Nature Reviews Endocrinology - Table of Contents alert Volume 12 Issue 4

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TABLE OF CONTENTS
April 2016 Volume 12 Number 4
Impact Factor 13.281 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Hypophosphatasia — aetiology, nosology, pathogenesis, diagnosis and treatment Michael P. Whyte
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RESEARCH HIGHLIGHTS Top Endocrine disruptors: Reproductive consequences of analgesic use during pregnancy Published online: 12 February 2016 p185 | doi:10.1038/nrendo.2016.21 PDF Diabetes: Concerns about long-term use of GLP-1 analogues Published online: 04 March 2016 p186 | doi:10.1038/nrendo.2016.33 PDF Gut microbiota: Growth impairment in undernourished children Published online: 04 March 2016 p186 | doi:10.1038/nrendo.2016.34 PDF Obesity: PKR not involved in metabolic diseases Published online: 19 February 2016 p187 | doi:10.1038/nrendo.2016.23 PDF NAFLD: Unravelling the path to steatohepatitis Published online: 19 February 2016 p187 | doi:10.1038/nrendo.2016.25 PDF Diabetes: Insulitic profiles in T1DM Published online: 26 February 2016 p187 | doi:10.1038/nrendo.2016.31 PDF Translational medicine: β cells from stomach-derived organoids Published online: 04 March 2016 p188 | doi:10.1038/nrendo.2016.35 PDF IN BRIEF Circadian rhythms: Not a morning person? Blame it on your genes | Neuroendocrinology: Glucose availability modulates neurogenesis | Adipose tissue: New pathway in BAT activation? PDF Endocrinology JOBS of the week Postdoctoral Positions Exploring the Role of Placental Function in Determining Life-Long Health University of Colorado Denver Full Professor in Comparative Physiology Museum national d'Histoire naturelle More Science jobs from
NEWS AND VIEWS		Top
Diabetes: Stress resilience and risk of type 2 diabetes mellitus Andrew Steptoe Published online: 05 February 2016 p189 | doi:10.1038/nrendo.2016.17 The ability of people to resist the consequences of psychological stress and cope effectively with the challenges of life might be associated with reduced risk of future type 2 diabetes mellitus, according to a very large study of young men followed-up into middle age. Full Text | PDF
Therapy: New findings on vitamin D3 supplementation and falls — when more is perhaps not better Kerrie M. Sanders & Markus J. Seibel Published online: 26 February 2016 p190 | doi:10.1038/nrendo.2016.29 Results from a recent randomized controlled trial on vitamin D3 supplementation suggest that even modestly high doses of vitamin D3, when given once monthly, might be associated with an increased rate of falls in older people. These findings support the conservative approach of the Institute of Medicine's recommendations of 800 IU of vitamin D3 per day for older adults. Full Text | PDF
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Special Feature on molecular pathophysiology of obesity and metabolic diseases This special feature of Experimental & Molecular Medicine contains six review articles dealing with recent findings on the crosstalk between metabolic organs in the regulation of energy homeostasis and the etiology of obesity.  Access the special feature on pathophysiology of obesity and metabolic diseases today!
REVIEWS		Top
A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma Cristina Romei, Raffaele Ciampi & Rossella Elisei Published online: 12 February 2016 p192 | doi:10.1038/nrendo.2016.11 Since mutations in the RET proto-oncogene were discovered in thyroid carcinoma 20 years ago, research has focused on determining the prevalence of these alterations, their role in disease development and potential clinical applications. In this Review, the authors discuss these findings with respect to the pathogenic, diagnostic and prognostic roles of RET in patients with papillary thyroid carcinoma and medullary thyroid carcinoma. Abstract | Full Text | PDF
BMP signalling in skeletal development, disease and repair Valerie S. Salazar, Laura W. Gamer & Vicki Rosen Published online: 19 February 2016 p203 | doi:10.1038/nrendo.2016.12 Bone morphogenetic proteins (BMPs) have been implicated in almost all aspects of bone, cartilage and joint biology. Here, Valerie Salazar and colleagues discuss BMP superfamily signalling in the context of skeletal development and joint morphogenesis, and summarize the status of the BMP pathway as a therapeutic target for treating skeletal trauma and disease. Abstract | Full Text | PDF | Supplementary information
Diabetic emergencies — ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia Guillermo Umpierrez & Mary Korytkowski Published online: 19 February 2016 p222 | doi:10.1038/nrendo.2016.15 Diabetic ketoacidosis, hyperglycaemic osmolar state and hypoglycaemia are serious complications of diabetes mellitus. Here, Guillermo Umpierrez and Mary Korytkowski discuss the clinical presentation, precipitating causes, diagnosis and acute management of these diabetic emergencies and suggest practical strategies for their prevention. Abstract | Full Text | PDF
Hypophosphatasia — aetiology, nosology, pathogenesis, diagnosis and treatment Michael P. Whyte Published online: 19 February 2016 p233 | doi:10.1038/nrendo.2016.14 Hypophosphatasia — a form of metabolic bone disease characterized by low serum alkaline phosphatase activity — results from loss-of-function mutations in the gene encoding the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Here, Michael Whyte discusses the aetiology, nosology, pathogenesis, diagnosis and treatment of hypophosphatasia, which is particularly timely given the recently reported successes and approvals of treating the disease using asfotase alfa, a bone-targeted, recombinant TNSALP. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2014. Nature Reviews Endocrinology was previously published as Nature Clinical Practice Endocrinology & Metabolism.

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