Nature Reviews Cardiology - Table of Contents alert Volume 13 Issue 3

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TABLE OF CONTENTS
March 2016 Volume 13 Number 3
Impact Factor 9.183 *	In this issue Research Highlights News and Views Reviews Errata Also this month  Featured article: Comorbidity of atrial fibrillation and heart failure Liang-Han Ling, Peter M. Kistler, Jonathan M. Kalman, Richard J. Schilling & Ross J. Hunter
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RESEARCH HIGHLIGHTS Top Cardiomyopathies: Genetic overlap between peripartum and dilated cardiomyopathies Published online: 22 January 2016 p121 | doi:10.1038/nrcardio.2016.3 PDF Gene therapy: No improvement in outcomes with gene therapy for heart failure Published online: 04 February 2016 p122 | doi:10.1038/nrcardio.2016.14 PDF Risk factors: Negative risk markers for CVD Published online: 11 February 2016 p122 | doi:10.1038/nrcardio.2016.21 PDF Heart failure: Ketone bodies as fuel in heart failure Published online: 11 February 2016 p122 | doi:10.1038/nrcardio.2016.22 PDF Venous thromboembolism: 5-year follow-up data from CaVenT Published online: 22 January 2016 p124 | doi:10.1038/nrcardio.2016.4 PDF Obituary: Henry Krum Published online: 29 January 2016 p124 | doi:10.1038/nrcardio.2016.6 PDF Risk factors: Periodontitis increases risk of a first MI Published online: 29 January 2016 p124 | doi:10.1038/nrcardio.2016.7 PDF IN BRIEF Arrhythmias: No increased risk of cardiovascular disease or death with bradycardia | Aortic diseases: FBN1 mutation affects survival in Marfan syndrome PDF
NEWS AND VIEWS		Top
Hypertension: Benefits of strict blood-pressure lowering in hypertension Kazuomi Kario Published online: 04 February 2016 p125 | doi:10.1038/nrcardio.2016.13 A new meta-analysis by Ettehad and colleagues, which included >613,000 patients with hypertension from randomized, controlled trials, clearly demonstrates that antihypertensive medication reduces cardiovascular events and death in all patients, including those with systolic blood pressure <130 mmHg and regardless of concomitant diseases. The risks of stroke and heart failure were particularly reduced. Full Text | PDF
Heart failure: Mechanisms of spinal cord neuromodulation for heart disease Jeffrey L. Ardell Published online: 04 February 2016 p127 | doi:10.1038/nrcardio.2016.8 Successful application of spinal cord stimulation (SCS) is dependent on the location of bioelectric stimuli, the stimulation protocol employed, and the substrate being targeted (neural and cardiac). Safety concerns for bioelectrical treatment of heart failure with reduced ejection fraction have been addressed, but optimization of SCS delivery remains a concern. Full Text | PDF
Coronary artery disease: Can aminothiols be distinguished from reactive oxygen species? Luc Rochette & Catherine Vergely Published online: 11 February 2016 p128 | doi:10.1038/nrcardio.2016.20 Glutathione is considered the major natural antioxidant, protecting cells from oxidative stress. Patel and colleagues used plasma levels of the aminothiols cystine and glutathione to quantify oxidative stress in patients with coronary artery disease, and show that the cystine/glutathione ratio is associated with increased mortality. Is this a new approach for clinical risk stratification? Full Text | PDF
REVIEWS		Top
Comorbidity of atrial fibrillation and heart failure Liang-Han Ling, Peter M. Kistler, Jonathan M. Kalman, Richard J. Schilling & Ross J. Hunter Published online: 10 December 2015 p131 | doi:10.1038/nrcardio.2015.191 Atrial fibrillation (AF) and heart failure (HF) are evolving epidemics with increasing global prevalence. HF is known to promote AF, but how AF exacerbates or even causes HF is uncertain. In this Review, Ling and colleagues present the current understanding of the epidemiology and pathophysiology of AF-HF, and the roles of pharmacological and interventional therapies in the management of patients with this comorbidity. Abstract | Full Text | PDF
Predictors, treatment, and outcomes of STEMI occurring in hospitalized patients Xuming Dai, Prashant Kaul, Sidney C. Smith, Jr & George A. Stouffer Published online: 03 November 2015 p148 | doi:10.1038/nrcardio.2015.165 Systems of care have been established to optimize treatment of ST-segment elevation myocardial infarction (STEMI) occurring out of hospital, but not for patients in hospital. Unfavourable clinical characteristics of patients, combined with suboptimal strategies for diagnosis and treatment, mean that inpatient STEMI is associated with high mortality. Eliminating system delays and increasing use of reperfusion therapy could improve outcomes for inpatient STEMI. Abstract | Full Text | PDF
Ventricular arrhythmias and the His-Purkinje system Michel Haissaguerre, Edward Vigmond, Bruno Stuyvers, Meleze Hocini & Olivier Bernus Published online: 04 January 2016 p155 | doi:10.1038/nrcardio.2015.193 The Purkinje system can be a source of arrhythmias and has been shown to trigger ventricular fibrillation. The complexity of the molecular mechanisms of ventricular fibrillation, and the incomplete understanding of Purkinje arrhythmogenicity, make the identification of vulnerable individuals challenging. In this Review, Haissaguerre and colleagues discuss the current knowledge of the pathophysiological mechanisms underlying Purkinje-related arrhythmias, and highlight the current therapeutic options. Abstract | Full Text | PDF
Regulatory T cells in cardiovascular diseases Xiao Meng, Jianmin Yang, Mei Dong, Kai Zhang, Eric Tu, Qi Gao, Wanjun Chen, Cheng Zhang & Yun Zhang Published online: 03 November 2015 p167 | doi:10.1038/nrcardio.2015.169 Regulatory T (TREG) cells are important for the induction and maintenance of immune homeostasis and tolerance. Numerous experimental and clinical studies have suggested a role for TREG cells in protection against cardiovascular diseases, particularly atherosclerosis and abdominal aortic aneurysms. In this Review, Meng and colleagues summarize the available evidence on the role of TREG cells in several cardiovascular disorders, such as atherosclerosis, hypertension, Kawasaki disease, and myocardial infarction. Abstract | Full Text | PDF
ERRATA		Top
Erratum: Newly designed leadless pacemaker Karina Huynh Published online: 22 January 2016 p123 | doi:10.1038/nrcardio.2016.2 Full Text | PDF
Erratum: Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias Laurent Macle & Stanley Nattel Published online: 29 January 2016 p179 | doi:10.1038/nrcardio.2016.11 Full Text | PDF
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Cardiology was previously published as Nature Clinical Practice Cardiovascular Medicine.

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