Nature Reviews Endocrinology - Table of Contents alert Volume 11 Issue 12

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TABLE OF CONTENTS
December 2015 Volume 11 Number 12
Impact Factor 13.281 *	In this issue Research Highlights News and Views Reviews Corrigendum Also this month  Featured article: Impaired insulin action in the human brain: causes and metabolic consequences Martin Heni, Stephanie Kullmann, Hubert Preissl, Andreas Fritsche & Hans-Ulrich Häring
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RESEARCH HIGHLIGHTS Top Paediatric endocrinology: Defining treatment thresholds for neonatal hypoglycaemia—how low is too low? Published online: 03 November 2015 p687 | doi:10.1038/nrendo.2015.188 PDF Obesity: Adiponectin—good for the mother and her offspring? Published online: 20 October 2015 p688 | doi:10.1038/nrendo.2015.183 PDF Diabetes: Circulating factors implicated in diabetic enteropathy Published online: 20 October 2015 p688 | doi:10.1038/nrendo.2015.184 PDF Development: Maternal hyperglycaemia affects cardiac development Published online: 29 September 2015 p689 | doi:10.1038/nrendo.2015.172 PDF Bone: Irisin boosts bone mass Published online: 06 October 2015 p689 | doi:10.1038/nrendo.2015.174 PDF Inflammation: Immune recovery drives bone loss Published online: 13 October 2015 p689 | doi:10.1038/nrendo.2015.180 PDF Bone: IGFBP1—hepatokine and target for FGF21-mediated bone loss Published online: 27 October 2015 p690 | doi:10.1038/nrendo.2015.187 PDF IN BRIEF Risk factors: Marijuana increases risk of prediabetes | Diabetes: Hyaluronan is involved in the development of T1DM | Nutrition: Modelling effects of different trans fatty acids policies on death from coronary heart disease PDF
NEWS AND VIEWS		Top
Pregnancy: Managing obesity during pregnancy—what are the options? Jodie M. Dodd Published online: 18 August 2015 p691 | doi:10.1038/nrendo.2015.141 In a new trial, provision of antenatal dietary and lifestyle advice to pregnant women who are obese is associated with modest improvements in maternal diet. This intervention is, however, inadequate to affect pregnancy and birth outcomes, and challenges the notion that limiting gestational weight gain can improve pregnancy outcomes. Full Text | PDF
Diabetes: Metformin and renal insufficiency—is 45, or even 30, the new 60? Zachary Bloomgarden Published online: 29 September 2015 p693 | doi:10.1038/nrendo.2015.166 In an analysis of data from NHANES spanning from 1999 to 2010, Tuot et al. address two linked questions. Which patients with diabetes mellitus and renal insufficiency are reasonable candidates for metformin therapy and how does this treatment depend on the approach used to measure renal function? Full Text | PDF
Obesity: Beige adipocytes—will they beat obesity? Camilla H. Sandholt & Oluf Pedersen Published online: 06 October 2015 p694 |doi:10.1038/nrendo.2015.178 The mechanistic link between the FTO locus and risk of obesity has remained elusive. However, a new study presents compelling evidence suggesting that the browning of white adipocytes into beige adipocytes (together with regulation of thermogenesis), might be an important and potentially modifiable pathway for development of obesity therapeutics. Full Text | PDF
Dyslipidaemia: Lysosomal acid lipase deficiency—a cautious leap forward Carla E. M. Hollak & G. Kees Hovingh Published online: 27 October 2015 p696 |doi:10.1038/nrendo.2015.182 Lysosomal acid lipase deficiency can lead to liver failure and early death. A recently published placebo-controlled trial shows that enzyme-replacement therapy improves plasma levels of lipids and aminotransferases, and reduces liver fat content. However, the effect on clinical end points and an appropriate indication for treatment remain to be established. Full Text | PDF
Therapy: Risk of metformin use in patients with T2DM and advanced CKD Guntram Schernthaner & Marie Helene Schernthaner-Reiter Published online: 18 August 2015 p697 |doi:10.1038/nrendo.2015.132 In a new study published in The Lancet Diabetes & Endocrinology, metformin use is associated with significantly increased all-cause mortality in patients with type 2 diabetes mellitus and stage 5 chronic kidney disease (CKD). The findings support current recommendations that metformin should not be used in patients with stage 5 CKD. Full Text | PDF
REVIEWS		Top
Impaired insulin action in the human brain: causes and metabolic consequences Martin Heni, Stephanie Kullmann, Hubert Preissl, Andreas Fritsche & Hans-Ulrich Häring Published online: 13 October 2015 p701 | doi:10.1038/nrendo.2015.173 In this Review, Martin Heni and colleagues outline the effects of insulin in the brain in humans and the relevance of the effects for physiology. The metabolic consequences of brain insulin resistance are discussed and possible future approaches to overcome brain insulin resistance and thereby prevent or treat obesity and type 2 diabetes mellitus are outlined. Abstract |Full Text | PDF
PTH receptor-1 signalling—mechanistic insights and therapeutic prospects Ross W. Cheloha, Samuel H. Gellman, Jean-Pierre Vilardaga & Thomas J. Gardella Published online: 25 August 2015 p712 | doi:10.1038/nrendo.2015.139 Parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR1) is a family B G-protein-coupled receptor and is involved in the regulation of skeletal development, bone turnover and mineral ion homeostasis. This Review discusses fundamental aspects of ligand-binding and signalling mechanisms at PTHR1, highlighting the relationship between ligand structural modification and variation in PTHR1 signalling responses. The action of these signalling mechanisms in disease states in which PTHR1 function has an important role are also discussed. Abstract | Full Text | PDF
Molecular insights into the aetiology of female reproductive ageing John R. B. Perry, Anna Murray, Felix R. Day & Ken K. Ong Published online: 13 October 2015 p725 | doi:10.1038/nrendo.2015.167 Genetic studies have identified dozens of mutations that are associated with reproductive disorders, including common variants associated with the timing of puberty and/or menopause. This Review discusses the contribution of such genetic findings to our understanding of the molecular regulation of reproductive timing and the biological basis of the epidemiological links between reproductive ageing and disease risk. Abstract | Full Text | PDF
Short and tall stature: a new paradigm emerges Jeffrey Baron, Lars Sävendahl, Francesco De Luca, Andrew Dauber, Moshe Phillip, Jan M. Wit & Ola Nilsson Published online: 06 October 2015 p735 | doi:10.1038/nrendo.2015.165 In this Review, Jeffrey Baron and colleagues explore the latest discoveries in the molecular and cell biology of childhood growth and in the clinical genetics of childhood growth disorders. These findings challenge the established theory that childhood growth is primarily controlled by growth hormone and insulin-like growth factor 1, leading the authors to suggest a broader framework for understanding linear growth disorders. Abstract | Full Text | PDF
CORRIGENDUM		Top
Thyroid hormone transporters—functions and clinical implications Juan Bernal, Ana Guadaño-Ferraz & Beatriz Morte Published online: 20 October 2015 p690 |doi:10.1038/nrendo.2015.186 Full Text | PDF
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Endocrinology was previously published as Nature Clinical Practice Endocrinology & Metabolism.

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