Nature Reviews Cardiology - Table of Contents alert Volume 13 Issue 2

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TABLE OF CONTENTS
February 2016 Volume 13 Number 2
Impact Factor 9.183 *	In this issue Research Highlights News and Views Year in Review Reviews Also this month  Featured article: Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis Kazuyuki Yahagi, Frank D. Kolodgie, Fumiyuki Otsuka, Aloke V. Finn, Harry R. Davis, Michael Joner & Renu Virmani
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RESEARCH HIGHLIGHTS Top Heart failure: Gut flora — pathogenic role in chronic heart failure Published online: 24 December 2015 p61 | doi:10.1038/nrcardio.2015.200 PDF Acute coronary syndromes: Low prognostic utility of measuring PCSK9 levels in ACS Published online: 24 December 2015 p62 | doi:10.1038/nrcardio.2015.197 PDF Venous thromboembolism: Thromboprophylaxis for patients with HF Published online: 24 December 2015 p62 | doi:10.1038/nrcardio.2015.198 PDF Diabetes: Lixisenatide does not increase rates of CVD events Published online: 24 December 2015 p63 | doi:10.1038/nrcardio.2015.199 PDF Risk factors: Moderate coffee drinking is associated with lower risk of death from CVD Published online: 03 December 2015 p64 | doi:10.1038/nrcardio.2015.189 PDF Pharmacogenetics: HCRTR2 gene is associated with response to HF therapy Published online: 17 December 2015 p64 | doi:10.1038/nrcardio.2015.195 PDF Cardiology JOBS of the week Tenure-Track Positions in Vascular Biology University of Calgary, Cumming School of Medicine Postdoctoral Fellow in Cardiac Regeneration or Mechanotransduction Heart Institute (InCor)/Univ Sao Paulo Med Sch - Lab Genetics & Mol Cardiol More Science jobs from Cardiology EVENT World Congress of Cardiology & Cardiovascular Health 2016 04.06.16 Mexico City, Mexico More science events from
NEWS AND VIEWS		Top
Valvular disease: Functional mitral regurgitation: should all valves be replaced? Maurizio Taramasso & Francesco Maisano Published online: 04 January 2016 p65 | doi:10.1038/nrcardio.2015.206 In the first multicentre, randomized trial to compare undersized annuloplasty versus mitral replacement in severe ischaemic mitral regurgitation (MR), higher recurrence of clinically significant MR and increased rehospitalization occurred after repair. With the rapid development of transcatheter mitral valve interventions, valve replacement might be the preferable transcatheter mitral valve therapy. Full Text | PDF
YEAR IN REVIEW		Top
Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias Laurent Macle & Stanley Nattel Published online: 04 January 2016 p67 | doi:10.1038/nrcardio.2015.196 Cardiac arrhythmias produce considerable morbidity and mortality, and are challenging to treat. Advances reported in 2015 will help to guide physicians in the use of therapeutic approaches ranging from established pharmaceutical agents through ablation of arrhythmic sources to novel uses of implanted devices for life-threatening bradyarrhythmias and tachyarrhythmias. Full Text | PDF
Coronary intervention in 2015: Improvement of long-term outcomes after PCI Uwe Zeymer Published online: 14 January 2016 p69 | doi:10.1038/nrcardio.2015.204 Third-generation drug-eluting stents (DES) have emerged as first-line devices for percutaneous coronary intervention, even in patients with high bleeding risk. Studies published in 2015 report that bioabsorbable vascular scaffolds are equally effective and safe as DES in low-risk populations and, with the addition of extended dual antiplatelet therapy, might improve long-term outcomes. Full Text | PDF
Cardiac resuscitation in 2015: Improving outcomes after OHCA — targeting the layperson Clifton W. Callaway Published online: 14 January 2016 p70 | doi:10.1038/nrcardio.2015.201 The proportion of the lay population that is trained in cardiopulmonary resuscitation is closely linked to the probability of an individual surviving cardiac arrest. New mobile-assisted technologies might increase the benefit of population-based training. Furthermore, admission of patients to specialized hospitals can increase the likelihood of survival. Full Text | PDF
Genetics of CVD in 2015: Using genomic approaches to identify CVD-causing variants Donna K. Arnett Published online: 14 January 2016 p72 | doi:10.1038/nrcardio.2015.202 Cardiovascular genomics has evolved substantially in the past 2 decades. Numerous papers published in 2015 demonstrate that new genomic approaches, often used synergistically, can yield noteworthy findings. A range of laboratory, analytical, and bioinformatic techniques to uncover genetic contributors to coronary artery disease, myocardial infarction, and dilated cardiomyopathy are described. Full Text | PDF
Dyslipidaemia in 2015: Advances in treatment of dyslipidaemia Scott M. Grundy Published online: 14 January 2016 p74 | doi:10.1038/nrcardio.2015.208 Statins remain the first-line therapy for dyslipidaemia. In 2015, however, effectiveness in reducing serum cholesterol levels and decreasing rates of cardiovascular disease in combination with statins has been demonstrated for two new classes of drugs: cholesterol-absorption inhibitors and PCSK9 inhibitors. The latter rival statins in their capacity to lower cholesterol levels. Full Text | PDF
Heart failure in 2015: Better results from prevention than from additional treatment Lars Køber Published online: 04 January 2016 p75 | doi:10.1038/nrcardio.2015.205 In 2015, success in clinical trials in heart failure was obtained mainly from prevention, whereas treatments showed neutral or even adverse effects. A new glucose-lowering medication prevents development of heart failure. Treating central sleep apnoea might be harmful. In Chagas cardiomyopathy, benznidazole treatment did not affect long-term clinical outcomes. Full Text | PDF
REVIEWS		Top
Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis Kazuyuki Yahagi, Frank D. Kolodgie, Fumiyuki Otsuka, Aloke V. Finn, Harry R. Davis, Michael Joner & Renu Virmani Published online: 27 October 2015 p79 | doi:10.1038/nrcardio.2015.164 The structural and temporal characteristics of atherosclerotic plaques differ between native coronary artery disease, vein-graft atherosclerosis, and in-stent neoatherosclerosis. In this Review, Yahagi et al. compare the shared and divergent morphological features, giving insight into the pathogenesis of atheroma formation, and provide an updated classification scheme for atherosclerotic lesions. Abstract | Full Text | PDF
Recurrent pericarditis: new and emerging therapeutic options Massimo Imazio, George Lazaros, Antonio Brucato & Fiorenzo Gaita Published online: 11 August 2015 p99 | doi:10.1038/nrcardio.2015.115 Many patients with pericarditis experience recurrent episodes. In this Review, Imazio et al. emphasize the importance of identifying the aetiology of the disease, and summarize the available evidence for the various treatment options. First-line anti-inflammatory therapy involves aspirin, NSAIDs, and colchicine; additional and alternative options include corticosteroids, anakinra, azathioprine, and intravenous immunoglobulins. Abstract | Full Text | PDF
Targeting BMP signalling in cardiovascular disease and anaemia Nicholas W. Morrell, Donald B. Bloch, Peter ten Dijke, Marie-Jose T. H. Goumans, Akiko Hata, Jim Smith, Paul B. Yu & Kenneth D. Bloch Published online: 13 October 2015 p106 | doi:10.1038/nrcardio.2015.156 Bone morphogenetic proteins (BMPs) and their receptors are important for the development and modulation of cardiovascular structure and function. Morrell and colleagues discuss physiological roles and regulation of BMP signalling in cardiovascular health and disease, and based on this advancing knowledge, they suggest opportunities for therapeutic intervention for a range of cardiovascular diseases, such as atherosclerosis and pulmonary arterial hypertension. Abstract | Full Text | PDF
Erratum: MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis Andreas Schober, Maliheh Nazari-Jahantigh & Christian Weber Published online: 03 December 2015 p120 | doi:10.1038/nrcardio.2015.190 Full Text | PDF
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Cardiology was previously published as Nature Clinical Practice Cardiovascular Medicine.

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