Nature Reviews Nephrology - Table of Contents alert Volume 11 Issue 12

TABLE OF CONTENTS
December 2015 Volume 11 Number 12
Impact Factor 8.542 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Therapeutic use of human renal progenitor cells for kidney regeneration Benedetta Bussolati & Giovanni Camussi
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RESEARCH HIGHLIGHTS Top Developmental biology: Nephrogenesis in kidney organoids derived from human pluripotent stem cells Published online: 20 October 2015 p689 | doi:10.1038/nrneph.2015.170 PDF Hypertension: sFlt-1 removal seems to be beneficial in women with pre-eclampsia Published online: 13 October 2015 p690 | doi:10.1038/nrneph.2015.168 PDF Glomerular disease: Protective role of TGR5 activation Published online: 20 October 2015 p690 | doi:10.1038/nrneph.2015.171 PDF Stem cells: Young nephron progenitors might extend the lifespan of old progenitors Published online: 03 November 2015 p690 | doi:10.1038/nrneph.2015.179 PDF Nephrology EVENT 35th Annual Advanced Nephrology: Nephrology for the Consultant 27.01.16 San Diego, USA More science events from
NEWS AND VIEWS		Top
Diabetic nephropathy: Nonsteroidal MRA added to RAS blockade reduces albuminuria Matthew R. Weir Published online: 13 October 2015 p691 | doi:10.1038/nrneph.2015.167 A new study reports that addition of the nonsteroidal mineralocorticoid receptor antagonist finerenone to renin-angiotensin system (RAS) blockade resulted in a reduction in albuminuria in patients with diabetic nephropathy. Such a strategy might provide an opportunity to maximize the beneficial effects of RAS blockade without increasing the risk of hyperkalaemia. Full Text | PDF
Therapy: New data do not support use of abatacept in diabetic nephropathy Gerald B. Appel Published online: 16 November 2015 p692 | doi:10.1038/nrneph.2015.178 A new study reports that B7-1 is not expressed on the podocytes of patients or mice with diabetic nephropathy. In contrast to the findings of some previous studies, these data suggest that targeting B7-1 on podocytes using abatacept might not be an appropriate therapeutic strategy for diabetic renal disease. Full Text | PDF
REVIEWS		Top
Therapeutic use of human renal progenitor cells for kidney regeneration Benedetta Bussolati & Giovanni Camussi Published online: 04 August 2015 p695 | doi:10.1038/nrneph.2015.126 Cell therapy holds promise to enable efficient repair of the adult human kidney, which could reverse damage caused by repeated renal injury. In this Review, Bussolati and Camussi consider the latest evidence for the existence and origin of functional renal progenitor cells in adult humans and the role of these cells in renal repair. They then discuss strategies for generating renal progenitor cells from pluripotent stem cells, human fetal cells and adult renal cells that could be used for cell therapy. Abstract | Full Text | PDF
Kidney-brain crosstalk in the acute and chronic setting Renhua Lu, Matthew C. Kiernan, Anne Murray, Mitchell H. Rosner & Claudio Ronco Published online: 18 August 2015 p707 | doi:10.1038/nrneph.2015.131 The kidney and the brain exhibit extensive organ crosstalk due to similarities in their vasculature and shared humoral and non-humoral pathways. In this Review, Claudio Ronco et al. evaluate the effects of chronic kidney disease, end-stage renal disease, and acute kidney injury on cognitive and cerebrovascular function. The authors also highlight the risk factors for cognitive impairment in patients undergoing dialysis. Abstract | Full Text | PDF
Genetic, environmental, and epigenetic factors involved in CAKUT Nayia Nicolaou, Kirsten Y. Renkema, Ernie M. H. F. Bongers, Rachel H. Giles & Nine V. A. M. Knoers Published online: 18 August 2015 p720 | doi:10.1038/nrneph.2015.140 Congenital anomalies of the kidney and urinary tract (CAKUT) are a spectrum of renal disorders that commonly cause end-stage renal disease in children, but their genetic basis is largely unknown. In this Review, Nine Knoers et al. discuss the difficulties in identifying the genetic basis of CAKUT, the approaches used to detect genetic variants that confer risk of these anomalies, and the complex interplay between environmental factors, epigenetics, and genetic variants in contributing to the development of these syndromes. Abstract | Full Text | PDF
Strategies to overcome the ABO barrier in kidney transplantation Georg A. Bohmig, Andreas M. Farkas, Farsad Eskandary & Thomas Wekerle Published online: 01 September 2015 p732 | doi:10.1038/nrneph.2015.144 The development of effective desensitization strategies has enabled ABO incompatible (ABOi) kidney transplantation to become an established treatment option for patients with end-stage renal disease. Here, the authors review the mechanisms that underlie acceptance and rejection of ABOi grafts, recipient desensitization strategies, patient outcomes and novel treatment strategies that might promote graft acceptance and enable minimization of immunosuppression. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2014. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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