Nature Reviews Nephrology - Table of Contents alert Volume 11 Issue 9

TABLE OF CONTENTS
September 2015 Volume 11 Number 9
Impact Factor 5.594 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Management of hypertension in chronic kidney disease Raymond R. Townsend & Sandra J. Taler
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RESEARCH HIGHLIGHTS Top Immunology: T-cell exhaustion limits immune reactivity and is associated with good prognosis in autoimmune disease Published online: 14 July 2015 p503 | doi:10.1038/nrneph.2015.115 PDF Acute kidney injury: IL-34 promotes persistent ischaemia-induced AKI Published online: 14 July 2015 p504 | doi:10.1038/nrneph.2015.116 PDF Glomerular disease: TRPC6 and NPHS1 mediate FSGS risk Published online: 21 July 2015 p505 | doi:10.1038/nrneph.2015.111 PDF Chronic kidney disease-mineral and bone disorder: Fracture burden in children with CKD Published online: 21 July 2015 p505 | doi:10.1038/nrneph.2015.120 PDF Chronic kidney disease: ECGs help predict risk of death in CKD Published online: 28 July 2015 p505 | doi:10.1038/nrneph.2015.129 PDF Chronic kidney disease: Serious adverse effects associated with IV iron in CKD Published online: 07 July 2015 p506 | doi:10.1038/nrneph.2015.112 PDF Renal injury: Prevention of talin-1-mediated activation of neutrophils protects against renal ischaemia-reperfusion injury Published online: 28 July 2015 p506 | doi:10.1038/nrneph.2015.130 PDF IN BRIEF Acute kidney injury: AKI is a risk factor for elevated blood pressure | Transplantation: Fc-silent anti-CD40 antibody prolongs allograft survival | Genetics: Clinical correlates of APOL1 risk genotypes | Polycystic kidney disease: Predicting renal survival in ADPKD PDF Nephrology JOBS of the week Full-Time Medical Faculty Position Miriam Hospital and the Rhode Island Hospital More Science jobs from
NEWS AND VIEWS		Top
RAS blockade: Nephroprotection by dual RAS blockade—a welcome back Piero Ruggenenti & Giuseppe Remuzzi Published online: 04 August 2015 p507 | doi:10.1038/nrneph.2015.132 A new meta-analysis shows that dual blockade of the renin-angiotensin system is the most effective approach to prevent end-stage renal disease in patients with diabetes and kidney disease. Combination therapy should therefore be reconsidered as the most powerful tool for nephroprotection, provided that treatment is individually tailored by careful dose-titration. Full Text | PDF | Supplementary information
Acute kidney injury: Steroids for prevention of AKI after cardiopulmonary bypass Chirag R. Parikh & Jennifer A. Schaub Published online: 30 June 2015 p509 | doi:10.1038/nrneph.2015.106 Cardiac surgery often requires the use of cardiopulmonary bypass, which can cause an inflammatory cascade that results in acute kidney injury (AKI). A recent post hoc analysis of a placebo-controlled, randomized trial suggests that intraoperative steroids might lower the risk of renal replacement therapy for AKI after cardiac surgery. Full Text | PDF
Risk factors: The kidneys find a voice in cardiovascular risk prediction Maarten W. Taal Published online: 07 July 2015 p510 | doi:10.1038/nrneph.2015.109 Chronic kidney disease is associated with an increased risk of cardiovascular disease that often exceeds risk of progression to end-stage renal disease. A meta-analysis has shown that the addition of glomerular filtration rate and albuminuria to traditional risk factors for cardiovascular outcomes improves the discrimination of cardiovascular risk prediction models. Full Text | PDF
Acute kidney injury: Can remote ischaemic preconditioning prevent AKI? Anna Zuk & Joseph V. Bonventre Published online: 28 July 2015 p512 | doi:10.1038/nrneph.2015.119 A randomized multicentre controlled study of 240 cardiac surgery patients at high risk of acute kidney injury (AKI) has demonstrated that remote ischaemic preconditioning can reduce the rate of AKI and requirement for renal replacement therapy. These findings suggest this procedure could be a promising therapeutic option for this high-risk patient group. Full Text | PDF
REVIEWS		Top
The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease Tamina Seeger-Nukpezah et al. Published online: 14 April 2015 p515 | doi:10.1038/nrneph.2015.46 Autosomal dominant polycystic kidney disease (ADPKD) is a progressive inherited disorder in which renal tissue is gradually replaced with fluid-filled cysts. Interestingly, improved understanding of the signalling and pathological derangements characteristic of ADPKD has revealed marked similarities to those of solid tumours. Here, the authors examine the pathological features and signalling pathways common to both ADPKD and cancer. Their analysis highlights potential avenues for further research and therapeutic potential in both diseases. Abstract | Full Text | PDF
Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease Lili Zhou & Youhua Liu Published online: 09 June 2015 p535 | doi:10.1038/nrneph.2015.88 Podocytes are susceptible to injury and undergo a series of adaptive, maladaptive or catastrophic responses depending on the severity and duration of the insult. Emerging evidence indicates a central role for Wnt/β-catenin signalling in mediating podocyte dysfunction and the development of proteinuria. Here, Lili Zhou and Youhua Liu describe advances in current understanding of the pathomechanisms of Wnt/β-catenin signalling in mediating podocyte injury and discuss the therapeutic potential of targeting this pathway for the treatment of proteinuric kidney disease. Abstract | Full Text | PDF
Development and application of human adult stem or progenitor cell organoids Maarten B. Rookmaaker, Frans Schutgens, Marianne C. Verhaar & Hans Clevers Published online: 28 July 2015 p546 | doi:10.1038/nrneph.2015.118 Human adult stem or progenitor cell organoid cultures have been established for multiple organs and have proved valuable in the basic study of pathophysiology as well as in clinical applications. Such an organoid culture system has not yet, however, been developed for the kidney. Here the authors describe the development and application of the available adult stem or progenitor cell organoid cultures, the challenges and feasibility of developing such a system for the kidney, and the potential kidney-specific applications of organoids. Abstract | Full Text | PDF
Management of hypertension in chronic kidney disease Raymond R. Townsend & Sandra J. Taler Published online: 28 July 2015 p555 | doi:10.1038/nrneph.2015.114 The association between hypertension and chronic kidney disease is cyclic and complex. In this Review, Townsend and Taler discuss the underlying mechanisms of this association and emphasize the importance of achieving and maintaining adequate blood pressure control in renal disease. They outline the necessity of accurate blood pressure monitoring, the value of drug and non-drug therapies, and assess the current blood pressure targets recommended by different guidelines for patients with chronic kidney disease. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2014. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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