Molecular Systems Biology - New articles published - 1 May 2015

April 2015 | Volume 11, Number 4 Submit Table of Contents Reports Articles Reports Volume 11, Number 4 Reports A growth‐rate composition formula for the growth of E. coli on co‐utilized carbon substrates When cultured in medium containing two carbon substrates, E. coli frequently consumes both simultaneously. A mathematical formula based on simple assumptions accurately predicts the resulting growth rate from the growth rate on each substrate alone. Rutger Hermsen, Hiroyuki Okano, Conghui You, Nicole Werner, and Terence Hwa Published online 09.04.2015 Articles Integrative network analysis reveals molecular mechanisms of blood pressure regulation A systems biology approach integrating genome‐wide genetic variation and transcriptome profiling data from participants of the Framingham Heart Study identifies key regulatory genes and gene networks underlying blood pressure control. Tianxiao Huan, Qingying Meng, Mohamed A Saleh, Allison E Norlander, Roby Joehanes, Jun Zhu, Brian H Chen, Bin Zhang, Andrew D Johnson, Saixia Ying, Paul Courchesne, Nalini Raghavachari, Richard Wang, Poching Liu, The International Consortium for Blood Pressure GWAS (ICBP), Christopher J O'Donnell, Ramachandran Vasan, Peter J Munson, Meena S Madhur, David G Harrison, Xia Yang, and Daniel Levy Published online 16.04.2015 Differential genetic interactions of yeast stress response MAPK pathways A differential genetic interaction screen performed in different stress conditions shows that genetic interactions are often context specific. Conditional genetic interactions recapitulate known signalling interactions and can be used to identify novel conditional functional associations. Humberto Martin, Michael Shales, Pablo Fernandez‐Piñar, Ping Wei, Maria Molina, Dorothea Fiedler, Kevan M Shokat, Pedro Beltrao, Wendell Lim, and Nevan J Krogan Published online 17.04.2015 Inferring causal metabolic signals that regulate the dynamic TORC1‐dependent transcriptome Dynamic experiments and a computational method are co‐designed to infer causal interactions between metabolism, signaling and transcription. Model‐based data integration suggests new candidates for inputs and targets of yeast nitrogen signaling via TOR complex 1. Ana Paula Oliveira, Sotiris Dimopoulos, Alberto Giovanni Busetto, Stefan Christen, Reinhard Dechant, Laura Falter, Morteza Haghir Chehreghani, Szymon Jozefczuk, Christina Ludwig, Florian Rudroff, Juliane Caroline Schulz, Asier González, Alexandre Soulard, Daniele Stracka, Ruedi Aebersold, Joachim M Buhmann, Michael N Hall, Matthias Peter, Uwe Sauer, and Jörg Stelling Published online 17.04.2015 Using light to shape chemical gradients for parallel and automated analysis of chemotaxis A new strategy, involving optical shaping of gradients, allows systematically analyzing components regulating cell migration speed and directionality. The approach is applied to characterize migration and chemotaxis phenotypes for 285 siRNA perturbations in human neutrophils. Sean R Collins, Hee Won Yang, Kimberly M Bonger, Emmanuel G Guignet, Thomas J Wandless, and Tobias Meyer Published online 23.04.2015 Reports Systematic discovery of drug interaction mechanisms A general principle of bacterial growth enables the prediction of mutant growth rates under drug combinations. Rare violations of this principle expose cellular functions that control drug interactions and can be targeted by small molecules to alter drug interactions in predictable ways. Guillaume Chevereau and Tobias Bollenbach Published online 29.04.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.