Nature Reviews Endocrinology - Table of Contents alert Volume 11 Issue 4

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TABLE OF CONTENTS
April 2015 Volume 11 Number 4
Impact Factor 12.958*	In this issue Research Highlights News and Views Reviews Also this month  Featured article: The endocrinology of taste receptors Sara Santa-Cruz Calvo & Josephine M. Egan
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RESEARCH HIGHLIGHTS Top Obesity: Unravelling the neural networks that drive different eating behaviours Published online: 17 February 2015 p191 | doi:10.1038/nrendo.2015.16 PDF Bone: Osteocyte-specific activation of the canonical Wnt-β catenin pathway stimulates bone formation Published online: 03 February 2015 p192 | doi:10.1038/nrendo.2015.11 PDF Diabetes: Genetically engineered Lactobacilli reprogram intestinal cells to secrete insulin and ameliorate hyperglycaemia Published online: 03 March 2015 p192 | doi:10.1038/nrendo.2015.45 PDF Diabetes: IL-6 mediates the protective effects of exercise on β cells Published online: 10 February 2015 p193 | doi:10.1038/nrendo.2015.12 PDF Autoimmunity: T1DM and the gut microbiome Published online: 24 February 2015 p193 | doi:10.1038/nrendo.2015.15 PDF Metabolism: Hepatic insulin resistance—missing link identified Published online: 24 February 2015 p193 | doi:10.1038/nrendo.2015.17 PDF Therapy: Aptamer-lipid nanoparticle conjugates for RNAi in bone Published online: 24 February 2015 p194 | doi:10.1038/nrendo.2015.18 PDF IN BRIEF Obesity: New pathway in the distribution of body fat identified | Metabolism: Limostatin—a decretin—suppresses insulin production | Thyroid gland: Improving survival in patients with papillary thyroid cancer | Neuroendocrine cancer: Genomics of phaeochromocytomas and paragangliomas PDF Endocrinology JOBS of the week Postdoc Research Associate - Endocrinology, Metabolism & Lipid Research - 30113 Washington University School of Medicine More Science jobs from Endocrinology EVENT Diet and Optimum Health Conference 09.09.15 Oregon, USA More science events from
NEWS AND VIEWS		Top
Surgery: Papillary thyroid cancer—how aggressive should surgery be? Sarah E. Tevis & Herbert Chen Published online: 17 February 2015 p195 | doi:10.1038/nrendo.2015.13 A prospective randomized controlled trial in patients with papillary thyroid cancer without lymph node metastases demonstrated similar oncologic outcomes in patients who underwent total thyroidectomy with prophylactic central compartment lymph node dissection (pCCND) and in those who underwent total thyroidectomy without pCCND. However, pCCND was associated with an increased rate of complications. Full Text | PDF
Obesity: A new paradigm for treating obesity and diabetes mellitus André J. Scheen & Nicolas Paquot Published online: 27 January 2015 p196 | doi:10.1038/nrendo.2015.3 An innovative strategy that uses a well-balanced monomeric peptide triagonist to target three metabolically related hormone receptors has been developed. This strategy seems to be the most effective pharmacological approach to reverse obesity and its metabolic comorbidities in rodents and could open new ways to tackle the dual burden of obesity and diabetes mellitus in humans. Full Text | PDF
Metabolism: Exercise remodels subcutaneous fat tissue and improves metabolism Harriet Wallberg-Henriksson & Juleen R. Zierath Published online: 24 February 2015 p198 | doi:10.1038/nrendo.2015.24 Exercise training is one of the key interventions for preventing and treating type 2 diabetes mellitus. Although the health-promoting effects of exercise are largely ascribed to improvements in skeletal muscle insulin sensitivity, new data published in Diabetes suggest 'exercise-trained' subcutaneous adipose tissue might also have an important role in enhancing glucose homeostasis. Full Text | PDF
REVIEWS		Top
Diabetes mellitus—advances and challenges in human β-cell proliferation Peng Wang, Nathalie M. Fiaschi-Taesch, Rupangi C. Vasavada, Donald K. Scott, Adolfo García-Ocaña & Andrew F. Stewart Published online: 17 February 2015 p201 | doi:10.1038/nrendo.2015.9 The replacement or regeneration of pancreatic β cells has the potential to reverse the progression of diabetes mellitus. This Review discusses the physiology of normal β-cell replication, the signalling pathways and epigenetic mechanisms that regulate entry to the cell cycle in β cells, and approaches for discovering novel molecules that drive β-cell replication. The potential and challenges of implementing strategies that replace or regenerate β-cells in humans is also discussed. Abstract | Full Text | PDF
The endocrinology of taste receptors Sara Santa-Cruz Calvo & Josephine M. Egan Published online: 24 February 2015 p213 | doi:10.1038/nrendo.2015.7 In contemporary society, the ready availability of calorie-dense, highly palatable foods has contributed to the global obesity epidemic. Individuals with obesity often consume an excess of food, despite knowledge of the associated adverse consequences. In this Review, Santa-Cruz Calvo and Egan explore the physiology of taste perception with regard to taste receptors, neuronal signalling and hormonal control of food intake. Abstract | Full Text | PDF
Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations Luca Antonioli, Corrado Blandizzi, Balázs Csóka, Pál Pacher & György Haskó Published online: 17 February 2015 p228 | doi:10.1038/nrendo.2015.10 The adenosine-adenosine receptor system has a key role in regulating glucose homeostasis and in the pathophysiology of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). In this Review, the authors discuss the role of the adenosinergic system in regulating both the onset and progression of T1DM and T2DM, and the potential of manipulating this system as an approach to manage T1DM, T2DM and their associated complications. Abstract | Full Text | PDF
Novel RAAS agonists and antagonists: clinical applications and controversies Cesar A. Romero, Marcelo Orias & Matthew R. Weir Published online: 10 February 2015 p242 | doi:10.1038/nrendo.2015.6 The renin-angiotensin-aldosterone system (RAAS) regulates blood pressure homeostasis via multiple mechanisms that act on a variety of organs. The development of drugs that target RAAS components is an active area of research. The authors of this Review discuss current and future therapeutic manipulation of the RAAS and its promise in improving the care of patients with hypertension. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Endocrinology was previously published as Nature Clinical Practice Endocrinology & Metabolism.

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