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| June 2015 Volume 12 Number 6 | |||||||||||||||||||||||||||||||||||||
In this issue
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| NEWS AND VIEWS | Top | ||||||||||||||||||||||||||||||||||||
| Genetics: Genetic risk scores—new promises for drug evaluation J. Wouter Jukema & Stella Trompet Published online: 21 April 2015 p321 | doi:10.1038/nrcardio.2015.62 Two types of genetic risk scores (GRS) have been devised to identify patients who will benefit most from cardiovascular-drug treatment: one related to the intermediate phenotype within a causal pathway, and another related to the expected clinical event. These GRS are promising and might have clinical implications for future practice. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| Acute coronary syndromes: Acute MI in women—the fountain of youth has run dry Cindy L. Grines Published online: 28 April 2015 p322 | doi:10.1038/nrcardio.2015.66 Women—especially younger women—have greater morbidity and mortality from myocardial infarction than men. The VIRGO study involving young patients (aged 18-55 years) suggests that delay in arrival to hospital and suboptimal management occurs more commonly in young women than men. Female sex was an independent predictor of delay. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| Corrigendum: Traditional Chinese medication for cardiovascular disease Pan-Pan Hao, Fan Jiang, Yu-Guo Chen, Jianmin Yang, Kai Zhang, Ming-Xiang Zhang, Cheng Zhang, Yu-Xia Zhao & Yun Zhang Published online: 02 April 2015 p318 | doi:10.1038/nrcardio.2015.60 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| REVIEWS | Top | ||||||||||||||||||||||||||||||||||||
| Causes, assessment, and treatment of stent thrombosis—intravascular imaging insights Daniel S. Ong & Ik-Kyung Jang Published online: 17 March 2015 p325 | doi:10.1038/nrcardio.2015.32 Stent thrombosis is a rare, but serious, complication of percutaneous coronary intervention and is associated with severe morbidity and mortality. In this Review, Ong and Jang discuss the use of intravascular imaging to study stent underexpansion, malapposition, uncovered struts, and neoatherosclerosis as risk factors for stent thrombosis. They also discuss the potential utility of intravascular imaging in the optimization of stent deployment and treatment of stent thrombosis events. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| Management of atrial fibrillation in bradyarrhythmias Giuseppe Boriani & Luigi Padeletti Published online: 17 March 2015 p337 | doi:10.1038/nrcardio.2015.30 Patients with sinus node disease (SND) and an implanted cardiac pacemaker have high prevalence of atrial tachyarrhythmias and atrial fibrillation (AF). In this Review, Boriani and Padeletti describe new developments in pacemaker technology that enable continuous monitoring of the atrial rhythm and allow detection of the burden of AF. These clinical advances could improve guidelines and management of AF and atrial tachyarrhythmias. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| The mobile revolution—using smartphone apps to prevent cardiovascular disease Lis Neubeck, Nicole Lowres, Emelia J. Benjamin, S. Ben Freedman, Genevieve Coorey & Julie Redfern Published online: 24 March 2015 p350 | doi:10.1038/nrcardio.2015.34 In an increasingly digital world, widespread access to smartphones and mobile technology might be harnessed to improve cardiovascular disease prevention, management, and rehabilitation. In this Review, Neubeck et al. discuss the burgeoning market of health-related mobile apps, and question whether they are evidence-based and beneficial to individuals with cardiovascular disease, and what design features might encourage behavioural change. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis Andreas Schober, Maliheh Nazari-Jahantigh & Christian Weber Published online: 07 April 2015 p361 | doi:10.1038/nrcardio.2015.38 The accumulation of lipid-laden macrophages in atherosclerotic lesions occurs preferentially at branching sites owing to poor adaptation of endothelial cells to disturbed blood flow. MicroRNAs (miRNAs) have been implicated in the pathogenic mechanisms of unresolved inflammation that precede and potentiate atherosclerosis. In this Review, Schober and colleagues provide an overview of the role of miRNAs in homeostasis and dysfunction of endothelial cells and macrophages in atherosclerosis, and explore the potential of novel miRNA-based diagnostics and therapeutic strategies. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| CORRESPONDENCE | Top | ||||||||||||||||||||||||||||||||||||
| Integrating traditional Chinese medicine into Western cardiovascular medicine: an evidence-based approach Xingjiang Xiong Published online: 28 April 2015 p374 | doi:10.1038/nrcardio.2014.177-c1 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| REPLY | Top | ||||||||||||||||||||||||||||||||||||
| Evidence for traditional Chinese medication to treat cardiovascular disease Pan-Pan Hao, Fan Jiang, Yu-Guo Chen, Jianmin Yang, Kai Zhang, Ming-Xiang Zhang, Cheng Zhang, Yu-Xia Zhao & Yun Zhang. Published online: 28 April 2015 p374 | doi:10.1038/nrcardio.2014.177-c2 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| CORRESPONDENCE | Top | ||||||||||||||||||||||||||||||||||||
| Assessment of atrial appendage stasis and thrombosis using MDCT Mecit Kantarci, Recep Sade & Abdurrahim Colak Published online: 28 April 2015 p374 | doi:10.1038/nrcardio.2014.77-c1 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| ACE2-angiotensin-(1-7)-Mas axis might be a promising therapeutic target for pulmonary arterial hypertension Hailong Dai, Lihong Jiang, Zhicheng Xiao & Xuefeng Guang Published online: 05 May 2015 p374 | doi:10.1038/nrcardio.2015.6-c1 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| PERSPECTIVES | Top | ||||||||||||||||||||||||||||||||||||
| OPINION Ethics of preparticipation cardiovascular screening for athletes Barry J. Maron, Richard A. Friedman & Arthur Caplan Published online: 24 February 2015 p375 | doi:10.1038/nrcardio.2015.21 Preparicipation screening for cardiovascular disease in young competitive athletes is a controversial topic. Moreover, young people not engaged in competitive sports can harbour the same conditions that cause sudden death in athletes. In this Perspectives article, Maron et al. question whether arbitrarily excluding individuals from potentially life-saving clinical screening because they do not engage in competitive sports programmes is ethical. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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| *Journal Citation Reports, Thomson, 2013. Nature Reviews Cardiology was previously published as Nature Clinical Practice Cardiovascular Medicine. |
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