Nature Reviews Nephrology - Table of Contents alert Volume 11 Issue 5

TABLE OF CONTENTS
May 2015 Volume 11 Number 5
Impact Factor 8.368 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD David A. Ferenbach & Joseph V. Bonventre
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RESEARCH HIGHLIGHTS Top Acute kidney injury: Mitsugumin 53 mediates repair of the damaged proximal tubular epithelium Published online: 07 April 2015 p253 | doi:10.1038/nrneph.2015.50 PDF Acute kidney injury: Proximal tubule cells modulate inflammation after renal injury Published online: 31 March 2015 p254 | doi:10.1038/nrneph.2015.40 PDF Hypertension: Complement C1 and β-catenin in hypertensive arterial remodelling Published online: 17 March 2015 p255 | doi:10.1038/nrneph.2015.31 PDF Hypertension: Redox-sensitive transcription factors regulate the renal dopamine receptor Published online: 17 March 2015 p255 | doi:10.1038/nrneph.2015.32 PDF Transplantation: The molecular landscape of ABMR Published online: 31 March 2015 p255 | doi:10.1038/nrneph.2015.41 PDF Chronic kidney disease: Procoagulant microparticles provide a novel pathogenic link between hyperphosphataemia and cardiovascular risk Published online: 24 March 2015 p256 | doi:10.1038/nrneph.2015.34 PDF Diabetic nephropathy: Defective podocyte XBP1 signalling in diabetic nephropathy Published online: 24 March 2015 p256 | doi:10.1038/nrneph.2015.35 PDF IN BRIEF Critical care: EGDT does not improve outcomes in septic shock | Epidemiology: Disparities in access to renal replacement therapy | Critical care: No benefit of fresh red blood cells over standard-issue cells | Fibrosis: TGF-β signalling and renal fibrosis PDF
NEWS AND VIEWS		Top
Nephrotic syndrome: Efficacy of rituximab in challenging nephrotic syndrome Kevin V. Lemley & Robert H. Mak Published online: 10 March 2015 p257 | doi:10.1038/nrneph.2015.26 A new trial provides further evidence that rituximab treatment can reduce the risk of relapse in children with steroid-dependent idiopathic nephrotic syndrome. Addition of a single infusion of rituximab to steroid therapy was associated with a decrease in proteinuria at 3 months and a significant increase in the relapse-free period. Full Text | PDF
Hypertension: Renal denervation—promising data from the DENERHTN trial Wen-Yi Yang & Jan A. Staessen Published online: 10 March 2015 p258 | doi:10.1038/nrneph.2015.28 In patients with resistant hypertension, renal denervation plus standardized stepped-care antihypertensive treatment (SSAHT) resulted in significant blood-pressure lowering compared with SSAHT alone. These new data from the DENERHTN trial may indicate that despite the failure of SYMPLICITY HTN-3, there is light at the end of the tunnel for renal denervation. Full Text | PDF
Heart failure: New data do not SUPPORT triple RAAS blockade A. H. Jan Danser & Anton H. van den Meiracker Published online: 24 March 2015 p260 | doi:10.1038/nrneph.2015.30 The SUPPORT trial evaluated the effect of adding the angiotensin-receptor blocker olmesartan to a combination of angiotensin-converting-enzyme inhibitors and β-blockers in hypertensive patients with chronic stable heart failure. Unfortunately, this triple renin–angiotensin–aldosterone system blockade was associated with worsening of renal function and increases in cardiac events and mortality. Full Text | PDF
Chronic kidney disease: Statins in chronic kidney disease: time to move on? Richard Haynes & Christoph Wanner Published online: 24 March 2015 p262 | doi:10.1038/nrneph.2015.36 Statins reduce the risk of atherosclerotic vascular disease in healthy individuals and those with chronic kidney disease (CKD); however, clinical trials have suggested a minimal effect of statins on CKD progression. The PLANET trials compared the renal effects of rosuvastatin and atorvastatin, but the findings leave many questions unanswered. Full Text | PDF
REVIEWS		Top
Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD David A. Ferenbach & Joseph V. Bonventre Published online: 03 February 2015 p264 | doi:10.1038/nrneph.2015.3 Acute kidney injury (AKI) is associated with high levels of mortality and an increased risk of progressive chronic kidney disease. Here, David Ferenbach and Joseph Bonventre describe the mechanisms involved in the initiation and propagation of AKI. They discuss the prototypic mechanisms employed by the damaged kidney to repair, and how the adaptive processes of repair can become maladaptive, leading to the development of progressive fibrotic kidney disease and a state that can be considered accelerated kidney ageing. Abstract | Full Text | PDF
The genetics of diabetic complications Emma Ahlqvist, Natalie R. van Zuydam, Leif C. Groop & Mark I. McCarthy Published online: 31 March 2015 p277 | doi:10.1038/nrneph.2015.37 Diabetes mellitus is often accompanied by numerous microvascular and/or macrovascular complications. Identification of risk alleles for diabetic complications could lead to improved understanding of the underlying mechanistic processes, but has so far been limited. Here, McCarthy and colleagues discuss the utility of human genetic studies in identifying novel risk variants for diabetic complications, the challenges faced in identifying robust genetic associations for diabetic kidney disease and the benefits that genome-wide association studies can offer. Abstract | Full Text | PDF
Renal artery embolization—indications, technical approaches and outcomes Arnaud Muller & Olivier Rouvière Published online: 23 December 2014 p288 | doi:10.1038/nrneph.2014.231 Renal artery embolization (RAE) is becoming increasingly recognized as a beneficial adjunct in the treatment of numerous renal diseases. In this Review, the authors discuss the advantages and disadvantages of RAE in the management of conditions such as renal traumatisms, tumours, angiomyolipomas and aneurysms. The technical approaches are compared, and the benefits and complications associated with RAE are discussed. Abstract | Full Text | PDF | Supplementary information
Haemodialysis-induced hypoglycaemia and glycaemic disarrays Masanori Abe & Kamyar Kalantar-Zadeh Published online: 07 April 2015 p302 | doi:10.1038/nrneph.2015.38 In diabetic patients undergoing maintenance haemodialysis, extremely high and low glycaemic levels are associated with increased morbidity and mortality owing to vascular and diabetic complications. The prevention of glycaemic disarrays in this population is challenging owing to factors including changes in the metabolism of glucose and drugs, malnutrition and insulin resistance. Here, the authors review the pathophysiology and management of haemodialysis-induced hypoglycaemia and hyperglycaemia in patients with diabetes. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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