Nature Reviews Neurology - Table of Contents alert Volume 11 Issue 11

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TABLE OF CONTENTS
November 2015 Volume 11 Number 11
Impact Factor 15.358 *	In this issue Editorial Research Highlights News and Views Focus on: 10th anniversary Perspectives Reviews Correspondence Also this month  Web Focus: 10th Anniversary
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EDITORIAL		Top
Nature Reviews Neurology: the early years Heather Wood Published online: 04 November 2015 p607 | doi:10.1038/nrneurol.2015.204 Full Text | PDF
RESEARCH HIGHLIGHTS Top Alzheimer disease: Neurogranin in the CSF signals early Alzheimer disease and predicts disease progression Published online: 29 September 2015 p609 | doi:10.1038/nrneurol.2015.178 PDF Multiple sclerosis: Smoking in patients with multiple sclerosis—is it ever too late to quit? Published online: 29 September 2015 p610 | doi:10.1038/nrneurol.2015.179 PDF Alzheimer disease: APOE*ε4-associated increase in AD risk linked to phospholipid dysregulation Published online: 29 September 2015 p610 | doi:10.1038/nrneurol.2015.180 PDF Stroke: Alcohol consumption does not seem to protect against stroke Published online: 13 October 2015 p611 | doi:10.1038/nrneurol.2015.181 PDF Alzheimer disease: Possible prion-like transmission of AD-like pathology in humans Published online: 29 September 2015 p612 | doi:10.1038/nrneurol.2015.190 PDF IN BRIEF Neurodegenerative disease: Tau acetylation is an early pathological event in neurodegenerative disease | Demyelinating disease: Neurodegeneration distinguishes MS from NMO | Traumatic brain injury: Functional connectivity is altered after mild TBI | Movement disorders: Is essential tremor a neurological channelopathy? | Multiple sclerosis: Daclizumab HYP shows superiority to IFN-β1a for reducing relapses in multiple sclerosis | Stroke: Intravenous thrombolysis should not be ruled out for stroke recurring within 3 months | Neurodegenerative disease: Transgenic songbirds provide a model for vocal impairments in Huntington disease | Neuromuscular disease: Exon skipping rescues γ-sarcoglycan deficiency PDF Nature Reviews Neurology EVENT The 15th Asian Oceanian Congress of Neurology (AOCN 2016) 18.08.16 Kuala Lumpur , Malaysia More science events from
NEWS AND VIEWS		Top
Decade in review-dementia: A decade of discovery and disappointment in dementia research John R. Hodges Published online: 06 October 2015 p613 | doi:10.1038/nrneurol.2015.191 In my personal view, the past decade in dementia research has been marked by remarkable discoveries in the field of frontotemporal dementia, accompanied by steady scientific consolidation tinged with therapeutic disappointments related to Alzheimer disease. Full Text | PDF
Decade in review—multiple sclerosis: New drugs and personalized medicine for multiple sclerosis Paul M. Matthews Published online: 27 October 2015 p614 | doi:10.1038/nrneurol.2015.200 The past decade of multiple sclerosis research has been marked by important advances in understanding the disease, a dramatic increase in the range of treatment options and a new spirit of data sharing in research for patient benefit. This progress has made personalized medicine in multiple sclerosis a realistic possibility. Full Text | PDF
Decade in review—epilepsy: Edging toward breakthroughs in epilepsy diagnostics and care Daniel H. Lowenstein Published online: 13 October 2015 p616 | doi:10.1038/nrneurol.2015.193 The past decade has yielded a host of important conceptual advances in epilepsy, along with some promising findings related to diagnostics and therapeutics. We are on an upswing where precise identification of the cause of a patient's seizure disorder can be matched to therapy that has a high likelihood of success. Full Text | PDF
Decade in review—movement disorders: Tracking the pathogenesis of movement disorders Oksana Suchowersky Published online: 27 October 2015 p618 | doi:10.1038/nrneurol.2015.201 Since 2005, we have made substantial progress in understanding the pathophysiology and natural history of movement disorders such as Parkinson disease and Huntington disease. However, disease-modifying therapies for these conditions have proved elusive and, as a consequence, treatments remain largely symptomatic. Full Text | PDF
Decade in review-stroke: Progress in acute ischaemic stroke treatment and prevention Jose G. Romano & Ralph L. Sacco Published online: 20 October 2015 p619 | doi:10.1038/nrneurol.2015.199 Recent decades have seen a dramatic reduction in age-adjusted stroke-related mortality, presumably owing to better control of vascular risk factors, use of antithrombotic agents and improvements in acute stroke care. Here, we highlight a few developments in stroke prevention and acute care that have particularly influenced the care of patients. Full Text | PDF
Decade in review—migraine: Incredible progress for an era of better migraine care Peter J. Goadsby Published online: 27 October 2015 p621 | doi:10.1038/nrneurol.2015.203 In the past 10 years, the realization that migraine is a brain disorder rather than a vascular disorder has facilitated development of various treatments, ranging from innovative immunopharmaceuticals through to neurostimulation. Many clinical trials have been successful, and such considerable progress holds promise for the coming decade of migraine treatment. Full Text | PDF | Supplementary information
Decade in review—CNS infections: Major advances against a moving target of CNS infections Lisa F. P. Ng & Tom Solomon Published online: 27 October 2015 p623 | doi:10.1038/nrneurol.2015.202 CNS infections have severe manifestations, often leading to high mortality, but the CNS is usually not the primary target of pathogens, leaving a window of opportunity to prevent neuroinvasion. We must prioritize development of therapies to prevent neurological sequelae that cause long-lasting morbidity and disease burden on society. Full Text | PDF
Focus on: 10th anniversary PERSPECTIVES Top ESSAY Progress in inflammatory neuropathy —the legacy of Dr Jack Griffin Eva L. Feldman, Richard A. C. Hughes & Hugh J. Willison Published online: 13 October 2015 p646 | doi:10.1038/nrneurol.2015.192 John W. 'Jack' Griffin (1942-2011) was the launch Editor-in-Chief of Nature Clinical Practice Neurology, and continued to serve on the Advisory Board after the journal was rebranded as Nature Reviews Neurology in 2009. In this Essay, the authors pay tribute to Jack, highlighting his seminal contributions to the field of inflammatory neuropathies, and reviewing recent progress in this area, including the emergence of the node of Ranvier as a site of intensive investigation. Abstract | Full Text | PDF OPINION Brain health and shared risk factors for dementia and stroke Hannah Gardener, Clinton B. Wright, Tatjana Rundek & Ralph L. Sacco Published online: 20 October 2015 p651 | doi:10.1038/nrneurol.2015.195 The risk factors for cardiovascular disease are largely the same as those that harm brain health, and—importantly—these shared risk factors are modifiable. This Perspectives article discusses how the conceptual shift from avoiding vascular risk factors to promoting brain health creates opportunities for reducing morbidity and mortality associated with poor brain health. Abstract | Full Text | PDF VIEWPOINT Neurology—the next 10 years Ralf Baron, Donna M. Ferriero, Giovanni B. Frisoni, Chetan Bettegowda, Ziya L. Gokaslan, John A. Kessler, Annamaria Vezzani, Stephen G. Waxman, Sven Jarius, Brigitte Wildemann & Michael Weller Published online: 27 October 2015 p658 | doi:10.1038/nrneurol.2015.196 Since the launch of Nature Clinical Practice Neurology in 2005, we have seen remarkable progress in many areas of neurology research, but what does the future hold? For this special Viewpoint article, we invited a panel of Advisory Board members and other journal contributors to outline their research priorities and predictions for the next 10 years. Abstract | Full Text | PDF
REVIEWS		Top
Pathogenesis of Parkinson disease—the gut-brain axis and environmental factors Lisa Klingelhoefer & Heinz Reichmann Published online: 27 October 2015 p625 | doi:10.1038/nrneurol.2015.197 Parkinson disease is defined by its motor symptoms, but onset of nonmotor symptoms, including constipation, can start much earlier. In this Review, Klingelhoefer and Reichmann present the evidence that the pathogenesis of Parkinson disease starts in the gut and is transferred to the CNS via trans-synaptic cell-to-cell transport that initiates a cascade of α-synuclein aggregation. They also consider how this process might be triggered by environmental factors, and how these earliest stages of pathogenesis might be targeted to delay or prevent disease progression. Abstract | Full Text | PDF
Ocular motor signatures of cognitive dysfunction in multiple sclerosis Joanne Fielding, Meaghan Clough, Shin Beh, Lynette Millist, Derek Sears, Ashley N. Frohman, Nathaniel Lizak, Jayne Lim, Scott Kolbe, Robert L. Rennaker, Teresa C. Frohman, Owen B. White & Elliot M. Frohman Published online: 15 September 2015 p637 | doi:10.1038/nrneurol.2015.174 Cognitive dysfunction is frequently observed in patients with multiple sclerosis (MS), and can have a substantial impact on daily activities and quality of life. In this Review, Fielding and colleagues discuss how ocular motor measures in patients with MS might be used to characterize disruption to wide-ranging networks that support cognitive function, and to track disease progression and responses to novel therapies in these individuals. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Polyneuritis cranialis—subtype of Guillain-Barre syndrome? Benjamin R. Wakerley & Nobuhiro Yuki Published online: 15 September 2015 p664 | doi:10.1038/nrneurol.2015.115 Full Text | PDF
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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