Nature Reviews Endocrinology - Table of Contents alert Volume 11 Issue 10

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TABLE OF CONTENTS
October 2015 Volume 11 Number 10
Impact Factor 13.281 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Short-chain fatty acids in control of body weight and insulin sensitivity Emanuel E. Canfora, Johan W. Jocken & Ellen E. Blaak
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RESEARCH HIGHLIGHTS Top Paediatric endocrinology: Paradigm shift in genetic testing for neonatal diabetes mellitus—new framework for clinical care Published online: 18 August 2015 p565 | doi:10.1038/nrendo.2015.135 PDF Diabetes: Breakfast most important meal of the day, especially for patients with T2DM Published online: 18 August 2015 p566 | doi:10.1038/nrendo.2015.136 PDF Nutrition: All calories are not equal—cutting dietary fat is more effective than cutting carbohydrates Published online: 25 August 2015 p566 | doi:10.1038/nrendo.2015.144 PDF Pancreas: Fatty pancreas linked to increased BMI and insulin resistance in children Published online: 11 August 2015 p567 | doi:10.1038/nrendo.2015.131 PDF Obesity: Bariatric surgery—long-term effects Published online: 18 August 2015 p567 | doi:10.1038/nrendo.2015.137 PDF Adrenal gland: Aldosterone-producing mutations in normal adrenal glands Published online: 25 August 2015 p567 | doi:10.1038/nrendo.2015.145 PDF News: Circulating irisin confirmed by mass spectrometry Published online: 01 September 2015 p568 | doi:10.1038/nrendo.2015.148 PDF IN BRIEF Reproductive endocrinology: Updated guidance on evaluating suspected DSDs | PCOS: Susceptibility loci identified in women of European descent | Diabetes: Mechanistic insights into diabetes-associated fluid loss PDF Endocrinology JOBS of the week Postdoctoral Fellowship Icahn School of Medicine at Mount Sinai More Science jobs from
NEWS AND VIEWS		Top
Obesity: Liraglutide—another weapon in the war against obesity? George A. Bray Published online: 11 August 2015 p569 | doi:10.1038/nrendo.2015.133 Liraglutide is an agonist of glucagon-like receptor-1, which is a component of an important biological system that inhibits food intake and enhances insulin secretion from the pancreas in the presence of glucose. This drug can therefore facilitate weight loss and glucose control at the same time. Full Text | PDF
Bone: Sequential osteoporosis treatment—the order of things Bo Abrahamsen Published online: 11 August 2015 p570 | doi:10.1038/nrendo.2015.134 A recent study shows that preceding teriparatide treatment with 2 years of denosumab treatment leads to lower BMD after 4 years than either administering these interventions in the opposite order or combining them initially. However, BMD measurements could be biased in favour of using teriparatide first, owing to the time required for completion of secondary mineralization. Full Text | PDF
Transplantation: Sustained benefits of islet transplants for T1DM Bernhard J. Hering & Melena D. Bellin Published online: 04 August 2015 p572 | doi:10.1038/nrendo.2015.126 In a retrospective multicentre study of patients with type 1 diabetes mellitus, islet transplantation was associated with sustained HbA1c levels of <7% and freedom from severe hypoglycaemia for 5 years in 60% of immunosuppressed recipients, including those with recurrent severe pretransplant hypoglycaemia. Will islet transplant utilization in patient care now expand? Full Text | PDF
Trial Watch: Antisenses working overtime in lipids Sali M. K. Farhan & Robert A. Hegele Published online: 25 August 2015 p574 | doi:10.1038/nrendo.2015.146 Antisense oligonucleotides have proven effective at preventing protein synthesis as a result of their on-target specificity. Recent data from several clinical trials including a phase I trial targeting Lp(a), published in The Lancet, highlight the therapeutic potential of antisense oligonucleotides in regulating plasma lipid levels. Full Text | PDF
REVIEWS		Top
Short-chain fatty acids in control of body weight and insulin sensitivity Emanuel E. Canfora, Johan W. Jocken & Ellen E. Blaak Published online: 11 August 2015 p577 | doi:10.1038/nrendo.2015.128 Short-chain fatty acids (SCFA) are produced by the gut microbiota from indigestible food stuffs, and might have beneficial effects on metabolism and insulin sensitivity. Here, Canfora and colleagues discuss how SCFA can modulate energy homeostasis and metabolism in adipose tissue, muscle and the liver. The authors also discuss whether SCFA might be used to modulate glucose homeostasis in humans. Abstract | Full Text | PDF
Metabolic functions of FABPs—mechanisms and therapeutic implications Gökhan S. Hotamisligil & David A. Bernlohr Published online: 11 August 2015 p592 | doi:10.1038/nrendo.2015.122 Fatty acid-binding proteins (FABPs) improve the solubility of fatty acids. Here, Hotamisligil and Bernlohr describe the structure and function of FABPs in the control of fatty acid metabolism and obesity. The authors focus on FABP4 and FABP5, the most abundant FABPs in adipose tissue, and discuss how targeting these proteins might be exploited to treat metabolic diseases. Abstract | Full Text | PDF | Supplementary information
Preventing and treating foot complications associated with diabetes mellitus Frank L. Bowling, S. Tawqeer Rashid & Andrew J. M. Boulton Published online: 18 August 2015 p606 | doi:10.1038/nrendo.2015.130 For individuals with diabetes mellitus, the lifetime risk of developing a foot ulcer can be as high as 25%, but these complications are preventable. Here, Bowling and colleagues discuss the mechanisms that lead to foot ulcers in patients with diabetes mellitus. The authors emphasise the need for a multidisciplinary management strategy to prevent and treat diabetic foot complications. Abstract | Full Text | PDF
Acylcarnitines—old actors auditioning for new roles in metabolic physiology Colin S. McCoin, Trina A. Knotts & Sean H. Adams Published online: 25 August 2015 p617 | doi:10.1038/nrendo.2015.129 Long-chain acylcarnitines (LCACs) are widely used as diagnostic markers in several metabolic disorders; however, research into the potential effects of excessive accumulation of LCACs or the roles of acylcarnitines as physiological modulators of cell metabolism is lacking. This Review, therefore, aims to provide a theoretical framework for the potential consequences of tissue build-up of LCACs among individuals with metabolic disorders. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2014. Nature Reviews Endocrinology was previously published as Nature Clinical Practice Endocrinology & Metabolism.

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