Nobel Prize in Chemistry 2014 The 2014 Nobel Prize in Chemistry was awarded for the development of super-resolution fluorescence microscopy. This collection of news pieces and articles by the Nobel laureates and their collaborators celebrates this achievement. Produced with support from  ZEISS Microscopy
RESEARCH HIGHLIGHTS Top Traumatic brain injury: No benefit of progesterone therapy in patients with TBI Published online: 06 January 2015 p65 | doi:10.1038/nrneurol.2014.258 PDF Neurodevelopmental disorders: Unmuting Ube3a in mice alleviates Angelman syndrome Published online: 16 December 2014 p66 | doi:10.1038/nrneurol.2014.240 PDF Parkinson disease: Gut reactions—can changes in the intestinal microbiome provide new insights into Parkinson disease? Published online: 23 December 2014 p66 | doi:10.1038/nrneurol.2014.256 PDF Dementia: Criminality can be an early sign of frontotemporal dementia Published online: 20 January 2015 p67 | doi:10.1038/nrneurol.2015.1 PDF Parkinson disease: Reduced level of dietary vitamin D is associated with PD Published online: 13 January 2015 p68 | doi:10.1038/nrneurol.2014.265 PDF IN BRIEF Multiple sclerosis: IgM bands indicate reduced risk of PML on natalizumab | Neurodegenerative disease: Acetylation controls TDP-43 function and aggregation | Sensory systems: Cochlear implantation can ameliorate symptoms of OPA1-associated auditory neuropathy | Dementia: Improved decision tree aids differentiation of atypical Alzheimer disease from Creutzfeld-Jakob disease | Multiple sclerosis: Quadrivalent HPV vaccination does not increase risk of MS | Neurodegenerative disease: Crucial role for miR-219 in the development of tauopathies | Neuro-oncology: Patients with low-grade gliomas respond well to proton-based radiotherapy | Neuro-oncology: Expression of miR-125a-3p is related to glioma malignancy PDF Neurology JOBS of the week PostDoctoral Fellow Hospital for Special Surgery Neuropathologist The University of Wisconsin-Madison Department of Pathology and Laboratory Medicine Faculty Positions in Epilepsy Research Columbia University Medical Center More Science jobs from Neurology EVENT The Lancet Neurology Autoimmune Disorders Conference 26th Mar - 27th Mar 2015 Barcelona, Spain More science events from
YEAR IN REVIEW		Top
Dementia in 2014: Towards early diagnosis in Alzheimer disease Agneta Nordberg Published online: 27 January 2015 p69 | doi:10.1038/nrneurol.2014.257 Improved neuroimaging and molecular markers of Alzheimer disease (AD) have aided diagnosis of AD in the very early stages, and have facilitated differential diagnosis between AD and other neurodegenerative disorders with dementia. The finding that some older individuals can show amyloid-β pathology while remaining cognitively intact raises important questions regarding prevention strategies. Full Text | PDF
Traumatic brain injury in 2014: Progress, failures and new approaches for TBI research David K. Menon & Andrew I. R. Maas Published online: 13 January 2015 p71 | doi:10.1038/nrneurol.2014.261 The past year saw the 40th anniversary of the Glasgow Coma Scale, which continues to be effective for monitoring patients with traumatic brain injury. Three new clinical trials were completed, but none revealed beneficial interventions. These failures have prompted exploration of more-subtle therapy targets, novel disease classifications and collaborative research paradigms. Full Text | PDF
Motor neuron disease in 2014: Biomarkers for ALS—in search of the Promised Land Adriano Chiò & Bryan J. Traynor Published online: 23 December 2014 p72 | doi:10.1038/nrneurol.2014.250 The past year has seen some extraordinary activity in clinical amyotrophic lateral sclerosis (ALS) research. Two trials were completed, with negative results, but the discovery of novel ALS-associated genes, and body fluid and imaging biomarkers warrants cautious optimism. Here, we provide a snapshot of some of the main findings in 2014. Full Text | PDF
Epilepsy in 2014: Novel and large collaborations drive advances in epilepsy Piero Perucca & Terence J. O'Brien Published online: 06 January 2015 p74 | doi:10.1038/nrneurol.2014.255 In 2014, novel, large-scale collaborative efforts and frameworks resulted in major advances in the epilepsy field, from publication of a new definition of epilepsy to important discoveries regarding aetiology, pathophysiology and management. These collaborative works provide a platform from which further advances are anticipated, and a model for future research. Full Text | PDF
Multiple sclerosis in 2014: Progress in MS—classification, mechanisms and treatment Jiwon Oh & Paul W. O'Connor Published online: 13 January 2015 p76 | doi:10.1038/nrneurol.2014.259 Scientific progress in multiple sclerosis (MS) research spanned a number of areas in 2014, including therapeutics, disease classification, risk management, and disease mechanisms. Advances were particularly notable in the field of progressive MS. Altogether, the findings move us one step closer to a better understanding of this complex disease. Full Text | PDF
Movement disorders in 2014: Genetic advances spark a revolution in dystonia phenotyping Tom J. de Koning & Marina A. J. Tijssen Published online: 06 January 2015 p78 | doi:10.1038/nrneurol.2014.254 Genetic revelations in 2014 are testing traditional classification systems for movement disorders, and our approach to clinical diagnostics. Mutations in dystonia-associated genes lead to a spectrum of disorders with different phenotypes, underscoring the need for stringent clinical phenotyping of patients with movement disorders, as well as next-generation sequencing approaches. Full Text | PDF
REVIEWS		Top
Intravenous immunoglobulin in neurology—mode of action and clinical efficacy Jan D. Lünemann, Falk Nimmerjahn & Marinos C. Dalakas Published online: 06 January 2015 p80 | doi:10.1038/nrneurol.2014.253 Intravenous immunoglobulin (IVIg), is an effective anti-inflammatory and immunomodulatory treatment for many autoimmune diseases. In this Review, Lunemann and colleagues catalogue the evidence to support the use of IVIg in several neurological disorders, including Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. The authors also address diseases in which IVIg has not proven to be effective, and highlight avenues for future research, including drug development studies and clinical trials. Abstract | Full Text | PDF
A new prion disease: relationship with central and peripheral amyloidoses Simon Mead & Mary M. Reilly Published online: 27 January 2015 p90 | doi:10.1038/nrneurol.2014.263 In this Review, Mead and Reilly present a new form of prion disease, characterized by systemic amyloidosis, diarrhoea, neuropathic pain and postural hypotension. So-called PrP systemic amyloidosis is caused by mutations in the prion protein gene that result in a premature stop codon, and all mutations identified to date are autosomal dominant. The authors recommend a standardized and conservative approach to the diagnosis and treatment of patients with PrP systemic amyloidosis. Abstract | Full Text | PDF
Axial disability and deep brain stimulation in patients with Parkinson disease Alfonso Fasano, Camila C. Aquino, Joachim K. Krauss, Christopher R. Honey & Bastiaan R. Bloem Published online: 13 January 2015 p98 | doi:10.1038/nrneurol.2014.252 Deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus internus can substantially improve appendicular motor symptoms of Parkinson disease (PD); however, the effect of DBS on axial motor signs—such as gait impairment, postural instability and postural abnormalities—is less clear. In this practically oriented Review, Fasano et al. discuss the most important considerations to establish the reasons for gait problems in patients receiving DBS, and suggest how to manage axial disability in these patients. Abstract | Full Text | PDF | Supplementary information
Targeting secondary injury in intracerebral haemorrhage—perihaematomal oedema Sebastian Urday, W. Taylor Kimberly, Lauren A. Beslow, Alexander O. Vortmeyer, Magdy H. Selim, Jonathan Rosand, J. Marc Simard & Kevin N. Sheth Published online: 27 January 2015 p111 | doi:10.1038/nrneurol.2014.264 Perihaematomal oedema (PHO) is an important pathophysiological marker of secondary injury following intracerebral haemorrhage. In this Review, the authors consider PHO in a novel framework and highlight the clinical relevance of the condition, both as a therapeutic target and as a surrogate marker for novel interventions that target secondary injury. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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