Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 12 Issue 9

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TABLE OF CONTENTS
September 2015 Volume 12 Number 9
Impact Factor 12.610 *	In this issue Research Highlights News and Views Focus on: Coeliac disease & gluten sensitivity Reviews Also this month  Web focus: Coeliac disease & gluten sensitivity: Epithelial stress enters the dance in coeliac disease
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RESEARCH HIGHLIGHTS Top Barrett oesophagus: Tracing the genetic pathway to oesophageal cancer Published online: 11 August 2015 p487 | doi:10.1038/nrgastro.2015.138 PDF Surgery: Bile diversion comparable to bariatric surgery in mice Published online: 28 July 2015 p488 | doi:10.1038/nrgastro.2015.130 PDF Pancreas: Fatty pancreas linked to increased BMI and insulin resistance in children Published online: 11 August 2015 p489 | doi:10.1038/nrgastro.2015.143 PDF Malnutrition: New mouse model of EE Published online: 18 August 2015 p489 | doi:10.1038/nrgastro.2015.144 PDF Oesophageal cancer: Neoadjuvant chemoradiotherapy and surgery superior to surgery alone Published online: 18 August 2015 p489 | doi:10.1038/nrgastro.2015.145 PDF Biliary tract: Solving the conundrum of cholangiocyte differentiation Published online: 28 July 2015 p490 | doi:10.1038/nrgastro.2015.129 PDF NASH: CX3CR1—a direct line to gut-liver crosstalk? Published online: 04 August 2015 p490 | doi:10.1038/nrgastro.2015.133 PDF IN BRIEF Barrett oesophagus: Statin use reduces risk of oesophageal adenocarcinoma | Stem cells: Functional stomach tissue developed in culture | Liver: Regulation of lipid profiles by the autonomic nervous system | Hepatitis: Prenylation inhibition is effective for chronic HDV infection PDF Gastroenterology & Hepatology JOBS of the week Full-Time Faculty Position in the division of Gastroenterology Stony Brook University Chief of Hepatology and Liver Disease University of Kentucky More Science jobs from
NEWS AND VIEWS		Top
Coeliac disease & gluten sensitivity: Epithelial stress enters the dance in coeliac disease Nadine Cerf-Bensussan & Bertrand Meresse Published online: 21 July 2015 p491 | doi:10.1038/nrgastro.2015.120 Coeliac disease is an immune-mediated enteropathy induced by gluten. Generation of gluten-specific CD4+ T cells is necessary but not sufficient to induce overt disease. Now, epithelial stress has been proposed as a distinct factor that synergizes with the anti-gluten adaptive immune response to induce intraepithelial lymphocyte activation and tissue damage. Full Text | PDF
Liver: A new copper cut-off value for diagnosis of Wilson disease? Wolfgang Stremmel & Uta Merle Published online: 11 August 2015 p493 | doi:10.1038/nrgastro.2015.132 Measurements of liver copper content are considered the gold standard for diagnosis of Wilson disease. New evidence shows that a reduction of the diagnostic threshold indicative for Wilson disease potentially improves diagnostic accuracy. Full Text | PDF
Gut microbiota: Microbiota and neuroimmune signalling—Metchnikoff to microglia John F. Cryan & Timothy G. Dinan Published online: 28 July 2015 p494 | doi:10.1038/nrgastro.2015.127 The role of the gut microbiota in brain development and behaviour is emerging. New research demonstrates that maturation and activation of microglia are regulated by the gut microbiota, providing more evidence for the link between the microbiota and brain health. Full Text | PDF
Focus on: Coeliac disease & gluten sensitivity REVIEWS Top Novel players in coeliac disease pathogenesis: role of the gut microbiota Elena F. Verdu, Heather J. Galipeau & Bana Jabri Published online: 09 June 2015 p497 | doi:10.1038/nrgastro.2015.90 Emerging evidence indicates that the gut microbiota might have a role in the development of coeliac disease. In this Review, Verdu and colleagues describe how alterations in the composition and function of the gut microbiota might influence coeliac disease pathogenesis, presenting the latest data from human and experimental studies. Abstract | Full Text | PDF | Supplementary information Coeliac disease and autoimmune disease—genetic overlap and screening Knut E. A. Lundin & Cisca Wijmenga Published online: 25 August 2015 p507 | doi:10.1038/nrgastro.2015.136 Many autoimmune diseases are known to occur alongside coeliac disease and, in some instances, patients see improvements in both if coeliac disease is diagnosed and treated. Shared genetic traits have been identified between coeliac disease and many of these forms of autoimmunity. In this Review, an overview is presented of the genetic and immunological features of coeliac disease, its overlap with other autoimmune diseases and implications for screening strategies. Abstract | Full Text | PDF The spectrum of noncoeliac gluten sensitivity Imran Aziz, Marios Hadjivassiliou & David S. Sanders Published online: 30 June 2015 p516 | doi:10.1038/nrgastro.2015.107 Individuals are increasingly self-reporting gluten sensitivity and placing themselves on a gluten-free diet without diagnosis of coeliac disease or IgE-mediated allergy. This new clinical entity has been termed noncoeliac gluten sensitivity (NCGS). In this Review, the authors provide an overview of NCGS, including immunopathogenesis, clinical features, diagnosis and management, as well as the controversies associated with this condition. Abstract | Full Text | PDF Coeliac disease and gluten-related disorders in childhood Sabine L. Vriezinga, Joachim J. Schweizer, Frits Koning & M. Luisa Mearin Published online: 23 June 2015 p527 | doi:10.1038/nrgastro.2015.98 Gluten-related disorders are increasingly being diagnosed in children. In this Review, Vriezinga and colleagues provide an overview of the most common gluten-related disorders in children: coeliac disease, wheat allergy and noncoeliac gluten sensitivity. Pathogenesis, diagnosis and management of each condition are described. Abstract | Full Text | PDF
REVIEWS		Top
Biologic agents for IBD: practical insights Silvio Danese, Lucine Vuitton & Laurent Peyrin-Biroulet Published online: 18 August 2015 p537 | doi:10.1038/nrgastro.2015.135 The landscape of treatment for IBD changed dramatically with the introduction of biologic agents, of which several are now in use for this condition. Here, the authors provide practical insights into the use of biologic agents in IBD, discussing issues such as comparative effectiveness, safety, immunogenicity, cost and patient preference. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2014. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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