Scientific Reports Table of Contents e-alert: 8 September 2015

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08 September 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Join us for the Naturejobs Career Expo London on 18 September! This career fair offers young, talented researchers an excellent opportunity to meet a diverse selection of national and international employers from academic institutions and scientific industries. The event is free and offers you a chance to get your CV checked, meet and network with employers and leading scientific institutions and attend useful workshops. Register and find out more.          Jump to the content that matters to you ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Health Sciences               Biological Sciences ▲ top               Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice ▶     Giuseppe Fiume, Annarita Scialdone, Francesco Albano et al.     Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue …             LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells ▶     Yuho Maki, Junya Fujimoto, Wenhua Lang et al.     We recently demonstrated that lysosomal protein transmembrane 4 beta (LAPTM4B) is elevated in non-small cell lung cancers (NSCLCs) and in the surrounding premalignant airway …             Identification and analysis of the N6-methyladenosine in the Saccharomyces cerevisiae transcriptome ▶     Wei Chen, Hong Tran, Zhiyong Liang et al.     Knowledge of the distribution of N6-methyladenosine (m6A) is invaluable for understanding RNA biological functions. However, limitation in experimental methods impedes the …             Unveiling the metabolic potential of two soil-derived microbial consortia selected on wheat straw ▶     Diego Javier Jiménez, Diego Chaves-Moreno, Jan Dirk van Elsas     Based on the premise that plant biomass can be efficiently degraded by mixed microbial cultures and/or enzymes, we here applied a targeted metagenomics-based approach to explore …             Young dispersal of xerophil Nitraria lineages in intercontinental disjunctions of the Old World ▶     Ming-Li Zhang, Kamshat Temirbayeva, Stewart C. Sanderson et al.     Many cases of intercontinental disjunct distributions of seed plants have been investigated, however few have concerned the continents of Eurasia (mainly Central Asia), Africa, …             Electrophysiological evidences demonstrating differences in brain functions between nonmusicians and musicians ▶     Li Zhang, Weiwei Peng, Jie Chen et al.     Long-term music training can improve sensorimotor skills, as playing a musical instrument requires the functional integration of information related to multimodal sensory …             Evaluation of drug-targetable genes by defining modes of abnormality in gene expression ▶     Junseong Park, Jungsul Lee, Chulhee Choi     In the post-genomic era, many researchers have taken a systematic approach to identifying abnormal genes associated with various diseases. However, the gold standard has not been …             Personality traits predict brain activation and connectivity when witnessing a violent conflict ▶     Jan Van den Stock, Ruud Hortensius, Charlotte Sinke et al.     As observers we excel in decoding the emotional signals telling us that a social interaction is turning violent. The neural substrate and its modulation by personality traits …             Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics ▶     Ching-Wei Chang, Sanjay Kumar     While is widely acknowledged that nonmuscle myosin II (NMMII) enables stress fibers (SFs) to generate traction forces against the extracellular matrix, little is known about how …             Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria ▶     Daniel Garrido, Santiago Ruiz-Moyano, Danielle G. Lemay et al.     Breast milk enhances the predominance of Bifidobacterium species in the infant gut, probably due to its large concentration of human milk oligosaccharides (HMO). Here we screened …             Light pollution disrupts sleep in free-living animals ▶     Thomas Raap, Rianne Pinxten, Marcel Eens     Artificial lighting can alter individual behaviour, with often drastic and potentially negative effects on biological rhythms, daily activity and reproduction. Whether this is …             Molecular Evolution of the Capsid Gene in Norovirus Genogroup I ▶     Miho Kobayashi, Shima Yoshizumi, Sayaka Kogawa et al.     We studied the molecular evolution of the capsid gene in all genotypes (genotypes 1–9) of human norovirus (NoV) genogroup I. The evolutionary time scale and rate were estimated …             Circadian Modulation of 8-Oxoguanine DNA Damage Repair ▶     Nicola Manzella, Massimo Bracci, Elisabetta Strafella et al.     The DNA base excision repair pathway is the main system involved in the removal of oxidative damage to DNA such as 8-Oxoguanine (8-oxoG) primarily via the 8-Oxoguanine DNA …             Proteomic Changes Associated with Successive Reproductive Periods in Male Polychaetous Neanthes arenaceodentata ▶     Kondethimmanahalli H. Chandramouli, Donald Reish, Huoming Zhang et al.     The polychaetous annelid Neanthes acuminata complex has a widespread distribution, with the California population referred to as N. arenaceodentata. The reproductive pattern in …             Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells ▶     Xiaodong Jin, Feifei Li, Xiaogang Zheng et al.     Heavy ion beams have advantages over conventional radiation in radiotherapy due to their superb biological effectiveness and dose conformity. However, little information is …             The nitric oxide synthase 3 G894T polymorphism associated with Alzheimer’s disease risk: a meta-analysis ▶     Shengyuan Liu, Fangfang Zeng, Changyi Wang et al.     The association between the G894T polymorphism (Glu298Asp) of nitric oxide synthase 3 (NOS3) and risk of Alzheimer’s disease (AD) was explored by performing a meta-analysis of …             A protein with simultaneous capsid scaffolding and dsRNA-binding activities enhances the birnavirus capsid mechanical stability ▶     Johann Mertens, Santiago Casado, Carlos P. Mata et al.     Viral capsids are metastable structures that perform many essential processes; they also act as robust cages during the extracellular phase. Viruses can use multifunctional …             Chick tendon fibroblast transcriptome and shape depend on whether the cell has made its own collagen matrix ▶     Ching-Yan Chloé Yeung, Leo A. H. Zeef, Chloe Lallyett et al.     Collagen- and fibrin-based gels are extensively used to study cell behaviour. However, 2D–3D and collagen-fibrin comparisons of gene expression, cell shape and …             A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells ▶     Huan He, Dong-Wei Li, Li-Yun Yang et al.     Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that …             EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway ▶     Meng-Feng Tsai, Tzu-Hua Chang, Shang-Gin Wu et al.     Malignant pleural effusion (MPE) is a common clinical problem in non-small cell lung carcinoma (NSCLC) patients; however, the underlying mechanisms are still largely unknown. …             Whole-genome Sequencing for Tracing the Transmission Link between Two ARD Outbreaks Caused by a Novel HAdV Serotype 7 Variant, China ▶     Shaofu Qiu, Peng Li, Hongbo Liu et al.     From December 2012 to February 2013, two outbreaks of acute respiratory disease caused by HAdV-7 were reported in China. We investigated possible transmission links between these …             Reduced greenhouse gas mitigation potential of no-tillage soils through earthworm activity ▶     Ingrid M. Lubbers, Kees Jan van Groenigen, Lijbert Brussaard et al.     Concerns about rising greenhouse gas (GHG) concentrations have spurred the promotion of no-tillage practices as a means to stimulate carbon storage and reduce CO2 emissions in …             Stabilizing synchrony by inhomogeneity ▶     Ehsan Bolhasani, Alireza Valizadeh     We show that for two weakly coupled identical neuronal oscillators with strictly positive phase resetting curve, isochronous synchrony can only be seen in the absence of noise …             Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function ▶     Somayeh Jamali, Michael Klier, Samantha Ames et al.     The most aggressive tumour cells, which often reside in hypoxic environments, rely on glycolysis for energy production. Thereby they release vast amounts of lactate and protons …             Effects of acoustic levitation on the development of zebrafish, Danio rerio, embryos ▶     Maria Sundvik, Heikki J. Nieminen, Ari Salmi et al.     Acoustic levitation provides potential to characterize and manipulate material such as solid particles and fluid in a wall-less environment. While attempts to levitate small …             Dimeric interactions and complex formation using direct coevolutionary couplings ▶     Ricardo N. dos Santos, Faruck Morcos, Biman Jana et al.     We develop a procedure to characterize the association of protein structures into homodimers using coevolutionary couplings extracted from Direct Coupling Analysis (DCA) in …             Associations between antioxidant vitamins and the risk of invasive cervical cancer in Chinese women: A case-control study ▶     Liyuan Guo, Hong Zhu, Chengjun Lin et al.     Previous studies on the associations between dietary antioxidant vitamins and the risk of cervical cancer remain inconsistent, and little evidence is available for serum …             The motility-proliferation-metabolism interplay during metastatic invasion ▶     Inbal Hecht, Sari Natan, Assaf Zaritsky et al.     Metastasis is the major cause for cancer patients’ death, and despite all the recent advances in cancer research it is still mostly incurable. Understanding the mechanisms that …             Binding interface between the Salmonella σS/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl ▶     Paola Cavaliere, Christina Sizun, Fabienne Levi-Acobas et al.     In many Gram-negative bacteria, including Salmonella enterica serovar Typhimurium (S. Typhimurium), the sigma factor RpoS/σS accumulates during stationary phase of growth, and …             A novel recombinant slow-release TNF α-derived peptide effectively inhibits tumor growth and angiogensis ▶     Yi Ma, Shaojun Zhao, Shutao Shen et al.     RMP16, a recombinant TNF α-derived polypeptide comprising a specific human serum albumin (HSA)-binding 7-mer peptide identified by phage display screening (WQRPSSW), a cleavage …             NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells ▶     Yanan Liu, Gengbiao Zhou, Zhenglian Wang et al.     Cell apoptosis induced by heat stress is regulated by a complex signaling network. We previously reported that a p53-dependent pathway is involved. Here, we present evidence that …             The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex ▶     Jamie E. Marshall, Bayan H. A. Faraj, Alexandre R. Gingras et al.     Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in …             Hidden biodiversity in an ancient lake: phylogenetic congruence between Lake Tanganyika tropheine cichlids and their monogenean flatworm parasites ▶     Maarten P. M. Vanhove, Antoine Pariselle, Maarten Van Steenberge et al.     The stunning diversity of cichlid fishes has greatly enhanced our understanding of speciation and radiation. Little is known about the evolution of cichlid parasites. Parasites …             Competition with wind-pollinated plant species alters floral traits of insect-pollinated plant species ▶     Floriane Flacher, Xavier Raynaud, Amandine Hansart et al.     Plant traits related to attractiveness to pollinators (e.g. flowers and nectar) can be sensitive to abiotic or biotic conditions. Soil nutrient availability, as well as …             Evidence for loss of nepotism in the evolution of permanent sociality ▶     Reut Berger-Tal, Yael Lubin, Virginia Settepani et al.     Kin selected benefits of cooperation result in pronounced kin discrimination and nepotism in many social species and favour the evolution of sociality. However, low variability …             Evidence for equal size cell divisions during gametogenesis in a marine green alga Monostroma angicava ▶     Tatsuya Togashi, Yusuke Horinouchi, Hironobu Sasaki et al.     In cell divisions, relative size of daughter cells should play fundamental roles in gametogenesis and embryogenesis. Differences in gamete size between the two mating types …             Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules ▶     S. Windschüttl, C. Kampfer, C. Mayer et al.     Male fertility depends on spermatogenesis, which takes place in the seminiferous tubules of the testis. This compartment is devoid of blood vessels, which are however found in …             Establishment of immunoassay for detecting HPV16 E6 and E7 RNA ▶     Sen Ding, Steven Y. Qian, Yang Zhang et al.     Cervical carcinoma is the most prevalent malignancy second only to breast cancer among women worldwide. Since more than 99% of cervical cancers are caused by human papilloma …             Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse ▶     Daniel J. Adams, Christopher P. Arthur, Michael H. B. Stowell     We have purified the mammalian synaptophysin/synaptobrevin (SYP/VAMP2) complex to homogeneity in the presence of cholesterol and determined the 3D EM structure by single particle …             Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex ▶     Christoph M. Zehendner, Anne Sebastiani, André Hugonnet et al.     Accumulating evidence suggests a pivotal role of PDGFRß positive cells, a specific marker for central nervous system (CNS) pericytes, in tissue scarring. Identification of cells …             Identification of outliers in a genomic scan for selection along environmental gradients in the bamboo locust, Ceracris kiangsu ▶     Xiao-Jing Feng, Guo-Fang Jiang, Zhou Fan     Identification of loci under divergent selection is a key step in understanding the evolutionary process because those loci are responsible for the genetic variations that affect …             Aphid-induced Defences in Chilli Affect Preferences of the Whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae) ▶     Khalid A. Saad, M. N. Mohamad Roff, Rebecca H. Hallett et al.     The sweetpotato whitefly (WF), Bemisia tabaci, is a major pest that damages a wide range of vegetable crops in Malaysia. WF infestation is influenced by a variety of factors, …             The novel ABC transporter ABCH1 is a potential target for RNAi-based insect pest control and resistance management ▶     Zhaojiang Guo, Shi Kang, Xun Zhu et al.     Insect pests cause serious crop damage and develop high-level resistance to chemical insecticides and Bacillus thuringiensis (Bt) insecticidal Cry toxins. A new promising …             FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization ▶     Yaling Jiang, Yixin Liao, Hui He et al.     Human endometrium decidualization, which involves endometrial stromal proliferation and differentiation, is a prerequisite for embryo implantation, thus successful pregnancy. The …             High-resolution non-contact measurement of the electrical activity of plants in situ using optical recording ▶     Dong-Jie Zhao, Yang Chen, Zi-Yang Wang et al.     The limitations of conventional extracellular recording and intracellular recording make high-resolution multisite recording of plant bioelectrical activity in situ challenging. …             Comparative Proteomics Analyses of Two Races of Fusarium oxysporum f. sp. conglutinans that Differ in Pathogenicity ▶     Erfeng Li, Jian Ling, Gang Wang et al.     Fusarium oxysporum is a soil-inhabiting fungus that induces vascular wilt and root rot in a variety of plants. F. oxysporum f. sp. conglutinans (Foc), which comprises two races, …             Mixed gaits in small avian terrestrial locomotion ▶     Emanuel Andrada, Daniel Haase, Yefta Sutedja et al.     Scientists have historically categorized gaits discretely (e.g. regular gaits such as walking, running). However, previous results suggest that animals such as birds might mix or …             Multigenerational effects of parental prenatal exposure to famine on adult offspring cognitive function ▶     Jie Li, Lixin Na, Hao Ma et al.     The effects of prenatal nutrition on adult cognitive function have been reported for one generation. However, human evidence for multigenerational effects is lacking. We examined …             The Optimized Fabrication of Nanobubbles as Ultrasound Contrast Agents for Tumor Imaging ▶     Wen Bin Cai, Heng Li Yang, Jian Zhang et al.     Nanobubbles, which have the potential for ultrasonic targeted imaging and treatment in tumors, have been a research focus in recent years. With the current methods, however, the …             Novel approach for label free super-resolution imaging in far field ▶     Sergey A. Alexandrov, James McGrath, Hrebesh Subhash et al.     Progress in the emerging areas of science and technology, such as bio- and nano-technologies, depends on development of corresponding techniques for imaging and probing the …             Genetic association of RIT2 rs12456492 polymorphism and Parkinson’s disease susceptibility in Asian populations: a meta-analysis ▶     Yanjun Lu, Wei Liu, Kun Tan et al.     Recent studies investigating the association of the Ras-like without CAAX 2 (RIT2) polymorphism, rs12456492, with Parkinson’s disease (PD) are controversial. We performed a …             K-factor image deshadowing for three-dimensional fluorescence microscopy ▶     Tali Ilovitsh, Aryeh Weiss, Amihai Meiri et al.     The ability to track single fluorescent particles within a three dimensional (3D) cellular environment can provide valuable insights into cellular processes. In this paper, we …             CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X ▶     Madina Karimova, Niklas Beschorner, Werner Dammermann et al.     Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which primarily persists in …             Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection ▶     Shuo-Chun Weng, Kuo-Hsiung Shu, Ming-Ju Wu et al.     Decoy receptor 3 (DcR3) expression in kidneys has been shown to predict progression of chronic kidney disease. We prospectively investigated a cohort comprising 96 renal …             Self-organization of waves and pulse trains by molecular motors in cellular protrusions ▶     A. Yochelis, S. Ebrahim, B. Millis et al.     Actin-based cellular protrusions are an ubiquitous feature of cells, performing a variety of critical functions ranging from cell-cell communication to cell motility. The …             Erratum: 18 GHz electromagnetic field induces permeability of Gram-positive cocci ▶     The Hong Phong Nguyen, Yury Shamis, Rodney J. Croft et al.                 Erratum: Retina specific GCAPs in zebrafish acquire functional selectivity in Ca2+-sensing by myristoylation and Mg2+-binding ▶     Stefan Sulmann, Farina Vocke, Alexander Scholten et al.                 Phosphoproteomic profiling of tumor tissues identifies HSP27 Ser82 phosphorylation as a robust marker of early ischemia ▶     Muhammad Saddiq Zahari, Xinyan Wu, Sneha M. Pinto et al.     Delays between tissue collection and tissue fixation result in ischemia and ischemia-associated changes in protein phosphorylation levels, which can misguide the examination of …             Corrigendum: Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy ▶     Guozhen Cui, Luchen Shan, Lin Guo et al.                 Biological Sources of Intrinsic and Extrinsic Noise in cI Expression of Lysogenic Phage Lambda ▶     Xue Lei, Wei Tian, Hongyuan Zhu et al.     Genetically identical cells exposed to homogeneous environment can show remarkable phenotypic difference. To predict how phenotype is shaped, understanding of how each factor …             Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation ▶     Ana Paula Crestani, Flávia Zacouteguy Boos, Josué Haubrich et al.     Memories can be destabilized by the reexposure to the training context, and may reconsolidate into a modified engram. Reconsolidation relies on some particular molecular …             Mimicking a natural pathway for de novo biosynthesis: natural vanillin production from accessible carbon sources ▶     Jun Ni, Fei Tao, Huaiqing Du et al.     Plant secondary metabolites have been attracting people’s attention for centuries, due to their potentials; however, their production is still difficult and costly. The rich …             Tet-mediated imprinting erasure in H19 locus following reprogramming of spermatogonial stem cells to induced pluripotent stem cells ▶     P. Bermejo-Álvarez, P. Ramos-Ibeas, K.E. Park et al.     Selective methylation of CpG islands at imprinting control regions (ICR) determines the monoparental expression of a subset of genes. Currently, it is unclear whether artificial …             18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination ▶     Jieru Zhou, Wei Cai, Min Jin et al.     Microglia are intrinsic immune cells in the central nervous system (CNS). The under controlled microglia activation plays important roles in inflammatory demyelination diseases, …             PEA-CLARITY: 3D molecular imaging of whole plant organs ▶     William M. Palmer, Antony P. Martin, Jamie R. Flynn et al.     Here we report the adaptation of the CLARITY technique to plant tissues with addition of enzymatic degradation to improve optical clearing and facilitate antibody probe …             MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer ▶     Lihua Yang, Jie Yang, Jingqiu Li et al.     Understanding the molecular mechanism by which epithelial mesenchymal transition (EMT)-mediated cancer metastasis and how microRNA (miRNA) regulates lung cancer progression via …             Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease ▶     Jiexia Ding, Meng Li, Xingyong Wan et al.     MicroRNA-34a (miR-34a) is thought to be involved in nonalcoholic fatty liver disease (NAFLD). However, the association between altered expression of miR-34a and the …             High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma ▶     Fei Han, Wenbin Liu, Hualiang Xiao et al.     In our previous study, we had identified SOX30 as a novel tumor suppressor that acts through direct regulation of p53 transcription in human lung cancer. Here, we sought to …             Micro-concentration Lipopolysaccharide as a Novel Stimulator of Megakaryocytopoiesis that Synergizes with IL-6 for Platelet Production ▶     Di Wu, Jun Xie, Xuejun Wang et al.     Lipopolysaccharide (LPS) induces platelet activation and enhances platelet sensitivity to aggregation, which might alter platelet counts. We found that serial doses of …             BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS ▶     Shixuan Zhang, Yongming Bao, Xiulan Ju et al.     Cyclin-dependent kinase 1 (CDK1) is the only necessary CDK in cell proliferation and a novel target in the development of anticancer drugs. 8-Hydroxypiperidinemethyl-baicalein …             Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms ▶     Yuan Xu, Xian Liu, Yulan Wang et al.     A combinatorial pharmacophore (CP) model for Multidrug and toxin extrusion 1 (MATE1/SLC47A1) inhibitors was developed based on a data set including 881 compounds. The CP model …             The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop ▶     Rosina Noto, Loredana Randazzo, Samuele Raccosta et al.     Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin …             Multiplexed In-cell Immunoassay for Same-sample Protein Expression Profiling ▶     Jing Shang, Pavel Zrazhevskiy, Nadia Postupna et al.     In-cell immunoassays have become a valuable tool for protein expression analysis complementary to established assay formats. However, comprehensive molecular characterization of …             Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone ▶     Baoli Wang, Hongting Jin, Bing Shu et al.     Bone marrow stromal cells/osteoblasts were originally thought to be the major player in regulating osteoclast differentiation through expressing RANKL/OPG cytokines. Recent …             Erratum: A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients ▶     Aniruddha Chatterjee, Anna L. Leichter, Vicky Fan et al.                 Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity ▶     Wen Zhang, Min Chen, Yan Ling Wu et al.     G-quadruplexes formed in telomeric DNA sequences at human chromosome ends can be a novel target for the development of therapeutics for the treatment of cancer patients. Herein, …             Evidence for the expression of abundant microRNAs in the locust genome ▶     Yanli Wang, Feng Jiang, Huimin Wang et al.     Substantial accumulation of neutral sequences accounts for genome size expansion in animal genomes. Numerous novel microRNAs (miRNAs), which evolve in a birth and death manner, …             Role of local and distant functional connectivity density in the development of minimal hepatic encephalopathy ▶     Rongfeng Qi, Long Jiang Zhang, Hui Juan Chen et al.     The progression of functional connectivity (FC) patterns from non-hepatic encephalopathy (non-HE) to minimal HE (MHE) is not well known. This resting-state functional magnetic …             LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia ▶     Yaping Wang, Peng Wu, Rufeng Lin et al.     Long non-coding RNA (lncRNA) was referred to be participating in various malignant tumors. Location based analysis of the mechanism in lncRNA and genes have been highly focused. …             Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy ▶     Lauren Scarfe, Aleksandra Rak-Raszewska, Stefania Geraci et al.     Maximising the use of preclinical murine models of progressive kidney disease as test beds for therapies ideally requires kidney function to be measured repeatedly in a safe, …             SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway ▶     Kunkun Han, Xin Xu, Zhuan Xu et al.     The mammalian target of rapamycin (mTOR) is extensively involved in multiple myeloma (MM) pathophysiology. In the present study, we reported a novel small molecule SC06 that …             Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma ▶     J. Zhang, J. Y. Huang, Y. N. Chen et al.     Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, …             Rapid, high efficiency isolation of pancreatic ß-cells ▶     Susan M. Clardy, James F. Mohan, Claudio Vinegoni et al.     The ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid …             Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway ▶     Shulan Su, Jinao Duan, Ting Chen et al.     Frankincense and myrrh are highly effective in treatment of inflammatary diseases, but lacking of the therapy mechanisms. We undertook this stuty to evaluate the effects on …             Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways ▶     Andrew P. Coveney, Wei Wang, Justin Kelly et al.     Myeloid-related protein 8 (Mrp8) is the active component of Mrp8/14 protein complex released by phagocytes at the site of infection and stimulates inflammatory responses. …             Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells ▶     Yan-Ru Lou, Liisa Kanninen, Bryan Kaehr et al.     Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, …             IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway ▶     Kentaro Sumida, Yosuke Ohno, Junya Ohtake et al.     Myeloid-derived suppressor cells (MDSCs) are immune negative regulators in the tumour microenvironment. Interleukin (IL)-11, a member of IL-6 family cytokines, functions through …             Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides ▶     Ana Maranha, Patrick J. Moynihan, Vanessa Miranda et al.     Mycobacteria synthesize unique intracellular methylglucose lipopolysaccharides (MGLP) proposed to modulate fatty acid metabolism. In addition to the partial esterification of …             Molecular insights into Zeaxanthin-dependent quenching in higher plants ▶     Pengqi Xu, Lijin Tian, Miroslav Kloz et al.     Photosynthetic organisms protect themselves from high-light stress by dissipating excess absorbed energy as heat in a process called non-photochemical quenching (NPQ). Zeaxanthin …             Glucanocellulosic ethanol: the undiscovered biofuel potential in energy crops and marine biomass ▶     Christian Falter, Claudia Zwikowics, Dennis Eggert et al.     Converting biomass to biofuels is a key strategy in substituting fossil fuels to mitigate climate change. Conventional strategies to convert lignocellulosic biomass to ethanol …             The Synergetic Coupling among the Cellular Antioxidants Glutathione Peroxidase/Peroxiredoxin and Other Antioxidants and its Effect on the Concentration of H2O2 ▶     Hamid Molavian, Ali Madani Tonekaboni, Mohammad Kohandel et al.     Glutathione peroxidase (GPx), peroxiredoxin (Prx), and catalase are the major antioxidants at the cellular level and protect cell compartments against hydrogen peroxide (H2O2). …             Mass spectrometry imaging reveals new biological roles for choline esters and Tyrian purple precursors in muricid molluscs ▶     David Rudd, Maurizio Ronci, Martin R. Johnston et al.     Despite significant advances in chemical ecology, the biodistribution, temporal changes and ecological function of most marine secondary metabolites remain unknown. One such …             Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli ▶     Junjun Wu, Guocheng Du, Jian Chen et al.     The limited supply of intracellular malonyl-CoA in Escherichia coli impedes the biological synthesis of polyketides, flavonoids and biofuels. Here, a clustered regularly …             PI4K-beta and MKNK1 are regulators of hepatitis C virus IRES-dependent translation ▶     Joachim Lupberger, Claudia Casanova, Benoit Fischer et al.     Cellular translation is down-regulated by host antiviral responses. Picornaviridae and Flaviviridae including hepatitis C virus (HCV) evade this process using internal ribosomal …             Inhibitory effects of magnolol and honokiol on human calcitonin aggregation ▶     Caiao Guo, Liang Ma, Yudan Zhao et al.     Amyloid formation is associated with multiple amyloidosis diseases. Human calcitonin (hCT) is a typical amyloidogenic peptide, its aggregation is associated with medullary …             Whole Genome Phylogeny of Bacillus by Feature Frequency Profiles (FFP) ▶     Aisuo Wang, Gavin J. Ash     Fifty complete Bacillus genome sequences and associated plasmids were compared using the “feature frequency profile” (FFP) method. The resulting whole-genome phylogeny supports …             Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells ▶     B. Santos-Carballal, L. J. Aaldering, M. Ritzefeld et al.     Cancer gene therapy requires the design of non-viral vectors that carry genetic material and selectively deliver it with minimal toxicity. Non-viral vectors based on cationic …             Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors ▶     Geoffrey Masuyer, Jonathan R. Davies, Kevin Moore et al.     The botulinum neurotoxin type D is one of seven highly potent toxins produced by Clostridium botulinum which inhibit neurotransmission at cholinergic nerve terminals. A …             Can you see what I am talking about? Human speech triggers referential expectation in four-month-old infants ▶     Hanna Marno, Teresa Farroni, Yamil Vidal Dos Santos et al.     Infants’ sensitivity to selectively attend to human speech and to process it in a unique way has been widely reported in the past. However, in order to successfully acquire …             Long-Term Exposure to High Altitude Affects Response Inhibition in the Conflict-monitoring Stage ▶     Hailin Ma, Yan Wang, Jianhui Wu et al.     To investigate the effects of high-altitude exposure on response inhibition, event-related potential (ERP) components N2 and P3 were measured in Go/NoGo task. The participants …             Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice ▶     Le Yang, Zhen Han, Lei Tian et al.     Sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) system has been implicated in the pathological process of liver injury. This study was designed to evaluate the effects of …             Super-resolution mapping of glutamate receptors in C. elegans by confocal correlated PALM ▶     Jeroen Vangindertael, Isabel Beets, Susana Rocha et al.     Photoactivated localization microscopy (PALM) is a super-resolution imaging technique based on the detection and subsequent localization of single fluorescent molecules. PALM is …             Segmented molecular design of self-healing proteinaceous materials ▶     Veikko Sariola, Abdon Pena-Francesch, Huihun Jung et al.     Hierarchical assembly of self-healing adhesive proteins creates strong and robust structural and interfacial materials, but understanding of the molecular design and …             One-Step Synthesis of Chiral Oxindole-type Analogues with Potent Anti-inflammatory and Analgesic Activities ▶     Yulong Sun, Jia Liu, Xianxing Jiang et al.     Here we report a facile approach to synthesize highly optically active oxindole-type analogues with both high yield and enantioselectivity. This single-step synthesis strategy …             Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization ▶     Meixiang Yang, Yanguo Liu, Guangwen Ren et al.     A low partial oxygen pressure (hypoxia) occurs in many pathological environments, such as solid tumors and inflammatory lesions. Understanding the cellular response to hypoxic …             Infrared video tracking of Anopheles gambiae at insecticide-treated bed nets reveals rapid decisive impact after brief localised net contact ▶     Josephine E.A. Parker, Natalia Angarita-Jaimes, Mayumi Abe et al.     Long-lasting insecticidal bed nets (LLINs) protect humans from malaria transmission and are fundamental to malaria control worldwide, but little is known of how mosquitoes …             Selective in vivo and in vitro activities of 3,3′-4-nitrobenzylidene-bis-4-hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III ▶     Zheng Hou, Ying Zhou, Jing Li et al.     As the persistent resistance of Staphylococcus aureus to available antibiotics is associated with high infection incidence, mortality rate and treatment cost, novel antibacterial …             The diversity and abundance of As(III) oxidizers on root iron plaque is critical for arsenic bioavailability to rice ▶     Min Hu, Fangbai Li, Chuanping Liu et al.     Iron plaque is a strong adsorbent on rice roots, acting as a barrier to prevent metal uptake by rice. However, the role of root iron plaque microbes in governing metal redox …             PrP charge structure encodes interdomain interactions ▶     Javier Martínez, Rosa Sánchez, Milagros Castellanos et al.     Almost all proteins contain charged residues, and their chain distribution is tailored to fulfill essential ionic interactions for folding, binding and catalysis. Among proteins, …             A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects ▶     Puvaneswari Meganathan, Rafid Salim Jabir, Ho Gwo Fuang et al.     Gamma and delta tocotrienols are isomers of Vitamin E with established potency in pre-clinical anti-cancer research. This single-dose, randomized, crossover study aimed to …             Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model ▶     Qinjie Wu, Ning Wang, Tao He et al.     Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, …             Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice ▶     Jiali Liu, Fang Zhou, Qianying Chen et al.     Patients with inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, often suffer drug intolerance. This resistance can be divided into intrinsic …             The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis ▶     Thomas Lanzicher, Valentina Martinelli, Luca Puzzi et al.     Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insights into biomechanical behavior of cardiomyocytes carrying the lamin A/C …                 Open for Submissions   A new open access, multi-and interdisciplinary journal dedicated to publishing the finest research on both microbial biofilms and microbiomes, the journal is now open for submissions.   Explore the benefits of submitting your next research article.         Chemical Sciences ▲ top               Long-Range Ruthenium-Amine Electronic Communication through the para-Oligophenylene Wire ▶     Jun-Jian Shen, Yu-Wu Zhong     The studies of long-range electronic communication are hampered by solubility and potential-splitting issues. A “hybridized redox-asymmetry” method using a combination of organic …             Mechanisms for Enhanced Hydrophobicity by Atomic-Scale Roughness ▶     Yumi Katasho, Yunfeng Liang, Sumihiko Murata et al.     It is well known that the close-packed CF3-terminated solid surface is among the most hydrophobic surfaces in nature. Molecular dynamic simulations show that this hydrophobicity …             Tunable growth of silver nanobelts on monolithic activated carbon with size-dependent plasmonic response ▶     Hong Zhao, Yuesheng Ning, Binyuan Zhao et al.     Silver is one of the most important materials in plasmonics. Tuning the size of various silver nanostructures has been actively pursued in the last decade. However, silver …             Stability of a new cubic monoxide of Thorium under pressure ▶     Weiwei Sun, Wei Luo, Rajeev Ahuja     Density functional theory has been applied to elucidate the stability of thorium monoxide (ThO). It is found out that the pressure can stabilize the rocksalt phase of ThO, and …             Highly Efficient Photocatalytic Hydrogen Production of Flower-like Cadmium Sulfide Decorated by Histidine ▶     Qizhao Wang, Juhong Lian, Jiajia Li et al.     Morphology-controlled synthesis of CdS can significantly enhance the efficiency of its photocatalytic hydrogen production. In this study, a novel three-dimensional (3D) …             The impact of surface chemistry on the performance of localized solar-driven evaporation system ▶     Shengtao Yu, Yao Zhang, Haoze Duan et al.     This report investigates the influence of surface chemistry (or wettability) on the evaporation performance of free-standing double-layered thin film on the surface of water. …             Quantifying Molecular-Level Cell Adhesion on Electroactive Conducting Polymers using Electrochemical-Single Cell Force Spectroscopy ▶     Hongrui Zhang, Paul J. Molino, Gordon G. Wallace et al.     Single Cell Force Spectroscopy was combined with Electrochemical-AFM to quantify the adhesion between live single cells and conducting polymers whilst simultaneously applying a …             The Hardest Superconducting Metal Nitride ▶     Shanmin Wang, Daniel Antonio, Xiaohui Yu et al.     Transition–metal (TM) nitrides are a class of compounds with a wide range of properties and applications. Hard superconducting nitrides are of particular interest for electronic …             High-performance multi-functional reverse osmosis membranes obtained by carbon nanotube·polyamide nanocomposite ▶     Shigeki Inukai, Rodolfo Cruz-Silva, Josue Ortiz-Medina et al.     Clean water obtained by desalinating sea water or by purifying wastewater, constitutes a major technological objective in the so-called water century. In this work, a …             Layered Seed-Growth of AgGe Football-like Microspheres via Precursor-Free Picosecond Laser Synthesis in Water ▶     Dongshi Zhang, Bilal Gökce, Christian Notthoff et al.     Hybrid particles are of great significance in terms of their adjustable optical, electronic, magnetic, thermal and mechanical properties. As a novel technique, laser ablation in …             Boron-rich benzene and pyrene derivatives for the detection of thermal neutrons ▶     Henok A. Yemam, Adam Mahl, Unsal Koldemir et al.     A synthetic methodology is developed to generate boron rich aromatic small molecules based on benzene and pyrene moieties for the detection of thermal neutrons. The prepared …             Droplet Digital Enzyme-Linked Oligonucleotide Hybridization Assay for Absolute RNA Quantification ▶     Weihua Guan, Liben Chen, Tushar D. Rane et al.     We present a continuous-flow droplet-based digital Enzyme-Linked Oligonucleotide Hybridization Assay (droplet digital ELOHA) for sensitive detection and absolute quantification …             Unravelling the origin of the giant Zn deficiency in wurtzite type ZnO nanoparticles ▶     Adèle Renaud, Laurent Cario, Xavier Rocquelfelte et al.     Owing to its high technological importance for optoelectronics, zinc oxide received much attention. In particular, the role of defects on its physical properties has been …             Intermediates in the cation reactions in solution probed by an in situ surface enhanced Raman scattering method ▶     Chih-Shan Tan, Hung-Ying Chen, Hsueh-Szu Chen et al.     For chemical reactions in liquid state, such as catalysis, understanding of dynamical changes is conducive to practical applications. Solvation of copper salts in aqueous …             Assembling strategy to synthesize palladium modified kaolin nanocomposites with different morphologies ▶     Xiaoyu Li, Jing Ouyang, Yonghua Zhou et al.     Nanocomposites of aluminosilicate minerals, kaolins (kaolinite and halloysite) with natural different morphologies assembling with palladium (Pd) nanoparticles have been …             Polyhedral Palladium–Silver Alloy Nanocrystals as Highly Active and Stable Electrocatalysts for the Formic Acid Oxidation Reaction ▶     Geng-Tao Fu, Chang Liu, Qi Zhang et al.     Polyhedral noble–metal nanocrystals have received much attention and wide applications as electrical and optical devices as well as catalysts. In this work, a straightforward and …             Europium Luminescence: Electronic Densities and Superdelocalizabilities for a Unique Adjustment of Theoretical Intensity Parameters ▶     José Diogo L. Dutra, Nathalia B. D. Lima, Ricardo O. Freire et al.     We advance the concept that the charge factors of the simple overlap model and the polarizabilities of Judd-Ofelt theory for the luminescence of europium complexes can be …             Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity ▶     Wen Zhang, Min Chen, Yan Ling Wu et al.     G-quadruplexes formed in telomeric DNA sequences at human chromosome ends can be a novel target for the development of therapeutics for the treatment of cancer patients. Herein, …             Corrigendum: Selecting water-alcohol mixed solvent for synthesis of polydopamine nano-spheres using solubility parameter ▶     Xiaoli Jiang, Yinling Wang, Maoguo Li                 Understanding Phase-Change Memory Alloys from a Chemical Perspective ▶     A.V. Kolobov, P. Fons, J. Tominaga     Phase-change memories (PCM) are associated with reversible ultra-fast low-energy crystal-to-amorphous switching in GeTe-based alloys co-existing with the high stability of the …             Carrier density effect on recombination in PTB7-based solar cell ▶     Yutaka Moritomo, Kouhei Yonezawa, Takeshi Yasuda     Organic solar cells (OSCs) are promising alternatives to the conventional inorganic solar cells due to their low-cost processing and compatibility with flexible substrates. The …             Stable magnesium peroxide at high pressure ▶     Sergey S. Lobanov, Qiang Zhu, Nicholas Holtgrewe et al.     Rocky planets are thought to comprise compounds of Mg and O as these are among the most abundant elements, but knowledge of their stable phases may be incomplete. MgO is known to …             One-Step Synthesis of Chiral Oxindole-type Analogues with Potent Anti-inflammatory and Analgesic Activities ▶     Yulong Sun, Jia Liu, Xianxing Jiang et al.     Here we report a facile approach to synthesize highly optically active oxindole-type analogues with both high yield and enantioselectivity. This single-step synthesis strategy …                 Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.         Physical Sciences ▲ top               Long-Range Ruthenium-Amine Electronic Communication through the para-Oligophenylene Wire ▶     Jun-Jian Shen, Yu-Wu Zhong     The studies of long-range electronic communication are hampered by solubility and potential-splitting issues. A “hybridized redox-asymmetry” method using a combination of organic …             Foldable and Cytocompatible Sol-gel TiO2 Photonics ▶     Lan Li, Ping Zhang, Wei-Ming Wang et al.     Integrated photonics provides a miniaturized and potentially implantable platform to manipulate and enhance the interactions between light and biological molecules or tissues in …             Stability of a new cubic monoxide of Thorium under pressure ▶     Weiwei Sun, Wei Luo, Rajeev Ahuja     Density functional theory has been applied to elucidate the stability of thorium monoxide (ThO). It is found out that the pressure can stabilize the rocksalt phase of ThO, and …             Strong, spectrally-tunable chirality in diffractive metasurfaces ▶     Israel De Leon, Matthew J. Horton, Sebastian A. Schulz et al.     Metamaterials and metasurfaces provide a paradigm-changing approach for manipulating light. Their potential has been evinced by recent demonstrations of chiral responses much …             Tunable growth of silver nanobelts on monolithic activated carbon with size-dependent plasmonic response ▶     Hong Zhao, Yuesheng Ning, Binyuan Zhao et al.     Silver is one of the most important materials in plasmonics. Tuning the size of various silver nanostructures has been actively pursued in the last decade. However, silver …             Interface-Free Area-Scalable Self-Powered Electroluminescent System Driven by Triboelectric Generator ▶     Xiao Yan Wei, Shuang Yang Kuang, Hua Yang Li et al.     Self-powered system that is interface-free is greatly desired for area-scalable application. Here we report a self-powered electroluminescent system that consists of a …             Acoustic build-up in on-chip stimulated Brillouin scattering ▶     C. Wolff, M. J. Steel, B. J. Eggleton et al.     We investigate the role of the spatial evolution of the acoustic field in stimulated Brillouin scattering processes in short high-gain structures. When the gain is strong enough …             Highly Efficient Photocatalytic Hydrogen Production of Flower-like Cadmium Sulfide Decorated by Histidine ▶     Qizhao Wang, Juhong Lian, Jiajia Li et al.     Morphology-controlled synthesis of CdS can significantly enhance the efficiency of its photocatalytic hydrogen production. In this study, a novel three-dimensional (3D) …             Photoluminescence studies of a perceived white light emission from a monolithic InGaN/GaN quantum well structure ▶     N. Ben Sedrine, T. C. Esteves, J. Rodrigues et al.     In this work we demonstrate by photoluminescence studies white light emission from a monolithic InGaN/GaN single quantum well structure grown by metal organic chemical vapour …             Mechanisms for Enhanced Hydrophobicity by Atomic-Scale Roughness ▶     Yumi Katasho, Yunfeng Liang, Sumihiko Murata et al.     It is well known that the close-packed CF3-terminated solid surface is among the most hydrophobic surfaces in nature. Molecular dynamic simulations show that this hydrophobicity …             Effect of Ag nanoparticle concentration on the electrical and ferroelectric properties of Ag/P(VDF-TrFE) composite films ▶     Haemin Paik, Yoon-Young Choi, Seungbum Hong et al.     We investigated the effect of the Ag nanoparticles on the ferroelectric and piezoelectric properties of Ag/poly(vinylidenefluoride-trifluoroethylene) (P(VDF-TrFE)) composite …             Highly Omnidirectional and Frequency Controllable Carbon/Polyaniline-based 2D and 3D Monopole Antenna ▶     Keun-Young Shin, Minkyu Kim, James S. Lee et al.     Highly omnidirectional and frequency controllable carbon/polyaniline (C/PANI)-based, two- (2D) and three-dimensional (3D) monopole antennas were fabricated using screen-printing …             Insight into Evolution, Processing and Performance of Multi-length-scale Structures in Planar Heterojunction Perovskite Solar Cells ▶     Yu-Ching Huang, Cheng-Si Tsao, Yi-Ju Cho et al.     The structural characterization correlated to the processing control of hierarchical structure of planar heterojunction perovskite layer is still incomplete due to the …             Low-Energy Electron Potentiometry: Contactless Imaging of Charge Transport on the Nanoscale ▶     J. Kautz, J. Jobst, C. Sorger et al.     Charge transport measurements form an essential tool in condensed matter physics. The usual approach is to contact a sample by two or four probes, measure the resistance and …             Columnar grown copper films on polyimides strained beyond 100% ▶     Jeong-Yun Sun, Hae-Ryung Lee, Kyu Hwan Oh     Many flexible electronic devices contain metal films on polymer substrates to satisfy requirements for both electrical conductivity and mechanical durability. Despite numerous …             The impact of surface chemistry on the performance of localized solar-driven evaporation system ▶     Shengtao Yu, Yao Zhang, Haoze Duan et al.     This report investigates the influence of surface chemistry (or wettability) on the evaporation performance of free-standing double-layered thin film on the surface of water. …             Effects of acoustic levitation on the development of zebrafish, Danio rerio, embryos ▶     Maria Sundvik, Heikki J. Nieminen, Ari Salmi et al.     Acoustic levitation provides potential to characterize and manipulate material such as solid particles and fluid in a wall-less environment. While attempts to levitate small …             Water-enhanced Removal of Ciprofloxacin from Water by Porous Graphene Hydrogel ▶     Jie Ma, Mingxuan Yang, Fei Yu et al.     An environmentally benign and efficient hydrothermal reduction method was applied for the preparation of three-dimensional (3D) porous graphene hydrogel (GH) adsorbents. The …             Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics ▶     Ching-Wei Chang, Sanjay Kumar     While is widely acknowledged that nonmuscle myosin II (NMMII) enables stress fibers (SFs) to generate traction forces against the extracellular matrix, little is known about how …             Stabilizing synchrony by inhomogeneity ▶     Ehsan Bolhasani, Alireza Valizadeh     We show that for two weakly coupled identical neuronal oscillators with strictly positive phase resetting curve, isochronous synchrony can only be seen in the absence of noise …             The motility-proliferation-metabolism interplay during metastatic invasion ▶     Inbal Hecht, Sari Natan, Assaf Zaritsky et al.     Metastasis is the major cause for cancer patients’ death, and despite all the recent advances in cancer research it is still mostly incurable. Understanding the mechanisms that …             Dimeric interactions and complex formation using direct coevolutionary couplings ▶     Ricardo N. dos Santos, Faruck Morcos, Biman Jana et al.     We develop a procedure to characterize the association of protein structures into homodimers using coevolutionary couplings extracted from Direct Coupling Analysis (DCA) in …             The Hardest Superconducting Metal Nitride ▶     Shanmin Wang, Daniel Antonio, Xiaohui Yu et al.     Transition–metal (TM) nitrides are a class of compounds with a wide range of properties and applications. Hard superconducting nitrides are of particular interest for electronic …             High-performance multi-functional reverse osmosis membranes obtained by carbon nanotube·polyamide nanocomposite ▶     Shigeki Inukai, Rodolfo Cruz-Silva, Josue Ortiz-Medina et al.     Clean water obtained by desalinating sea water or by purifying wastewater, constitutes a major technological objective in the so-called water century. In this work, a …             Virus based Full Colour Pixels using a Microheater ▶     Won-Geun Kim, Kyujung Kim, Sung-Hun Ha et al.     Mimicking natural structures has been received considerable attentions, and there have been a few practical advances. Tremendous efforts based on a self-assembly technique have …             Assembling strategy to synthesize palladium modified kaolin nanocomposites with different morphologies ▶     Xiaoyu Li, Jing Ouyang, Yonghua Zhou et al.     Nanocomposites of aluminosilicate minerals, kaolins (kaolinite and halloysite) with natural different morphologies assembling with palladium (Pd) nanoparticles have been …             Quantifying Molecular-Level Cell Adhesion on Electroactive Conducting Polymers using Electrochemical-Single Cell Force Spectroscopy ▶     Hongrui Zhang, Paul J. Molino, Gordon G. Wallace et al.     Single Cell Force Spectroscopy was combined with Electrochemical-AFM to quantify the adhesion between live single cells and conducting polymers whilst simultaneously applying a …             Boron-rich benzene and pyrene derivatives for the detection of thermal neutrons ▶     Henok A. Yemam, Adam Mahl, Unsal Koldemir et al.     A synthetic methodology is developed to generate boron rich aromatic small molecules based on benzene and pyrene moieties for the detection of thermal neutrons. The prepared …             Laser optomechanics ▶     Weijian Yang, Stephen Adair Gerke, Kar Wei Ng et al.     Cavity optomechanics explores the interaction between optical field and mechanical motion. So far, this interaction has relied on the detuning between a passive optical resonator …             Dynamic response of polar nanoregions under an electric field in a paraelectric KTa0.61Nb0.39O3 single crystal near the para-ferroelectric phase boundary ▶     Hao Tian, Bo Yao, Lei Wang et al.     The dynamic response of polar nanoregions under an AC electric field was investigated by measuring the frequency dependence of the quadratic electro-optic (QEO) effect in a …             Ice-templated Self-assembly of VOPO4–Graphene Nanocomposites for Vertically Porous 3D Supercapacitor Electrodes ▶     Kwang Hoon Lee, Young-Woo Lee, Seung Woo Lee et al.     A simple ice-templated self-assembly process is used to prepare a three-dimensional (3D) and vertically porous nanocomposite of layered vanadium phosphates (VOPO4) and graphene …             Silver Nanowire Transparent Conductive Electrodes for High-Efficiency III-Nitride Light-Emitting Diodes ▶     Munsik Oh, Won-Yong Jin, Hyeon Jun Jeong et al.     Silver nanowires (AgNWs) have been successfully demonstrated to function as next-generation transparent conductive electrodes (TCEs) in organic semiconductor devices owing to …             Layered Seed-Growth of AgGe Football-like Microspheres via Precursor-Free Picosecond Laser Synthesis in Water ▶     Dongshi Zhang, Bilal Gökce, Christian Notthoff et al.     Hybrid particles are of great significance in terms of their adjustable optical, electronic, magnetic, thermal and mechanical properties. As a novel technique, laser ablation in …             Multi-wavelength emission through self-induced second-order wave-mixing processes from a Nd3+ doped crystalline powder random laser ▶     André L. Moura, Vladimir Jerez, Lauro J. Q. Maia et al.     Random lasers (RLs) based on neodymium ions (Nd3+) doped crystalline powders rely on multiple light scattering to sustain laser oscillation. Although Stokes and anti-Stokes Nd3+ …             Effects of stoichiometry on the transport properties of crystalline phase-change materials ▶     Wei Zhang, Matthias Wuttig, Riccardo Mazzarello     It has recently been shown that a metal-insulator transition due to disorder occurs in the crystalline state of the GeSb2Te4 phase-change compound. The transition is triggered by …             Antiferromagnetic Spin Coupling between Rare Earth Adatoms and Iron Islands Probed by Spin-Polarized Tunneling ▶     David Coffey, José Luis Diez-Ferrer, David Serrate et al.     High-density magnetic storage or quantum computing could be achieved using small magnets with large magnetic anisotropy, a requirement that rare-earth iron alloys fulfill in …             Intermediates in the cation reactions in solution probed by an in situ surface enhanced Raman scattering method ▶     Chih-Shan Tan, Hung-Ying Chen, Hsueh-Szu Chen et al.     For chemical reactions in liquid state, such as catalysis, understanding of dynamical changes is conducive to practical applications. Solvation of copper salts in aqueous …             Droplet Digital Enzyme-Linked Oligonucleotide Hybridization Assay for Absolute RNA Quantification ▶     Weihua Guan, Liben Chen, Tushar D. Rane et al.     We present a continuous-flow droplet-based digital Enzyme-Linked Oligonucleotide Hybridization Assay (droplet digital ELOHA) for sensitive detection and absolute quantification …             Electrically Tunable and Negative Schottky Barriers in Multi-layered Graphene/MoS2 Heterostructured Transistors ▶     Dongri Qiu, Eun Kyu Kim     We fabricated multi-layered graphene/MoS2 heterostructured devices by positioning mechanically exfoliated bulk graphite and single-crystalline 2H-MoS2 onto Au metal pads on a SiO2…             Anisotropic thermoelectric behavior in armchair and zigzag mono- and fewlayer MoS2 in thermoelectric generator applications ▶     Abbas Arab, Qiliang Li     In this work, we have studied thermoelectric properties of monolayer and fewlayer MoS2 in both armchair and zigzag orientations. Density functional theory (DFT) using …             Tailoring optical complex field with spiral blade plasmonic vortex lens ▶     Guanghao Rui, Qiwen Zhan, Yiping Cui     Optical complex fields have attracted increasing interests because of the novel effects and phenomena arising from the spatially inhomogeneous state of polarizations and optical …             Unravelling the origin of the giant Zn deficiency in wurtzite type ZnO nanoparticles ▶     Adèle Renaud, Laurent Cario, Xavier Rocquelfelte et al.     Owing to its high technological importance for optoelectronics, zinc oxide received much attention. In particular, the role of defects on its physical properties has been …             K-factor image deshadowing for three-dimensional fluorescence microscopy ▶     Tali Ilovitsh, Aryeh Weiss, Amihai Meiri et al.     The ability to track single fluorescent particles within a three dimensional (3D) cellular environment can provide valuable insights into cellular processes. In this paper, we …             An information-theoretic model for link prediction in complex networks ▶     Boyao Zhu, Yongxiang Xia     Various structural features of networks have been applied to develop link prediction methods. However, because different features highlight different aspects of network …             Self-assembled large scale metal alloy grid patterns as flexible transparent conductive layers ▶     Melinda Mohl, Aron Dombovari, Robert Vajtai et al.     The development of scalable synthesis techniques for optically transparent, electrically conductive coatings is in great demand due to the constantly increasing market price and …             Generalized Kirchhoff-Law-Johnson-Noise (KLJN) secure key exchange system using arbitrary resistors ▶     Gergely Vadai, Robert Mingesz, Zoltan Gingl     The Kirchhoff-Law-Johnson-Noise (KLJN) secure key exchange system has been introduced as a simple, very low cost and efficient classical physical alternative to quantum key …             Symmetry issues in the hybridization of multi-mode waves with resonators: an example with Lamb waves metamaterial ▶     Matthieu Rupin, Philippe Roux, Geoffroy Lerosey et al.     Locally resonant metamaterials derive their effective properties from hybridization between their resonant unit cells and the incoming wave. This phenomenon is well understood in …             Novel approach for label free super-resolution imaging in far field ▶     Sergey A. Alexandrov, James McGrath, Hrebesh Subhash et al.     Progress in the emerging areas of science and technology, such as bio- and nano-technologies, depends on development of corresponding techniques for imaging and probing the …             Granular friction: Triggering large events with small vibrations ▶     Henri Lastakowski, Jean-Christophe Géminard, Valérie Vidal     Triggering large-scale motion by imposing vibrations to a system can be encountered in many situations, from daily-life shaking of saltcellar to silo unclogging or dynamic …             Self-organization of waves and pulse trains by molecular motors in cellular protrusions ▶     A. Yochelis, S. Ebrahim, B. Millis et al.     Actin-based cellular protrusions are an ubiquitous feature of cells, performing a variety of critical functions ranging from cell-cell communication to cell motility. The …             Mixed gaits in small avian terrestrial locomotion ▶     Emanuel Andrada, Daniel Haase, Yefta Sutedja et al.     Scientists have historically categorized gaits discretely (e.g. regular gaits such as walking, running). However, previous results suggest that animals such as birds might mix or …             The generalized Shockley-Queisser limit for nanostructured solar cells ▶     Yunlu Xu, Tao Gong, Jeremy N. Munday     The Shockley-Queisser limit describes the maximum solar energy conversion efficiency achievable for a particular material and is the standard by which new photovoltaic …             Europium Luminescence: Electronic Densities and Superdelocalizabilities for a Unique Adjustment of Theoretical Intensity Parameters ▶     José Diogo L. Dutra, Nathalia B. D. Lima, Ricardo O. Freire et al.     We advance the concept that the charge factors of the simple overlap model and the polarizabilities of Judd-Ofelt theory for the luminescence of europium complexes can be …             Ultralow threading dislocation density in GaN epilayer on near-strain-free GaN compliant buffer layer and its applications in hetero-epitaxial LEDs ▶     Huan-Yu Shih, Makoto Shiojiri, Ching-Hsiang Chen et al.     High threading dislocation (TD) density in GaN-based devices is a long unresolved problem because of the large lattice mismatch between GaN and the substrate, which causes a …             Diverse lattice dynamics in ternary Cu-Sb-Se compounds ▶     Wujie Qiu, Lihua Wu, Xuezhi Ke et al.     Searching and designing materials with extremely low lattice thermal conductivity (LTC) has attracted considerable attention in material sciences. Here we systematically …             Robust and highly performant ring detection algorithm for 3d particle tracking using 2d microscope imaging ▶     Eldad Afik     Three-dimensional particle tracking is an essential tool in studying dynamics under the microscope, namely, fluid dynamics in microfluidic devices, bacteria taxis, cellular …             Erratum: Strategical incoherence regulates cooperation in social dilemmas on multiplex networks ▶     Joan T. Matamalas, Julia Poncela-Casasnovas, Sergio Gómez et al.                 Inversed Vernier effect based single-mode laser emission in coupled microdisks ▶     Meng Li, Nan Zhang, Kaiyang Wang et al.     Recently, on-chip single-mode laser emissions in coupled microdisks have attracted considerable research attention due to their wide applications. While most of single-mode …             Dissolution-and-reduction CVD synthesis of few-layer graphene on ultra-thin nickel film lifted off for mode-locking fiber lasers ▶     Kaung-Jay Peng, Yung-Hsiang Lin, Chung-Lun Wu et al.     The in-situ dissolution-and-reduction CVD synthesized few-layer graphene on ultra-thin nickel catalyst film is demonstrated at temperature as low as 550 °C, which can be employed …             Polyhedral Palladium–Silver Alloy Nanocrystals as Highly Active and Stable Electrocatalysts for the Formic Acid Oxidation Reaction ▶     Geng-Tao Fu, Chang Liu, Qi Zhang et al.     Polyhedral noble–metal nanocrystals have received much attention and wide applications as electrical and optical devices as well as catalysts. In this work, a straightforward and …             Time Circular Birefringence in Time-Dependent Magnetoelectric Media ▶     Ruo-Yang Zhang, Yan-Wang Zhai, Shi-Rong Lin et al.     Light traveling in time-dependent media has many extraordinary properties which can be utilized to convert frequency, achieve temporal cloaking, and simulate cosmological …             Experimental Demonstration of a Synthetic Lorentz Force by Using Radiation Pressure ▶     N. Šantić, T. Dubček, D. Aumiler et al.     Synthetic magnetism in cold atomic gases opened the doors to many exciting novel physical systems and phenomena. Ubiquitous are the methods used for the creation of synthetic …             The roles of Eu during the growth of eutectic Si in Al-Si alloys ▶     Jiehua Li, Fredrik Hage, Manfred Wiessner et al.     Controlling the growth of eutectic Si and thereby modifying the eutectic Si from flake-like to fibrous is a key factor in improving the properties of Al-Si alloys. To date, it is …             Reconfigurable multi-scale colloidal assembly on excluded volume patterns ▶     Tara D. Edwards, Yuguang Yang, W. Neil Everett et al.     The ability to create multi-scale, periodic colloidal assemblies with unique properties is important to emerging applications. Dynamically manipulating colloidal structures via …             Nonlinear increase of X-ray intensities from thin foils irradiated with a 200 TW femtosecond laser ▶     A. Ya. Faenov, J. Colgan, S. B. Hansen et al.     We report, for the first time, that the energy of femtosecond optical laser pulses, E, with relativistic intensities I > 1021  W/cm2 is efficiently converted to X-ray radiation, …             Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity ▶     Wen Zhang, Min Chen, Yan Ling Wu et al.     G-quadruplexes formed in telomeric DNA sequences at human chromosome ends can be a novel target for the development of therapeutics for the treatment of cancer patients. Herein, …             Systematic Dimensionality Reduction for Quantum Walks: Optimal Spatial Search and Transport on Non-Regular Graphs ▶     Leonardo Novo, Shantanav Chakraborty, Masoud Mohseni et al.     Continuous time quantum walks provide an important framework for designing new algorithms and modelling quantum transport and state transfer problems. Often, the graph …             Imaging transplanted stem cells in real time using an MRI dual-contrast method ▶     Ethel J. Ngen, Lee Wang, Yoshinori Kato et al.     Stem cell therapies are currently being investigated for the repair of brain injuries. Although exogenous stem cell labelling with superparamagnetic iron oxide nanoparticles …             Multiplexed In-cell Immunoassay for Same-sample Protein Expression Profiling ▶     Jing Shang, Pavel Zrazhevskiy, Nadia Postupna et al.     In-cell immunoassays have become a valuable tool for protein expression analysis complementary to established assay formats. However, comprehensive molecular characterization of …             Motion Driven by Strain Gradient Fields ▶     Chao Wang, Shaohua Chen     A new driving mechanism for direction-controlled motion of nano-scale objects is proposed, based on a model of stretching a graphene strip linked to a rigid base with linear …             Photoluminescence of monovalent indium centres in phosphate glass ▶     Hirokazu Masai, Yasuhiro Yamada, Shun Okumura et al.     Valence control of polyvalent cations is important for functionalization of various kinds of materials. Indium oxides have been used in various applications, such as indium tin …             Light intensity modulation by coccoliths of Emiliania huxleyi as a micro-photo-regulator ▶     Yuri Mizukawa, Yuito Miyashita, Manami Satoh et al.     In this study, we present experimental evidence showing that coccoliths have light-scattering anisotropy that contributes to a possible control of solar light exposure in the …             Corrigendum: Selecting water-alcohol mixed solvent for synthesis of polydopamine nano-spheres using solubility parameter ▶     Xiaoli Jiang, Yinling Wang, Maoguo Li                 AGM2015: Antineutrino Global Map 2015 ▶     S.M. Usman, G.R. Jocher, S.T. Dye et al.     Every second greater than 1025 antineutrinos radiate to space from Earth, shining like a faint antineutrino star. Underground antineutrino detectors have revealed the rapidly …             Transmission and full-band coherent detection of polarization-multiplexed all-optical Nyquist signals generated by Sinc-shaped Nyquist pulses ▶     Junwen Zhang, Jianjun Yu, Nan Chi     All optical method is considered as a promising technique for high symbol rate Nyquist signal generation, which has attracted a lot of research interests for high …             Carrier density effect on recombination in PTB7-based solar cell ▶     Yutaka Moritomo, Kouhei Yonezawa, Takeshi Yasuda     Organic solar cells (OSCs) are promising alternatives to the conventional inorganic solar cells due to their low-cost processing and compatibility with flexible substrates. The …             Ultraviolet Lasers Realized via Electrostatic Doping Method ▶     X. Y. Liu, C. X. Shan, H. Zhu et al.     P-type doping of wide-bandgap semiconductors has long been a challenging issue for the relatively large activation energy and strong compensation of acceptor states in these …             Clusters in sedimentation equilibrium for an experimental hard-sphere-plus-dipolar Brownian colloidal system ▶     Hugh D. Newman, Anand Yethiraj     In this work, we use structure and dynamics in sedimentation equilibrium, in the presence of gravity, to examine, via confocal microscopy, a Brownian colloidal system in the …             Segmented molecular design of self-healing proteinaceous materials ▶     Veikko Sariola, Abdon Pena-Francesch, Huihun Jung et al.     Hierarchical assembly of self-healing adhesive proteins creates strong and robust structural and interfacial materials, but understanding of the molecular design and …             Understanding Phase-Change Memory Alloys from a Chemical Perspective ▶     A.V. Kolobov, P. Fons, J. Tominaga     Phase-change memories (PCM) are associated with reversible ultra-fast low-energy crystal-to-amorphous switching in GeTe-based alloys co-existing with the high stability of the …             Quantitative analysis on electric dipole energy in Rashba band splitting ▶     Jisook Hong, Jun-Won Rhim, Changyoung Kim et al.     We report on quantitative comparison between the electric dipole energy and the Rashba band splitting in model systems of Bi and Sb triangular monolayers under a perpendicular …             Remote control of magnetostriction-based nanocontacts at room temperature ▶     S. Narayana Jammalamadaka, Sebastian Kuntz, Oliver Berg et al.     The remote control of the electrical conductance through nanosized junctions at room temperature will play an important role in future nano-electromechanical systems and …             Nanomesh electrode on MgZnO-based metal-semiconductor-metal ultraviolet photodetectors ▶     Ching-Ting Lee, Heng-Yu Lin, Chun-Yen Tseng     In this work, the nano-scaled mesh electrodes are fabricated by obliquely depositing metals through the highly ordered polystyrene nanosphere mask. Furthermore, the intrinsic …             Domain wall of a ferromagnet on a three-dimensional topological insulator ▶     Ryohei Wakatsuki, Motohiko Ezawa, Naoto Nagaosa     Topological insulators (TIs) show rich phenomena and functions which can never be realized in ordinary insulators. Most of them come from the peculiar surface or edge states. …             Single-point position and transition defects in continuous time quantum walks ▶     Z. J. Li, J. B. Wang     We present a detailed analysis of continuous time quantum walks (CTQW) with both position and transition defects defined at a single point in the line. Analytical solutions of …             Evidence of Filamentary Switching in Oxide-based Memory Devices via Weak Programming and Retention Failure Analysis ▶     Adnan Younis, Dewei Chu, Sean Li     Further progress in high-performance microelectronic devices relies on the development of novel materials and device architectures. However, the components and designs that are …             Temperature-Dependent Asymmetry of Anisotropic Magnetoresistance in Silicon p-n Junctions ▶     D. Z. Yang, T. Wang, W. B. Sui et al.     We report a large but asymmetric magnetoresistance in silicon p-n junctions, which contrasts with the fact of magnetoresistance being symmetric in magnetic metals and …             Trends in (LaMnO3)n/(SrTiO3)m superlattices with varying layer thicknesses ▶     J. Jilili, F. Cossu, U. Schwingenschlögl     We investigate the thickness dependence of the structural, electronic, and magnetic properties of (LaMnO3)n/(SrTiO3)m (n, m = 2, 4, 6, 8) superlattices using density functional …             Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells ▶     Yan-Ru Lou, Liisa Kanninen, Bryan Kaehr et al.     Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, …             Stable magnesium peroxide at high pressure ▶     Sergey S. Lobanov, Qiang Zhu, Nicholas Holtgrewe et al.     Rocky planets are thought to comprise compounds of Mg and O as these are among the most abundant elements, but knowledge of their stable phases may be incomplete. MgO is known to …             One-Step Synthesis of Chiral Oxindole-type Analogues with Potent Anti-inflammatory and Analgesic Activities ▶     Yulong Sun, Jia Liu, Xianxing Jiang et al.     Here we report a facile approach to synthesize highly optically active oxindole-type analogues with both high yield and enantioselectivity. This single-step synthesis strategy …             The Synergetic Coupling among the Cellular Antioxidants Glutathione Peroxidase/Peroxiredoxin and Other Antioxidants and its Effect on the Concentration of H2O2 ▶     Hamid Molavian, Ali Madani Tonekaboni, Mohammad Kohandel et al.     Glutathione peroxidase (GPx), peroxiredoxin (Prx), and catalase are the major antioxidants at the cellular level and protect cell compartments against hydrogen peroxide (H2O2). …             Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model ▶     Qinjie Wu, Ning Wang, Tao He et al.     Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, …               Earth & Environmental Sciences ▲ top               Young dispersal of xerophil Nitraria lineages in intercontinental disjunctions of the Old World ▶     Ming-Li Zhang, Kamshat Temirbayeva, Stewart C. Sanderson et al.     Many cases of intercontinental disjunct distributions of seed plants have been investigated, however few have concerned the continents of Eurasia (mainly Central Asia), Africa, …             An 80 kyr-long continuous speleothem record from Dim Cave, SW Turkey with paleoclimatic implications for the Eastern Mediterranean ▶     Ezgi Ünal-İmer, James Shulmeister, Jian-Xin Zhao et al.     Speleothem-based stable isotope records are valuable in sub-humid and semi-arid settings where many other terrestrial climate proxies are fragmentary. The Eastern Mediterranean …             Copper induced oxidative stresses, antioxidant responses and phytoremediation potential of Moso bamboo (Phyllostachys pubescens) ▶     Junren Chen, Mohammad Shafi, Song Li et al.     Moso bamboo is recognized as phytoremediation plant due to production of huge biomass and high tolerance in stressed environment. Hydroponics and pot experiments were conducted …             Reduced greenhouse gas mitigation potential of no-tillage soils through earthworm activity ▶     Ingrid M. Lubbers, Kees Jan van Groenigen, Lijbert Brussaard et al.     Concerns about rising greenhouse gas (GHG) concentrations have spurred the promotion of no-tillage practices as a means to stimulate carbon storage and reduce CO2 emissions in …             Water-enhanced Removal of Ciprofloxacin from Water by Porous Graphene Hydrogel ▶     Jie Ma, Mingxuan Yang, Fei Yu et al.     An environmentally benign and efficient hydrothermal reduction method was applied for the preparation of three-dimensional (3D) porous graphene hydrogel (GH) adsorbents. The …             Competition with wind-pollinated plant species alters floral traits of insect-pollinated plant species ▶     Floriane Flacher, Xavier Raynaud, Amandine Hansart et al.     Plant traits related to attractiveness to pollinators (e.g. flowers and nectar) can be sensitive to abiotic or biotic conditions. Soil nutrient availability, as well as …             Granular friction: Triggering large events with small vibrations ▶     Henri Lastakowski, Jean-Christophe Géminard, Valérie Vidal     Triggering large-scale motion by imposing vibrations to a system can be encountered in many situations, from daily-life shaking of saltcellar to silo unclogging or dynamic …             Regional paleofire regimes affected by non-uniform climate, vegetation and human drivers ▶     Olivier Blarquez, Adam A. Ali, Martin P. Girardin et al.     Climate, vegetation and humans act on biomass burning at different spatial and temporal scales. In this study, we used a dense network of sedimentary charcoal records from …             Does the climate warming hiatus exist over the Tibetan Plateau? ▶     Anmin Duan, Zhixiang Xiao     The surface air temperature change over the Tibetan Plateau is determined based on historical observations from 1980 to 2013. In contrast to the cooling trend in the rest of …             δ13C-CH4 reveals CH4 variations over oceans from mid-latitudes to the Arctic ▶     Juan Yu, Zhouqing Xie, Liguang Sun et al.     The biogeochemical cycles of CH4 over oceans are poorly understood, especially over the Arctic Ocean. Here we report atmospheric CH4 levels together with δ13C-CH4 from offshore …             Stable magnesium peroxide at high pressure ▶     Sergey S. Lobanov, Qiang Zhu, Nicholas Holtgrewe et al.     Rocky planets are thought to comprise compounds of Mg and O as these are among the most abundant elements, but knowledge of their stable phases may be incomplete. MgO is known to …             Shifts in the eruptive styles at Stromboli in 2010–2014 revealed by ground-based InSAR data ▶     Federico Di Traglia, Maurizio Battaglia, Teresa Nolesini et al.     Ground-Based Interferometric Synthetic Aperture Radar (GBInSAR) is an efficient technique for capturing short, subtle episodes of conduit pressurization in open vent volcanoes …             New ground-based lidar enables volcanic CO2 flux measurements ▶     Alessandro Aiuppa, Luca Fiorani, Simone Santoro et al.     There have been substantial advances in the ability to monitor the activity of hazardous volcanoes in recent decades. However, obtaining early warning of eruptions remains …             The diversity and abundance of As(III) oxidizers on root iron plaque is critical for arsenic bioavailability to rice ▶     Min Hu, Fangbai Li, Chuanping Liu et al.     Iron plaque is a strong adsorbent on rice roots, acting as a barrier to prevent metal uptake by rice. However, the role of root iron plaque microbes in governing metal redox …               Health Sciences ▲ top               Corrigendum: Nicotine absorption from electronic cigarette use: comparison between experienced consumers (vapers) and naïve users (smokers) ▶     Konstantinos E. Farsalinos, Alketa Spyrou, Christos Stefopoulos et al.                 Clinical characteristics of protracted bacterial bronchitis in Chinese infants ▶     Yuqing Wang, Chuangli Hao, FanFan Chi et al.     Protracted bacterial bronchitis (PBB) is the common cause of chronic cough in children worldwide, but its etiology has not been fully recognized in China. We retrospectively …             Changes in Gene Expression Patterns of Circadian-Clock, Transient Receptor Potential Vanilloid-1 and Nerve Growth Factor in Inflamed Human Esophagus ▶     Shu-Chuan Yang, Chien-Lin Chen, Chih-Hsun Yi et al.     Circadian rhythm is driven by the molecular circadian-clock system and regulates many physiological functions. Diurnal rhythms in the gastrointestinal tract are known to be …             The comparative cost-effectiveness of colorectal cancer screening using faecal immunochemical test vs. colonoscopy ▶     Martin CS Wong, Jessica YL Ching, Victor CW Chan et al.     Faecal immunochemical tests (FITs) and colonoscopy are two common screening tools for colorectal cancer(CRC). Most cost-effectiveness studies focused on survival as the outcome, …             Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer ▶     Bo Tang, Yang Li, Guangying Qi et al.     The prognosis of pancreatic cancer patients is very poor, with a 5-year survival of less than 6%. Previous studies demonstrated that the loss of function of CDKN2A is mainly …             Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss ▶     Yong Zhang, Hanfeng Guan, Jing Li et al.     The activity of protein kinases IKK-ε and TANK-binding kinase 1 (TBK1) has been shown to be associated with inflammatory diseases. As an inhibitor of IKK-ε and TBK1, amlexanox is …             Higher blood hematocrit predicts hyperuricemia: a prospective study of 62897 person-years of follow-up ▶     Chao Zeng, Jie Wei, Tuo Yang et al.     This prospective study aimed to investigate the relationship between higher hematocrit (Hct) level and hyperuricemia (HU) incidence. A total of 27540 subjects were included. …             Whole-genome Sequencing for Tracing the Transmission Link between Two ARD Outbreaks Caused by a Novel HAdV Serotype 7 Variant, China ▶     Shaofu Qiu, Peng Li, Hongbo Liu et al.     From December 2012 to February 2013, two outbreaks of acute respiratory disease caused by HAdV-7 were reported in China. We investigated possible transmission links between these …             Associations between antioxidant vitamins and the risk of invasive cervical cancer in Chinese women: A case-control study ▶     Liyuan Guo, Hong Zhu, Chengjun Lin et al.     Previous studies on the associations between dietary antioxidant vitamins and the risk of cervical cancer remain inconsistent, and little evidence is available for serum …             A novel recombinant slow-release TNF α-derived peptide effectively inhibits tumor growth and angiogensis ▶     Yi Ma, Shaojun Zhao, Shutao Shen et al.     RMP16, a recombinant TNF α-derived polypeptide comprising a specific human serum albumin (HSA)-binding 7-mer peptide identified by phage display screening (WQRPSSW), a cleavage …             NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells ▶     Yanan Liu, Gengbiao Zhou, Zhenglian Wang et al.     Cell apoptosis induced by heat stress is regulated by a complex signaling network. We previously reported that a p53-dependent pathway is involved. Here, we present evidence that …             High Risk of Herpes Zoster among Patients with Advance Acute Kidney Injury – A Population-Based Study ▶     Wei-Shun Yang, Fu-Chang Hu, Meng-Kan Chen et al.     The risk for herpes zoster (HZ) in acute kidney injury (AKI) survivors was never explored. We identified 2,387 adults in the Taiwan National Health Insurance Research Database …             Multigenerational effects of parental prenatal exposure to famine on adult offspring cognitive function ▶     Jie Li, Lixin Na, Hao Ma et al.     The effects of prenatal nutrition on adult cognitive function have been reported for one generation. However, human evidence for multigenerational effects is lacking. We examined …             Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection ▶     Shuo-Chun Weng, Kuo-Hsiung Shu, Ming-Ju Wu et al.     Decoy receptor 3 (DcR3) expression in kidneys has been shown to predict progression of chronic kidney disease. We prospectively investigated a cohort comprising 96 renal …             Monomeric C-reactive protein-a key molecule driving development of Alzheimer’s disease associated with brain ischaemia? ▶     M. Slevin, S. Matou, Y. Zeinolabediny et al.     Alzheimer’s disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears in the ECM of ischaemic tissue after stroke, …             Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules ▶     S. Windschüttl, C. Kampfer, C. Mayer et al.     Male fertility depends on spermatogenesis, which takes place in the seminiferous tubules of the testis. This compartment is devoid of blood vessels, which are however found in …             Genetic association of RIT2 rs12456492 polymorphism and Parkinson’s disease susceptibility in Asian populations: a meta-analysis ▶     Yanjun Lu, Wei Liu, Kun Tan et al.     Recent studies investigating the association of the Ras-like without CAAX 2 (RIT2) polymorphism, rs12456492, with Parkinson’s disease (PD) are controversial. We performed a …             FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization ▶     Yaling Jiang, Yixin Liao, Hui He et al.     Human endometrium decidualization, which involves endometrial stromal proliferation and differentiation, is a prerequisite for embryo implantation, thus successful pregnancy. The …             The Optimized Fabrication of Nanobubbles as Ultrasound Contrast Agents for Tumor Imaging ▶     Wen Bin Cai, Heng Li Yang, Jian Zhang et al.     Nanobubbles, which have the potential for ultrasonic targeted imaging and treatment in tumors, have been a research focus in recent years. With the current methods, however, the …             CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X ▶     Madina Karimova, Niklas Beschorner, Werner Dammermann et al.     Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which primarily persists in …             Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling ▶     Yohei Tomita, Toshihide Kurihara, Atsuro Uchida et al.     Wide-angle viewing systems (WAVSs) were originally established for pars plana vitrectomy. However, their application to scleral buckling surgery was recently reported. In this …             Fibroblast growth factor 21 in breast milk controls neonatal intestine function ▶     Aleix Gavaldà-Navarro, Elayne Hondares, Marta Giralt et al.     FGF21 is a hormonal factor with important functions in the control of metabolism. FGF21 is found in rodent and human milk. Radiolabeled FGF21 administered to lactating dams …             Class effect of beta-blockers in survivors of ST-elevation myocardial infarction: A nationwide cohort study using an insurance claims database ▶     Ting-Tse Lin, K. Arnold Chan, Ho-Min Chen et al.     Beta-blockers can help reduce mortality following acute myocardial infarction (MI); however, whether beta-blockers exert a class effect remains controversial. This study …             Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors ▶     Xueli Bai, Qi Zhang, Song Wu et al.     Pancreatic cancer has a poor prognosis and few effective treatments. The failure of treatment is partially due to the high heterogeneity of cancer cells within the tumor. T cells …             Imaging transplanted stem cells in real time using an MRI dual-contrast method ▶     Ethel J. Ngen, Lee Wang, Yoshinori Kato et al.     Stem cell therapies are currently being investigated for the repair of brain injuries. Although exogenous stem cell labelling with superparamagnetic iron oxide nanoparticles …             Erratum: A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients ▶     Aniruddha Chatterjee, Anna L. Leichter, Vicky Fan et al.                 Corrigendum: Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy ▶     Guozhen Cui, Luchen Shan, Lin Guo et al.                 LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia ▶     Yaping Wang, Peng Wu, Rufeng Lin et al.     Long non-coding RNA (lncRNA) was referred to be participating in various malignant tumors. Location based analysis of the mechanism in lncRNA and genes have been highly focused. …             SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway ▶     Kunkun Han, Xin Xu, Zhuan Xu et al.     The mammalian target of rapamycin (mTOR) is extensively involved in multiple myeloma (MM) pathophysiology. In the present study, we reported a novel small molecule SC06 that …             Role of local and distant functional connectivity density in the development of minimal hepatic encephalopathy ▶     Rongfeng Qi, Long Jiang Zhang, Hui Juan Chen et al.     The progression of functional connectivity (FC) patterns from non-hepatic encephalopathy (non-HE) to minimal HE (MHE) is not well known. This resting-state functional magnetic …             Rapid, high efficiency isolation of pancreatic ß-cells ▶     Susan M. Clardy, James F. Mohan, Claudio Vinegoni et al.     The ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid …             Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma ▶     J. Zhang, J. Y. Huang, Y. N. Chen et al.     Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, …             MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer ▶     Lihua Yang, Jie Yang, Jingqiu Li et al.     Understanding the molecular mechanism by which epithelial mesenchymal transition (EMT)-mediated cancer metastasis and how microRNA (miRNA) regulates lung cancer progression via …             Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy ▶     Lauren Scarfe, Aleksandra Rak-Raszewska, Stefania Geraci et al.     Maximising the use of preclinical murine models of progressive kidney disease as test beds for therapies ideally requires kidney function to be measured repeatedly in a safe, …             Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity ▶     Wen Zhang, Min Chen, Yan Ling Wu et al.     G-quadruplexes formed in telomeric DNA sequences at human chromosome ends can be a novel target for the development of therapeutics for the treatment of cancer patients. Herein, …             Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway ▶     Shulan Su, Jinao Duan, Ting Chen et al.     Frankincense and myrrh are highly effective in treatment of inflammatary diseases, but lacking of the therapy mechanisms. We undertook this stuty to evaluate the effects on …             Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways ▶     Andrew P. Coveney, Wei Wang, Justin Kelly et al.     Myeloid-related protein 8 (Mrp8) is the active component of Mrp8/14 protein complex released by phagocytes at the site of infection and stimulates inflammatory responses. …             A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects ▶     Puvaneswari Meganathan, Rafid Salim Jabir, Ho Gwo Fuang et al.     Gamma and delta tocotrienols are isomers of Vitamin E with established potency in pre-clinical anti-cancer research. This single-dose, randomized, crossover study aimed to …             Selective in vivo and in vitro activities of 3,3′-4-nitrobenzylidene-bis-4-hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III ▶     Zheng Hou, Ying Zhou, Jing Li et al.     As the persistent resistance of Staphylococcus aureus to available antibiotics is associated with high infection incidence, mortality rate and treatment cost, novel antibacterial …             Dose-volume factors associated with ear disorders following intensity modulated radiotherapy in nasopharyngeal carcinoma ▶     Ji-Jin Yao, Guan-Qun Zhou, Li Lin et al.     This study is to identify significant dosimetric parameters for ear disorders in nasopharyngeal carcinoma (NPC) patients treated with intensity modulated therapy only. …             Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice ▶     Le Yang, Zhen Han, Lei Tian et al.     Sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) system has been implicated in the pathological process of liver injury. This study was designed to evaluate the effects of …             Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization ▶     Meixiang Yang, Yanguo Liu, Guangwen Ren et al.     A low partial oxygen pressure (hypoxia) occurs in many pathological environments, such as solid tumors and inflammatory lesions. Understanding the cellular response to hypoxic …             Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model ▶     Qinjie Wu, Ning Wang, Tao He et al.     Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, …             The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis ▶     Thomas Lanzicher, Valentina Martinelli, Luca Puzzi et al.     Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insights into biomechanical behavior of cardiomyocytes carrying the lamin A/C …             Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice ▶     Jiali Liu, Fang Zhou, Qianying Chen et al.     Patients with inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, often suffer drug intolerance. 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