Nature Reviews Cardiology - Table of Contents alert Volume 13 Issue 5

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TABLE OF CONTENTS
May 2016 Volume 13 Number 5		Advertisement
Impact Factor 9.183 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Acute coronary syndromes without coronary plaque rupture Siddak S. Kanwar, Gregg W. Stone, Mandeep Singh, Renu Virmani, Jeffrey Olin, Takashi Akasaka & Jagat Narula	Nature Reviews Nephrology: Poster on Hyperphosphataemia in CKD This poster outlines the pathophysiology of hyperphosphataemia in CKD and the potential adverse effects of excess phosphate on the heart, bone and vasculature. Available to download free online Produced with support from: Keryx Biopharmaceuticals, Inc.
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RESEARCH HIGHLIGHTS Top Genetics: Polymorphisms in ANGPTL4 link triglycerides with CAD Published online: 24 March 2016 p245 | doi:10.1038/nrcardio.2016.46 PDF Cardiac resuscitation: Optimal duration of prehospital resuscitation after OHCA Published online: 17 March 2016 p246 | doi:10.1038/nrcardio.2016.40 PDF Cardiomyopathies: The happy heart syndrome Published online: 17 March 2016 p246 | doi:10.1038/nrcardio.2016.41 PDF Coronary disease: Sex differences in CAD diagnosis Published online: 07 April 2016 p246 | doi:10.1038/nrcardio.2016.51 PDF Thrombosis: Gut microbes modulate platelet function and thrombosis risk Published online: 24 March 2016 p247 | doi:10.1038/nrcardio.2016.47 PDF Coronary artery disease: Gastroprotection in patients with CAD requiring DAPT Published online: 07 April 2016 p248 | doi:10.1038/nrcardio.2016.52 PDF Cardiac rehabilitation: Stress management lowers CHD risk Published online: 07 April 2016 p248 | doi:10.1038/nrcardio.2016.54 PDF Diabetes: No increased risk of heart failure with incretin-based drugs Published online: 07 April 2016 p248 | doi:10.1038/nrcardio.2016.55 PDF
NEWS AND VIEWS		Top
Coronary artery disease: Scavenger receptor class B1 — a target to reduce CHD risk? Philip J. Barter & Kerry-Anne Rye Published online: 07 April 2016 p249 | doi:10.1038/nrcardio.2016.50 A loss-of-function mutation in the gene encoding scavenger receptor class B member 1 (SRB1) has been identified. This mutation increases the risk of coronary heart disease (CHD) despite being associated with increased concentration of HDL cholesterol. Upregulation of SRB1 expression might be a novel therapeutic approach for reducing CHD risk. Full Text | PDF
Hypertension: Definition of pulmonary hypertension challenged? Adam Torbicki Published online: 24 March 2016 p250 | doi:10.1038/nrcardio.2016.44 The current definition of pulmonary hypertension (PH) is based on resting mean pulmonary arterial pressure (mPAP) ≥25 mmHg; however, analysis of long-term follow-up data now reveals increased mortality even with mPAP ≥19 mmHg. Do we need to modify the definition of PH, and what are the implications for clinical practice? Full Text | PDF
Hypertension: When should we treat hypertension in patients with diabetes? Sverre E. Kjeldsen & Ingrid Os Published online: 07 April 2016 p252 | doi:10.1038/nrcardio.2016.49 Diabetes mellitus and hypertension are closely related, and guidelines have recommended aggressive treatment of hypertension in patients with diabetes. However, no single clinical trial is conclusive. An extensive review of the use of blood-pressure-lowering drugs in patients with diabetes supports treating blood pressure >140/90 mmHg, whereas reducing blood pressure in people with normal or high-normal blood pressure might have untoward effects. Full Text | PDF
Imaging: Focusing light on the vulnerable plaque Peter J. Psaltis & Stephen J. Nicholls p253 | doi:10.1038/nrcardio.2016.53 A new report has demonstrated the combined use of optical coherence tomography and molecular imaging within human coronary arteries. This combination provides a unique opportunity to look at plaque from a view not previously possible, opening the field for greater understanding of plaque biology in research and clinical practice. Full Text | PDF
REVIEWS		Top
Acute coronary syndromes without coronary plaque rupture Siddak S. Kanwar, Gregg W. Stone, Mandeep Singh, Renu Virmani, Jeffrey Olin, Takashi Akasaka & Jagat Narula Published online: 25 February 2016 p257 | doi:10.1038/nrcardio.2016.19 A large number of acute coronary syndrome (ACS) events originate from plaques with an intact fibrous cap (IFC). In this Review, Kanwar et al. provide an overview of the latest advances in our understanding of plaque morphology in ACS with IFC, reviewing contemporary data from multimodality imaging. They also discuss whether the use of such imaging might result in more effective management of patients with ACS. Abstract | Full Text | PDF
Noninvasive cardiac imaging in suspected acute coronary syndrome Pankaj Garg, S. Richard Underwood, Roxy Senior, John P. Greenwood & Sven Plein Published online: 25 February 2016 p266 | doi:10.1038/nrcardio.2016.18 Advanced noninvasive imaging techniques add diagnostic and prognostic value in patients with suspected acute coronary syndrome, complementing patient history, electrocardiogram, and cardiac biomarkers for timely identification or ruling out of acute coronary syndrome. In this Review, Garg and colleagues summarize the current guidelines and clinical use of the most common noninvasive imaging techniques, and provide an update on developments in noninvasive imaging. Abstract | Full Text | PDF
Assessment, treatment, and prognostic implications of CAD in patients undergoing TAVI Edward Danson, Peter Hansen, Sayan Sen, Justin Davies, Ian Meredith & Ravinay Bhindi Published online: 11 February 2016 p276 | doi:10.1038/nrcardio.2016.9 Coronary artery disease (CAD) is common in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI), but its clinical relevance is controversial. In this Review, Danson et al. summarize the methods of assessing CAD in TAVI populations, and the data on the safety and efficacy of percutaneous coronary intervention in patients undergoing TAVI. Abstract | Full Text | PDF
Assessing quality-of-life outcomes in cardiovascular clinical research Daniel B. Mark Published online: 18 February 2016 p286 | doi:10.1038/nrcardio.2016.10 In this Review, Daniel Mark examines the use of health-related quality of life (QOL) as an outcome measure in clinical cardiovascular research. The main concepts, assumptions, tools, and methods used to assess QOL are discussed. Applied research into QOL outcomes in coronary artery disease, heart failure, and atrial fibrillation are also summarized, with an emphasis on experience from large, randomized clinical trials. Abstract | Full Text | PDF | Supplementary information
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Cardiology was previously published as Nature Clinical Practice Cardiovascular Medicine.

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