Scientific Reports Table of Contents e-alert: 19 January 2016

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19 January 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports             Jump to the content that matters to you ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Health Sciences               Biological Sciences ▲ top               dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes ▶     Jagpreet Singh Nanda, Rahul Kumar, Gajendra P. S. Raghava     We have developed a database called dbEM (database of Epigenetic Modifiers) to maintain the genomic information of about 167 epigenetic modifiers/proteins, which are considered …             Cells and Stripes: A novel quantitative photo-manipulation technique ▶     Martin Mistrik, Eva Vesela, Tomas Furst et al.     Laser micro-irradiation is a technology widely used in the DNA damage response, checkpoint signaling, chromatin remodeling and related research fields, to assess chromatin …             Global patterns of insect diversification: towards a reconciliation of fossil and molecular evidence? ▶     Fabien L. Condamine, Matthew E. Clapham, Gael J. Kergoat     Macroevolutionary studies of insects at diverse taxonomic scales often reveal dynamic evolutionary patterns, with multiple inferred diversification rate shifts. Responses to …             The nutritional and hedonic value of food modulate sexual receptivity in Drosophila melanogaster females ▶     Jenke A. Gorter, Samyukta Jagadeesh, Christoph Gahr et al.     Food and sex often go hand in hand because of the nutritional cost of reproduction. For Drosophila melanogaster females, this relationship is especially intimate because their …             Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells ▶     Han Wu, Lili Shi, Qing Wang et al.     Mumps virus (MuV) infection frequently causes orchitis and impairs male fertility. However, the mechanisms underlying the innate immune responses to MuV infection in the testis …             Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer ▶     David N. Brown, Irene Caffa, Gabriella Cirmena et al.     SQLE encodes squalene epoxidase, a key enzyme in cholesterol synthesis. SQLE has sporadically been reported among copy-number driven transcripts in multi-omics cancer projects. …             Gel electrophoresis in a polyvinylalcohol coated fused silica capillary for purity assessment of modified and secondary-structured oligo- and polyribonucleotides ▶     Martyna Barciszewska, Agnieszka Sucha, Sandra Balabanska et al.     Application of a polyvinylalcohol-coated (PVA-coated) capillary in capillary gel electrophoresis (CGE) enables the selective separation of oligoribonucleotides and their …             Nested Machine Learning Facilitates Increased Sequence Content for Large-Scale Automated High Resolution Melt Genotyping ▶     Stephanie I. Fraley, Pornpat Athamanolap, Billie J. Masek et al.     High Resolution Melt (HRM) is a versatile and rapid post-PCR DNA analysis technique primarily used to differentiate sequence variants among only a few short amplicons. We …             A network analysis of cofactor-protein interactions for analyzing associations between human nutrition and diseases ▶     Marie Pier Scott-Boyer, Sebastien Lacroix, Marco Scotti et al.     The involvement of vitamins and other micronutrients in intermediary metabolism was elucidated in the mid 1900's at the level of individual biochemical reactions. Biochemical …             Enhanced photoelectrochemical aptasensing platform for TXNDC5 gene based on exciton energy transfer between NCQDs and TiO2 nanorods ▶     Xuehui Pang, Lin Wang, Hongmin Ma et al.     The over expression of thioredoxin domain-containing protein 5 (TXNDC5) can promote the growth of castration-resistant prostate cancer (CRPC). A novel highly sensitive …             Structure of the transmembrane domain of human nicastrin-a component of γ-secretase ▶     Yan Li, Lynette Sin Yee Liew, Qingxin Li et al.     Nicastrin is the largest component of γ-secretase that is an intramembrane protease important in the development of Alzheimer's disease. Nicastrin contains a large extracellular …             The effects of organic solvents on the folding pathway and associated thermodynamics of proteins: a microscopic view ▶     Yuqi Yu, Jinan Wang, Qiang Shao et al.     Protein folding is subject to the effects of solvation environment. A variety of organic solvents are used as additives for in vitro refolding of denatured proteins. Examination …             Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells ▶     Soichiro Sonoda, Haruyoshi Yamaza, Lan Ma et al.     Clinically, irreversible pulpitis is treated by the complete removal of pulp tissue followed by replacement with artificial materials. There is considered to be a high potential …             A CRISPR/Cas9 and Cre/Lox system-based express vaccine development strategy against re-emerging Pseudorabies virus ▶     Xun Liang, Leqiang Sun, Teng Yu et al.     Virus evolves rapidly to escape vaccine-induced immunity, posing a desperate demand for efficient vaccine development biotechnologies. Here we present an express vaccine …             Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4+and CD8+T-cell responses in older adults positively correlates with response size ▶     Yen-Ling Chiu, Chung-Hao Lin, Bo-Yi Sung et al.     Cytomegalovirus (CMV) infection is one of the most common persistent viral infections in humans worldwide and is epidemiologically associated with many adverse health …             Fosfomycin enhances phagocyte-mediated killing of Staphylococcus aureus by extracellular traps and reactive oxygen species ▶     Fengge Shen, Xudong Tang, Wei Cheng et al.     The successful treatment of bacterial infections is the achievement of a synergy between the host's immune defences and antibiotics. Here, we examined whether fosfomycin (FOM) …             Sulindac, a non-steroidal anti-inflammatory drug, mediates breast cancer inhibition as an immune modulator ▶     Tao Yin, Guoping Wang, Tinghong Ye et al.     The cooperation of adaptive immunity with pharmacologic therapy influences cancer progression. Though non-steroidal anti-inflammatory drugs (NSAIDs) have a long history of cancer …             Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice ▶     Kosuke Watari, Tomohiro Shibata, Hiroshi Nabeshima et al.     N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study …             Extrapolating microdomain Ca2+ dynamics using BK channels as a Ca2+ sensor ▶     Panpan Hou, Feng Xiao, Haowen Liu et al.     Ca2+ ions play crucial roles in mediating physiological and pathophysiological processes, yet Ca2+ dynamics local to the Ca2+ source, either from influx via calcium permeable ion …             Auranofin-loaded nanoparticles as a new therapeutic tool to fight streptococcal infections ▶     Roberto Diez-Martinez, Esther Garcia-Fernandez, Miguel Manzano et al.     Drug-loaded nanoparticles (NPs) can improve infection treatment by ensuring drug concentration at the right place within the therapeutic window. Poly(lactic-co-glycolic acid) …             Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program ▶     Ho-Keun Kwon, Gi-Cheon Kim, Ji Sun Hwang et al.     Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor …             An evaluation of the accuracy and speed of metagenome analysis tools ▶     Stinus Lindgreen, Karen L. Adair, Paul P. Gardner     Metagenome studies are becoming increasingly widespread, yielding important insights into microbial communities covering diverse environments from terrestrial and aquatic …             Comparative transcriptome analysis highlights the crucial roles of photosynthetic system in drought stress adaptation in upland rice ▶     Zheng-Feng Zhang, Yuan-Yuan Li, Ben-Ze Xiao     Drought stress is one of the major adverse environmental factors reducing plant growth. With the aim to elucidate the underlying molecular basis of rice response to drought …             The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels ▶     Szu-Han Chen, Ssu-Ju Fu, Jing-Jia Huang et al.     Voltage-gated potassium (Kv) channels are essential for setting neuronal membrane excitability. Mutations in human Kv1.1 channels are linked to episodic ataxia type 1 (EA1). The …             Structural understanding of the recycling of oxidized ascorbate by dehydroascorbate reductase (OsDHAR) from Oryza sativa L. japonica ▶     Hackwon Do, Il-Sup Kim, Byoung Wook Jeon et al.     Dehydroascorbate reductase (DHAR) is a key enzyme involved in the recycling of ascorbate, which catalyses the glutathione (GSH)-dependent reduction of oxidized ascorbate …             Interplay Between Intracellular Ca2+ Oscillations and Ca2+-stimulated Mitochondrial Metabolism ▶     Benjamin Wacquier, Laurent Combettes, Guy Tran Van Nhieu et al.     Oscillations of cytosolic Ca2+ concentration are a widespread mode of signalling. Oscillatory spikes rely on repetitive exchanges of Ca2+ between the endoplasmic reticulum (ER) …             Stable multilineage xenogeneic replacement of definitive hematopoiesis in adult zebrafish ▶     Isabell Hess, Thomas Boehm     Bony fishes are the most numerous and phenotypically diverse group of vertebrates inhabiting our planet, making them an ideal target for identifying general principles of tissue …             The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways ▶     M. Duhamel, F. Rodet, A. N. Murgoci et al.     Endosomal TLR9 is considered as a potent anti-tumoral therapeutic target. Therefore, it is crucial to decipher the mechanisms controlling its trafficking since it determines TLR9 …             Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism ▶     Sebastian Krossa, Annette Faust, Dietrich Ober et al.     The highly conserved bacterial homospermidine synthase (HSS) is a key enzyme of the polyamine metabolism of many proteobacteria including pathogenic strains such as Legionella …             Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: "Herniated" HDL, a common feature in diabetes ▶     Nuria Amigo, Roger Mallol, Mercedes Heras et al.     Recent studies have shown that pharmacological increases in HDL cholesterol concentrations do not necessarily translate into clinical benefits for patients, raising concerns …             Global nitrogen budgets in cereals: A 50-year assessment for maize, rice, and wheat production systems ▶     J. K. Ladha, A. Tirol-Padre, C. K. Reddy et al.     Industrially produced N-fertilizer is essential to the production of cereals that supports current and projected human populations. We constructed a top-down global N budget for …             Food supply confers calcifiers resistance to ocean acidification ▶     Laura Ramajo, Elia Perez-Leon, Iris E. Hendriks et al.     Invasion of ocean surface waters by anthropogenic CO2 emitted to the atmosphere is expected to reduce surface seawater pH to 7.8 by the end of this century compromising marine …             Enhancement of human sodium iodide symporter gene therapy for breast cancer by HDAC inhibitor mediated transcriptional modulation ▶     Madhura G. Kelkar, Kalimuthu Senthilkumar, Smita Jadhav et al.     The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate …             A gigantic new dinosaur from Argentina and the evolution of the sauropod hind foot ▶     Bernardo J. Gonzalez Riga, Matthew C. Lamanna, Leonardo D. Ortiz David et al.     Titanosauria is an exceptionally diverse, globally-distributed clade of sauropod dinosaurs that includes the largest known land animals. Knowledge of titanosaurian pedal …             Isolation of highly enriched primary human microglia for functional studies ▶     Justin Rustenhoven, Thomas I-H Park, Patrick Schweder et al.     Microglia, the resident macrophages of the central nervous system play vital roles in brain homeostasis through clearance of pathogenic material. Microglia are also implicated in …             An integrated Pan-European perspective on coastal Lagoons management through a mosaic-DPSIR approach ▶     Marina Dolbeth, Per Stalnacke, Fatima L. Alves et al.     A decision support framework for the management of lagoon ecosystems was tested using four European Lagoons: Ria de Aveiro (Portugal), Mar Menor (Spain), Tyligulskyi Liman (Uk…             Role of Carbonyl Modifications on Aging-Associated Protein Aggregation ▶     Maya Tanase, Aleksandra M. Urbanska, Valerio Zolla et al.     Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate …             NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea ▶     Yohei Honkura, Hirotaka Matsuo, Shohei Murakami et al.     Noise-induced hearing loss (NIHL) is one of the most common sensorineural hearing deficits. Recent studies have demonstrated that the pathogenesis of NIHL is closely related to …             Effect of spatial constraints on Hardy-Weinberg equilibrium ▶     Yi-Shin Chen, Yi-Cheng Su, Wei Pan     Panmixia is a key issue in maintaining genetic diversity, which facilitates evolutionary potential during environmental changes. Additionally, conservation biologists suggest the …             Soil microbial responses to forest floor litter manipulation and nitrogen addition in a mixed-wood forest of northern China ▶     Xiao-Lu Sun, Jing Zhao, Ye-Ming You et al.     Changes in litterfall dynamics and soil properties due to anthropogenic or natural perturbations have important implications to soil carbon (C) and nutrient cycling via microbial …             Identification of a novel family of carbohydrate-binding modules with broad ligand specificity ▶     Cheng-Jie Duan, Yu-Liang Feng, Qi-Long Cao et al.     Most enzymes that act on carbohydrates include non-catalytic carbohydrate-binding modules (CBMs) that recognize and target carbohydrates. CBMs bring their appended catalytic …             An in vitro reproduction of stress-induced memory defects: Effects of corticoids on dendritic spine dynamics ▶     Shinichi Saito, Satoshi Kimura, Naoki Adachi et al.     Previously, in organotypic slice culture of rodent hippocampus we found that three repeated inductions of LTP, but not a single induction, led to a slow-developing long-lasting …             Single-Cell Electrical Phenotyping Enabling the Classification of Mouse Tumor Samples ▶     Yang Zhao, Mei Jiang, Deyong Chen et al.     Single-cell electrical phenotyping (e.g., specific membrane capacitance (Cm) and cytoplasm conductivity (σp)) has long been regarded as potential label-free biophysical markers …             Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus ▶     Jin-Hyung Lee, Yong-Guy Kim, Shi Yong Ryu et al.     Staphylococcal biofilms are problematic and play a critical role in the persistence of chronic infections because of their abilities to tolerate antimicrobial agents. Thus, the …             Novel Methods of Determining Urinary Calculi Composition: Petrographic Thin Sectioning of Calculi and Nanoscale Flow Cytometry Urinalysis ▶     Carson T Gavin, Sohrab N Ali, Thomas Tailly et al.     Accurate determination of urinary stone composition has significant bearing on understanding pathophysiology, choosing treatment modalities and preventing recurrence. A need …             An early Oligocene fossil demonstrates treeshrews are slowly evolving "living fossils" ▶     Qiang Li, Xijun Ni     Treeshrews are widely considered a "living model" of an ancestral primate, and have long been called "living fossils". Actual fossils of treeshrews, however, are extremely rare. …             Purification and Partial Characterization of a Novel Bacteriocin Synthesized by Lactobacillus paracasei HD1-7 Isolated from Chinese Sauerkraut Juice ▶     Jingping Ge, Yanyang Sun, Xing Xin et al.     Bacteriocins have antimicrobial activities against food-spoiling bacteria and food-borne pathogens. Paracin 1.7, a bacteriocin synthesized by Lactobacillus paracasei HD1-7 …             Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN ▶     Leah Gillespie, Paula Roosendahl, Wy Ching Ng et al.     The ubiquitous presence of cell-surface sialic acid (SIA) has complicated efforts to identify specific transmembrane glycoproteins that function as bone fide entry receptors for …             Cysteine Dioxygenase Type 1 Inhibits Osteogenesis by Regulating Wnt Signaling in Primary Mouse Bone Marrow Stromal Cells ▶     Xuefeng Zhao, Peng Deng, Jie Feng et al.     Mesenchymal stem cells (MSCs) are multipotent cells, which can give rise to variety of cell types, including adipocytes and osteoblasts. Previously, we have shown that cysteine …             Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming ▶     Adele G. Marthaler, Kenjiro Adachi, Ulf Tiemann et al.     Adenoviral early region 1A (E1A) is a viral gene that can promote cellular proliferation and de-differentiation in mammalian cells, features required for the reprogramming of …             Alterations of the volatile metabolome in mouse models of Alzheimer's disease ▶     Bruce A. Kimball, Donald A. Wilson, Daniel W. Wesson     In the present study, we tested whether the volatile metabolome was altered by mutations of the Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and …             The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma ▶     J. C. Coltherd, D. T. Rodgers, R. E. Lawrie et al.     Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, …             Evolutionary Footprints of Short Tandem Repeats in Avian Promoters ▶     Hideaki Abe, Neil J. Gemmell     Short tandem repeats (STRs) or microsatellites are well-known sequence elements that may change the spacing between transcription factor binding sites (TFBSs) in promoter regions …             Comparative transcriptome and metabolome provides new insights into the regulatory mechanisms of accelerated senescence in litchi fruit after cold storage ▶     Ze Yun, Hongxia Qu, Hui Wang et al.     Litchi is a non-climacteric subtropical fruit of high commercial value. The shelf life of litchi fruit under ambient conditions (AC) is approximately 4-6 days. Post-harvest cold …             Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8+ T Lymphocyte Fates ▶     Patrick J. Metz, Justine Lopez, Stephanie H. Kim et al.     Naive CD8+ T lymphocytes responding to microbial pathogens give rise to effector T cells that provide acute defense and memory T cells that provide long-lived immunity. Upon …             Experimental Model for Successful Liver Cell Therapy by Lenti TTR-YapERT2 Transduced Hepatocytes with Tamoxifen Control of Yap Subcellular Location ▶     Mladen Yovchev, Fadi L. Jaber, Zhonglei Lu et al.     Liver repopulation by transplanted hepatocytes has not been achieved previously in a normal liver microenvironment. Here we report that adult rat hepatocytes transduced ex vivo …             Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas ▶     G. Pujadas, S. Cervantes, A. Tutusaus et al.     Transcriptional and signaling networks establish complex cross-regulatory interactions that drive cellular differentiation during development. Using microarrays we identified the …             Focal Adhesion Kinase Regulates Fibroblast Migration via Integrin beta-1 and Plays a Central Role in Fibrosis ▶     Xue-Ke Zhao, Yiju Cheng, Ming Liang Cheng et al.     Lung fibrosis is a major medical problem for the aging population worldwide. Fibroblast migration plays an important role in fibrosis. Focal Adhesion Kinase (FAK) senses the …             Radiation-induced alternative transcription and splicing events and their applicability to practical biodosimetry ▶     Ellina Macaeva, Yvan Saeys, Kevin Tabury et al.     Accurate assessment of the individual exposure dose based on easily accessible samples (e.g. blood) immediately following a radiological accident is crucial. We aimed at …             Whole mitochondrial DNA sequencing in Alpine populations and the genetic history of the Neolithic Tyrolean Iceman ▶     V. Coia, G. Cipollini, P. Anagnostou et al.     The Tyrolean Iceman is an extraordinarily well-preserved natural mummy that lived south of the Alpine ridge ~5,200 years before present (ybp), during the Copper Age. Despite …             Transcriptome responses in alfalfa associated with tolerance to intensive animal grazing ▶     Junjie Wang, Yan Zhao, Ian Ray et al.     Tolerance of alfalfa (Medicago sativa L.) to animal grazing varies widely within the species. However, the molecular mechanisms influencing the grazing tolerant phenotype remain …             DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli ▶     Geraldine Fulcrand, Samantha Dages, Xiaoduo Zhi et al.     Escherichia coli lac repressor (LacI) is a paradigmatic transcriptional factor that controls the expression of lacZYA in the lac operon. This tetrameric protein specifically …             Phytoliths reveal the earliest fine reedy textile in China at the Tianluoshan site ▶     Jianping Zhang, Houyuan Lu, Guoping Sun et al.     Textiles are among the longest and most widespread technologies in human history, although poor preservation of perishable artifacts in Paleolithic and Neolithic contexts makes …             The effect of transcranial direct current stimulation on contrast sensitivity and visual evoked potential amplitude in adults with amblyopia ▶     Zhaofeng Ding, Jinrong Li, Daniel P. Spiegel et al.     Amblyopia is a neurodevelopmental disorder of vision that occurs when the visual cortex receives decorrelated inputs from the two eyes during an early critical period of …             A Search for Blood Biomarkers for Autism: Peptoids ▶     Sayed Zaman, Umar Yazdani, Yan Deng et al.     Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, and restricted, repetitive patterns of …             Architecture and Function of Mechanosensitive Membrane Protein Lattices ▶     Osman Kahraman, Peter D. Koch, William S. Klug et al.     Experiments have revealed that membrane proteins can form two-dimensional clusters with regular translational and orientational protein arrangements, which may allow cells to …             Modular structure of brain functional networks: breaking the resolution limit by Surprise ▶     Carlo Nicolini, Angelo Bifone     The modular organization of brain networks has been widely investigated using graph theoretical approaches. Recently, it has been demonstrated that graph partitioning methods …             Bioactivity of periodontal ligament stem cells on sodium titanate coated with graphene oxide ▶     Qi Zhou, Pishan Yang, Xianlei Li et al.     As a biocompatible and low cytotoxic nanomaterial, graphene oxide (GO) has captured tremendous interests in tissue engineering. However, little is known about the behavior of …             Benchmarking Deep Networks for Predicting Residue-Specific Quality of Individual Protein Models in CASP11 ▶     Tong Liu, Yiheng Wang, Jesse Eickholt et al.     Quality assessment of a protein model is to predict the absolute or relative quality of a protein model using computational methods before the native structure is available. …             Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC ▶     Yi Feng, Yutaka Takebe, Huamian Wei et al.     To determine the origin and evolutionary history of two predominant and closely-related circulating recombinant forms (CRF07_BC and CRF08_BC), recombinant structures and …             Combinatorial Treatment with Apelin-13 Enhances the Therapeutic Efficacy of a Preconditioned Cell-Based Therapy for Peripheral Ischemia ▶     Makoto Samura, Noriyasu Morikage, Kotaro Suehiro et al.     Hypoxic pretreatment of peripheral blood mononuclear cells (PBMNCs) enhances therapeutic angiogenesis in ischemic tissues after cell transplantation. However, newly formed …             METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion ▶     Zhe Zhang, Guojun Zhang, Chuize Kong et al.     The incidence of bladder cancer has increased in the last few decades, thus novel markers for early diagnosis and more efficacious treatment are urgently needed. It found that …             Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-β/Smad pathway in vascular smooth muscle cells ▶     Yaqian Huang, Zhizhou Shen, Qinghua Chen et al.     The study was designed to investigate the role of endogenous sulfur dioxide (SO2) in collagen remodeling and its mechanisms in vascular smooth muscle cells (VSMCs). …             Larval cases of caddisfly (Insecta: Trichoptera) affinity in Early Permian marine environments of Gondwana ▶     Lucas D. Mouro, Michal Zaton, Antonio C.S. Fernandes et al.     Caddisflies (Trichoptera) are small, cosmopolitan insects closely related to the Lepidoptera (moths and butterflies). Most caddisflies construct protective cases during their …             The relationship of spectral sensitivity with growth and reproductive response in avian breeders (Gallus gallus) ▶     Ye-Feng Yang, Jing-Song Jiang, Jin-Ming Pan et al.     A previous study demonstrated that birds that are exposed to light at night develop advanced reproductive systems. However, spectrum might also affect the photoperiodic response …             Lack of effects on key cellular parameters of MRC-5 human lung fibroblasts exposed to 370mT static magnetic field ▶     Stefania Romeo, Anna Sannino, Maria Rosaria Scarfi et al.     The last decades have seen increased interest toward possible adverse effects arising from exposure to intense static magnetic fields. This concern is mainly due to the wider and …             Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism ▶     Chengjian Zhao, Wei Zhang, Yuwei Zhao et al.     The angiogenic switch is an important oncogenic step that determines whether microtumors remain dormant or progresses further. It has been generally perceived that the primary …             Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte ▶     Yan Gu, Mulan He, Xiaoqin Zhou et al.     Mesenchymal stem cell (MSC) transplantation reduces the neurological impairment caused by hypoxic-ischemic brain damage (HIBD) via immunomodulation. In the current study, we …             PCB pollution continues to impact populations of orcas and other dolphins in European waters ▶     Paul D. Jepson, Rob Deaville, Jonathan L. Barber et al.     Organochlorine (OC) pesticides and the more persistent polychlorinated biphenyls (PCBs) have well-established dose-dependent toxicities to birds, fish and mammals in experimental …             DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders ▶     Fan Wang, Hongqin Xu, Hongyu Zhao et al.     DNA methylome alterations in the prefrontal cortex (PFC) may contribute to risk for alcohol use disorders (AUDs). We examined postmortem PFC DNA methylomes of 16 male and seven …             Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells ▶     Leli Zeng, Yu Chen, Jiangping Liu et al.     Cisplatin was the first metal-based therapeutic agent approved for the treatment of human cancers, but its clinical activity is greatly limited by tumor drug resistance. This …             Texture analysis in gel electrophoresis images using an integrative kernel-based approach ▶     Carlos Fernandez-Lozano, Jose A. Seoane, Marcos Gestal et al.     Texture information could be used in proteomics to improve the quality of the image analysis of proteins separated on a gel. In order to evaluate the best technique to identify …             Visual attention modulates the asymmetric influence of each cerebral hemisphere on spatial perception ▶     Meijian Wang, Xiuhai Wang, Lingyan Xue et al.     Although the allocation of brain functions across the two cerebral hemispheres has aroused public interest over the past century, asymmetric interhemispheric cooperation under …             The trade-off between heat tolerance and metabolic cost drives the bimodal life strategy at the air-water interface ▶     Marco Fusi, Stefano Cannicci, Daniele Daffonchio et al.     The principle of oxygen and capacity limitation of thermal tolerance in ectotherms suggests that the long-term upper limits of an organism's thermal niche are equivalent to the …             α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane ▶     Elodie Monsellier, Luc Bousset, Ronald Melki     Fibrillar aggregates involved in neurodegenerative diseases have the ability to spread from one cell to another in a prion-like manner. The underlying molecular mechanisms, in …             Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain ▶     Ting Dong, Weilong Liu, Zhirong Shen et al.     The use of chemoprotective agents to minimize the side effects of the chemotherapy, primarily via activation of the Nrf2 pathway, is an emerging research field, which has …             Vitamin D status predicts reproductive fitness in a wild sheep population ▶     Ian Handel, Kathryn A. Watt, Jill G. Pilkington et al.     Vitamin D deficiency has been associated with the development of many human diseases, and with poor reproductive performance in laboratory rodents. We currently have no idea how …             Quantification of the Metabolic State in Cell-Model of Parkinson's Disease by Fluorescence Lifetime Imaging Microscopy ▶     Sandeep Chakraborty, Fang-Shin Nian, Jin-Wu Tsai et al.     Intracellular endogenous fluorescent co-enzymes, reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), play a pivotal role in cellular …             Genetic affinities of the Jewish populations of India ▶     Gyaneshwer Chaubey, Manvendra Singh, Niraj Rai et al.     Due to the lack of written records or inscription, the origin and affiliation of Indian Jewish populations with other world populations remain contentious. Previous genetic …             Sublethal Dosage of Imidacloprid Reduces the Microglomerular Density of Honey Bee Mushroom Bodies ▶     Yi-Chan Peng, En-Cheng Yang     The dramatic loss of honey bees is a major concern worldwide. Previous studies have indicated that neonicotinoid insecticides cause behavioural abnormalities and have proven that …             Ectopic expression of R3 MYB transcription factor gene OsTCL1 in Arabidopsis, but not rice, affects trichome and root hair formation ▶     Kaijie Zheng, Hainan Tian, Qingnan Hu et al.     In Arabidopsis, a MYB-bHLH-WD40 (MBW) transcriptional activator complex activates the homeodomain protein gene GLABRA2 (GL2), leading to the promotion of trichome formation and …             Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia ▶     Aurelien Ducat, Ludivine Doridot, Rosamaria Calicchio et al.     Preeclampsia is a disease of pregnancy involving systemic endothelial dysfunction. However, cardiovascular consequences of preeclampsia are difficult to analyze in humans. The …             Genomic investigation reveals evolution and lifestyle adaptation of endophytic Staphylococcus epidermidis ▶     Vasvi Chaudhry, Prabhu B. Patil     Staphylococcus epidermidis is a major human associated bacterium and also an emerging nosocomial pathogen. There are reports of its association to rodents, sheep and plants. …             Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses ▶     Julia C. Frei, Elisabeth K. Nyakatura, Samantha E. Zak et al.     Filoviruses (Ebola and Marburg) cause severe hemorrhagic fever. There are five species of ebolavirus; among these, the Ebola (Zaire) and Sudan viruses (EBOV and SUDV, …             Psmir: a database of potential associations between small molecules and miRNAs ▶     Fanlin Meng, Jing Wang, Enyu Dai et al.     miRNAs are key post-transcriptional regulators of many essential biological processes, and their dysregulation has been validated in almost all human cancers. Restoring …             An efficient full-length cDNA amplification strategy based on bioinformatics technology and multiplexed PCR methods ▶     Nan Chen, Wei-Min Wang, Huan-Ling Wang     A novel strategy for amplification full-length cDNA and promoter sequences has been developed using bioinformatics technology and multiplexed PCR methods in this study. The …             Bacterial flagellar motility on hydrated rough surfaces controlled by aqueous film thickness and connectedness ▶     Robin Tecon, Dani Or     Recent studies have shown that rates of bacterial dispersion in soils are controlled by hydration conditions that define size and connectivity of the retained aqueous phase. …             Transcriptome analyses reveal genotype- and developmental stage-specific molecular responses to drought and salinity stresses in chickpea ▶     Rohini Garg, Rama Shankar, Bijal Thakkar et al.     Drought and salinity are the major factors that limit chickpea production worldwide. We performed whole transcriptome analyses of chickpea genotypes to investigate the molecular …             Host-associated coral reef microbes respond to the cumulative pressures of ocean warming and ocean acidification ▶     N. S. Webster, A. P. Negri, E. S. Botte et al.     Key calcifying reef taxa are currently threatened by thermal stress associated with elevated sea surface temperatures (SST) and reduced calcification linked to ocean …             PCNA appears in two populations of slow and fast diffusion with a constant ratio throughout S-phase in replicating mammalian cells ▶     Patrick J. M. Zessin, Anje Sporbert, Mike Heilemann     DNA replication is a fundamental cellular process that precedes cell division. Proliferating cell nuclear antigen (PCNA) is a central scaffold protein that orchestrates DNA …             Attentional biases to faces expressing disgust in children with autism spectrum disorders: an exploratory study ▶     Xin Zhao, Peng Zhang, Li Fu et al.     Previous studies on attentional bias towards emotional faces in individuals with autism spectrum disorders (ASD) provided mixed results. This might be due to differences in the …             Performances of survival, feeding behavior, and gene expression in aphids reveal their different fitness to host alteration ▶     Hong Lu, Pengcheng Yang, Yongyu Xu et al.     Insect populations feeding on different plant species are under selection pressure to adapt to these differences. A study integrating elements of the ecology, behavior, and gene …             Establishment of a novel in vitro model of stratified epithelial wound healing with barrier function ▶     Miguel Gonzalez-Andrades, Luis Alonso-Pastor, Jerome Mauris et al.     The repair of wounds through collective movement of epithelial cells is a fundamental process in multicellular organisms. In stratified epithelia such as the cornea and skin, …             Assessing the toxicity of Pb- and Sn-based perovskite solar cells in model organism Danio rerio ▶     Aslihan Babayigit, Dinh Duy Thanh, Anitha Ethirajan et al.     Intensive development of organometal halide perovskite solar cells has lead to a dramatic surge in power conversion efficiency up to 20%. Unfortunately, the most efficient …             Microbial community profiling shows dysbiosis in the lesional skin of Vitiligo subjects ▶     Parul Ganju, Sunil Nagpal, MH Mohammed et al.     Healthy human skin harbours a diverse array of microbes that comprise the skin microbiome. Commensal bacteria constitute an important component of resident microbiome and are …             A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction ▶     Michael A. Kennedy, Tia C. Moffat, Kenneth Gable et al.     Fundamental changes in the composition and distribution of lipids within the brain are believed to contribute to the cognitive decline associated with Alzheimer's disease (AD). …             Evaluating and excluding swap errors in analogue tests of working memory ▶     Paul M Bays     When observers retrieve simple visual features from working memory, two kinds of error are typically confounded in their recall. First, responses reflect noise or variability …             Molecular markers for tolerance of European ash (Fraxinus excelsior) to dieback disease identified using Associative Transcriptomics ▶     Andrea L. Harper, Lea Vig McKinney, Lene Rostgaard Nielsen et al.     Tree disease epidemics are a global problem, impacting food security, biodiversity and national economies. The potential for conservation and breeding in trees is hampered by …             Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells ▶     Andreas Reimer, Aliaksei Vasilevich, Frits Hulshof et al.     It is well established that topographical features modulate cell behaviour, including cell morphology, proliferation and differentiation. To define the effects of topography on …             DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia ▶     Jing Wang, Ke Sun, Yun Shen et al.     Hypodontia is caused by interactions among genetic, epigenetic, and environmental factors during tooth development, but the actual mechanism is unknown. DNA methylation now …             Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy ▶     Marine C C Raman, Pierre J Rizkallah, Ruth Simmons et al.     Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging …             Stochastic expression of a multiple antibiotic resistance activator confers transient resistance in single cells ▶     Imane El Meouche, Yik Siu, Mary J. Dunlop     Transient resistance can allow microorganisms to temporarily survive lethal concentrations of antibiotics. This can be accomplished through stochastic mechanisms, where …             Selective Audiovisual Semantic Integration Enabled by Feature-Selective Attention ▶     Yuanqing Li, Jinyi Long, Biao Huang et al.     An audiovisual object may contain multiple semantic features, such as the gender and emotional features of the speaker. Feature-selective attention and audiovisual semantic …             Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity ▶     Akira Kitamura, Yusaku Nakayama, Ai Shibasaki et al.     A hallmark of amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is formation of inclusion bodies (IBs) from misfolded proteins in neuronal cells. TAR …             Down regulated lncRNA MEG3 eliminates mycobacteria in macrophages via autophagy ▶     Kamlesh Pawar, Carlos Hanisch, Sergio Eliseo Palma Vera et al.     Small non-coding RNA play a major part in host response to bacterial agents. However, the role of long non-coding RNA (lncRNA) in this context remains unknown. LncRNA regulate …             Uncoupling shear and uniaxial elastic moduli of semiflexible biopolymer networks: compression-softening and stretch-stiffening ▶     Anne S. G. van Oosten, Mahsa Vahabi, Albert J. Licup et al.     Gels formed by semiflexible filaments such as most biopolymers exhibit non-linear behavior in their response to shear deformation, e.g., with a pronounced strain stiffening and …             SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis ▶     Viviana P. Ferreira, Vladimir Fazito Vale, Michael K. Pangburn et al.     Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the …             Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries ▶     Longfei Jia, Juan Li, Bin He et al.     Polycystic ovarian syndrome (PCOS) is associated with hyperhomocysteinemia and polycystic ovaries (PCO) usually produce oocytes of poor quality. However, the intracellular …             Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase ▶     Shi-Chong Han, Hui-Chen Guo, Shi-Qi Sun et al.     Virus entry is an attractive target for therapeutic intervention. Here, using a combination of electron microscopy, immunofluorescence assay, siRNA interference, specific …             Venturing in coral larval chimerism: a compact functional domain with fostered genotypic diversity ▶     Baruch Rinkevich, Lee Shaish, Jacob Douek et al.     The globally distributed coral species Pocillopora damicornis is known to release either sexual or asexual derived planula-larvae in various reef locations. Using microsatellite …             Large molecular systems landscape uncovers T cell trapping in human skin cancer ▶     Reyk Hillert, Anne Gieseler, Andreas Krusche et al.     Immune surveillance of tumour cells is an important function of CD8 T lymphocytes, which has failed in cancer for reasons still unknown in many respect but mainly related to …             An innovative platform for quick and flexible joining of assorted DNA fragments ▶     Henrique Cestari De Paoli, Gerald A. Tuskan, Xiaohan Yang     Successful synthetic biology efforts rely on conceptual and experimental designs in combination with testing of multi-gene constructs. Despite recent progresses, several …             FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin ▶     Shizhi Wang, Shenshen Wu, Qingtao Meng et al.     FAS rs2234767 (-1377G>A), rs1800682 (-670A>G) and FASLG rs763110 (-844C>T) promoter polymorphisms can influence transcriptional activities of the genes and thus multiple …             Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization ▶     Eva Auffenberg, Angela Jurik, Corinna Mattusch et al.     Manipulating the function of neurons and circuits that translate electrical and chemical signals into behavior represents a major challenges in neuroscience. In addition to …             Polysaccharide-based Noncovalent Assembly for Targeted Delivery of Taxol ▶     Yang Yang, Ying-Ming Zhang, Yong Chen et al.     The construction of synthetic straightforward, biocompatible and biodegradable targeted drug delivery system with fluorescent tracking abilities, high anticancer activities and …             Support for the Microgenderome: Associations in a Human Clinical Population ▶     Amy Wallis, Henry Butt, Michelle Ball et al.     The 'microgenderome' provides a paradigm shift that highlights the role of sex differences in the host-microbiota interaction relevant for autoimmune and neuro-immune conditions. …             Levels of maternal care in dogs affect adult offspring temperament ▶     Pernilla Foyer, Erik Wilsson, Per Jensen     Dog puppies are born in a state of large neural immaturity; therefore, the nervous system is sensitive to environmental influences early in life. In primates and rodents, early …             Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea ▶     Romano Mwirichia, Intikhab Alam, Mamoon Rashid et al.     The candidate Division MSBL1 (Mediterranean Sea Brine Lakes 1) comprises a monophyletic group of uncultured archaea found in different hypersaline environments. Previous studies …             Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated A β-peptide ▶     Georg Meisl, Xiaoting Yang, Birgitta Frohm et al.     Disease related mutations and environmental factors are key determinants of the aggregation mechanism of the amyloid-β peptide implicated in Alzheimer's disease. Here we present …                     Chemical Sciences ▲ top               Disorder and defects are not intrinsic to boron carbide ▶     Swastik Mondal, Elena Bykova, Somnath Dey et al.     A unique combination of useful properties in boron-carbide, such as extreme hardness, excellent fracture toughness, a low density, a high melting point, thermoelectricity, …             Carbon incorporation effects and reaction mechanism of FeOCl cathode materials for chloride ion batteries ▶     Xiangyu Zhao, Qiang Li, Tingting Yu et al.     Metal oxychlorides are proved to be new cathode materials for chloride ion batteries. However, this kind of cathode materials is still in a very early stage of research and …             Ptychographic Imaging of Branched Colloidal Nanocrystals Embedded in Free-Standing Thick Polystyrene Films ▶     Liberato De Caro, Davide Altamura, Milena Arciniegas et al.     Research on composite materials is facing, among others, the challenging task of incorporating nanocrystals, and their superstructures, in polymer matrices. Electron microscopy …             Polarized Raman scattering study of kesterite type Cu2ZnSnS4 single crystals ▶     Maxim Guc, Sergiu Levcenko, Ivan V. Bodnar et al.     A non-destructive Raman spectroscopy has been widely used as a complimentary method to X-ray diffraction characterization of Cu2ZnSnS4 (CZTS) thin films, yet our knowledge of the …             Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine ▶     Lihua Lu, Hai-Jing Zhong, Bingyong He et al.     A panel of six luminescent iridium(III) complexes were synthesized and evaluated for their ability to act as G-quadruplex-selective probes. The novel iridium(III) complex 1 was …             Magnetic MoS2 pizzas and sandwiches with Mnn (n=1-4) cluster toppings and fillings: A first-principles investigation ▶     Meng Zhang, Zhongjia Huang, Xiao Wang et al.     The inorganic layered crystal (ILC) MoS2 in low dimensions is considered as one of the most promising and efficient semiconductors. To enable the magnetism and keep intrinsic …             Fabrication of Wide-Range-Visible Photocatalyst Bi2WO6-x nanoplates via Surface Oxygen Vacancies ▶     Yanhui Lv, Wenqing Yao, Ruilong Zong et al.     Bi2WO6 as a high visible-light-driven catalyst has been aroused broad interest. However, it can only be excitated by the light with &lamda;<450nm and the solar energy utilization …             Graphene/GaSe-Nanosheet Hybrid: Towards High Gain and Fast Photoresponse ▶     Rongtao Lu, Jianwei Liu, Hongfu Luo et al.     While high photoconductive gain has been recently achieved in graphene-based hybrid phototransistors using semiconductor two-dimensional transition/post-transition metal …             Perovskite LaFeO3/montmorillonite nanocomposites: synthesis, interface characteristics and enhanced photocatalytic activity ▶     Kang Peng, Liangjie Fu, Huaming Yang et al.     Perovskite LaFeO3/montmorillonite nanocomposites (LaFeO3/MMT) have been successfully prepared via assembling LaFeO3 nanoparticles on the surface of montmorillonite with citric …             Matrix-Assisted Plasma Atomization Emission Spectrometry for Surface Sampling Elemental Analysis ▶     Xin Yuan, Xuefang Zhan, Xuemei Li et al.     An innovative technology has been developed involving a simple and sensitive optical spectrometric method termed matrix-assisted plasma atomization emission spectrometry (MAPAES) …             Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells ▶     Leli Zeng, Yu Chen, Jiangping Liu et al.     Cisplatin was the first metal-based therapeutic agent approved for the treatment of human cancers, but its clinical activity is greatly limited by tumor drug resistance. This …             Crystal-Size Effects on Carbon Dioxide Capture of a Covalently Alkylamine-Tethered Metal-Organic Framework Constructed by a One-Step Self-Assembly ▶     Yun Kyeong Kim, Sung-min Hyun, Jae Hwa Lee et al.     To enhance the carbon dioxide (CO2) uptake of metal-organic frameworks (MOFs), amine functionalization of their pore surfaces has been studied extensively. In general, …             High Efficiency Dye-sensitized Solar Cells Constructed with Composites of TiO2 and the Hot-bubbling Synthesized Ultra-Small SnO2 Nanocrystals ▶     Xiaoli Mao, Ru Zhou, Shouwei Zhang et al.     An efficient photo-anode for the dye-sensitized solar cells (DSSCs) should have features of high loading of dye molecules, favorable band alignments and good efficiency in …             Accurate quantification of creatinine in serum by coupling a measurement standard to extractive electrospray ionization mass spectrometry ▶     Keke Huang, Ming Li, Hongmei Li et al.     Ambient ionization (AI) techniques have been widely used in chemistry, medicine, material science, environmental science, forensic science. AI takes advantage of direct …             Polysaccharide-based Noncovalent Assembly for Targeted Delivery of Taxol ▶     Yang Yang, Ying-Ming Zhang, Yong Chen et al.     The construction of synthetic straightforward, biocompatible and biodegradable targeted drug delivery system with fluorescent tracking abilities, high anticancer activities and …             Synthesis, optical properties, and helical self-assembly of a bivaline-containing tetraphenylethene ▶     Hongkun Li, Xiaoyan Zheng, Huimin Su et al.     A chiral tetraphenylethene derivative with two valine-containing attachments (TPE-DVAL), was synthesized by Cu(I)-catalyzed azide-alkyne "click" reaction. The optical properties …             The Mesoscopic Electrochemistry of Molecular Junctions ▶     Paulo R. Bueno, Tiago A. Benites, Jason J. Davis     Within the context of an electron dynamic (time-dependent) perspective and a voltage driving force acting to redistribute electrons between metallic and addressable molecular …             Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide ▶     Georg Meisl, Xiaoting Yang, Birgitta Frohm et al.     Disease related mutations and environmental factors are key determinants of the aggregation mechanism of the amyloid-β peptide implicated in Alzheimer's disease. Here we present …                       Open for Submissions Molecular Therapy — Oncolytics is an online-only, open access journal, focusing on the development and clinical testing of viral, cellular, and other biological therapies targeting cancer. Explore the benefits of submitting your next research article.               Physical Sciences ▲ top               Aligned silver nanowire-based transparent electrodes for engineering polarisation-selective optoelectronics ▶     Byoungchoo Park, In-Gon Bae, Yoon Ho Huh     We herein report on a remarkably simple, fast, and economic way of fabricating homogeneous and well oriented silver nanowires (AgNWs) that exhibit strong in-plane electrical and …             Evidencing the existence of exciting half-metallicity in two-dimensional TiCl3 and VCl3 sheets ▶     Yungang Zhou, Haifeng Lu, Xiaotao Zu et al.     Half-metallicity combined with wide half-metallic gap, unique ferromagnetic character and high Curie temperature has become a key driving force to develop next-generation …             On-chip integratable all-optical quantizer using strong cross-phase modulation in a silicon-organic hybrid slot waveguide ▶     Zhe Kang, Jinhui Yuan, Xianting Zhang et al.     High performance all-optical quantizer based on silicon waveguide is believed to have significant applications in photonic integratable optical communication links, optical …             Disorder and defects are not intrinsic to boron carbide ▶     Swastik Mondal, Elena Bykova, Somnath Dey et al.     A unique combination of useful properties in boron-carbide, such as extreme hardness, excellent fracture toughness, a low density, a high melting point, thermoelectricity, …             Polarized Raman scattering study of kesterite type Cu2ZnSnS4 single crystals ▶     Maxim Guc, Sergiu Levcenko, Ivan V. Bodnar et al.     A non-destructive Raman spectroscopy has been widely used as a complimentary method to X-ray diffraction characterization of Cu2ZnSnS4 (CZTS) thin films, yet our knowledge of the …             Bi deficiency-tuned functionality in multiferroic Bi1-δFe0.95Mn0.05O3 films ▶     Jingyi Chen, Yao Wang, Hui Wang et al.     Structural evolution and ferroelectric (FE)-to-antiferroelectric (AFE) transition behaviors were observed in Bi1-δFe0.95Mn0.05O3 (100)-textured films with a carefully controlled …             Magnetic MoS2 pizzas and sandwiches with Mnn (n=1-4) cluster toppings and fillings: A first-principles investigation ▶     Meng Zhang, Zhongjia Huang, Xiao Wang et al.     The inorganic layered crystal (ILC) MoS2 in low dimensions is considered as one of the most promising and efficient semiconductors. To enable the magnetism and keep intrinsic …             A New Raman Metric for the Characterisation of Graphene oxide and its Derivatives ▶     Alice A. K. King, Benjamin R. Davies, Nikan Noorbehesht et al.     Raman spectroscopy is among the primary techniques for the characterisation of graphene materials, as it provides insights into the quality of measured graphenes including their …             Ptychographic Imaging of Branched Colloidal Nanocrystals Embedded in Free-Standing Thick Polystyrene Films ▶     Liberato De Caro, Davide Altamura, Milena Arciniegas et al.     Research on composite materials is facing, among others, the challenging task of incorporating nanocrystals, and their superstructures, in polymer matrices. Electron microscopy …             Exotic vortex lattices in a rotating binary dipolar Bose-Einstein condensate ▶     Xiao-Fei Zhang, Lin Wen, Cai-Qing Dai et al.     In the last decade, considerable advances have been made in the investigation of dipolar quantum gases. Previous theoretical investigations of a rotating binary dipolar …             Fabrication of Wide-Range-Visible Photocatalyst Bi2WO6-x nanoplates via Surface Oxygen Vacancies ▶     Yanhui Lv, Wenqing Yao, Ruilong Zong et al.     Bi2WO6 as a high visible-light-driven catalyst has been aroused broad interest. However, it can only be excitated by the light with λ<450nm and the solar energy utilization …             Graphene/GaSe-Nanosheet Hybrid: Towards High Gain and Fast Photoresponse ▶     Rongtao Lu, Jianwei Liu, Hongfu Luo et al.     While high photoconductive gain has been recently achieved in graphene-based hybrid phototransistors using semiconductor two-dimensional transition/post-transition metal …             Vertical La0.7Ca0.3MnO3 nanorods tailored by high magnetic field assisted pulsed laser deposition ▶     Kejun Zhang, Jianming Dai, Xuebin Zhu et al.     La0.7Ca0.3MnO3 (LCMO) thin films on (LaAlO3)0.3(Sr2AlTaO6)0.7 (001) [LSAT (001)] single crystal substrates have been prepared by high magnetic field assisted pulsed laser …             Perovskite LaFeO3/montmorillonite nanocomposites: synthesis, interface characteristics and enhanced photocatalytic activity ▶     Kang Peng, Liangjie Fu, Huaming Yang et al.     Perovskite LaFeO3/montmorillonite nanocomposites (LaFeO3/MMT) have been successfully prepared via assembling LaFeO3 nanoparticles on the surface of montmorillonite with citric …             Carbon incorporation effects and reaction mechanism of FeOCl cathode materials for chloride ion batteries ▶     Xiangyu Zhao, Qiang Li, Tingting Yu et al.     Metal oxychlorides are proved to be new cathode materials for chloride ion batteries. However, this kind of cathode materials is still in a very early stage of research and …             Anisotropic Effects on the Thermoelectric Properties of Highly Oriented Electrodeposited Bi2Te3 Films ▶     Cristina V. Manzano, Begona Abad, Miguel Munoz Rojo et al.     Highly oriented [1 1 0] Bi2Te3 films were obtained by pulsed electrodeposition. The structure, composition, and morphology of these films were characterized. The thermoelectric …             Locating influential nodes in complex networks ▶     Fragkiskos D. Malliaros, Maria-Evgenia G. Rossi, Michalis Vazirgiannis     Understanding and controlling spreading processes in networks is an important topic with many diverse applications, including information dissemination, disease propagation and …             Direct measurement of nonlocal entanglement of two-qubit spin quantum states ▶     Liu-Yong Cheng, Guo-Hui Yang, Qi Guo et al.     We propose efficient schemes of direct concurrence measurement for two-qubit spin and photon-polarization entangled states via the interaction between single-photon pulses and …             Single Droplet on Micro Square-Post Patterned Surfaces - Theoretical Model and Numerical Simulation ▶     Y. Q. Zu, Y. Y. Yan     In this study, the wetting behaviors of single droplet on a micro square-post patterned surface with different geometrical parameters are investigated theoretically and …             A Novel Equivalent Agglomeration Model for Heat Conduction Enhancement in Nanofluids ▶     Jize Sui, Liancun Zheng, Xinxin Zhang et al.     We propose a multilevel equivalent agglomeration (MEA) model in which all particles in an irregular cluster are treated as a new particle with equivalent volume, the liquid …             Impurity Resonant States p-type Doping in Wide-Band-Gap Nitrides ▶     Zhiqiang Liu, Xiaoyan Yi, Zhiguo Yu et al.     In this work, a new strategy for achieving efficient p-type doping in high bandgap nitride semiconductors to overcome the fundamental issue of high activation energy has been …             Ion-beam assisted laser fabrication of sensing plasmonic nanostructures ▶     Aleksandr Kuchmizhak, Stanislav Gurbatov, Oleg Vitrik et al.     Simple high-performance, two-stage hybrid technique was developed for fabrication of different plasmonic nanostructures, including nanorods, nanorings, as well as more complex …             Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine ▶     Lihua Lu, Hai-Jing Zhong, Bingyong He et al.     A panel of six luminescent iridium(III) complexes were synthesized and evaluated for their ability to act as G-quadruplex-selective probes. The novel iridium(III) complex 1 was …             X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study ▶     Hanwook Park, Eunseop Yeom, Sang Joon Lee     X-ray PIV measurement is a noninvasive approach to measure opaque blood flows. However, it is not easy to measure real pulsatile blood flows in the blood vessels located at deep …             Thermally triggered phononic gaps in liquids at THz scale ▶     Dima Bolmatov, Mikhail Zhernenkov, Dmitry Zav'yalov et al.     In this paper we present inelastic X-ray scattering experiments in a diamond anvil cell and molecular dynamic simulations to investigate the behavior of phononic excitations in …             Revisiting the concept of a symmetric index of agreement for continuous datasets ▶     Gregory Duveiller, Dominique Fasbender, Michele Meroni     Quantifying how close two datasets are to each other is a common and necessary undertaking in scientific research. The Pearson product-moment correlation coefficient r is a …             Nanofibril scaffold assisted MEMS artificial hydrogel neuromasts for enhanced sensitivity flow sensing ▶     Ajay Giri Prakash Kottapalli, Meghali Bora, Mohsen Asadnia et al.     We present the development and testing of superficial neuromast-inspired flow sensors that also attain high sensitivity and resolution through a biomimetic hyaulronic acid-based …             Magnetic phase separation in double layer ruthenates Ca3(Ru1-xTix)2O7 ▶     Jin Peng, J. Y. Liu, J. Hu et al.     A phase transition from metallic AFM-b antiferromagnetic state to Mott insulating G-type antiferromagnetic (G-AFM) state was found in Ca3(Ru1-xTix)2O7 at about x=0.03 in our …             One-Minute Room-Temperature Transfer-Free Production of Mono- and Few-Layer Polycrystalline Graphene on Various Substrates ▶     Shenglin Jiang, Yike Zeng, Wenli Zhou et al.     Graphene deposited on various substrates has attracted the attention of the scientific and technical communities for use in a wide range of applications. Graphene on substrates …             Mapping of Low-Frequency Raman Modes in CVD-Grown Transition Metal Dichalcogenides: Layer Number, Stacking Orientation and Resonant Effects ▶     Maria O'Brien, Niall McEvoy, Damien Hanlon et al.     Layered inorganic materials, such as the transition metal dichalcogenides (TMDs), have attracted much attention due to their exceptional electronic and optical properties. …             Fabrication of in-situ grown graphene reinforced Cu matrix composites ▶     Yakun Chen, Xiang Zhang, Enzuo Liu et al.     Graphene/Cu composites were fabricated through a graphene in-situ grown approach, which involved ball-milling of Cu powders with PMMA as solid carbon source, in-situ growth of …             Matrix-Assisted Plasma Atomization Emission Spectrometry for Surface Sampling Elemental Analysis ▶     Xin Yuan, Xuefang Zhan, Xuemei Li et al.     An innovative technology has been developed involving a simple and sensitive optical spectrometric method termed matrix-assisted plasma atomization emission spectrometry (MAPAES) …             Graphene quantum dots as the electrolyte for solid state supercapacitors ▶     Su Zhang, Yutong Li, Huaihe Song et al.     We propose that graphene quantum dots (GQDs) with a sufficient number of acidic oxygen-bearing functional groups such as -COOH and -OH can serve as solution- and solid- type …             Geometry Dependent Evolution of the Resonant Mode in ZnO Elongated Hexagonal Microcavity ▶     Hongxing Dong, Yang Liu, Shulin Sun et al.     We have developed a novel but simple approach to obtain ZnO microcombs with parallelogram stems and elongated hexagonal branches. We found that the present elongated hexagonal …             Angle Insensitive Color Filters in Transmission Covering the Visible Region ▶     Kening Mao, Weidong Shen, Chenying Yang et al.     Angle insensitive color filter based on Metal-SiOx-Metal structure is proposed in this paper, which can keep the same perceived transmitted color when the incidence angle changes …             Bonding and Anti-bonding Modes of Plasmon Coupling Effects in TiO2-Ag Core-shell Dimers ▶     Quanshui Li, Zhili Zhang     Bonding and anti-bonding modes of plasmon coupling effects are numerically investigated in TiO2-Ag core-shell nano dimers. First, splitting phenomena of the coupled anti-bonding …             Generation of attosecond electron packets via conical surface plasmon electron acceleration ▶     S. R. Greig, A. Y. Elezzabi     We present a method for the generation of high kinetic energy attosecond electron packets via magnetostatic and aperture filtering of conical surface plasmon (SP) accelerated …             Two-dimensional Topological Crystalline Insulator Phase in Sb/Bi Planar Honeycomb with Tunable Dirac Gap ▶     Chia-Hsiu Hsu, Zhi-Quan Huang, Christian P. Crisostomo et al.     We predict planar Sb/Bi honeycomb to harbor a two-dimensional (2D) topological crystalline insulator (TCI) phase based on first-principles computations. Although buckled Sb and …             Benchmarking Deep Networks for Predicting Residue-Specific Quality of Individual Protein Models in CASP11 ▶     Tong Liu, Yiheng Wang, Jesse Eickholt et al.     Quality assessment of a protein model is to predict the absolute or relative quality of a protein model using computational methods before the native structure is available. …             Transparent superwetting nanofilms with enhanced durability at model physiological condition ▶     Sunghee Hwangbo, Jiwoong Heo, Xiangde Lin et al.     There have been many studies on superwetting surfaces owing to the variety of their potential applications. There are some drawbacks to developing these films for biomedical …             Facile Synthesis of Non-Graphitizable Polypyrrole-Derived Carbon/Carbon Nanotubes for Lithium-ion Batteries ▶     Bo Jin, Fan Gao, Yong-Fu Zhu et al.     Graphite is usually used as an anode material in the commercial lithium ion batteries (LIBs). The relatively low lithium storage capacity of 372mAh g-1 and the confined rate …             Harnessing click detectors for the genuine characterization of light states ▶     Rene Heilmann, Jan Sperling, Armando Perez-Leija et al.     The key requirement for harnessing the quantum properties of light is the capability to detect and count individual photons. Of particular interest are photon-number-resolving …             Water as an agent for the morphology modification of metal oxalate materials on the nanoscale: from sheets to rods ▶     Minog Kim, YooJin Kim, WonJong Kwon et al.     A number of approaches have been used to control the shape of metal oxalates, which often used as precursors for metal oxide nanomaterials. However, attempts to use water as a …             Effect of spatial constraints on Hardy-Weinberg equilibrium ▶     Yi-Shin Chen, Yi-Cheng Su, Wei Pan     Panmixia is a key issue in maintaining genetic diversity, which facilitates evolutionary potential during environmental changes. Additionally, conservation biologists suggest the …             Modular structure of brain functional networks: breaking the resolution limit by Surprise ▶     Carlo Nicolini, Angelo Bifone     The modular organization of brain networks has been widely investigated using graph theoretical approaches. Recently, it has been demonstrated that graph partitioning methods …             Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition ▶     Praveen Nedumpully-Govindan, Aleksandr Kakinen, Emily H. Pilkington et al.     Experimental studies have shown that many naturally occurring polyphenols have inhibitory effect on the aggregation of several proteins. Here, we use discrete molecular dynamics …             Architecture and Function of Mechanosensitive Membrane Protein Lattices ▶     Osman Kahraman, Peter D. Koch, William S. Klug et al.     Experiments have revealed that membrane proteins can form two-dimensional clusters with regular translational and orientational protein arrangements, which may allow cells to …             Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells ▶     Leli Zeng, Yu Chen, Jiangping Liu et al.     Cisplatin was the first metal-based therapeutic agent approved for the treatment of human cancers, but its clinical activity is greatly limited by tumor drug resistance. This …             InGaN/Dilute-As GaNAs Interface Quantum Well for Red Emitters ▶     Chee-Keong Tan, Damir Borovac, Wei Sun et al.     The design of InGaN/dilute-As GaNAs interface quantum well (QW) leads to significant redshift in the transition wavelength with improvement in electron-hole wave function overlap …             Two-Photon Excitation STED Microscopy with Time-Gated Detection ▶     Ivan Coto Hernandez, Marco Castello, Luca Lanzano et al.     We report on a novel two-photon excitation stimulated emission depletion (2PE-STED) microscope based on time-gated detection. The time-gated detection allows for the effective …             Long-distance continuous-variable quantum key distribution by controlling excess noise ▶     Duan Huang, Peng Huang, Dakai Lin et al.     Quantum cryptography founded on the laws of physics could revolutionize the way in which communication information is protected. Significant progresses in long-distance quantum …             Electrical current through individual pairs of phosphorus donor atoms and silicon dangling bonds ▶     K. Ambal, P. Rahe, A. Payne et al.     Nuclear spins of phosphorus [P] donor atoms in crystalline silicon are among the most coherent qubits found in nature. For their utilization in scalable quantum computers, …             Observation of giant Goos-Hanchen and angular shifts at designed metasurfaces ▶     Venkata Jayasurya Yallapragada, Ajith P. Ravishankar, Gajendra L. Mulay et al.     Metasurfaces with sub-wavelength features are useful in modulating the phase, amplitude or polarization of electromagnetic fields. While several applications are reported for …             Hyperuniform disordered terahertz quantum cascade laser ▶     R. Degl'Innocenti, Y. D. Shah, L. Masini et al.     Laser cavities have been realized in various different photonic systems. One of the forefront research fields regards the investigation of the physics of amplifying random …             Crystal-Size Effects on Carbon Dioxide Capture of a Covalently Alkylamine-Tethered Metal-Organic Framework Constructed by a One-Step Self-Assembly ▶     Yun Kyeong Kim, Sung-min Hyun, Jae Hwa Lee et al.     To enhance the carbon dioxide (CO2) uptake of metal-organic frameworks (MOFs), amine functionalization of their pore surfaces has been studied extensively. In general, …             A Fluctuating State in the Framework Compounds (Ba,Sr)Al2O4 ▶     Yui Ishii, Hirofumi Tsukasaki, Eri Tanaka et al.     The structural fluctuation in hexagonal Ba1-xSrxAl2O4 with a corner-sharing AlO4 tetrahedral network was characterized at various temperatures using transmission electron …             Stiffness in vortex-like structures due to chirality-domains within a coupled helical rare-earth superlattice ▶     Amitesh Paul     Vortex domain walls poses chirality or 'handedness' which can be exploited to act as memory units by changing their polarity with electric field or driving/manupulating the …             Synthesis, optical properties, and helical self-assembly of a bivaline-containing tetraphenylethene ▶     Hongkun Li, Xiaoyan Zheng, Huimin Su et al.     A chiral tetraphenylethene derivative with two valine-containing attachments (TPE-DVAL), was synthesized by Cu(I)-catalyzed azide-alkyne "click" reaction. The optical properties …             High Efficiency Dye-sensitized Solar Cells Constructed with Composites of TiO2 and the Hot-bubbling Synthesized Ultra-Small SnO2 Nanocrystals ▶     Xiaoli Mao, Ru Zhou, Shouwei Zhang et al.     An efficient photo-anode for the dye-sensitized solar cells (DSSCs) should have features of high loading of dye molecules, favorable band alignments and good efficiency in …             Synthesis of Large-Area WS2 monolayers with Exceptional Photoluminescence ▶     Kathleen M. McCreary, Aubrey T. Hanbicki, Glenn G. Jernigan et al.     Monolayer WS2 offers great promise for use in optical devices due to its direct bandgap and high photoluminescence intensity. While fundamental investigations can be performed on …             Liquid-induced colour change in a beetle: the concept of a photonic cell ▶     Sebastien R. Mouchet, Eloise Van Hooijdonk, Victoria L. Welch et al.     The structural colour of male Hoplia coerulea beetles is notable for changing from blue to green upon contact with water. In fact, reversible changes in both colour and …             Direct comparison of shot-to-shot noise performance of all normal dispersion and anomalous dispersion supercontinuum pumped with sub-picosecond pulse fiber-based laser ▶     Mariusz Klimczak, Grzegorz Sobon, Rafal Kasztelanic et al.     Coherence of supercontinuum sources is critical for applications involving characterization of ultrafast or rarely occurring phenomena. With the demonstrated spectral coverage of …             Field-induced magnetic instability and quantum criticality in the antiferromagnet CeCu2Ge2 ▶     Yi Liu, Donghua Xie, Xiaoying Wang et al.     The magnetic quantum criticality in strongly correlated electron systems has been considered to be closely related with the occurrence of unconventional superconductivity. …             Single-crystalline ZnO sheet Source-Gated Transistors ▶     A. S. Dahiya, C. Opoku, R. A. Sporea et al.     Due to their fabrication simplicity, fully compatible with low-cost large-area device assembly strategies, source-gated transistors (SGTs) have received significant research …             Uncoupling shear and uniaxial elastic moduli of semiflexible biopolymer networks: compression-softening and stretch-stiffening ▶     Anne S. G. van Oosten, Mahsa Vahabi, Albert J. Licup et al.     Gels formed by semiflexible filaments such as most biopolymers exhibit non-linear behavior in their response to shear deformation, e.g., with a pronounced strain stiffening and …             Temperature based Restricted Boltzmann Machines ▶     Guoqi Li, Lei Deng, Yi Xu et al.     Restricted Boltzmann machines (RBMs), which apply graphical models to learning probability distribution over a set of inputs, have attracted much attention recently since being …             A True Metasurface Antenna ▶     Mohamed El Badawe, Thamer S. Almoneef, Omar M. Ramahi     We present a true metasurface antenna based on electrically-small resonators. The resonators are placed on a flat surface and connected to one feed point using corporate feed. Un…             The Mesoscopic Electrochemistry of Molecular Junctions ▶     Paulo R. Bueno, Tiago A. Benites, Jason J. Davis     Within the context of an electron dynamic (time-dependent) perspective and a voltage driving force acting to redistribute electrons between metallic and addressable molecular …             Surface passivation of semiconducting oxides by self-assembled nanoparticles ▶     Dae-Sung Park, Haiyuan Wang, Sepehr K. Vasheghani Farahani et al.     Physiochemical interactions which occur at the surfaces of oxide materials can significantly impair their performance in many device applications. As a result, surface …             Unveiling Spatial Epidemiology of HIV with Mobile Phone Data ▶     Sanja Brdar, Katarina Gavric, Dubravko Culibrk et al.     An increasing amount of geo-referenced mobile phone data enables the identification of behavioral patterns, habits and movements of people. With this data, we can extract the …             Accurate quantification of creatinine in serum by coupling a measurement standard to extractive electrospray ionization mass spectrometry ▶     Keke Huang, Ming Li, Hongmei Li et al.     Ambient ionization (AI) techniques have been widely used in chemistry, medicine, material science, environmental science, forensic science. AI takes advantage of direct …             Polysaccharide-based Noncovalent Assembly for Targeted Delivery of Taxol ▶     Yang Yang, Ying-Ming Zhang, Yong Chen et al.     The construction of synthetic straightforward, biocompatible and biodegradable targeted drug delivery system with fluorescent tracking abilities, high anticancer activities and …             Localized crystallization in shear bands of a metallic glass ▶     Zhijie Yan, Kaikai Song, Yong Hu et al.     Stress-induced viscous flow is the characteristic of atomic movements during plastic deformation of metallic glasses in the absence of substantial temperature increase, which …             Use of a novel smart heating sleeping bag to improve wearers' local thermal comfort in the feet ▶     W. F. Song, C. J. Zhang, D. D. Lai et al.     Previous studies have revealed that wearers had low skin temperatures and cold and pain sensations in the feet, when using sleeping bags under defined comfort and limit …             Assessing the toxicity of Pb- and Sn-based perovskite solar cells in model organism Danio rerio ▶     Aslihan Babayigit, Dinh Duy Thanh, Anitha Ethirajan et al.     Intensive development of organometal halide perovskite solar cells has lead to a dramatic surge in power conversion efficiency up to 20%. Unfortunately, the most efficient …             Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated A β-peptide ▶     Georg Meisl, Xiaoting Yang, Birgitta Frohm et al.     Disease related mutations and environmental factors are key determinants of the aggregation mechanism of the amyloid-β peptide implicated in Alzheimer's disease. Here we present …               Earth & Environmental Sciences ▲ top               Mechanistic understanding of MeHg-Se antagonism in soil-rice systems: the key role of antagonism in soil ▶     Yongjie Wang, Fei Dang, R. Douglas Evans et al.     Methylmercury (MeHg) accumulation in rice has great implications for human health. Here, effects of selenium (Se) on MeHg availability to rice are explored by growing rice under …             Surface-Atmosphere Moisture Interactions in the Frozen Ground Regions of Eurasia ▶     Trent W. Ford, Oliver W. Frauenfeld     Climate models simulate an intensifying Arctic hydrologic cycle in response to climatic warming, however the role of surface-atmosphere interactions from degrading frozen ground …             Global nitrogen budgets in cereals: A 50-year assessment for maize, rice, and wheat production systems ▶     J. K. Ladha, A. Tirol-Padre, C. K. Reddy et al.     Industrially produced N-fertilizer is essential to the production of cereals that supports current and projected human populations. We constructed a top-down global N budget for …             Food supply confers calcifiers resistance to ocean acidification ▶     Laura Ramajo, Elia Perez-Leon, Iris E. Hendriks et al.     Invasion of ocean surface waters by anthropogenic CO2 emitted to the atmosphere is expected to reduce surface seawater pH to 7.8 by the end of this century compromising marine …             An integrated Pan-European perspective on coastal Lagoons management through a mosaic-DPSIR approach ▶     Marina Dolbeth, Per Stalnacke, Fatima L. Alves et al.     A decision support framework for the management of lagoon ecosystems was tested using four European Lagoons: Ria de Aveiro (Portugal), Mar Menor (Spain), Tyligulskyi Liman (Uk…             The relationship of spectral sensitivity with growth and reproductive response in avian breeders (Gallus gallus) ▶     Ye-Feng Yang, Jing-Song Jiang, Jin-Ming Pan et al.     A previous study demonstrated that birds that are exposed to light at night develop advanced reproductive systems. However, spectrum might also affect the photoperiodic response …             Revisiting the concept of a symmetric index of agreement for continuous datasets ▶     Gregory Duveiller, Dominique Fasbender, Michele Meroni     Quantifying how close two datasets are to each other is a common and necessary undertaking in scientific research. The Pearson product-moment correlation coefficient r is a …             Phytoliths reveal the earliest fine reedy textile in China at the Tianluoshan site ▶     Jianping Zhang, Houyuan Lu, Guoping Sun et al.     Textiles are among the longest and most widespread technologies in human history, although poor preservation of perishable artifacts in Paleolithic and Neolithic contexts makes …             Larval cases of caddisfly (Insecta: Trichoptera) affinity in Early Permian marine environments of Gondwana ▶     Lucas D. Mouro, Michal Zaton, Antonio C.S. Fernandes et al.     Caddisflies (Trichoptera) are small, cosmopolitan insects closely related to the Lepidoptera (moths and butterflies). Most caddisflies construct protective cases during their …             PCB pollution continues to impact populations of orcas and other dolphins in European waters ▶     Paul D. Jepson, Rob Deaville, Jonathan L. Barber et al.     Organochlorine (OC) pesticides and the more persistent polychlorinated biphenyls (PCBs) have well-established dose-dependent toxicities to birds, fish and mammals in experimental …             Critical carbon input to maintain current soil organic carbon stocks in global wheat systems ▶     Guocheng Wang, Zhongkui Luo, Pengfei Han et al.     Soil organic carbon (SOC) dynamics in croplands is a crucial component of global carbon (C) cycle. Depending on local environmental conditions and management practices, typical C …             A graphene oxide/amidoxime hydrogel for enhanced uranium capture ▶     Feihong Wang, Hongpeng Li, Qi Liu et al.     The efficient development of selective materials for the recovery of uranium from nuclear waste and seawater is necessary for their potential application in nuclear fuel and the …             Fractal density and singularity analysis of heat flow over ocean ridges ▶     Cheng Qiuming     Peak heat flow occurs at mid-ocean ridges and decreases with the age of the oceanic lithosphere. Several plate models, including the Parsons and Sclater (PSM) model, Global Depth …             Venturing in coral larval chimerism: a compact functional domain with fostered genotypic diversity ▶     Baruch Rinkevich, Lee Shaish, Jacob Douek et al.     The globally distributed coral species Pocillopora damicornis is known to release either sexual or asexual derived planula-larvae in various reef locations. Using microsatellite …             Levels of maternal care in dogs affect adult offspring temperament ▶     Pernilla Foyer, Erik Wilsson, Per Jensen     Dog puppies are born in a state of large neural immaturity; therefore, the nervous system is sensitive to environmental influences early in life. In primates and rodents, early …             Assessing the toxicity of Pb- and Sn-based perovskite solar cells in model organism Danio rerio ▶     Aslihan Babayigit, Dinh Duy Thanh, Anitha Ethirajan et al.     Intensive development of organometal halide perovskite solar cells has lead to a dramatic surge in power conversion efficiency up to 20%. Unfortunately, the most efficient …             Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea ▶     Romano Mwirichia, Intikhab Alam, Mamoon Rashid et al.     The candidate Division MSBL1 (Mediterranean Sea Brine Lakes 1) comprises a monophyletic group of uncultured archaea found in different hypersaline environments. Previous studies …               Health Sciences ▲ top               Alcohol drinking as an unfavorable prognostic factor for male patients with nasopharyngeal carcinoma ▶     Yu-Pei Chen, Bing-Cheng Zhao, Chen Chen et al.     The relationship between alcohol drinking and the prognosis of nasopharyngeal carcinoma (NPC) is unknown. To investigate the prognostic value of alcohol drinking on NPC, this …             Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models ▶     S. Miquel, R. Martin, A. Lashermes et al.     Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In …             Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: "Herniated" HDL, a common feature in diabetes ▶     Nuria Amigo, Roger Mallol, Mercedes Heras et al.     Recent studies have shown that pharmacological increases in HDL cholesterol concentrations do not necessarily translate into clinical benefits for patients, raising concerns …             Chlamydia gallinacea, not C. psittaci, is the endemic chlamydial species in chicken (Gallus gallus) ▶     Weina Guo, Jing Li, Bernhard Kaltenboeck et al.     To investigate the prevalence and diversity of Chlamydia spp. in domestic birds in China, oral and cloacal swabs of healthy chickens, ducks, geese and pigeons were collected …             Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury ▶     Huafeng Wang, Huan Zhang, Zimu Zhang et al.     Adiponectin is an adipocyte-derived circulating protein with beneficial effects on injured livers. Adiponectin-deficient (adipo(-/-)) mice develop enhanced liver fibrosis, …             Bone alterations are associated with ankle osteoarthritis joint pain ▶     Yukio Nakamura, Shigeharu Uchiyama, Mikio Kamimura et al.     The etiology of ankle osteoarthritis (OA) is largely unknown. We analyzed 24 ankle OA of 21 patients diagnosed by plain radiographs using magnetic resonance imaging (MRI). Ankle …             Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice ▶     Sarah Mundt, Michael Basler, Stefanie Buerger et al.     Apart from its role in MHC class I antigen processing, the immunoproteasome has recently been implicated in the modulation of T helper cell differentiation under polarizing …             A network analysis of cofactor-protein interactions for analyzing associations between human nutrition and diseases ▶     Marie Pier Scott-Boyer, Sebastien Lacroix, Marco Scotti et al.     The involvement of vitamins and other micronutrients in intermediary metabolism was elucidated in the mid 1900's at the level of individual biochemical reactions. Biochemical …             Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency ▶     Yu Zhang, Ming Gu, Wujie Cai et al.     Studies on peroxisome proliferator-activated receptor (PPAR)-γ ligands have been focused on agonists. However, PPARγ activation may induce obesity and nonalcoholic fatty liver …             X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study ▶     Hanwook Park, Eunseop Yeom, Sang Joon Lee     X-ray PIV measurement is a noninvasive approach to measure opaque blood flows. However, it is not easy to measure real pulsatile blood flows in the blood vessels located at deep …             Isolation of highly enriched primary human microglia for functional studies ▶     Justin Rustenhoven, Thomas I-H Park, Patrick Schweder et al.     Microglia, the resident macrophages of the central nervous system play vital roles in brain homeostasis through clearance of pathogenic material. Microglia are also implicated in …             Stable multilineage xenogeneic replacement of definitive hematopoiesis in adult zebrafish ▶     Isabell Hess, Thomas Boehm     Bony fishes are the most numerous and phenotypically diverse group of vertebrates inhabiting our planet, making them an ideal target for identifying general principles of tissue …             NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea ▶     Yohei Honkura, Hirotaka Matsuo, Shohei Murakami et al.     Noise-induced hearing loss (NIHL) is one of the most common sensorineural hearing deficits. Recent studies have demonstrated that the pathogenesis of NIHL is closely related to …             Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program ▶     Ho-Keun Kwon, Gi-Cheon Kim, Ji Sun Hwang et al.     Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor …             Reproducibility of Intra- and Inter-scanner Measurements of Liver Fat Using Complex Confounder-corrected Chemical Shift Encoded MRI at 3.0 Tesla ▶     Bing Wu, Wei Han, Zhenhong Li et al.     The purpose of this study was to prospectively evaluate the reproducibility of the proton density fat-fraction (PDFF) of the liver using the IDEAL algorithm, a quantitative …             Application of FDM three-dimensional printing technology in the digital manufacture of custom edentulous mandible trays ▶     Hu Chen, Xu Yang, Litong Chen et al.     The objective was to establish and evaluate a method for manufacture of custom trays for edentulous jaws using computer aided design and fused deposition modeling (FDM) …             Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway ▶     Jin Li, Ruzhi Deng, Xia Hua et al.     Blueberries have been recognized to possess protective properties from inflammation and various diseases, but not for eye and ocular disorders. This study explores potential …             Effect of topical rebamipide on conjunctival goblet cell recovery after vitrectomy ▶     Kumiko Kato, Yuko Takashima, Koichi Matsunaga et al.     In vitro and in vivo experiments have shown that topical rebamipide will increase the number of goblet cells in the bulbar conjunctiva. The purpose of this study was to determine …             Teratocarcinomas Arising from Allogeneic Induced Pluripotent Stem Cell-Derived Cardiac Tissue Constructs Provoked Host Immune Rejection in Mice ▶     Ai Kawamura, Shigeru Miyagawa, Satsuki Fukushima et al.     Transplantation of induced pluripotent stem cell-derived cardiac tissue constructs is a promising regenerative treatment for cardiac failure: however, its tumourigenic potential …             Antinociceptive effects of vitexin in a mouse model of postoperative pain ▶     Qing Zhu, Li-Na Mao, Cheng-Peng Liu et al.     Vitexin, a C-glycosylated flavone present in several medicinal herbs, has showed various pharmacological activities including antinociception. The present study investigated the …             Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration ▶     Xingdi Zhang, Deliang Zeng, Nan Li et al.     Mesoporous bioactive glass (MBG), which possesses excellent bioactivity, biocompatibility and osteoconductivity, has played an important role in bone tissue regeneration. …             The effect of transcranial direct current stimulation on contrast sensitivity and visual evoked potential amplitude in adults with amblyopia ▶     Zhaofeng Ding, Jinrong Li, Daniel P. Spiegel et al.     Amblyopia is a neurodevelopmental disorder of vision that occurs when the visual cortex receives decorrelated inputs from the two eyes during an early critical period of …             Lack of effects on key cellular parameters of MRC-5 human lung fibroblasts exposed to 370mT static magnetic field ▶     Stefania Romeo, Anna Sannino, Maria Rosaria Scarfi et al.     The last decades have seen increased interest toward possible adverse effects arising from exposure to intense static magnetic fields. This concern is mainly due to the wider and …             Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-β/Smad pathway in vascular smooth muscle cells ▶     Yaqian Huang, Zhizhou Shen, Qinghua Chen et al.     The study was designed to investigate the role of endogenous sulfur dioxide (SO2) in collagen remodeling and its mechanisms in vascular smooth muscle cells (VSMCs). …             Combinatorial Treatment with Apelin-13 Enhances the Therapeutic Efficacy of a Preconditioned Cell-Based Therapy for Peripheral Ischemia ▶     Makoto Samura, Noriyasu Morikage, Kotaro Suehiro et al.     Hypoxic pretreatment of peripheral blood mononuclear cells (PBMNCs) enhances therapeutic angiogenesis in ischemic tissues after cell transplantation. However, newly formed …             Novel Methods of Determining Urinary Calculi Composition: Petrographic Thin Sectioning of Calculi and Nanoscale Flow Cytometry Urinalysis ▶     Carson T Gavin, Sohrab N Ali, Thomas Tailly et al.     Accurate determination of urinary stone composition has significant bearing on understanding pathophysiology, choosing treatment modalities and preventing recurrence. A need …             Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition ▶     Praveen Nedumpully-Govindan, Aleksandr Kakinen, Emily H. Pilkington et al.     Experimental studies have shown that many naturally occurring polyphenols have inhibitory effect on the aggregation of several proteins. Here, we use discrete molecular dynamics …             Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC ▶     Yi Feng, Yutaka Takebe, Huamian Wei et al.     To determine the origin and evolutionary history of two predominant and closely-related circulating recombinant forms (CRF07_BC and CRF08_BC), recombinant structures and …             Bioactivity of periodontal ligament stem cells on sodium titanate coated with graphene oxide ▶     Qi Zhou, Pishan Yang, Xianlei Li et al.     As a biocompatible and low cytotoxic nanomaterial, graphene oxide (GO) has captured tremendous interests in tissue engineering. However, little is known about the behavior of …             A Search for Blood Biomarkers for Autism: Peptoids ▶     Sayed Zaman, Umar Yazdani, Yan Deng et al.     Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, and restricted, repetitive patterns of …             METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion ▶     Zhe Zhang, Guojun Zhang, Chuize Kong et al.     The incidence of bladder cancer has increased in the last few decades, thus novel markers for early diagnosis and more efficacious treatment are urgently needed. It found that …             Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte ▶     Yan Gu, Mulan He, Xiaoqin Zhou et al.     Mesenchymal stem cell (MSC) transplantation reduces the neurological impairment caused by hypoxic-ischemic brain damage (HIBD) via immunomodulation. In the current study, we …             The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma ▶     J. C. Coltherd, D. T. Rodgers, R. E. Lawrie et al.     Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, …             DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders ▶     Fan Wang, Hongqin Xu, Hongyu Zhao et al.     DNA methylome alterations in the prefrontal cortex (PFC) may contribute to risk for alcohol use disorders (AUDs). We examined postmortem PFC DNA methylomes of 16 male and seven …             Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas ▶     G. Pujadas, S. Cervantes, A. Tutusaus et al.     Transcriptional and signaling networks establish complex cross-regulatory interactions that drive cellular differentiation during development. Using microarrays we identified the …             Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism ▶     Chengjian Zhao, Wei Zhang, Yuwei Zhao et al.     The angiogenic switch is an important oncogenic step that determines whether microtumors remain dormant or progresses further. It has been generally perceived that the primary …             Support for the Microgenderome: Associations in a Human Clinical Population ▶     Amy Wallis, Henry Butt, Michelle Ball et al.     The 'microgenderome' provides a paradigm shift that highlights the role of sex differences in the host-microbiota interaction relevant for autoimmune and neuro-immune conditions. …             Prevalence and care index of early childhood caries in mainland China: evidence from epidemiological surveys during 1987-2013 ▶     Xiaonan Zhang, Sheng Yang, Zhaoying Liao et al.     Early childhood caries (ECC) is the most common chronic disease in young children. Its reported prevalence varies greatly across China. This systematic review aimed to explore …             Parathyroidectomy Associates with Reduced Mortality in Taiwanese Dialysis Patients with Hyperparathyroidism: Evidence for the Controversy of Current Guidelines ▶     Li-Chun Ho, Shih-Yuan Hung, Hsi-Hao Wang et al.     Parathyroidectomy is recommended by the clinical guidelines for dialysis patients with unremitting secondary hyperparathyroidism (SHPT). However, the survival advantage of …             DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model ▶     Fuxu Wang, Jia Ma, Fei Han et al.     DL-3-n-butylphthalide (NBP) is a therapeutic drug used for ischemic stroke treatment. Here, we investigated the impact of NBP on the development of rat diabetic cataract induced …             Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation ▶     Hao Wu, Ning Li, Ronghua Jin et al.     Hepatocellular carcinoma (HCC) patients were grouped according to the degree of encephalopathy, with healthy volunteers as controls. We investigated clinical presentation, …             Variations in the buccal-lingual alveolar bone thickness of impacted mandibular third molar: our classification and treatment perspectives ▶     Jing Ge, Jia-Wei Zheng, Chi Yang et al.     Selecting either buccal or lingual approach for the mandibular third molar surgical extraction has been an intense debate for years. The aim of this observational retrospective …             Joint Effects of Intraocular Pressure and Myopia on Risk of Primary Open-Angle Glaucoma: The Singapore Epidemiology of Eye Diseases Study ▶     Yih-Chung Tham, Tin Aung, Qiao Fan et al.     We examined the joint effects of intraocular pressure (IOP) and myopia on the risk of primary open angle glaucoma (POAG) in a multi-ethnic Asian population. A total of 9,422 …             Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells ▶     Aifa Tang, Yi Huang, Zesong Li et al.     Differential methylation of the homologous chromosomes, a well-known mechanism leading to genomic imprinting and X-chromosome inactivation, is widely reported at the …             Parity and All-cause Mortality in Women and Men: A Dose-Response Meta-Analysis of Cohort Studies ▶     Yun Zeng, Ze-min Ni, Shu-yun Liu et al.     To quantitatively assess the association between parity and all-cause mortality, we conducted a meta-analysis of cohort studies. Relevant reports were identified from PubMed and …             Promotion of a cancer-like phenotype, through chronic exposure to inflammatory cytokines and hypoxia in a bronchial epithelial cell line model ▶     Anne-Marie Baird, Steven G. Gray, Derek J. Richard et al.     Globally, lung cancer accounts for approximately 20% of all cancer related deaths. Five-year survival is poor and rates have remained unchanged for the past four decades. There …             Use of a novel smart heating sleeping bag to improve wearers' local thermal comfort in the feet ▶     W. F. Song, C. J. Zhang, D. D. Lai et al.     Previous studies have revealed that wearers had low skin temperatures and cold and pain sensations in the feet, when using sleeping bags under defined comfort and limit …             The Neurochemical and Microstructural Changes in the Brain of Systemic Lupus Erythematosus Patients: A Multimodal MRI Study ▶     Zhiyan Zhang, Yukai Wang, Zhiwei Shen et al.     The diagnosis and pathology of neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging. Herein, we used multimodal imaging to assess anatomical and functional …             Large molecular systems landscape uncovers T cell trapping in human skin cancer ▶     Reyk Hillert, Anne Gieseler, Andreas Krusche et al.     Immune surveillance of tumour cells is an important function of CD8 T lymphocytes, which has failed in cancer for reasons still unknown in many respect but mainly related to …             FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin ▶     Shizhi Wang, Shenshen Wu, Qingtao Meng et al.     FAS rs2234767 (-1377G>A), rs1800682 (-670A>G) and FASLG rs763110 (-844C>T) promoter polymorphisms can influence transcriptional activities of the genes and thus multiple …             Accurate quantification of creatinine in serum by coupling a measurement standard to extractive electrospray ionization mass spectrometry ▶     Keke Huang, Ming Li, Hongmei Li et al.     Ambient ionization (AI) techniques have been widely used in chemistry, medicine, material science, environmental science, forensic science. AI takes advantage of direct …             Exposure to Polycyclic Aromatic Hydrocarbons, Plasma Cytokines, and Heart Rate Variability ▶     Binyao Yang, Qifei Deng, Wangzhen Zhang et al.     Epidemiological studies have suggested associations between polycyclic aromatic hydrocarbons (PAHs) and heart rate variability (HRV). However, the roles of plasma cytokines in …             Unveiling Spatial Epidemiology of HIV with Mobile Phone Data ▶     Sanja Brdar, Katarina Gavric, Dubravko Culibrk et al.     An increasing amount of geo-referenced mobile phone data enables the identification of behavioral patterns, habits and movements of people. 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