Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 13 Issue 4

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TABLE OF CONTENTS
April 2016 Volume 13 Number 4
Impact Factor 12.610*	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Circadian rhythms of liver physiology and disease: experimental and clinical evidence Yu Tahara & Shigenobu Shibata
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RESEARCH HIGHLIGHTS Top Enteric nervous system: Modelling and treating Hirschsprung disease: stem cells to the rescue? Published online: 24 February 2016 p187 | doi:10.1038/nrgastro.2016.34 PDF Pancreatic cancer: CYP3A5 contributes to PDAC chemoresistance Published online: 24 February 2016 p188 | doi:10.1038/nrgastro.2016.36 PDF Gut microbiota: Microbiota promote gut healing Published online: 17 February 2016 p189 | doi:10.1038/nrgastro.2016.31 PDF IBS: Snail venom for gut pain? Published online: 09 March 2016 p189 | doi:10.1038/nrgastro.2016.45 PDF Liver: Bioprinted liver lobules Published online: 24 February 2016 p190 | doi:10.1038/nrgastro.2016.35 PDF NAFLD: Loss of CD4+ T cells in HCC Published online: 16 March 2016 p190 | doi:10.1038/nrgastro.2016.47 PDF IN BRIEF Gut microbiota: Dysbiosis in fungal microbiota in IBD | Regenerative medicine: Reprogramming stomach tissue into β-like cells | Genomics: Molecular subtypes of pancreatic cancer PDF Nature Reviews Gastroenterology & Hepatology JOBS of the week More Science jobs from Nature Reviews Gastroenterology & Hepatology EVENT More science events from
NEWS AND VIEWS		Top
Alcoholic liver disease: New UK alcohol guidelines and Dry January: enough to give up boozing? Joaquin Cabezas & Ramon Bataller Published online: 09 March 2016 p191 | doi:10.1038/nrgastro.2016.39 The recently released UK Chief Medical Officers Alcohol Guidelines Review set up new restricted limitations in alcohol consumption—14 units, the same amount for both men and women. In parallel, the popular Dry January campaign was launched again, aimed at promoting prolonged abstinence. Are these campaigns enough to give up boozing? Full Text | PDF
Therapy: Positioning of dilation in eosinophilic oesophagitis Alex Straumann & Alain Schoepfer Published online: 02 March 2016 p192 | doi:10.1038/nrgastro.2016.38 Eosinophilic oesophagitis (EoE) is a clinicopathological condition. In addition to drugs and diets, dilation is an established treatment modality. Although the procedure was once considered risky, results from a new study add to the evidence that oesophageal dilation can be considered a safe and effective intervention to relieve dysphagia, the primary symptom of EoE. Full Text | PDF
Viral hepatitis: Drug-drug interactions in HCV treatment — the good, the bad and the ugly Jacob A. Langness & Gregory T. Everson Published online: 17 February 2016 p194 | doi:10.1038/nrgastro.2016.24 A recent study demonstrated that drug-drug interactions are common in patients with HCV and are a challenge for treatment. Identification of these interactions can be time-consuming and complex. A multidisciplinary approach to HCV treatment, including a clinical pharmacist, can help identify and manage HCV drug interactions. Full Text | PDF
Erratum: PPIs alter gut microbiota composition Published online: 17 February 2016 p188 | doi:10.1038/nrgastro.2016.32 Full Text | PDF
Erratum: New entry pathway for HCV Published online: 17 February 2016 p188 | doi:10.1038/nrgastro.2016.33 Full Text | PDF
REVIEWS		Top
Management of NAFLD: a stage-based approach Mary E. Rinella & Arun J. Sanyal Published online: 24 February 2016 p196 | doi:10.1038/nrgastro.2016.3 NAFLD is a leading cause of chronic liver disease worldwide. This Review discusses the diagnosis and stratification of patients with NAFLD by disease stage, and provides a stage-based approach to treatment. Pharmaceuticals in advanced development and potential future therapeutics are also addressed. Abstract | Full Text | PDF
Clostridium difficile infection: epidemiology, diagnosis and understanding transmission Jessica S. H. Martin, Tanya M. Monaghan & Mark H. Wilcox Published online: 09 March 2016 p206 | doi:10.1038/nrgastro.2016.25 Clostridium difficile infection (CDI) is a global health-care problem and represents an important infection in both health-care facilities and the wider community. Here, the authors describe advances in understanding of CDI epidemiology, transmission and diagnosis, which are all key factors in the management of CDI. Abstract | Full Text | PDF
Circadian rhythms of liver physiology and disease: experimental and clinical evidence Yu Tahara & Shigenobu Shibata Published online: 24 February 2016 p217 | doi:10.1038/nrgastro.2016.8 The circadian clock plays a central part in the regulation of liver function. In this Review, Tahara and Shibata discuss the mechanisms by which the circadian clock controls hepatic metabolism and the processing of xenobiotics, and how clock dysfunction can influence liver disease. Abstract | Full Text | PDF
Laparoscopic pancreatic surgery for benign and malignant disease Thijs de Rooij, Sjors Klompmaker, Mohammad Abu Hilal, Michael L. Kendrick, Olivier R. Busch & Marc G. Besselink Published online: 17 February 2016 p227 | doi:10.1038/nrgastro.2016.17 The use of laparoscopic techniques to treat benign and malignant pancreatic disease is becoming more common, but the benefits or limitations in comparison with conventional surgery are not fully clear as yet. Here, an overview of all the high-quality data to date on laparascopic is comprehensively assessed with a focus on laparoscopic Whipple and laparoscopic distal pancreatectomy. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Global strategies are required to cure and eliminate HBV infection Peter Revill, Barbara Testoni, Stephen Locarnini & Fabien Zoulim Published online: 24 February 2016 p239 | doi:10.1038/nrgastro.2016.7 The many gaps in our knowledge and understanding of HBV infection hampers our ability to develop and achieve a cure on a global scale. In this Perspective, Fabien Zoulim and colleagues propose the development of an international group consisting of four working groups (virology, immunology, innovative tools and clinical trials) to tackle the big questions and make important steps towards eradicating this disease. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2008. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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