Nature Reviews Rheumatology - Table of Contents alert Volume 11 Issue 11

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TABLE OF CONTENTS
November 2015 Volume 11 Number 11
Impact Factor 9.845 *	In this issue Focus issue: 10th Anniversary Research Highlights Reviews Correspondence Also this month  Featured article: Redox distress and genetic defects conspire in systemic autoinflammatory diseases Georg Varga, Marco Gattorno, Dirk Foell & Anna Rubartelli
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NEWS AND VIEWS		Top
Decade in review—translational rheumatology: Ten years after: rheumatology research from bench to bedside Nunzio Bottini & Gary S. Firestein Published online: 22 September 2015 p623 | doi:10.1038/nrrheum.2015.126 Defining key advances in any medical discipline can be challenging, but is especially so in rheumatology—a rapidly advancing field so broad that it defies traditional classifications. Here, we approach the Sisyphean task of summarizing the translational advances in rheumatology in the past decade within several broad categories of basic research. Full Text | PDF
Decade in review—paediatric rheumatology: A field on the move Seza Ozen Published online: 22 September 2015 p625 | doi:10.1038/nrrheum.2015.130 The study of rheumatic diseases that affect children has thrived in the past 10 years. A look at several important advances in this area illustrates how organized collaborations and advanced technologies are contributing to the understanding and, ultimately, to improving the treatment of these disorders. Full Text | PDF | Supplementary information
Decade in review—technology: Technological advances transforming rheumatology William H. Robinson & Rong Mao Published online: 06 October 2015 p626 | doi:10.1038/nrrheum.2015.137 Technological advances over the past decade have revolutionized many areas of rheumatology, ranging from diagnosis, prognosis and therapeutic development to the mechanistic understanding of rheumatic diseases. This overview highlights key technological innovations and discusses the major impact that these developments are having on research and clinical practice. Full Text | PDF | Supplementary information
Decade in review—clinical rheumatology: 10 years of therapeutic advances in the rheumatic diseases John D. Isaacs Published online: 13 October 2015 p628 | doi:10.1038/nrrheum.2015.138 In the past 10 years, the rheumatology community has seen an explosion in the number of new therapies licensed for use across the rheumatic diseases, many with outstanding clinical success. Here, the drugs and strategies that constitute landmarks in the management of rheumatic diseases are highlighted. Full Text | PDF
RESEARCH HIGHLIGHTS Top Rheumatoid arthritis: Hitting the brakes on ectopic lymphoid structure formation Published online: 13 October 2015 p621 | doi:10.1038/nrrheum.2015.141 PDF Osteoarthritis: Genetically modified ADSCs as cell therapy for OA? Published online: 29 September 2015 p622 | doi:10.1038/nrrheum.2015.136 PDF Rheumatoid arthritis: C5orf30 regulates severity of tissue destruction in RA Published online: 06 October 2015 p622 | doi:10.1038/nrrheum.2015.139 PDF
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Nature Medicine FOCUS ON INFLAMMATORY DISEASE  This series of Reviews highlights new data that point toward the influence of environmental factors and addresses recent advances in our knowledge of the cell types and signaling pathways involved in inflammatory disease onset and progression. Produced with support from Janssen Pharmaceutical Companies of Johnson & Johnson
REVIEWS		Top
Epidemiology research in rheumatology—progress and pitfalls Deborah P. M. Symmons Published online: 07 July 2015 p631 | doi:10.1038/nrrheum.2015.92 Epidemiological research—the study of the distribution and determinants of disease in populations—relies on knowledge of different data sources, solid study designs and the accurate interpretation of study results. Understanding the methodology of population and clinical epidemiology studies is vital for the study of the distribution and determinants of outcomes in patients with rheumatic diseases. Abstract | Full Text | PDF
Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome Geoffrey Littlejohn Published online: 04 August 2015 p639 | doi:10.1038/nrrheum.2015.100 Fibromyalgia and complex regional pain syndrome (CRPS) share many pathophysiological mechanisms. Central mechanisms predominate in both disorders, although peripheral mechanisms such as neurogenic neuroinflammation also contribute to their clinical features, albeit to differing degrees. This article discusses the evidence suggesting that neurogenic neuroinflammation is an important and potentially targetable link between the two disorders. Abstract | Full Text | PDF
Global epidemiology of gout: prevalence, incidence and risk factors Chang-Fu Kuo, Matthew J. Grainge, Weiya Zhang & Michael Doherty Published online: 07 July 2015 p649 | doi:10.1038/nrrheum.2015.91 This comprehensive overview brings together the latest data on the epidemiology of gout in various parts of the world. The authors discuss regional and temporal patterns in gout prevalence and incidence as well as known risk factors for the disease. Abstract | Full Text | PDF | Supplementary information
Pathogenesis and targeted treatment of skin injury in SLE Guo-Min Deng & George C. Tsokos Published online: 04 August 2015 p663 | doi:10.1038/nrrheum.2015.106 Ultraviolet light, immune cells, cytokines and deposition of immunoglobulins all seem to have a role in the development of skin lesions in SLE. This Review discusses recent advances in understanding of the cellular, cytokine and molecular processes underlying the cutaneous manifestations of SLE, focussing on processes or molecules that could potentially be exploited therapeutically. Abstract | Full Text | PDF
Redox distress and genetic defects conspire in systemic autoinflammatory diseases Georg Varga, Marco Gattorno, Dirk Foell & Anna Rubartelli Published online: 04 August 2015 p670 | doi:10.1038/nrrheum.2015.105 Inflammation can be initiated by exogenous pathogen-associated molecular patterns (PAMPs) or by endogenous damage-associated molecular patters (DAMPs), but the contribution of each activation mechanism to reduction-oxidation (redox) stress and, ultimately, to the immunopathogenesis of autoinflammatory diseases remains elusive. In this Review, Varga and colleagues discuss how improved knowledge of mechanisms of inflammation initiation and propagation might help identify new therapeutic targets for patients with autoinflammatory diseases. Abstract | Full Text | PDF
CORRESPONDENCE		Top
The inflammasome in fibromyalgia and CRPS: a microglial hypothesis? Mario D. Cordero Published online: 29 September 2015 p630 | doi:10.1038/nrrheum.2015.131 Full Text | PDF
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*Journal Citation Reports, Thomson, 2014. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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