Nature Reviews Nephrology - Table of Contents alert Volume 11 Issue 10

TABLE OF CONTENTS
October 2015 Volume 11 Number 10
Impact Factor 8.542 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus Detlef Bockenhauer & Daniel G. Bichet
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RESEARCH HIGHLIGHTS Top Fibrosis: Targeting EMT to reverse renal fibrosis Published online: 04 August 2015 p565 | doi:10.1038/nrneph.2015.133 PDF Transplantation: Mild hypothermia improves transplantation outcomes Published online: 11 August 2015 p566 | doi:10.1038/nrneph.2015.134 PDF Clinical trial: Lack of benefit of MMF in IgAN Published online: 11 August 2015 p567 | doi:10.1038/nrneph.2015.141 PDF Transplantation: Optimizing ECD graft outcomes Published online: 18 August 2015 p567 | doi:10.1038/nrneph.2015.143 PDF Renal physiology: Aldosterone-dependent NCC activation Published online: 25 August 2015 p567 | doi:10.1038/nrneph.2015.145 PDF Fibrosis: GLI2 inhibition reduces myofibroblast generation and kidney fibrosis Published online: 04 August 2015 p568 | doi:10.1038/nrneph.2015.135 PDF Obesity: Older age and high BMI are associated with increased risk of loss of kidney function Published online: 18 August 2015 p568 | doi:10.1038/nrneph.2015.142 PDF IN BRIEF Regenerative medicine: Expansion of nephron progenitor cells in vitro | Chronic kidney disease: ACR versus UAE | Nephrotoxicity: Bicarbonate versus saline in contrast-induced AKI | Fabry disease: Effects of agalsidase-β shortage in Fabry disease PDF Nephrology EVENT International Conference on Urology and Nephrology (ICUN 2015) 18.12.15 Guilin, China More science events from
NEWS AND VIEWS		Top
Therapy: Maintenance of steroid-free remission in nephrotic syndrome Jeroen K. Deegens & Jack F. Wetzels Published online: 21 July 2015 p569 | doi:10.1038/nrneph.2015.117 Maintaining steroid-free remission in children with idiopathic nephrotic syndrome is an important goal of therapy. A new trial provides evidence that mycophenolate mofetil can be added to the list of effective steroid-sparing agents. The majority of participants relapsed, however, highlighting an unmet need for more effective treatment modalities. Full Text | PDF
Transplantation: Little effect of state policies on organ donation in the USA Arthur J. Matas & Rebecca E. Hays Published online: 14 July 2015 p570 | doi:10.1038/nrneph.2015.113 A new study reports that state-level policies have had little effect on rates of organ donation in the USA, highlighting the limited ability of scattered initiatives to have a national effect. Regardless of their impact on donation rate, a need exists for policies that make donation financially neutral for donors. Full Text | PDF
Chronic kidney disease: Reductions in FGF-23 levels associated with improved outcomes Anna Jovanovich & Michel Chonchol Published online: 28 July 2015 p572 | doi:10.1038/nrneph.2015.125 Elevated levels of fibrobast growth factor 23 (FGF-23) are associated with cardiovascular and all-cause mortality in patients with kidney disease. A secondary analysis of the EVOLVE trial reports that cinacalcet-induced reductions in FGF-23 were associated with a reduced risk of cardiovascular events in patients with secondary hyperparathyroidism on dialysis. Full Text | PDF
Renal physiology: The proximal tubule and albuminuria—at last a starring role Philip Poronnik & David J. Nikolic-Paterson Published online: 28 July 2015 p573 | doi:10.1038/nrneph.2015.127 The constitutive uptake and degradation of filtered albumin by the proximal tubule has resulted in this process being relegated a passive player in albuminuria. Real-time intravital imaging of the rat kidney now describes a new paradigm in which the proximal tubule dynamically increases or decreases albumin uptake following changes in plasma albumin levels. Full Text | PDF
REVIEWS		Top
Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus Detlef Bockenhauer & Daniel G. Bichet Published online: 16 June 2015 p576 | doi:10.1038/nrneph.2015.89 Nephrogenic diabetes insipidus (NDI) is caused by inability of the kidneys to respond to arginine vasopressin and concentrate urine by reabsorption of water in the collecting duct. The disease can be congenital or acquired and has a substantial detrimental effect on the quality of life of affected patients. In this article, Bockenhauer and Bichet review the pathophysiology, diagnosis and current clinical management of NDI as well as potential future treatment strategies. Abstract | Full Text | PDF
Vascular complications in autosomal dominant polycystic kidney disease Ronald D. Perrone, Adel M. Malek & Terry Watnick Published online: 11 August 2015 p589 | doi:10.1038/nrneph.2015.128 Vascular abnormalities, particularly those associated with rupture of intracranial aneurysms (IAs) or arterial dissections are among the most serious complications of autosomal dominant polycystic kidney disease (ADPKD). In this article, the authors discuss the pathophysiological mechanisms that might be involved in the development of vascular complications in patients with ADPKD and review strategies for screening, diagnosis and treatment of IAs in this population. Abstract | Full Text | PDF
IgG4-related disease and the kidney Frank B. Cortazar & John H. Stone Published online: 30 June 2015 p599 | doi:10.1038/nrneph.2015.95 IgG4-related disease can affect any organ system, including the kidney. Renal involvement is an indication for prompt treatment, owing to an increased risk of chronic kidney disease. In this Review, Frank Cortazar and John Stone provide an overview of systemic IgG4-related disease before describing in detail the renal manifestations of IgG4-related tubulointerstitial nephritis and membranous glomerulonephropathy secondary to IgG4-related disease. They consider the pathophysiology, as well as current and future treatment options. Abstract | Full Text | PDF
The effects of environmental chemicals on renal function Anglina Kataria, Leonardo Trasande & Howard Trachtman Published online: 23 June 2015 p610 | doi:10.1038/nrneph.2015.94 The identification of modifiable risk factors that are associated with declining renal function is required to stem the increasing incidence of chronic kidney disease worldwide. In this Review, Howard Trachtman and colleagues discuss the impact of environmental chemicals on cardiorenal function. They highlight the ubiquity of exposure to environmental chemicals in the general public, the main sources of contamination, and the predominant adverse effects that might affect renal function. Abstract | Full Text | PDF | Supplementary information
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*Journal Citation Reports, Thomson, 2014. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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