 |  |  |  |  | Table of ContentsArticles Reports Articles News & Views Articles |  Volume 11, Number 7 |
Articles  | A genomewide study using two divergent mouse strains and their F1 hybrid demonstrates the predominant contribution of cis‐regulatory changes in the evolution of mouse alternative splicing. Qingsong Gao, Wei Sun, Marlies Ballegeer, Claude Libert, and Wei Chen |
Reports  | Theoretical modeling and experimental data show that the DYRK‐family kinase Pom1 auto‐phosphorylates intermolecularly. This mechanism confers robustness to Pom1 concentration gradients through super‐linear decay. Micha Hersch, Olivier Hachet, Sascha Dalessi, Pranav Ullal, Payal Bhatia, Sven Bergmann, and Sophie G Martin |
Articles  | A dynamical 2D computer model of limb development, combining tissue movements and spatially controlled gene regulatory interactions, allows reverse‐engineering the regulatory network controlling cell fate decisions along the main proximodistal (PD) axis. Manu Uzkudun, Luciano Marcon, and James Sharpe |
 | A proteome‐wide view of lung injury and repair was elucidated by mass spectrometry analysis of the dynamic composition of lung tissue compartments. In particular, the extracellular matrix proteome uncovers potential factors in stem cell mobilization and fibrosis resolution. Herbert B Schiller, Isis E Fernandez, Gerald Burgstaller, Christoph Schaab, Richard A Scheltema, Thomas Schwarzmayr, Tim M Strom, Oliver Eickelberg, and Matthias Mann |
 | Genetic variants contribute to individual variation in insulin response, including kinase activation, changes in gene expression and cell growth, suggesting kinase modulators as promising therapeutics for diseases characterized by insulin resistance. Isabel Xiaorong Wang, Girish Ramrattan, and Vivian G Cheung |
News & Views  | The application of the CRISPR‐Cas9 system marks a major breakthrough for genetic screens in mammalian cells. Parnas et al (2015) apply this technology to primary mouse dendritic cells in order to study immune regulatory networks at unprecedented resolution. Michael Aregger, Traver Hart, and Jason Moffat |
Articles  | Analysis of transcriptional bursting from time‐lapse imaging of single alleles in mammalian cells identifies the kinetic structure of promoter cycles underlying refractoriness, and explains noise in mRNA abundance. Benjamin Zoller, Damien Nicolas, Nacho Molina, and Felix Naef |
 | Cooperative growth dynamics can influence the minimum inhibitory concentration (MIC) of antibiotics. Quantifying the fitness of single cells (single‐cell MIC) provides a better metric for predicting the evolution of antibiotic resistance. Tatiana Artemova, Ylaine Gerardin, Carmel Dudley, Nicole M Vega, and Jeff Gore |
 | Analysis of genetic interactions using data from > 3,000 tumors shows that co‐occurrence and mutual exclusivity between cancer driver alterations change extensively in different cancer types, thus indicating plasticity of epistasis across cell types. Solip Park and Ben Lehner |
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