Scientific Reports Table of Contents e-alert: 26 April 2016

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26 April 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports             Jump to the content that matters to you ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Health Sciences                 BJC collections: Cancer Immunotherapy Immunotherapies have revolutionised therapy for some cancers. In parallel with therapeutic trials, many other mechanisms and pathways are being investigated in optimising these treatments. Access this collection from British Journal of Cancer - free online for six months Produced with support from: EMD Serono               Biological Sciences ▲ top               Two-Dimensional NMR Lineshape Analysis ▶     Christopher A. Waudby, Andres Ramos, Lisa D. Cabrita et al.     NMR titration experiments are a rich source of structural, mechanistic, thermodynamic and kinetic information on biomolecular interactions, which can be extracted through the …             A novel lineage restricted, pericyte-like cell line isolated from human embryonic stem cells ▶     Midori Greenwood-Goodwin, Jiwei Yang, Mohammad Hassanipour et al.     Pericytes (PCs) are endothelium-associated cells that play an important role in normal vascular function and maintenance. We developed a method comparable to GMP quality …             Kaempferol stimulates gene expression of low-density lipoprotein receptor through activation of Sp1 in cultured hepatocytes ▶     Ayasa Ochiai, Shingo Miyata, Masamori Iwase et al.     A high level of plasma low-density lipoprotein (LDL) cholesterol is considered a risk factor for atherosclerosis. Because the hepatic LDL receptor (LDLR) is essential for …             Strategies of Mesenchymal Invasion of Patient-derived Brain Tumors: Microenvironmental Adaptation ▶     Junghwa Cha, Seok-Gu Kang, Pilnam Kim     The high mortality in glioblastoma multiforme (GBM) patients is primarily caused by extensive infiltration into adjacent tissue and subsequent rapid recurrence. There are no …             Pan-cancer subtyping in a 2D-map shows substructures that are driven by specific combinations of molecular characteristics ▶     Erdogan Taskesen, Sjoerd M. H. Huisman, Ahmed Mahfouz et al.     The use of genome-wide data in cancer research, for the identification of groups of patients with similar molecular characteristics, has become a standard approach for …             Hedgehog signaling activation induces stem cell proliferation and hormone release in the adult pituitary gland ▶     Joanna Pyczek, Rolf Buslei, David Schult et al.     Hedgehog (HH) signaling is known to be essential during the embryonal development of the pituitary gland but the knowledge about its role in the adult pituitary and in associated …             Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure ▶     Jun Suzuki, Gabriel Corfas, M. Charles Liberman     In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary …             Blastomere removal from cleavage-stage mouse embryos alters placental function, which is associated with placental oxidative stress and inflammation ▶     Qi Yao, Li Chen, Yuanjiao Liang et al.     Blastomere biopsy is an essential technique in preimplantation genetic diagnosis (PGD), a screening test that can detect genetic abnormalities of embryos before their transfer …             Identification of residues crucial for the interaction between human neuroglobin and the α-subunit of heterotrimeric Gi protein ▶     Nozomu Takahashi, Keisuke Wakasugi     Mammalian neuroglobin (Ngb) protects neuronal cells under conditions of oxidative stress. We previously showed that human Ngb acts as a guanine nucleotide dissociation inhibitor …             Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle ▶     John M. Dye, Hua Wu, Jay W. Hooper et al.     Polyclonal antibodies, derived from humans or hyperimmunized animals, have been used prophylactically or therapeutically as countermeasures for a variety of infectious diseases. …             Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway ▶     Zhi-Hui Song, Zhong-Yin Li, Dan-Dan Li et al.     After insemination, a large number of leukocytes migrate into the uterus, which is accompanied by intense inflammation. However, the details of how seminal plasma interacts with …             Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis ▶     Wen-Hua Wei, John Bowes, Darren Plant et al.     Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a …             The effects of salinity on nitrification using halophilic nitrifiers in a Sequencing Batch Reactor treating hypersaline wastewater ▶     You-Wei Cui, Hong-Yu Zhang, Jie-Ran Ding et al.     With annual increases in the generation and use of saline wastewater, the need to avoid environmental problems such as eutrophication is critical. A previous study identified …             Mechano-adaptive sensory mechanism of α-catenin under tension ▶     Koichiro Maki, Sung-Woong Han, Yoshinori Hirano et al.     The contractile forces in individual cells drive the tissue processes, such as morphogenesis and wound healing, and maintain tissue integrity. In these processes, α-catenin …             A CRISPR/Cas9 system adapted for gene editing in marine algae ▶     Marianne Nymark, Amit Kumar Sharma, Torfinn Sparstad et al.     Here we report that the CRISPR/Cas9 technology can be used to efficiently generate stable targeted gene mutations in microalgae, using the marine diatom Phaeodactylum tricornutum …             Integrative Genomics and Transcriptomics Analysis Reveals Potential Mechanisms for Favorable Prognosis of Patients with HPV-Positive Head and Neck Carcinomas ▶     Wensheng Zhang, Andrea Edwards, Zhide Fang et al.     Patients with HPV-positive head neck squamous cell carcinomas (HNSCC) usually have a better prognosis than the HPV-negative cases while the underlying mechanism remains far from …             The development of a phosphite-mediated fertilization and weed control system for rice ▶     Mrinalini Manna, V. Mohan M. Achary, Tahmina Islam et al.     Fertilizers and herbicides are two vital components of modern agriculture. The imminent danger of phosphate reserve depletion and multiple herbicide tolerance casts doubt on …             1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice ▶     Christina B. Leibrock, Jakob Voelkl, Makoto Kuro-o et al.     Klotho, a protein mainly expressed in kidney and cerebral choroid plexus, is a powerful regulator of 1,25(OH)2D3 formation. Klotho-deficient mice (kl/kl) suffer from excessive …             Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP ▶     Anat Bren, Junyoung O. Park, Benjamin D. Towbin et al.     In most conditions, glucose is the best carbon source for E. coli: it provides faster growth than other sugars, and is consumed first in sugar mixtures. Here we identify …             Engineering a d-lactate dehydrogenase that can super-efficiently utilize NADPH and NADH as cofactors ▶     Hengkai Meng, Pi Liu, Hongbing Sun et al.     Engineering the cofactor specificity of a natural enzyme often results in a significant decrease in its activity on original cofactor. Here we report that a NADH-dependent …             Biofluorescence in Catsharks (Scyliorhinidae): Fundamental Description and Relevance for Elasmobranch Visual Ecology ▶     David F. Gruber, Ellis R. Loew, Dimitri D. Deheyn et al.     Biofluorescence has recently been found to be widespread in marine fishes, including sharks. Catsharks, such as the Swell Shark (Cephaloscyllium ventriosum) from the eastern …             Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease ▶     Meh Sameen Nawaz, Erik Sebastian Vik, Mia Elise Ronander et al.     Endonuclease V (EndoV) is an enzyme with specificity for deaminated adenosine (inosine) in nucleic acids. EndoV from Escherichia coli (EcEndoV) acts both on inosines in DNA and …             What does the nose know? Olfactory function predicts social network size in human ▶     Lai-quan Zou, Zhuo-ya Yang, Yi Wang et al.     Olfaction is an important medium of social communication in humans. However, it is not known whether olfactory function is associated with social network size. This study aimed …             Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses ▶     Julie S Lefebvre, April R Masters, Jacob W Hopkins et al.     T follicular helper (TFH) cell responses are essential for generation of protective humoral immunity during influenza infection. Aging has a profound impact on CD4+ T cell …             Exercise capacity and cardiac hemodynamic response in female ApoE/LDLR−/− mice: a paradox of preserved V’O2max and exercise capacity despite coronary atherosclerosis ▶     M. Wojewoda, U. Tyrankiewicz, P. Gwozdz et al.     We assessed exercise performance, coronary blood flow and cardiac reserve of female ApoE/LDLR−/− mice with advanced atherosclerosis compared with age-matched, wild-type C57BL6/J …             PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits ▶     Matthew J. Broadhead, Mathew H. Horrocks, Fei Zhu et al.     The molecular features of synapses in the hippocampus underpin current models of learning and cognition. Although synapse ultra-structural diversity has been described in the …             A genetic analysis of 23 Chinese patients with hemophilia B ▶     Qing-Yun Wang, Bei Hu, Hui Liu et al.     Hemophilia B (HB) is an X-linked recessive bleeding disorder caused by mutations in the coagulation factor IX (FIX) gene. Genotyping patients with HB is essential for genetic …             NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell ▶     Zhi-Li Zhao, Lu Zhang, Cong-Fa Huang et al.     Cancer stem cells (CSCs) are considered responsible for tumor initiation and chemoresistance. This study was aimed to investigate the possibility of targeting head neck squamous …             Genetic polymorphisms of cell adhesion molecules in Behcet’s disease in a Chinese Han population ▶     Minming Zheng, Lijun Zhang, Hongsong Yu et al.     Cell adhesion molecules (CAMs) are involved in various immune-mediated diseases. This study was conducted to investigate the association of single nucleotide polymorphisms (SNPs) …             Gene expression analysis and SNP/InDel discovery to investigate yield heterosis of two rubber tree F1 hybrids ▶     Dejun Li, Rizhong Zeng, Yan Li et al.     As an important industrial material, natural rubber is mainly harvested from the rubber tree. Rubber tree breeding is inefficient, expensive and time-consuming, whereas …             A comprehensive simulation framework for imaging single particles and biomolecules at the European X-ray Free-Electron Laser ▶     Chun Hong Yoon, Mikhail V. Yurkov, Evgeny A. Schneidmiller et al.     The advent of newer, brighter, and more coherent X-ray sources, such as X-ray Free-Electron Lasers (XFELs), represents a tremendous growth in the potential to apply coherent …             Identifying Reproducible Molecular Biomarkers for Gastric Cancer Metastasis with the Aid of Recurrence Information ▶     Mengyao Li, Guini Hong, Jun Cheng et al.     To precisely diagnose metastasis state is important for tailoring treatments for gastric cancer patients. However, the routinely employed radiological and pathologic tests for …             Sleep Deprivation and Advice Taking ▶     Jan Alexander Häusser, Johannes Leder, Charlene Ketturat et al.     Judgements and decisions in many political, economic or medical contexts are often made while sleep deprived. Furthermore, in such contexts individuals are required to integrate …             Role of oxidants in enhancing dewaterability of anaerobically digested sludge through Fe (II) activated oxidation processes: hydrogen peroxide versus persulfate ▶     Kang Song, Xu Zhou, Yiqi Liu et al.     Improving dewaterability of sludge is important for the disposal of sludge in wastewater treatment plants (WWTPs). This study, for the first time, investigated the Fe(II) …             Bioactivity Focus of α-Cyano-4-hydroxycinnamic acid (CHCA) Leads to Effective Multifunctional Aldose Reductase Inhibitors ▶     Laitao Zhang, Yi-Fang Li, Sheng Yuan et al.     Bioactivity focus on α-cyano-4-hydroxycinnamic acid (CHCA) scaffold results in a small library of novel multifunctional aldose reductase (ALR2) inhibitors. All the entities …             Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body ▶     Yasunari Seita, Tomoyuki Tsukiyama, Chizuru Iwatani et al.     Nonhuman primates are valuable for human disease modelling, because rodents poorly recapitulate some human diseases such as Parkinson’s disease and Alzheimer’s disease amongst …             Naringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone ▶     Xinlong Ma, Jianwei Lv, Xiaolei Sun et al.     Naringin maintains bone mass in various osteoporosis models, while its effect on bone in disuse osteoporosis has not been reported. The present study explores whether naringin …             Corrigendum: Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae ▶     Nicolas Gisch, Dominik Schwudke, Simone Thomsen et al.                 Structure of FIV capsid C-terminal domain demonstrates lentiviral evasion of genetic fragility by coevolved substitutions ▶     Aya Khwaja, Meytal Galilee, Ailie Marx et al.     Viruses use a strategy of high mutational rates to adapt to environmental and therapeutic pressures, circumventing the deleterious effects of random single-point mutations by …             Corrigendum: microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production ▶     Miao Li, Jinli Wang, Yimin Fang et al.                 Role of Berberine in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections ▶     Ming Chu, Ming-bo Zhang, Yan-chen Liu et al.     Berberine is an isoquinoline alkaloid widely used in the treatment of microbial infections. Recent studies have shown that berberine can enhance the inhibitory efficacy of …             Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles ▶     Itaru Sato, Masanari Umemura, Kenji Mitsudo et al.     We previously investigated the utility of μ-oxo N,N′- bis(salicylidene)ethylenediamine iron (Fe(Salen)) nanoparticles as a new anti-cancer agent for magnet-guided delivery with …             Negative incidental emotions augment fairness sensitivity ▶     Cuizhen Liu, Jing Wen Chai, Rongjun Yu     Previous studies have shown that task-unrelated emotions induced incidentally exert carryover effects on individuals’ subsequent decisions in financial negotiations. However, the …             Global antibody response to Staphylococcus aureus live-cell vaccination ▶     Martina Selle, Tobias Hertlein, Babett Oesterreich et al.     The pathogen Staphylococcus aureus causes a broad range of severe diseases and is feared for its ability to rapidly develop resistance to antibiotic substances. The increasing …             GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119 ▶     Qing Zhang, Yan Li, Yuxia Zhang et al.     Primary cilia are sensory organelles indispensable for organogenesis and tissue pattern formation. Ciliopathy small GTPase ARLs are proposed as prominent ciliary switches, which …             Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells ▶     Tatsuya Miyake, Keiichi Kumasawa, Noriko Sato et al.     Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR1/sFLT1) is an angiogenesis inhibitor that competes with angiogenic factors such as VEGF and Placental Growth Factor …             Erratum: Involvement of hormones in olfactory imprinting and homing in chum salmon ▶     Hiroshi Ueda, Shingo Nakamura, Taro Nakamura et al.                 Low-intensity pulsed ultrasound treatment improved the rate of autograft peripheral nerve regeneration in rat ▶     Wenli Jiang, Yuexiang Wang, Jie Tang et al.     Low intensity pulsed ultrasound (LIPUS) has been widely used in clinic for the treatment of repairing pseudarthrosis, bone fractures and of healing in various soft tissues. Some …             Corrigendum: Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca2+ release channel ▶     Dilyana Filipova, Anna M. Walter, John A. Gaspar et al.                 Corrigendum: Precipitation shapes communities of arbuscular mycorrhizal fungi in Tibetan alpine steppe ▶     Jing Zhang, Fang Wang, Rongxiao Che et al.                 Corrigendum: Masculinised Behaviour of XY Females in a Mammal with Naturally Occurring Sex Reversal ▶     Paul A. Saunders, Thomas Franco, Camille Sottas et al.                 Arbuscular mycorrhizal fungi in soil and roots respond differently to phosphorus inputs in an intensively managed calcareous agricultural soil ▶     Wei Liu, Yunlong Zhang, Shanshan Jiang et al.     Understanding the diversity and community structure of arbuscular mycorrhizal fungi (AMF) is important for potentially optimizing their role in mining phosphorus (P) in …             The sporulation of the green alga Ulva prolifera is controlled by changes in photosynthetic electron transport chain ▶     Hui Wang, Apeng Lin, Wenhui Gu et al.     Sporulation and spore release are essential phases of the life cycle in algae and land plants. Ulva prolifera, which is an ideal organism for studying sporulation and spore …             AtOPR3 specifically inhibits primary root growth in Arabidopsis under phosphate deficiency ▶     Hongyan Zheng, Xiaoying Pan, Yuxia Deng et al.     The primary root plays essential roles in root development, nutrient absorption, and root architectural establishment. Primary root growth is generally suppressed by phosphate …             Evaluation of voltage-dependent calcium channel γ gene families identified several novel potential susceptible genes to schizophrenia ▶     Fanglin Guan, Tianxiao Zhang, Xinshe Liu et al.     Voltage-gated L-type calcium channels (VLCC) are distributed widely throughout the brain. Among the genes involved in schizophrenia (SCZ), genes encoding VLCC subunits have …             The interactome of Streptococcus pneumoniae and its bacteriophages show highly specific patterns of interactions among bacteria and their phages ▶     Rachelle Mariano, Stefan Wuchty, Maria G. Vizoso-Pinto et al.     Although an abundance of bacteriophages exists, little is known about interactions between their proteins and those of their bacterial hosts. Here, we experimentally determined …             Clonify: unseeded antibody lineage assignment from next-generation sequencing data ▶     Bryan Briney, Khoa Le, Jiang Zhu et al.     Defining the dynamics and maturation processes of antibody clonal lineages is crucial to understanding the humoral response to infection and immunization. Although individual …             Glycoengineered Outer Membrane Vesicles: A Novel Platform for Bacterial Vaccines ▶     Nancy L. Price, Guillaume Goyette-Desjardins, Harald Nothaft et al.     The World Health Organization has indicated that we are entering into a post-antibiotic era in which infections that were routinely and successfully treated with antibiotics can …             Constructing and Validating High-Performance MIEC-SVM Models in Virtual Screening for Kinases: A Better Way for Actives Discovery ▶     Huiyong Sun, Peichen Pan, Sheng Tian et al.     The MIEC-SVM approach, which combines molecular interaction energy components (MIEC) derived from free energy decomposition and support vector machine (SVM), has been found …             Corrigendum: Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line ▶     Sheila Smiley, Philip E. Nickerson, Lacrimioara Comanita et al.                 Systematic Analysis of Adverse Event Reports for Sex Differences in Adverse Drug Events ▶     Yue Yu, Jun Chen, Dingcheng Li et al.     Increasing evidence has shown that sex differences exist in Adverse Drug Events (ADEs). Identifying those sex differences in ADEs could reduce the experience of ADEs for patients …             Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori ▶     Zhaoming Dong, Ping Zhao, Yan Zhang et al.     The silk gland is the only organ where silk proteins are synthesized and secreted in the silkworm, Bombyx mori. Silk proteins are stored in the lumen of the silk gland for around …             Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody ▶     Yue Tao, Xiaoqin Zhang, Xin Liang et al.     Ectodomain shedding of glycoprotein (GP) Ibα is thought to mediate the clearance of activated, aged or damaged platelets. A monoclonal antibody, 5G6, has been developed recently …             Plasiatine, an Unprecedented Indole–Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2 ▶     Zhong-Hua Gao, Yi-Ming Shi, Zhe Qiang et al.     Plasiatine (1), isolated from the seeds of Plantago asiatica, is an unprecedented indole analogue linked to a phenylpropanoid moiety via a carbon bond that builds up a novel …             Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes ▶     Alireza Ahadi, Samuel Brennan, Paul J. Kennedy et al.     Long non-coding RNAs (lncRNAs) form the largest transcript class in the human transcriptome. These lncRNA are expressed not only in the cells, but they are also present in the …             Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis ▶     Jian Shen, Ning Song, Christopher J. Williams et al.     Atrophic vaginitis (AV) is common in postmenopausal women, but its causes are not well understood. The symptoms, which include vaginal itching, burning, dryness, irritation, and …             Noise and the Perceptual Filling-in effect ▶     Ativ Zomet, Uri Polat, Dennis M. Levi     Nearby collinear flankers increase the false alarm rate (reports of the target being present when it is not) in a Yes-No experiment. This effect has been attributed to …             Gene expression of Lactobacillus plantarum and the commensal microbiota in the ileum of healthy and early SIV-infected rhesus macaques ▶     Benjamin L. Golomb, Lauren A. Hirao, Satya Dandekar et al.     Chronic HIV infection results in impairment of gut-associated lymphoid tissue leading to systemic immune activation. We previously showed that in early SIV-infected rhesus …             AtSWEET4, a hexose facilitator, mediates sugar transport to axial sinks and affects plant development ▶     Xiaozhu Liu, Yan Zhang, Chao Yang et al.     Plants transport photoassimilates from source organs to sink tissues through the phloem translocation pathway. In the transport phloem, sugars that escape from the sieve tubes …             Corrigendum: Laser spectrometry for multi-elemental imaging of biological tissues ▶     L. Sancey, V. Motto-Ros, B. Busser et al.                 VirB8-like protein TraH is crucial for DNA transfer in Enterococcus faecalis ▶     Christian Fercher, Ines Probst, Verena Kohler et al.     Untreatable bacterial infections caused by a perpetual increase of antibiotic resistant strains represent a serious threat to human healthcare in the 21st century. Conjugative …             Infection pattern and transmission potential of chikungunya virus in two New World laboratory-adapted Aedes aegypti strains ▶     Shengzhang Dong, Asher M. Kantor, Jingyi Lin et al.     Chikungunya virus (CHIKV) is an emerging mosquito-borne virus belonging to the Togaviridae, which is transmitted to humans by Aedes aegypti and Ae. albopictus. We describe the …             Perceptual drifts of real and artificial limbs in the rubber hand illusion ▶     Xaver Fuchs, Martin Riemer, Martin Diers et al.     In the rubber hand illusion (RHI), transient embodiment of an artificial hand is induced. An often-used indicator for this effect is the “proprioceptive drift”, a localization …             Altered microRNA expression and pre-mRNA splicing events reveal new mechanisms associated with early stage Mycobacterium avium subspecies paratuberculosis infection ▶     Guanxiang Liang, Nilusha Malmuthuge, Yongjuan Guan et al.     The molecular regulatory mechanisms of host responses to Mycobacterium avium subsp. paratuberculosis (MAP) infection during the early subclinical stage are still not clear. In …             Response of tomato wilt pathogen Ralstonia solanacearum to the volatile organic compounds produced by a biocontrol strain Bacillus amyloliquefaciens SQR-9 ▶     Waseem Raza, Ning Ling, Liudong Yang et al.     It is important to study the response of plant pathogens to the antibiosis traits of biocontrol microbes to design the efficient biocontrol strategies. In this study, we …             Warming effects on photosynthesis of subtropical tree species: a translocation experiment along an altitudinal gradient ▶     Yiyong Li, Juxiu Liu, Guoyi Zhou et al.     Ongoing climate warming induced by human activities may have great impacts on trees, yet it remains unresolved how subtropical tree species respond to rising temperature in the …             Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses ▶     Vilma Aho, Hanna M. Ollila, Erkki Kronholm et al.     Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were …             Crystal Structures and Binding Dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri ▶     Tom Northey, Herbert Venthur, Filomena De Biasio et al.     Aphids use chemical cues to locate hosts and find mates. The vetch aphid Megoura viciae feeds exclusively on the Fabaceae, whereas the currant-lettuce aphid Nasonovia ribisnigri …             Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes ▶     Masako Nakano, Kanna Nagaishi, Naoto Konari et al.     The incidence of dementia is higher in diabetic patients, but no effective treatment has been developed. This study showed that rat bone marrow mesenchymal stem cells (BM-MSCs) …             Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist ▶     Tom Macleod, Rosella Doble, Dennis McGonagle et al.     The interleukin-36 receptor antagonist (IL-36Ra) which regulates IL-36α, -β and -γ is linked to psoriatic inflammation, especially loss-of-function mutations in pustular …             Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin ▶     A. Ian Smith, Niwanthi W. Rajapakse, Oded Kleifeld et al.                 Interaction between IGFBP7 and insulin: a theoretical and experimental study ▶     Wenjing Ruan, Zhengzhong Kang, Youzhao Li et al.     Insulin-like growth factor binding protein 7 (IGFBP7) can bind to insulin with high affinity which inhibits the early steps of insulin action. Lack of recognition mechanism …             The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species ▶     Abdul A. Waheed, Scott MacDonald, Maisha Khan et al.     The HIV-1 accessory protein Vpu enhances virus release by counteracting the host restriction factor tetherin. To further understand the role of host cell proteins in Vpu …             Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats ▶     Gerard Aragonès, Manuel Suárez, Andrea Ardid-Ruiz et al.     Proanthocyanidins (PACs) have been reported to modulate multiple targets by simultaneously controlling many pivotal metabolic pathways in the liver. However, the precise …             Digital Signal Processing and Control for the Study of Gene Networks ▶     Yong-Jun Shin     Thanks to the digital revolution, digital signal processing and control has been widely used in many areas of science and engineering today. It provides practical and powerful …             Imaging mass spectrometry for the precise design of antibody-drug conjugates ▶     Yuki Fujiwara, Masaru Furuta, Shino Manabe et al.     Antibody-drug conjugates (ADCs) are a class of immunotherapeutic agents that enable the delivery of cytotoxic drugs to target malignant cells. Because various cancers and tumour …             From molecular interaction to acute promyelocytic leukemia: Calculating leukemogenesis and remission from endogenous molecular-cellular network ▶     Ruoshi Yuan, Xiaomei Zhu, Jerald P. Radich et al.     Acute promyelocytic leukemia (APL) remains the best example of a malignancy that can be cured clinically by differentiation therapy. We demonstrate that APL may emerge from a …             Newcastle disease virus NP and P proteins induce autophagy via the endoplasmic reticulum stress-related unfolded protein response ▶     Jing-Hua Cheng, Ying-Jie Sun, Fan-Qing Zhang et al.     Newcastle disease virus (NDV) can replicate and trigger autophagy in human tumor cells. Our previous study confirmed the critical role of autophagy in NDV infection. Here we …             LINE-1-like retrotransposons contribute to RNA-based gene duplication in dicots ▶     Zhenglin Zhu, Shengjun Tan, Yaqiong Zhang et al.     RNA-based duplicated genes or functional retrocopies (retrogenes) are known to drive phenotypic evolution. Retrogenes emerge via retroposition, which is mainly mediated by long …             Fine-scale behavioural differences distinguish resource use by ecomorphs in a closed ecosystem ▶     Kate L. Hawley, Carolyn M. Rosten, Guttorm Christensen et al.     Temporal differences in habitat use and foraging specialisms between ecomorphs represent aspects of behavioural phenotype that are poorly understood with regard to the origin and …             Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway ▶     Yixian Shi, Yongjun Li, Chenjie Huang et al.     The population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment …             Anxiety promotes memory for mood-congruent faces but does not alter loss aversion ▶     Caroline J. Charpentier, Chandni Hindocha, Jonathan P. Roiser et al.     Pathological anxiety is associated with disrupted cognitive processing, including working memory and decision-making. In healthy individuals, experimentally-induced state anxiety …             The germline-enriched Ppp1r36 promotes autophagy ▶     Qinghua Zhang, Maomao Gao, Ying Zhang et al.     Spermatogenesis is a highly regulated process during which haploid sperm cells are generated. Although autophagy is involved in the spermatogenesis process, the molecular …             Constrained evolvability of interferon suppression in an RNA virus ▶     Raquel Garijo, José M. Cuevas, Álvaro Briz et al.     Innate immunity responses controlled by interferon (IFN) are believed to constitute a major selective pressure shaping viral evolution. Viruses encode a variety of IFN …             Yeast V-ATPase Proteolipid Ring Acts as a Large-conductance Transmembrane Protein Pore ▶     Sergio Couoh-Cardel, Yi-Ching Hsueh, Stephan Wilkens et al.     The vacuolar H+ -ATPase (V-ATPase) is a rotary motor enzyme that acidifies intracellular organelles and the extracellular milieu in some tissues. Besides its canonical …             Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides ▶     Jixia Wang, Xiuli Zhang, Xiaolong Li et al.     Multicellular spheroids of cancer cells have been increasingly used to screen anti-tumor compounds, owing to their in vivo like microenvironment and structure as well as …             Regiospecific synthesis of prenylated flavonoids by a prenyltransferase cloned from Fusarium oxysporum ▶     Xiaoman Yang, Jiali Yang, Yueming Jiang et al.     Due to their impressive pharmaceutical activities and safety, prenylated flavonoids have a high potent to be applied as medicines and nutraceuticals. Biocatalysis is an effective …             In vitro template-change PCR to create single crossover libraries: a case study with B. thuringiensis Cry2A toxins ▶     Changlong Shu, Jianqiao Zhou, Neil Crickmore et al.     During evolution the creation of single crossover chimeras between duplicated paralogous genes is a known process for increasing diversity. Comparing the properties of …             Revealing the acute asthma ignorome: characterization and validation of uninvestigated gene networks ▶     Michela Riba, Jose Manuel Garcia Manteiga, Berislav Bošnjak et al.     Systems biology provides opportunities to fully understand the genes and pathways in disease pathogenesis. We used literature knowledge and unbiased multiple data meta-analysis …             Molecular simulations of conformation change and aggregation of HIV-1 Vpr13-33 on graphene oxide ▶     Songwei Zeng, Guoquan Zhou, Jianzhong Guo et al.     Recent experiments have reported that the fragment of viral protein R (Vpr), Vpr13-33, can assemble and change its conformation after adsorbed on graphene oxide (GO) and then …             KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer ▶     Yi-Zhen Liu, Hai Yang, Jian Cao et al.     Nowadays, no robust biomarkers have been applied to clinical practice to provide prognostic evaluation of non-small cell lung cancer (NSCLC). This study aims to identify new …             CRISPR/Cas9-mediated efficient and heritable targeted mutagenesis in tomato plants in the first and later generations ▶     Changtian Pan, Lei Ye, Li Qin et al.     The CRISPR/Cas9 system has successfully been used in various organisms for precise targeted gene editing. Although it has been demonstrated that CRISPR/Cas9 system can induce …             Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins ▶     Xia-Chun Li, Yu Hu, Zhi-hao Wang et al.     Intracellular accumulation of tau protein is hallmark of sporadic Alzheimer’s disease (AD), however, the cellular mechanism whereby tau accumulation causes neurodegeneration is …             Differences in vulnerability of neurons and astrocytes to heme oxygenase-1 modulation: Implications for mitochondrial ferritin ▶     Xiaojun Yu, Ning Song, Xinli Guo et al.     Induction of the antioxidant enzyme heme oxygenase-1 (HO-1) was observed in both astrocytes and neurons in the substantia nigra of patients with Parkinson’s disease (PD). In the …             Fat Metabolism Regulates Satiety Behavior in C. elegans ▶     Moonjung Hyun, Kristen Davis, Inhwan Lee et al.     Animals change feeding behavior depending on their metabolic status; starved animals are eager to eat and satiated animals stop eating. C. elegans exhibits satiety quiescence …             Thioflavin T as an efficient fluorescence sensor for selective recognition of RNA G-quadruplexes ▶     Shujuan Xu, Qian Li, Junfeng Xiang et al.     RNA G-quadruplexes (G4s) play important roles in translational regulation, mRNA processing events and gene expression. Therefore, a fluorescent probe that is capable of …             Antibiofilm efficacy of photoactivated curcumin, triple and double antibiotic paste, 2% chlorhexidine and calcium hydroxide against Enterococcus fecalis in vitro ▶     Sharmila Devaraj, Nithya Jagannathan, Prasanna Neelakantan     Root canal disinfection is one of the most important factors governing success of root canal treatment, especially when regenerative strategies are used. This study evaluated the …             Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts ▶     Meijuan Zou, Fang Wang, Rui Gao et al.     Transforming growth factor-β1 (TGF-β1) plays an important role on fibrogenesis in heart disease. MicroRNAs have exhibited as crucial regulators of cardiac homeostasis and …             One-pot non-enzymatic formation of firefly luciferin in a neutral buffer from p-benzoquinone and cysteine ▶     Shusei Kanie, Toshio Nishikawa, Makoto Ojika et al.     Firefly luciferin, the substrate for the bioluminescence reaction of luminous beetles, possesses a benzothiazole ring, which is rare in nature. Here, we demonstrate a novel …             Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks ▶     Rocco Pulizzi, Gabriele Musumeci, Chris Van den Haute et al.     Cell assemblies manipulation by optogenetics is pivotal to advance neuroscience and neuroengineering. In in vivo applications, photostimulation often broadly addresses a …             CD14 in the TLRs signaling pathway is associated with the resistance to E. coli F18 in Chinese domestic weaned piglets ▶     Zhengchang Wu, Ying Liu, Wenhua Dong et al.     Escherichia coli F18 (E. coli F18) is mainly responsible for post-weaning diarrhea (PWD) in piglets. The genetic basis and regulatory mechanism of E. coli F18 resistance in …             Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence ▶     Ana Lilia Martinez-Rocha, Mayada Woriedh, Jan Chemnitz et al.     Activation of eukaryotic translation initiation factor eIF5A requires a posttranslational modification, forming the unique amino acid hypusine. This activation is mediated by two …             Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism ▶     Céline Jouffe, Cédric Gobet, Eva Martin et al.     Through evolution, most of the living species have acquired a time keeping system to anticipate daily changes caused by the rotation of the Earth. In all of the systems this …             Structure, organization and evolution of ADP-ribosylation factors in rice and foxtail millet, and their expression in rice ▶     Mehanathan Muthamilarasan, Venkata R. Mangu, Hana Zandkarimi et al.     ADP-ribosylation factors (ARFs) have been reported to function in diverse physiological and molecular activities. Recent evidences also demonstrate the involvement of ARFs in …             Circulating microRNA profiles of Ebola virus infection ▶     Janice Duy, Jeffrey W. Koehler, Anna N. Honko et al.     Early detection of Ebola virus (EBOV) infection is essential to halting transmission and adjudicating appropriate treatment. However, current methods rely on viral …             Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones ▶     Jonathan D. Taylor, William J. Hawthorne, Joanne Lo et al.     Polypeptide aggregation into amyloid is linked with several debilitating human diseases. Despite the inherent risk of aggregation-induced cytotoxicity, bacteria control the …             Genome-wide association studies for fatty acid metabolic traits in five divergent pig populations ▶     Wanchang Zhang, Bin Yang, Junjie Zhang et al.     Fatty acid composition profiles are important indicators of meat quality and tasting flavor. Metabolic indices of fatty acids are more authentic to reflect meat nutrition and …             Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays ▶     Drew M. Titmarsh, Nick R. Glass, Richard J. Mills et al.     Inducing cardiomyocyte proliferation in post-mitotic adult heart tissue is attracting significant attention as a therapeutic strategy to regenerate the heart after injury. Model …             Neural circuitry involved in quitting after repeated failures: role of the cingulate and temporal parietal junction ▶     Weihua Zhao, Keith M Kendrick, Fei Chen et al.     The more times people fail the more likely they are to give up, however little is known about the neural mechanisms underlying this impact of repeated failure on decision making. …             Autonomous oscillation/separation of cell density artificially induced by optical interlink feedback as designed interaction between two isolated microalgae chips ▶     Kazunari Ozasa, June Won, Simon Song et al.     We demonstrate a designed interaction between two isolated cell populations of Euglena gracilis and Chlamydomonas reinhardtii, separately confined in two 25-square …             Field trial of medicinal plant, Bidens pilosa, against eimeriosis in broilers ▶     Cicero Lee-Tian Chang, Cheng-Ying Yang, Thangarasu Muthamilselvan et al.     Eimeriosis is a severe protozoan disease in poultry. Because of increasing concern about drug residue and drug resistance with the use of anticoccidial drugs, natural products …             Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human ▶     Amirah Amir, Bruce Russell, Jonathan Wee Kent Liew et al.     Plasmodium knowlesi is extensively used as an important malaria model and is now recognized as an important cause of human malaria in Malaysia. The strains of P. knowlesi …             Optogenetic control of human neurons in organotypic brain cultures ▶     My Andersson, Natalia Avaliani, Andreas Svensson et al.     Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including …             A upconversion luminescene biosensor based on dual-signal amplification for the detection of short DNA species of c-erbB-2 oncogene ▶     Jianming Lan, Yingxin Liu, Li Li et al.     High-sensitivity detection of trace amounts of c-erbB-2 oncogene was reported to be equal to or surpass the ability of CA 15-3 for early diagnosis and/or follow-up recurrent …             Physiological responses to daily light exposure ▶     Yefeng Yang, Yonghua Yu, Bo Yang et al.     Long daylength artificial light exposure associates with disorders, and a potential physiological mechanism has been proposed. However, previous studies have examined no more …             Response of AM fungi spore population to elevated temperature and nitrogen addition and their influence on the plant community composition and productivity ▶     Tao Zhang, Xue Yang, Rui Guo et al.     To examine the influence of elevated temperature and nitrogen (N) addition on species composition and development of arbuscular mycorrhizal fungi (AMF) and the effect of AMF on …             The Tumour Response to Induction Chemotherapy has Prognostic Value for Long-Term Survival Outcomes after Intensity-Modulated Radiation Therapy in Nasopharyngeal Carcinoma ▶     Hao Peng, Lei Chen, Yuan Zhang et al.     The prognostic value of the tumour response to induction chemotherapy (IC) for long-term survival outcomes after intensity-modulated radiation therapy in nasopharyngeal carcinoma …             Regulation of aldosterone secretion by Cav1.3 ▶     Catherine B. Xie, Lalarukh Haris Shaikh, Sumedha Garg et al.     Aldosterone-producing adenomas (APAs) vary in phenotype and genotype. Zona glomerulosa (ZG)-like APAs frequently have mutations of an L-type calcium channel (LTCC) CaV1.3. Using …             Comparison of Vertebral Artery and Middle Cerebral Artery Monitoring for Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler ▶     Yu-Zhu Guo, Yong-Sheng Gao, Zhen-Ni Guo et al.     Contrast-enhanced transcranial Doppler (c-TCD) is a reliable and reproducible method for right-to-left shunt (RLS) detection, with high sensitivity. Monitoring the middle …             Effectiveness of Multiple Blood-Cleansing Interventions in Sepsis, Characterized in Rats ▶     Ivan Stojkovic, Mohamed Ghalwash, Xi Hang Cao et al.     Sepsis is a serious, life-threatening condition that presents a growing problem in medicine, but there is still no satisfying solution for treating it. Several blood cleansing …             Genipin crosslinking reduced the immunogenicity of xenogeneic decellularized porcine whole-liver matrices through regulation of immune cell proliferation and polarization ▶     Yujia Wang, Ji Bao, Xiujuan Wu et al.     Decellularized xenogeneic whole-liver matrices are plausible biomedical materials for the bioengineering of liver transplantation. A common method to reduce the inflammatory …             Generation of a monoclonal antibody recognizing the CEACAM glycan structure and inhibiting adhesion using cancer tissue-originated spheroid as an antigen ▶     Yumi Sato, Hiroaki Tateno, Jun Adachi et al.     Spheroids cultured directly from tumours can better reflect in vivo tumour characteristics than two-dimensional monolayer culture or three-dimensional culture of established cell …             HSP27 and 70 expression in thymic epithelial tumors and benign thymic alterations: diagnostic, prognostic and physiologic implications ▶     S. Janik, A. I. Schiefer, C. Bekos et al.     Thymic Epithelial Tumors (TETs), the most common tumors in the anterior mediastinum in adults, show a unique association with autoimmune Myasthenia Gravis (MG) and represent a …             Complementarity of medium-throughput in situ RNA hybridization and tissue-specific transcriptomics: case study of Arabidopsis seed development kinetics ▶     Edith Francoz, Philippe Ranocha, Clémentine Pernot et al.     The rationale of this study is to compare and integrate two heterologous datasets intended to unravel the spatiotemporal specificities of gene expression in a rapidly growing and …             Characterization of the resistance to Vip3Aa in Helicoverpa armigera from Australia and the role of midgut processing and receptor binding ▶     Maissa Chakroun, Núria Banyuls, Tom Walsh et al.     Crops expressing genes from Bacillus thuringiensis (Bt crops) are among the most successful technologies developed for the control of pests but the evolution of resistance to …             miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling ▶     Sherien M. El-Daly, Mohammed L. Abba, Nitin Patil et al.     Growth factor receptor signalling plays a central and critical role in colorectal cancer. Most importantly, the EGFR signalling cascade involving PI3K/AKT/mTOR and Raf/MEK/ERK …             Erratum: Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis ▶     Jana Ninkovic, Vidhu Anand, Raini Dutta et al.                 Testing the causality between CYP9M10 and pyrethroid resistance using the TALEN and CRISPR/Cas9 technologies ▶     Kentaro Itokawa, Osamu Komagata, Shinji Kasai et al.     Recently-emerging genome editing technologies have enabled targeted gene knockout experiments even in non-model insect species. For studies on insecticide resistance, genome …             Erratum: New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases ▶     Louise Lassalle, Sylvain Engilberge, Dominique Madern et al.                 Transient potassium channels augment degeneracy in hippocampal active dendritic spectral tuning ▶     Rahul Kumar Rathour, Ruchi Malik, Rishikesh Narayanan     Hippocampal pyramidal neurons express an intraneuronal map of spectral tuning mediated by hyperpolarization-activated cyclic-nucleotide-gated nonspecific-cation channels. …             Erratum: Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals ▶     Alexandra Montagner, Agata Korecka, Arnaud Polizzi et al.                 UvHOG1 is important for hyphal growth and stress responses in the rice false smut fungus Ustilaginoidea virens ▶     Dawei Zheng, Yi Wang, Yu Han et al.     Rice false smut caused by Ustilaginoidea virens is one of the most important diseases of rice worldwide. Although its genome has been sequenced, to date there is no report on …             Identification of a residue crucial for the angiostatic activity of human mini tryptophanyl-tRNA synthetase by focusing on its molecular evolution ▶     Terumasa Nakamoto, Miki Miyanokoshi, Tomoaki Tanaka et al.     Human tryptophanyl-tRNA synthetase (TrpRS) exists in two forms: a full-length TrpRS and a mini TrpRS. We previously found that human mini, but not full-length, TrpRS is an …             The biochemical basis for thermoregulation in heat-producing flowers ▶     Yui Umekawa, Roger S. Seymour, Kikukatsu Ito     Thermoregulation (homeothermy) in animals involves a complex mechanism involving thermal receptors throughout the body and integration in the hypothalamus that controls shivering …             Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice ▶     Amandine Thomas, Elise Belaidi, Judith Aron-Wisnewsky et al.     Obesity is associated with local tissue hypoxia and elevated hypoxia-inducible factor 1 alpha (HIF-1α) in metabolic tissues. Prolyl hydroxylases (PHDs) play an important role in …             Are viruses important in the plankton of highly turbid glacier-fed lakes? ▶     Fabian Drewes, Hannes Peter, Ruben Sommaruga     Viruses are ubiquitous in aquatic ecosystems where they significantly contribute to microbial mortality. In glacier-fed turbid lakes, however, viruses not only encounter low host …             A putative nitroreductase from the DosR regulon of Mycobacterium tuberculosis induces pro-inflammatory cytokine expression via TLR2 signaling pathway ▶     Vidyullatha Peddireddy, Sankara Narayana Doddam, Insaf A. Qureshi et al.     Tuberculosis caused by Mycobacterium tuberculosis is a global encumbrance and it is estimated that nearly one third population of the world acts as a reservoir for this pathogen …             Neuronal basis of perceptual learning in striate cortex ▶     Zhen Ren, Jiawei Zhou, Zhimo Yao et al.     It is well known that, in humans, contrast sensitivity training at high spatial frequency (SF) not only leads to contrast sensitivity improvement, but also results in an …             Voxel-based analysis of grey and white matter degeneration in cervical spondylotic myelopathy ▶     Patrick Grabher, Siawoosh Mohammadi, Aaron Trachsler et al.     In this prospective study, we made an unbiased voxel-based analysis to investigate above-stenosis spinal degeneration and its relation to impairment in patients with cervical …             Early Preferential Responses to Fear Stimuli in Human Right Dorsal Visual Stream - A Meg Study ▶     Hanneke K. M. Meeren, Nouchine Hadjikhani, Seppo P. Ahlfors et al.     Emotional expressions of others are salient biological stimuli that automatically capture attention and prepare us for action. We investigated the early cortical dynamics of …             Microbial metabolite butyrate facilitates M2 macrophage polarization and function ▶     Jian Ji, Dingming Shu, Mingzhu Zheng et al.     Metabolites from intestinal microbes modulate the mucosal immune system by regulating the polarization and expansion of T cells. Whether the microbial metabolites influence …             Nitrogen hurdle of host alternation for a polyphagous aphid and the associated changes of endosymbionts ▶     Yan-Hong Liu, Zhi-Wei Kang, Ya Guo et al.     Low proportion of essential amino acids (EAAs) is one of the barriers for animals to use phloem as a diet. Endosymbionts with EAAs synthesis functions are considered crucial for …             Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5 ▶     Christopher Swale, Alexandre Monod, Laura Tengo et al.     The genome of influenza A virus (IAV) comprises eight RNA segments (vRNA) which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp). RdRp …             Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway ▶     Haroon Badshah, Tahir Ali, Myeong Ok Kim     Toll-like receptor 4 (TLR4) signaling in the brain mediates autoimmune responses and induces neuroinflammation that results in neurodegenerative diseases, such as Alzheimer’s …             Ablation of the androgen receptor from vascular smooth muscle cells demonstrates a role for testosterone in vascular calcification ▶     Dongxing Zhu, Patrick W. F. Hadoke, Junxi Wu et al.     Vascular calcification powerfully predicts mortality and morbidity from cardiovascular disease. Men have a greater risk of cardiovascular disease, compared to women of a similar …             Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function ▶     Claudio R. Cortés, Aideen M. McInerney-Leo, Ida Vogel et al.     Ciliopathies are a group of genetic disorders caused by defective assembly or dysfunction of the primary cilium, a microtubule-based cellular organelle that plays a key role in …             Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway ▶     Yifan Wang, Jingyi Liu, Xuhua Ying et al.     Twist is a key transcription factor for Epithelial-mesenchymal transition (EMT), which is a cellular de-differentiation program that promotes invasion and metastasis, confers …             Characterization of the resistome in manure, soil and wastewater from dairy and beef production systems ▶     Noelle R. Noyes, Xiang Yang, Lyndsey M. Linke et al.     It has been proposed that livestock production effluents such as wastewater, airborne dust and manure increase the density of antimicrobial resistant bacteria and genes in the …             Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex ▶     Ryosuke Imai, Seiji Komeda, Mari Shimura et al.     Chromatin DNA must be read out for various cellular functions, and copied for the next cell division. These processes are targets of many anticancer agents. Platinum-based drugs, …             Transcriptional, epigenetic and retroviral signatures identify regulatory regions involved in hematopoietic lineage commitment ▶     Oriana Romano, Clelia Peano, Guidantonio Malagoli Tagliazucchi et al.     Genome-wide approaches allow investigating the molecular circuitry wiring the genetic and epigenetic programs of human somatic stem cells. Hematopoietic stem/progenitor cells …             Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses ▶     Nathaniel Huebsch, Peter Loskill, Nikhil Deveshwar et al.     Tissue engineering approaches have the potential to increase the physiologic relevance of human iPS-derived cells, such as cardiomyocytes (iPS-CM). However, forming Engineered …             Zebrafish Müller glia-derived progenitors are multipotent, exhibit proliferative biases and regenerate excess neurons ▶     Curtis Powell, Eli Cornblath, Fairouz Elsaeidi et al.     Unlike mammals, zebrafish can regenerate a damaged retina. Key to this regenerative response are Müller glia (MG) that respond to injury by reprogramming and adopting retinal …             Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency ▶     Qiang Tu, Jia Yin, Jun Fu et al.     Bacterial competent cells are essential for cloning, construction of DNA libraries, and mutagenesis in every molecular biology laboratory. Among various transformation methods, …             Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragm ▶     Silvia Willadt, Mark Nash, Clarke R. Slater     As mammals age, their neuromuscular junctions (NMJs) gradually change their form, acquiring an increasingly fragmented appearance consisting of numerous isolated regions of …             Analyses of Endothelial Cells and Endothelial Progenitor Cells Released Microvesicles by Using Microbead and Q-dot Based Nanoparticle Tracking Analysis ▶     Jinju Wang, Yun Zhong, Xiaotang Ma et al.     Accurate analysis of specific microvesicles (MVs) from biofluids is critical and challenging. Here we described novel methods to purify and detect MVs shed from endothelial cells …             Corrigendum: ACEMg Diet Supplement Modifies Progression of Hereditary Deafness ▶     Kari L. Green, Donald L. Swiderski, Diane M. Prieskorn et al.                 Erratum: Scarce evidence of the causal role of germline mutations in UNC5C in hereditary colorectal cancer and polyposis ▶     Pilar Mur, Elena Sánchez-Cuartielles, Susanna Aussó et al.                 Corrigendum: Non-ionizing radiofrequency electromagnetic waves traversing the head can be used to detect cerebrovascular autoregulation responses ▶     M. Oziel, M. Hjouj, C. A. Gonzalez et al.                 Isolation and molecular characterisation of Achromobacter phage phiAxp-3, an N4-like bacteriophage ▶     Yanyan Ma, Erna Li, Zhizhen Qi et al.     Achromobacter xylosoxidans, an opportunistic pathogen, is responsible for various nosocomial and community-acquired infections. We isolated phiAxp-3, an N4-like bacteriophage …             Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study ▶     Katherine S. Ruth, John R. B. Perry, William E. Henley et al.     The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in …             Drug target identification using network analysis: Taking active components in Sini decoction as an example ▶     Si Chen, Hailong Jiang, Yan Cao et al.     Identifying the molecular targets for the beneficial effects of active small-molecule compounds simultaneously is an important and currently unmet challenge. In this study, we …             Genome-wide identification and expression analysis of the IQD gene family in moso bamboo (Phyllostachys edulis) ▶     Min Wu, Yuan Li, Danmei Chen et al.     Members of the plant-specific IQ67-domain (IQD) protein family are involved in various aspects of normal plant growth and developmental processes as well as basal defence …             The Cytochrome P450 gene CYP6P12 confers pyrethroid resistance in kdr-free Malaysian populations of the dengue vector Aedes albopictus ▶     Intan H. Ishak, Jacob M. Riveron, Sulaiman S. Ibrahim et al.     Control of Aedes albopictus, major dengue and chikungunya vector, is threatened by growing cases of insecticide resistance. The mechanisms driving this resistance remain poorly …             Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound ▶     Guo-Feng Li, Hui-Xia Zhao, Hui Zhou et al.     Low frequency ultrasound (<1 MHz) has been demonstrated to be a promising approach for non-invasive neuro-stimulation. However, the focal width is limited to be half centimeter …             Temporal correlations in neuronal avalanche occurrence ▶     F. Lombardi, H. J. Herrmann, D. Plenz et al.     Ongoing cortical activity consists of sequences of synchronized bursts, named neuronal avalanches, whose size and duration are power law distributed. These features have been …             The neglected nano-specific toxicity of ZnO nanoparticles in the yeast Saccharomyces cerevisiae ▶     Weicheng Zhang, Shaopan Bao, Tao Fang     Nanoparticles (NPs) with unique physicochemical properties induce nano-specific (excess) toxicity in organisms compared with their bulk counterparts. Evaluation and consideration …             Monochromatic X-Ray Induced Novel Synthesis of Plasmonic Nanostructure for Photovoltaic Application ▶     Amardeep Bharti, Richa Bhardwaj, Ashish K. Agrawal et al.     It has been universally delineated that the plasmonic metal nanoparticles can enhance the efficiency of photovoltaic cell by increasing the probability of energetic solar photons …             Rapid, controllable growth of silver nanostructured surface-enhanced Raman scattering substrates for red blood cell detection ▶     Shu Zhang, Xueli Tian, Jun Yin et al.     Silver nanostructured films suitable for use as surface-enhanced Raman scattering (SERS) substrates are prepared in just 2 hours by the solid-state ionics method. By changing the …             Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals ▶     Hong Weng, Yan Yan, Ying-Hui Jin et al.     We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using …             Microbiota-based Signature of Gingivitis Treatments: A Randomized Study ▶     Shi Huang, Zhen Li, Tao He et al.     Plaque-induced gingivitis can be alleviated by various treatment regimens. To probe the impacts of various anti-gingivitis treatments on plaque microflora, here a double blinded, …             Levels of human platelet-derived soluble CD40 ligand depend on haplotypes of CD40LG-CD40-ITGA2 ▶     Chaker Aloui, Antoine Prigent, Sofiane Tariket et al.     Increased circulating soluble CD40 ligand (sCD40L) is commonly associated with inflammatory disorders. We aimed to investigate whether gene polymorphisms in CD40LG, CD40 and ITGA2…             Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer ▶     Dong-Xu He, Feng Gu, Fei Gao et al.     Cancer chemoresistance is regulated by complex genetic and epigenetic networks. In this study, the features of gene expression, methylation, and microRNA (miRNA) expression were …             NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy ▶     Justin Chun, Hyunjae Chung, Xiangyu Wang et al.     Nod-like receptor pyrin domain-containing-3 (NLRP3) has been implicated in the pathogenesis of experimental renal injury, yet its characterization in human kidney disease remains …             Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists ▶     Vernon Seow, Junxian Lim, Adam J. Cotterell et al.     Drug discovery and translation are normally based on optimizing efficacy by increasing receptor affinity, functional potency, drug-likeness (rule-of-five compliance) and oral …             Nanodroplet-Vaporization-Assisted Sonoporation for Highly Effective Delivery of Photothermal Treatment ▶     Wei-Wen Liu, Shu-Wei Liu, Yu-Ren Liou et al.     Sonoporation refers to the use of ultrasound and acoustic cavitation to temporarily enhance the permeability of cellular membranes so as to enhance the delivery efficiency of …             A somatic reference standard for cancer genome sequencing ▶     David W. Craig, Sara Nasser, Richard Corbett et al.     Large-scale multiplexed identification of somatic alterations in cancer has become feasible with next generation sequencing (NGS). However, calibration of NGS somatic analysis …             Prioritizing functional phosphorylation sites based on multiple feature integration ▶     Qingyu Xiao, Benpeng Miao, Jie Bi et al.     Protein phosphorylation is an important type of post-translational modification that is involved in a variety of biological activities. Most phosphorylation events occur on …             Flow directionality, mountain barriers and functional traits determine diatom metacommunity structuring of high mountain streams ▶     Xiaoyu Dong, Bin Li, Fengzhi He et al.     Stream metacommunities are structured by a combination of local (environmental filtering) and regional (dispersal) processes. The unique characters of high mountain streams could …             Leveraging family-specific signatures for AMP discovery and high-throughput annotation ▶     Faiza Hanif Waghu, Ram Shankar Barai, Susan Idicula-Thomas     Antimicrobial peptides (AMPs) are diverse, biologically active, essential components of the innate immune system. As compared to conventional antibiotics, AMPs exhibit broad …             Bioprinting three-dimensional cell-laden tissue constructs with controllable degradation ▶     Zhengjie Wu, Xin Su, Yuanyuan Xu et al.     Alginate hydrogel is a popular biologically inert material that is widely used in 3D bioprinting, especially in extrusion-based printing. However, the printed cells in this …             Increased frequency of social interaction is associated with enjoyment enhancement and reward system activation ▶     Hiroaki Kawamichi, Sho K. Sugawara, Yuki H. Hamano et al.     Positive social interactions contribute to the sense that one’s life has meaning. Enjoyment of feelings associated through social interaction motivates humans to build social …             ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts ▶     Yongmei Qi, Qian Qiu, Xueyan Gu et al.     The ATM (ataxia telangiectasia mutated) protein has recently been proposed to play critical roles in the response to mitochondrial dysfunction by initiating mitophagy. Here, we …             Common neural correlates of real and imagined movements contributing to the performance of brain–machine interfaces ▶     Hisato Sugata, Masayuki Hirata, Takufumi Yanagisawa et al.     The relationship between M1 activity representing motor information in real and imagined movements have not been investigated with high spatiotemporal resolution using …             A MALDI-MS-based quantitative analytical method for endogenous estrone in human breast cancer cells ▶     Kyoung-Jin Kim, Hee-Jin Kim, Han-Gyu Park et al.     The level of endogenous estrone, one of the three major naturally occurring estrogens, has a significant correlation with the incidence of post-menopausal breast cancer. However, …             The signatures of Anthropocene defaunation: cascading effects of the seed dispersal collapse ▶     Néstor Pérez-Méndez, Pedro Jordano, Cristina García et al.     Anthropogenic activity is driving population declines and extinctions of large-bodied, fruit-eating animals worldwide. Loss of these frugivores is expected to trigger negative …             Disorder prediction-based construct optimization improves activity and catalytic efficiency of Bacillus naganoensis pullulanase ▶     Xinye Wang, Yao Nie, Xiaoqing Mu et al.     Pullulanase is a well-known starch-debranching enzyme. However, the production level of pullulanase is yet low in both wide-type strains and heterologous expression systems. We …             The role of silicon in enhancing resistance to bacterial blight of hydroponic- and soil-cultured rice ▶     Alin Song, Gaofeng Xue, Peiyuan Cui et al.     Here we report for the first time that bacterial blight of rice can be alleviated by silicon (Si) added. In both inoculated and uninoculated plants, shoot dry weight was …             Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia ▶     Mi Yang, Jiao Li, Yibo Li et al.     Several neuroimaging studies have examined cerebral function in patients who suffer from aphasia, but the mechanism underlying this disorder remains poorly understood. In this …             Single-step cycle pulse operation of the label-free electrochemiluminescence immunosensor based on branched polypyrrole for carcinoembryonic antigen detection ▶     Wenjuan Zhu, Qi Wang, Hongmin Ma et al.     A novel label-free electrochemiluminescence (ECL) immunosensor based on luminol functional-Au NPs@polypyrrole has been developed for the detection of carcinoembryonic antigen …             Isoform switching and exon skipping induced by the DNA methylation inhibitor 5-Aza-2′-deoxycytidine ▶     Xiao-Lei Ding, Xiaojing Yang, Gangning Liang et al.     DNA methylation in gene promoters leads to gene silencing and is the therapeutic target of methylation inhibitors such as 5-Aza-2′-deoxycytidine (5-Aza-CdR). By analyzing the …             Olfactory epithelium changes in germfree mice ▶     Adrien François, Denise Grebert, Moez Rhimi et al.     Intestinal epithelium development is dramatically impaired in germfree rodents, but the consequences of the absence of microbiota have been overlooked in other epithelia. In the …             Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4 ▶     Jinju Yang, Nannan Qin, Hongwei Zhang et al.     Our previous research showed that recombinant calcineurin B (rhCnB) stimulates cytokine secretion by immune cells, probably through TLR4. Exogenous CnB can be incorporated into …             Somatic embryogenesis and enhanced shoot organogenesis in Metabriggsia ovalifolia W. T. Wang ▶     Yao Ouyang, Yulu Chen, Jinfeng Lü et al.     An efficient protocol providing a dual regeneration pathway via direct shoot organogenesis and somatic embryogenesis for an endangered species, Metabriggsia ovalifolia W. T. …             Gpr97 is dispensable for metabolic syndrome but is involved in macrophage inflammation in high-fat diet-induced obesity in mice ▶     Jueping Shi, Xiaoyu Zhang, Shaoying Wang et al.     Local inflammation in tissues is one of primary causes in development of metabolic disorder in obesity. The accumulation of macrophages in some tissues can induce inflammatory …             Perceptual learning shapes multisensory causal inference via two distinct mechanisms ▶     David P. McGovern, Eugenie Roudaia, Fiona N. Newell et al.     To accurately represent the environment, our brains must integrate sensory signals from a common source while segregating those from independent sources. A reasonable strategy …             Detection and characterization of two co-infection variant strains of avian orthoreovirus (ARV) in young layer chickens using next-generation sequencing (NGS) ▶     Yi Tang, Lin Lin, Aswathy Sebastian et al.     Using next-generation sequencing (NGS) for full genomic characterization studies of the newly emerging avian orthoreovirus (ARV) field strains isolated in Pennsylvania poultry, …             The effects of Bt Cry1Ie toxin on bacterial diversity in the midgut of Apis mellifera ligustica (Hymenoptera: Apidae) ▶     Hui-Ru Jia, Li-Li Geng, Yun-He Li et al.     The honey bee has been regarded as a key species in the environmental risk assessment of biotech crops. Here, the potential adverse effects of Cry1Ie toxin on the midgut bacteria …             Reverse Transcription Cross-Priming Amplification–Nucleic Acid Test Strip for Rapid Detection of Porcine Epidemic Diarrhea Virus ▶     Feng-Xue Wang, Dan-Yi Yuan, Ya-Nan Jin et al.     Porcine epidemic diarrhea virus (PEDV) is a highly transmissible coronavirus that causes a severe enteric disease particularly in neonatal piglets. In this study, a rapid method …             Metabotypes with properly functioning mitochondria and anti-inflammation predict extended productive life span in dairy cows ▶     K. Huber, S. Dänicke, J. Rehage et al.     The failure to adapt metabolism to the homeorhetic demands of lactation is considered as a main factor in reducing the productive life span of dairy cows. The so far defined …             The hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns ▶     Hanane Hadj-Moussa, Jason A. Moggridge, Bryan E. Luu et al.     When faced with adverse environmental conditions, the marsupial Dromiciops gliroides uses either daily or seasonal torpor to support survival and is the only known hibernating …             Gene-set Analysis with CGI Information for Differential DNA Methylation Profiling ▶     Chia-Wei Chang, Tzu-Pin Lu, Chang-Xian She et al.     DNA methylation is a well-established epigenetic biomarker for many diseases. Studying the relationships among a group of genes and their methylations may help to unravel the …             Oncolytic Activity of a Recombinant Measles Virus, Blind to Signaling Lymphocyte Activation Molecule, Against Colorectal Cancer Cells ▶     Yosuke Amagai, Tomoko Fujiyuki, Misako Yoneda et al.     Oncolytic virotherapy is a distinctive antitumor therapy based on the cancer-cell-specific infectivity and killing activity of viruses, which exert a considerable antitumor …             Mitigating methane emission from paddy soil with rice-straw biochar amendment under projected climate change ▶     Xingguo Han, Xue Sun, Cheng Wang et al.     Elevated global temperatures and increased concentrations of carbon dioxide (CO2) in the atmosphere associated with climate change will exert profound effects on rice cropping …             Draft genome sequencing and secretome analysis of fungal phytopathogen Ascochyta rabiei provides insight into the necrotrophic effector repertoire ▶     Sandhya Verma, Rajesh Kumar Gazara, Shadab Nizam et al.     Constant evolutionary pressure acting on pathogens refines their molecular strategies to attain successful pathogenesis. Recent studies have shown that pathogenicity mechanisms …             Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway ▶     Vicenç Ruiz de Porras, Sara Bystrup, Anna Martínez-Cardús et al.     Resistance to oxaliplatin (OXA) is a complex process affecting the outcomes of metastatic colorectal cancer (CRC) patients treated with this drug. De-regulation of the NF-κB …             Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells ▶     B. A. Krishna, B. Lau, S. E. Jackson et al.     Human cytomegalovirus (HCMV) latency in the myeloid lineage is maintained by repressive histone modifications around the major immediate early promoter (MIEP), which results in …             Gene set of chemosensory receptors in the polyembryonic endoparasitoid Macrocentrus cingulum ▶     Tofael Ahmed, Tiantao Zhang, Zhenying Wang et al.     Insects are extremely successful animals whose odor perception is very prominent due to their sophisticated olfactory system. The main chemosensory organ, antennae play a …             The Asian arowana (Scleropages formosus) genome provides new insights into the evolution of an early lineage of teleosts ▶     Chao Bian, Yinchang Hu, Vydianathan Ravi et al.     The Asian arowana (Scleropages formosus), one of the world’s most expensive cultivated ornamental fishes, is an endangered species. It represents an ancient lineage of teleosts: …             Clinicopathological Analysis and Multipronged Quantitative Proteomics Reveal Oxidative Stress and Cytoskeletal Proteins as Possible Markers for Severe Vivax Malaria ▶     Sandipan Ray, Sandip K. Patel, Apoorva Venkatesh et al.     In Plasmodium vivax malaria, mechanisms that trigger transition from uncomplicated to fatal severe infections are obscure. In this multi-disciplinary study we have performed a …             A protease-based biosensor for the detection of schistosome cercariae ▶     A. J. Webb, R. Kelwick, M. J. Doenhoff et al.     Parasitic diseases affect millions of people worldwide, causing debilitating illnesses and death. Rapid and cost-effective approaches to detect parasites are needed, especially …             Use of the lichen Xanthoria mandschurica in monitoring atmospheric elemental deposition in the Taihang Mountains, Hebei, China ▶     Hua-Jie Liu, Liang-Cheng Zhao, Shi-Bo Fang et al.     Air pollution is a major concern in China. Lichens are a useful biomonitor for atmospheric elemental deposition but have rarely been used in North China. The aim of this study …             Facile preparation of salivary extracellular vesicles for cancer proteomics ▶     Yan Sun, Zhijun Xia, Zhi Shang et al.     Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent …             Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts ▶     Hua-Yu Zhu, Wen-Dong Bai, Chao Li et al.     Abnormally high activation of transforming growth factor-β (TGF-β) signaling has been demonstrated to be involved in the initiation and progression of keloids. However, the …             Orthogonal NGS for High Throughput Clinical Diagnostics ▶     Niru Chennagiri, Eric J. White, Alexander Frieden et al.     Next generation sequencing is a transformative technology for discovering and diagnosing genetic disorders. However, high-throughput sequencing remains error-prone, necessitating …             Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis ▶     Nao Nishida, Jun Ohashi, Seik-Soon Khor et al.     Associations of variants located in the HLA class II region with chronic hepatitis B (CHB) infection have been identified in Asian populations. Here, HLA imputation method was …             Erythroleukemia cells acquire an alternative mitophagy capability ▶     Jian Wang, Yixuan Fang, Lili Yan et al.     Leukemia cells are superior to hematopoietic cells with a normal differentiation potential in buffering cellular stresses, but the underlying mechanisms for this leukemic …             Cardiac troponin T and echocardiographic dimensions after repeated sprint vs. moderate intensity continuous exercise in healthy young males ▶     Matthias Weippert, Dimitar Divchev, Paul Schmidt et al.     Regular physical exercise can positively influence cardiac function; however, investigations have shown an increase of myocardial damage biomarkers after acute prolonged …             Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload ▶     Jie Ma, Qunfang Yang, Yuling Wei et al.     In the present study, the agonists and antagonists of DP receptor were used to examine whether the PGD2-DP signaling pathway affects neuronal function. Primary cultured …             A reliable Raman-spectroscopy-based approach for diagnosis, classification and follow-up of B-cell acute lymphoblastic leukemia ▶     Stefano Managò, Carmen Valente, Peppino Mirabelli et al.     Acute lymphoblastic leukemia type B (B-ALL) is a neoplastic disorder that shows high mortality rates due to immature lymphocyte B-cell proliferation. B-ALL diagnosis requires …             Dynamic Changes of Functional Pain Connectome in Women with Primary Dysmenorrhea ▶     Ting-Hsuan Wu, Cheng-Hao Tu, Hsiang-Tai Chao et al.     Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and …             High Resolution Dissection of Reactive Glial Nets in Alzheimer’s Disease ▶     David S. Bouvier, Emma V. Jones, Gaël Quesseveur et al.     Fixed human brain samples in tissue repositories hold great potential for unlocking complexities of the brain and its alteration with disease. However, current methodology for …             Feasibility of Leadless Cardiac Pacing Using Injectable Magnetic Microparticles ▶     Menahem Y. Rotenberg, Hovav Gabay, Yoram Etzion et al.     A noninvasive, effective approach for immediate and painless heart pacing would have invaluable implications in several clinical scenarios. Here we present a novel strategy that …                     Chemical Sciences ▲ top               Modulation of Protein Fouling and Interfacial Properties at Carbon Surfaces via Immobilization of Glycans Using Aryldiazonium Chemistry ▶     Federico Zen, M. Daniela Angione, James A. Behan et al.     Carbon materials and nanomaterials are of great interest for biological applications such as implantable devices and nanoparticle vectors, however, to realize their potential it …             A general and highly regioselective synthesis approach to multi-functionalized organoimido derivatives of Polyoxometalates ▶     Yichao Huang, Jiangwei Zhang, Jian Hao et al.     Organoimidoylization of Polyoxometalates (POMs) can dramatically modify the electronic structures of POMs and gives rise to novel “value-adding” properties of the POMs for …             Two-Dimensional NMR Lineshape Analysis ▶     Christopher A. Waudby, Andres Ramos, Lisa D. Cabrita et al.     NMR titration experiments are a rich source of structural, mechanistic, thermodynamic and kinetic information on biomolecular interactions, which can be extracted through the …             Electronic and chemical structure of the H2O/GaN(0001) interface under ambient conditions ▶     Xueqiang Zhang, Sylwia Ptasinska     We employed ambient pressure X-ray photoelectron spectroscopy to investigate the electronic and chemical properties of the H2O/GaN(0001) interface under elevated pressures and/or …             Bare and boron-doped cubic silicon carbide nanowires for electrochemical detection of nitrite sensitively ▶     Tao Yang, Liqin Zhang, Xinmei Hou et al.     Fabrication of eletrochemical sensors based on wide bandgap compound semiconductors has attracted increasing interest in recent years. Here we report for the first time …             Microwave-assisted Facile and Ultrafast Growth of ZnO Nanostructures and Proposition of Alternative Microwave-assisted Methods to Address Growth Stoppage ▶     Abu ul Hassan Sarwar Rana, Mingi Kang, Hyun-Seok Kim     The time constraint in the growth of ZnO nanostructures when using a hydrothermal method is of paramount importance in contemporary research, where a long fabrication time rots …             Joint Analysis of Radiative and Non-Radiative Electronic Relaxation Upon X-ray Irradiation of Transition Metal Aqueous Solutions ▶     Ronny Golnak, Sergey I. Bokarev, Robert Seidel et al.     L-edge soft X-ray spectroscopy has been proven to be a powerful tool to unravel the peculiarities of electronic structure of transition metal compounds in solution. However, the …             Liquid–liquid phase separation of N-isopropylpropionamide aqueous solutions above the lower critical solution temperature ▶     Kenji Mochizuki, Tomonari Sumi, Kenichiro Koga     We investigate driving forces of the liquid–liquid phase separation of N-isopropylpropionamide (NiPPA) aqueous solutions above the lower critical solution temperature using …             Thioflavin T as an efficient fluorescence sensor for selective recognition of RNA G-quadruplexes ▶     Shujuan Xu, Qian Li, Junfeng Xiang et al.     RNA G-quadruplexes (G4s) play important roles in translational regulation, mRNA processing events and gene expression. Therefore, a fluorescent probe that is capable of …             Highly Efficient F, Cu doped TiO2 anti-bacterial visible light active photocatalytic coatings to combat hospital-acquired infections ▶     Nigel S. Leyland, Joanna Podporska-Carroll, John Browne et al.     Bacterial infections are a major threat to the health of patients in healthcare facilities including hospitals. One of the major causes of patient morbidity is infection with …             Monochromatic X-Ray Induced Novel Synthesis of Plasmonic Nanostructure for Photovoltaic Application ▶     Amardeep Bharti, Richa Bhardwaj, Ashish K. Agrawal et al.     It has been universally delineated that the plasmonic metal nanoparticles can enhance the efficiency of photovoltaic cell by increasing the probability of energetic solar photons …             Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists ▶     Vernon Seow, Junxian Lim, Adam J. Cotterell et al.     Drug discovery and translation are normally based on optimizing efficacy by increasing receptor affinity, functional potency, drug-likeness (rule-of-five compliance) and oral …             Ultrafast charge separation dynamics in opaque, operational dye-sensitized solar cells revealed by femtosecond diffuse reflectance spectroscopy ▶     Elham Ghadiri, Shaik M. Zakeeruddin, Anders Hagfeldt et al.     Efficient dye-sensitized solar cells are based on highly diffusive mesoscopic layers that render these devices opaque and unsuitable for ultrafast transient absorption …             Ordered Monolayer Gold Nano-urchin Structures and Their Size Induced Control for High Gas Sensing Performance ▶     Ylias M. Sabri, Ahmad Esmaielzadeh Kandjani, Samuel J. Ippolito et al.     The synthesis of ordered monolayers of gold nano-urchin (Au-NU) nanostructures with controlled size, directly on thin films using a simple electrochemical method is reported in …             Facile preparation of salivary extracellular vesicles for cancer proteomics ▶     Yan Sun, Zhijun Xia, Zhi Shang et al.     Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent …             Rate-dependent interface capture beyond the coffee-ring effect ▶     Yanan Li, Qiang Yang, Mingzhu Li et al.     The mechanism of droplet drying is a widely concerned fundamental issue since controlling the deposition morphology of droplet has significant influence on printing, biology …             N7-(carboxymethyl)guanine-Lithium Crystalline Complex: A Bioinspired Solid Electrolyte ▶     Dipak Dutta, N. Nagapradeep, Haijin Zhu et al.     Electrochemical device with components having direct significance to biological life processes is a potent futuristic strategy for the realization of all-round green and …                       Open for Submissions  Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care. The journal has an Impact Factor of 2.504. Explore the benefits of submitting your next research article.               Physical Sciences ▲ top               Modulation of Protein Fouling and Interfacial Properties at Carbon Surfaces via Immobilization of Glycans Using Aryldiazonium Chemistry ▶     Federico Zen, M. Daniela Angione, James A. Behan et al.     Carbon materials and nanomaterials are of great interest for biological applications such as implantable devices and nanoparticle vectors, however, to realize their potential it …             3D Printed Reversible Shape Changing Components with Stimuli Responsive Materials ▶     Yiqi Mao, Zhen Ding, Chao Yuan et al.     The creation of reversibly-actuating components that alter their shapes in a controllable manner in response to environmental stimuli is a grand challenge in active materials, …             Optimized 2D array of thin silicon pillars for efficient antireflective coatings in the visible spectrum ▶     Julien Proust, Anne-Laure Fehrembach, Frédéric Bedu et al.     Light reflection occuring at the surface of silicon wafers is drastically diminished by etching square pillars of height 110 nm and width 140 nm separated by a 100 nm gap …             Electronic and chemical structure of the H2O/GaN(0001) interface under ambient conditions ▶     Xueqiang Zhang, Sylwia Ptasinska     We employed ambient pressure X-ray photoelectron spectroscopy to investigate the electronic and chemical properties of the H2O/GaN(0001) interface under elevated pressures and/or …             A comprehensive simulation framework for imaging single particles and biomolecules at the European X-ray Free-Electron Laser ▶     Chun Hong Yoon, Mikhail V. Yurkov, Evgeny A. Schneidmiller et al.     The advent of newer, brighter, and more coherent X-ray sources, such as X-ray Free-Electron Lasers (XFELs), represents a tremendous growth in the potential to apply coherent …             A general and highly regioselective synthesis approach to multi-functionalized organoimido derivatives of Polyoxometalates ▶     Yichao Huang, Jiangwei Zhang, Jian Hao et al.     Organoimidoylization of Polyoxometalates (POMs) can dramatically modify the electronic structures of POMs and gives rise to novel “value-adding” properties of the POMs for …             Closed-form solutions and scaling laws for Kerr frequency combs ▶     William H. Renninger, Peter T. Rakich     A single closed-form analytical solution of the driven nonlinear Schrödinger equation is developed, reproducing a large class of the behaviors in Kerr-comb systems, including …             Large gap electron-hole superfluidity and shape resonances in coupled graphene nanoribbons ▶     M. Zarenia, A. Perali, F. M. Peeters et al.     We predict enhanced electron-hole superfluidity in two coupled electron-hole armchair-edge terminated graphene nanoribbons separated by a thin insulating barrier. In contrast to …             Bare and boron-doped cubic silicon carbide nanowires for electrochemical detection of nitrite sensitively ▶     Tao Yang, Liqin Zhang, Xinmei Hou et al.     Fabrication of eletrochemical sensors based on wide bandgap compound semiconductors has attracted increasing interest in recent years. Here we report for the first time …             Amplitude dynamics favors synchronization in complex networks ▶     Lucia Valentina Gambuzza, Jesus Gómez-Gardeñes, Mattia Frasca     In this paper we study phase synchronization in random complex networks of coupled periodic oscillators. In particular, we show that, when amplitude dynamics is not negligible, …             Two-Dimensional NMR Lineshape Analysis ▶     Christopher A. Waudby, Andres Ramos, Lisa D. Cabrita et al.     NMR titration experiments are a rich source of structural, mechanistic, thermodynamic and kinetic information on biomolecular interactions, which can be extracted through the …             Mechano-adaptive sensory mechanism of α-catenin under tension ▶     Koichiro Maki, Sung-Woong Han, Yoshinori Hirano et al.     The contractile forces in individual cells drive the tissue processes, such as morphogenesis and wound healing, and maintain tissue integrity. In these processes, α-catenin …             Three-Dimensional Super-Resolution Morphology by Near-Field Assisted White-Light Interferometry ▶     Feifei Wang, Lianqing Liu, Peng Yu et al.     Recent developments in far-field fluorescent microscopy have enabled nanoscale imaging of biological entities by ingenious applications of fluorescent probes. For …             Snapshot Hyperspectral Volumetric Microscopy ▶     Jiamin Wu, Bo Xiong, Xing Lin et al.     The comprehensive analysis of biological specimens brings about the demand for capturing the spatial, temporal and spectral dimensions of visual information together. However, …             Mechanism Analysis of the Inverse Doppler Effect in Two-Dimensional Photonic Crystal based on Phase Evolution ▶     Qiang Jiang, Jiabi Chen, Yan Wang et al.     Although the inverse Doppler effect has been observed experimentally at optical frequencies in photonic crystal with negative effective refractive index, its explanation is based …             Exact comprehensive equations for the photon management properties of silicon nanowire ▶     Yingfeng Li, Meicheng Li, Ruike Li et al.     Unique photon management (PM) properties of silicon nanowire (SiNW) make it an attractive building block for a host of nanowire photonic devices including photodetectors, …             Laser-synthesized oxide-passivated bright Si quantum dots for bioimaging ▶     M. B. Gongalsky, L. A. Osminkina, A. Pereira et al.     Crystalline silicon (Si) nanoparticles present an extremely promising object for bioimaging based on photoluminescence (PL) in the visible and near-infrared spectral regions, but …             Multispectral imaging using a single bucket detector ▶     Liheng Bian, Jinli Suo, Guohai Situ et al.     Existing multispectral imagers mostly use available array sensors to separately measure 2D data slices in a 3D spatial-spectral data cube. Thus they suffer from low photon …             Microwave-assisted Facile and Ultrafast Growth of ZnO Nanostructures and Proposition of Alternative Microwave-assisted Methods to Address Growth Stoppage ▶     Abu ul Hassan Sarwar Rana, Mingi Kang, Hyun-Seok Kim     The time constraint in the growth of ZnO nanostructures when using a hydrothermal method is of paramount importance in contemporary research, where a long fabrication time rots …             Corrigendum: Laser spectrometry for multi-elemental imaging of biological tissues ▶     L. Sancey, V. Motto-Ros, B. Busser et al.                 Erratum: Optical detection of radon decay in air ▶     Johan Sand, Sakari Ihantola, Kari Peräjärvi et al.                 Erratum: Phase transitions via selective elemental vacancy engineering in complex oxide thin films ▶     Sang A. Lee, Hoidong Jeong, Sungmin Woo et al.                 Corrigendum: Improving Low-dose Cardiac CT Images based on 3D Sparse Representation ▶     Luyao Shi, Yining Hu, Yang Chen et al.                 Fabrication of Radially Symmetric Graded Porous Silicon using a Novel Cell Design ▶     Mingrui Zhao, Manish Keswani     A contactless method using a novel design of the experimental cell for formation of porous silicon with morphological gradient is reported. Fabricated porous silicon layers show …             Integratable quarter-wave plates enable one-way angular momentum conversion ▶     Yao Liang, Fengchun Zhang, Jiahua Gu et al.     Nanophotonic waveguides are the building blocks of integrated photonics. To date, while quarter-wave plates (QWPs) are widely used as common components for a wide range of …             Randomly Distributed Fabry-Pérot-type Metal Nanowire Resonators and Their Lasing Action ▶     Kyungmok Kwon, Youngho Jung, Minkyung Kim et al.     Optical feedback mechanisms are often obtained from well-defined resonator structures fabricated by top-down processes. Here, we demonstrate that two-dimensional networks of …             A new approach to epitaxially grow high-quality GaN films on Si substrates: the combination of MBE and PLD ▶     Wenliang Wang, Haiyan Wang, Weijia Yang et al.     High-quality GaN epitaxial films have been grown on Si substrates with Al buffer layer by the combination of molecular beam epitaxy (MBE) and pulsed laser deposition (PLD) …             Exceptional points and asymmetric mode conversion in quasi-guided dual-mode optical waveguides ▶     S. N. Ghosh, Y. D. Chong     Non-Hermitian systems host unconventional physical effects that be used to design new optical devices. We study a non-Hermitian system consisting of 1D planar optical waveguides …             Oxygen-enabled control of Dzyaloshinskii-Moriya Interaction in ultra-thin magnetic films ▶     Abderrezak Belabbes, Gustav Bihlmayer, Stefan Blügel et al.     The search for chiral magnetic textures in systems lacking spatial inversion symmetry has attracted a massive amount of interest in the recent years with the real space …             Ultra-sensitive Magnetic Microscopy with an Optically Pumped Magnetometer ▶     Young Jin Kim, Igor Savukov     Optically pumped magnetometers (OPMs) based on lasers and alkali-metal vapor cells are currently the most sensitive non-cryogenic magnetic field sensors. Many applications in …             Terahertz and mid-infrared reflectance of epitaxial graphene ▶     Cristiane N. Santos, Frédéric Joucken, Domingos De Sousa Meneses et al.     Graphene has emerged as a promising material for infrared (IR) photodetectors and plasmonics. In this context, wafer scale epitaxial graphene on SiC is of great interest in a …             Particulate-free porous silicon networks for efficient capacitive deionization water desalination ▶     Thomas Metke, Andrew S. Westover, Rachel Carter et al.     Energy efficient water desalination processes employing low-cost and earth-abundant materials is a critical step to sustainably manage future human needs for clean water …             Coherent Charge Transport in Ballistic InSb Nanowire Josephson Junctions ▶     S. Li, N. Kang, D. X. Fan et al.     Hybrid InSb nanowire-superconductor devices are promising for investigating Majorana modes and topological quantum computation in solid-state devices. An experimental realisation …             Modular design and development methodology for robotic multi-axis F/M sensors ▶     Qiao-Kang Liang, Dan Zhang, Gianmarc Coppola et al.     Accurate Force/Moment (F/M) measurements are required in many applications, and multi-axis F/M sensors have been utilized a wide variety of robotic systems since 1970s. A …             Size-Dependent Raman Shifts for nanocrystals ▶     Yukun Gao, Xinmei Zhao, Penggang Yin et al.     Raman spectroscopy is a very sensitive tool for probing semiconductor nanocrystals. The underlying mechanism behind the size-dependent Raman shifts is still quite controversial. …             Physical Modeling of Activation Energy in Organic Semiconductor Devices based on Energy and Momentum Conservations ▶     Ling-Feng Mao, H. Ning, Changjun Hu et al.     Field effect mobility in an organic device is determined by the activation energy. A new physical model of the activation energy is proposed by virtue of the energy and momentum …             Black Phosphorus Based Field Effect Transistors with Simultaneously Achieved Near Ideal Subthreshold Swing and High Hole Mobility at Room Temperature ▶     Xinke Liu, Kah-Wee Ang, Wenjie Yu et al.     Black phosphorus (BP) has emerged as a promising two-dimensional (2D) material for next generation transistor applications due to its superior carrier transport properties. Among …             Digital Signal Processing and Control for the Study of Gene Networks ▶     Yong-Jun Shin     Thanks to the digital revolution, digital signal processing and control has been widely used in many areas of science and engineering today. It provides practical and powerful …             Abrupt current switching in graphene bilayer tunnel transistors enabled by van Hove singularities ▶     Georgy Alymov, Vladimir Vyurkov, Victor Ryzhii et al.     In a continuous search for the energy-efficient electronic switches, a great attention is focused on tunnel field-effect transistors (TFETs) demonstrating an abrupt dependence of …             Negative thermal expansion and broad band photoluminescence in a novel material of ZrScMo2VO12 ▶     Xianghong Ge, Yanchao Mao, Xiansheng Liu et al.     In this paper, we present a novel material with the formula of ZrScMo2VO12 for the first time. It was demonstrated that this material exhibits not only excellent negative thermal …             Antiferromagnetic Skyrmion: Stability, Creation and Manipulation ▶     Xichao Zhang, Yan Zhou, Motohiko Ezawa     Magnetic skyrmions are particle-like topological excitations in ferromagnets, which have the topo-logical number Q = ± 1, and hence show the skyrmion Hall effect (SkHE) due to …             1700 nm dispersion managed mode-locked bismuth fiber laser ▶     Teppo Noronen, Sergei Firstov, Evgeny Dianov et al.     We demonstrate the first 1.7 μm bismuth-doped fiber laser generating ultrashort pulses via passive mode-locking. Pulse operation has been achieved for both anomalous and normal …             Diffraction-free beams in fractional Schrödinger equation ▶     Yiqi Zhang, Hua Zhong, Milivoj R. Belić et al.     We investigate the propagation of one-dimensional and two-dimensional (1D, 2D) Gaussian beams in the fractional Schrödinger equation (FSE) without a potential, analytically and …             Role of an Oxidant Mixture as Surface Modifier of Porous Silicon Microstructures Evaluated by Spectroscopic Ellipsometry ▶     Zeuz Montiel-González, Salvador Escobar, Rocío Nava et al.     Current research on porous silicon includes the construction of complex structures with luminescent and/or photonic properties. However, their preparation with both …             Broadband mode conversion via gradient index metamaterials ▶     HaiXiao Wang, YaDong Xu, Patrice Genevet et al.     We propose a design for broadband waveguide mode conversion based on gradient index metamaterials (GIMs). Numerical simulations demonstrate that the zeroth order of transverse …             In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures ▶     Xian-Zhen Yin, Ti-Qiao Xiao, Ashwini Nangia et al.     Polymorphism denotes the existence of more than one crystal structure of a substance, and great practical and theoretical interest for the chemical and pharmaceutical industries. …             New mechanism of kinetic exchange interaction induced by strong magnetic anisotropy ▶     Naoya Iwahara, Liviu F. Chibotaru     It is well known that the kinetic exchange interaction between single-occupied magnetic orbitals (s-s) is always antiferromagnetic, while between single- and double-occupied …             Nearly diffraction-limited X-ray focusing with variable-numerical-aperture focusing optical system based on four deformable mirrors ▶     Satoshi Matsuyama, Hiroki Nakamori, Takumi Goto et al.     Unlike the electrostatic and electromagnetic lenses used in electron microscopy, most X-ray focusing optical systems have fixed optical parameters with constant numerical …             Highly Efficient Domain Walls Injection in Perpendicular Magnetic Anisotropy Nanowire ▶     S. F. Zhang, W. L. Gan, J. Kwon et al.     Electrical injection of magnetic domain walls in perpendicular magnetic anisotropy nanowire is crucial for data bit writing in domain wall-based magnetic memory and logic …             Theoretical screening of intermetallic ThMn12-type phases for new hard-magnetic compounds with low rare earth content ▶     Wolfgang Körner, Georg Krugel, Christian Elsässer     We report on theoretical investigations of intermetallic phases derived from the ThMn12-type crystal structure. Our computational high-throughput screening (HTS) approach is …             Interaction driven quantum Hall effect in artificially stacked graphene bilayers ▶     Muhammad Zahir Iqbal, Muhammad Waqas Iqbal, Salma Siddique et al.     The honeycomb lattice structure of graphene gives rise to its exceptional electronic properties of linear dispersion relation and its chiral nature of charge carriers. The …             Molecular adsorbates as probes of the local properties of doped graphene ▶     Van Dong Pham, Frédéric Joucken, Vincent Repain et al.     Graphene-based sensors are among the most promising of graphene’s applications. The ability to signal the presence of molecular species adsorbed on this atomically thin substrate …             Precise control of coupling strength in photonic molecules over a wide range using nanoelectromechanical systems ▶     Han Du, Xingwang Zhang, Guoqiang Chen et al.     Photonic molecules have a range of promising applications including quantum information processing, where precise control of coupling strength is critical. Here, by laterally …             Liquid–liquid phase separation of N-isopropylpropionamide aqueous solutions above the lower critical solution temperature ▶     Kenji Mochizuki, Tomonari Sumi, Kenichiro Koga     We investigate driving forces of the liquid–liquid phase separation of N-isopropylpropionamide (NiPPA) aqueous solutions above the lower critical solution temperature using …             Radiation Resistant Vanadium-Graphene Nanolayered Composite ▶     Youbin Kim, Jinwook Baek, Sunghwan Kim et al.     Ultra high strength V-graphene nanolayers were developed for the first time that was demonstrated to have an excellent radiation tolerance as revealed by the He+ irradiation …             Joint Analysis of Radiative and Non-Radiative Electronic Relaxation Upon X-ray Irradiation of Transition Metal Aqueous Solutions ▶     Ronny Golnak, Sergey I. Bokarev, Robert Seidel et al.     L-edge soft X-ray spectroscopy has been proven to be a powerful tool to unravel the peculiarities of electronic structure of transition metal compounds in solution. However, the …             Self Calibrated Wireless Distributed Environmental Sensory Networks ▶     Barak Fishbain, Erick Moreno-Centeno     Recent advances in sensory and communication technologies have made Wireless Distributed Environmental Sensory Networks (WDESN) technically and economically feasible. WDESNs …             A study on the electron transport properties of ZnON semiconductors with respect to the relative anion content ▶     Jozeph Park, Yang Soo Kim, Kyung-Chul Ok et al.     High-mobility zinc oxynitride (ZnON) semiconductors were grown by RF sputtering using a Zn metal target in a plasma mixture of Ar, N2, and O2 gas. The RF power and the O2 to N2 …             Sub-kT/q Subthreshold-Slope Using Negative Capacitance in Low-Temperature Polycrystalline-Silicon Thin-Film Transistor ▶     Jae Hyo Park, Gil Su Jang, Hyung Yoon Kim et al.     Realizing a low-temperature polycrystalline-silicon (LTPS) thin-film transistor (TFT) with sub-kT/q subthreshold slope (SS) is significantly important to the development of next …             Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography ▶     Jun Song, Christine Leon Swisher, Hyungsoon Im et al.     Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of …             Highly Efficient F, Cu doped TiO2 anti-bacterial visible light active photocatalytic coatings to combat hospital-acquired infections ▶     Nigel S. Leyland, Joanna Podporska-Carroll, John Browne et al.     Bacterial infections are a major threat to the health of patients in healthcare facilities including hospitals. One of the major causes of patient morbidity is infection with …             Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers ▶     Reza Riahi, Seyed Ali Mousavi Shaegh, Masoumeh Ghaderi et al.     There is an increasing interest in developing microfluidic bioreactors and organs-on-a-chip platforms combined with sensing capabilities for continual monitoring of cell-secreted …             Thioflavin T as an efficient fluorescence sensor for selective recognition of RNA G-quadruplexes ▶     Shujuan Xu, Qian Li, Junfeng Xiang et al.     RNA G-quadruplexes (G4s) play important roles in translational regulation, mRNA processing events and gene expression. Therefore, a fluorescent probe that is capable of …             Use of handheld X-ray fluorescence as a non-invasive method to distinguish between Asian and African elephant tusks ▶     Kittisak Buddhachat, Chatchote Thitaram, Janine L. Brown et al.     We describe the use of handheld X-ray fluorescence, for elephant tusk species identification. Asian (n = 72) and African (n = 85) elephant tusks were scanned and we utilized the …             Emission of direct-gap band in germanium with Ge-GeSn layers on one-dimensional structure ▶     Zhong-Mei Huang, Wei-Qi Huang, Shi-Rong Liu et al.     In our experiment, it was observed that the emission of direct-gap band in germanium with Ge-GeSn layers on one-dimensional (1D) structure. The results of experiment and …             Genipin crosslinking reduced the immunogenicity of xenogeneic decellularized porcine whole-liver matrices through regulation of immune cell proliferation and polarization ▶     Yujia Wang, Ji Bao, Xiujuan Wu et al.     Decellularized xenogeneic whole-liver matrices are plausible biomedical materials for the bioengineering of liver transplantation. A common method to reduce the inflammatory …             Erratum: Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids ▶     Joanna Brunker, Paul Beard                 Corrigendum: Nonvolatile modulation of electronic structure and correlative magnetism of L10-FePt films using significant strain induced by shape memory substrates ▶     Chun Feng, Jiancheng Zhao, Feng Yang et al.                 Diffractive optics for combined spatial- and mode- division demultiplexing of optical vortices: design, fabrication and optical characterization ▶     Gianluca Ruffato, Michele Massari, Filippo Romanato     During the last decade, the orbital angular momentum (OAM) of light has attracted growing interest as a new degree of freedom for signal channel multiplexing in order to increase …             Theoretical Investigations of Optical Origins of Fluorescent Graphene Quantum Dots ▶     Jingang Wang, Shuo Cao, Yong Ding et al.     The optical properties of graphene quantum dots (GQDs) were investigated theoretically. We focused on the photoinduced charge transfer and electron-hole coherence of single-layer …             Corrigendum: Enhancement of artificial magnetism via resonant bianisotropy ▶     Dmitry Markovich, Kseniia Baryshnikova, Alexander Shalin et al.                 Monochromatic X-Ray Induced Novel Synthesis of Plasmonic Nanostructure for Photovoltaic Application ▶     Amardeep Bharti, Richa Bhardwaj, Ashish K. Agrawal et al.     It has been universally delineated that the plasmonic metal nanoparticles can enhance the efficiency of photovoltaic cell by increasing the probability of energetic solar photons …             Landauer’s formula with finite-time relaxation: Kramers’ crossover in electronic transport ▶     Daniel Gruss, Kirill A. Velizhanin, Michael Zwolak     Landauer’s formula is the standard theoretical tool to examine ballistic transport in nano- and meso-scale junctions, but it necessitates that any variation of the junction with …             Spin-orbital effects in metal-dichalcogenide semiconducting monolayers ▶     J. A. Reyes-Retana, F. Cervantes-Sodi     Metal-dioxide & metal-dichalcogenide monolayers are studied by means of Density Functional Theory. For an accurate reproduction of the electronic structure of transition metal …             The noisy voter model on complex networks ▶     Adrián Carro, Raúl Toral, Maxi San Miguel     We propose a new analytical method to study stochastic, binary-state models on complex networks. Moving beyond the usual mean-field theories, this alternative approach is based …             Fast Flexible Transistors with a Nanotrench Structure ▶     Jung-Hun Seo, Tao Ling, Shaoqin Gong et al.     The simplification of fabrication processes that can define very fine patterns for large-area flexible radio-frequency (RF) applications is very desirable because it is generally …             Corrigendum: Impurity Resonant States p-type Doping in Wide-Band-Gap Nitrides ▶     Zhiqiang Liu, Xiaoyan Yi, Zhiguo Yu et al.                 Bio-inspired dewetted surfaces based on SiC/Si interlocked structures for enhanced-underwater stability and regenerative-drag reduction capability ▶     By Junghan Lee, Zhuo Zhang, Seunghyun Baek et al.     Drag reduction has become a serious issue in recent years in terms of energy conservation and environmental protection. Among diverse approaches for drag reduction, …             Thermal frequency shift and tunable microwave absorption in BiFeO3 family ▶     Yong Li, Xiaoyong Fang, Maosheng Cao     Tunable frequency is highly sought-after task of researcher, because of the potential for applications in selecting frequency, absorber, imaging and biomedical diagnosis. Here, …             Temporal correlations in neuronal avalanche occurrence ▶     F. Lombardi, H. J. Herrmann, D. Plenz et al.     Ongoing cortical activity consists of sequences of synchronized bursts, named neuronal avalanches, whose size and duration are power law distributed. These features have been …             Nanocarbon synthesis by high-temperature oxidation of nanoparticles ▶     Ken-ichi Nomura, Rajiv K. Kalia, Ying Li et al.     High-temperature oxidation of silicon-carbide nanoparticles (nSiC) underlies a wide range of technologies from high-power electronic switches for efficient electrical grid and …             Breakdown of the Migdal approximation at Lifshitz transitions with giant zero-point motion in the H3S superconductor ▶     Thomas Jarlborg, Antonio Bianconi     While 203 K high temperature superconductivity in H3S has been interpreted by BCS theory in the dirty limit here we focus on the effects of hydrogen zero-point-motion and the …             Corrigendum: A universal mechanism of extreme events and critical phenomena ▶     J. H. Wu, Q. Jia                 Corrigendum: Non-ionizing radiofrequency electromagnetic waves traversing the head can be used to detect cerebrovascular autoregulation responses ▶     M. Oziel, M. Hjouj, C. A. Gonzalez et al.                 Ultrafast charge separation dynamics in opaque, operational dye-sensitized solar cells revealed by femtosecond diffuse reflectance spectroscopy ▶     Elham Ghadiri, Shaik M. Zakeeruddin, Anders Hagfeldt et al.     Efficient dye-sensitized solar cells are based on highly diffusive mesoscopic layers that render these devices opaque and unsuitable for ultrafast transient absorption …             Nanodroplet-Vaporization-Assisted Sonoporation for Highly Effective Delivery of Photothermal Treatment ▶     Wei-Wen Liu, Shu-Wei Liu, Yu-Ren Liou et al.     Sonoporation refers to the use of ultrasound and acoustic cavitation to temporarily enhance the permeability of cellular membranes so as to enhance the delivery efficiency of …             Molecular Structures of Al/Si and Fe/Si Coprecipitates and the Implication for Selenite Removal ▶     Ya-Ting Chan, Wen-Hui Kuan, Yu-Min Tzou et al.     Aluminum and iron oxides have been often used in the coagulation processes during water purification due to their unique surface properties toward anions. In the presence of …             Rapid, controllable growth of silver nanostructured surface-enhanced Raman scattering substrates for red blood cell detection ▶     Shu Zhang, Xueli Tian, Jun Yin et al.     Silver nanostructured films suitable for use as surface-enhanced Raman scattering (SERS) substrates are prepared in just 2 hours by the solid-state ionics method. By changing the …             Bi1−xLaxCuSeO as New Tunable Full Solar Light Active Photocatalysts ▶     Huanchun Wang, Shun Li, Yaochun Liu et al.     Photocatalysis is attracting enormous interest driven by the great promise of addressing current energy and environmental crises by converting solar light directly into chemical …             Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound ▶     Guo-Feng Li, Hui-Xia Zhao, Hui Zhou et al.     Low frequency ultrasound (<1 MHz) has been demonstrated to be a promising approach for non-invasive neuro-stimulation. However, the focal width is limited to be half centimeter …             Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists ▶     Vernon Seow, Junxian Lim, Adam J. Cotterell et al.     Drug discovery and translation are normally based on optimizing efficacy by increasing receptor affinity, functional potency, drug-likeness (rule-of-five compliance) and oral …             Angle-dependent magnetotransport in GaAs/InAs core/shell nanowires ▶     Fabian Haas, Tobias Wenz, Patrick Zellekens et al.     We study the impact of the direction of magnetic flux on the electron motion in GaAs/InAs core/shell nanowires. At small tilt angles, when the magnetic field is aligned nearly …             Intrinsic beam emittance of laser-accelerated electrons measured by x-ray spectroscopic imaging ▶     G. Golovin, S. Banerjee, C. Liu et al.     The recent combination of ultra-intense lasers and laser-accelerated electron beams is enabling the development of a new generation of compact x-ray light sources, the coherence …             Nucleation processes of nanobubbles at a solid/water interface ▶     Chung-Kai Fang, Hsien-Chen Ko, Chih-Wen Yang et al.     Experimental investigations of hydrophobic/water interfaces often return controversial results, possibly due to the unknown role of gas accumulation at the interfaces. Here, …             Universal lineshapes at the crossover between weak and strong critical coupling in Fano-resonant coupled oscillators ▶     Simone Zanotto, Alessandro Tredicucci     In this article we discuss a model describing key features concerning the lineshapes and the coherent absorption conditions in Fano-resonant dissipative coupled oscillators. The …             Ordered Monolayer Gold Nano-urchin Structures and Their Size Induced Control for High Gas Sensing Performance ▶     Ylias M. Sabri, Ahmad Esmaielzadeh Kandjani, Samuel J. Ippolito et al.     The synthesis of ordered monolayers of gold nano-urchin (Au-NU) nanostructures with controlled size, directly on thin films using a simple electrochemical method is reported in …             Topologic connection between 2-D layered structures and 3-D diamond structures for conventional semiconductors ▶     Jianwei Wang, Yong Zhang     When coming to identify new 2D materials, our intuition would suggest us to look from layered instead of 3D materials. However, since graphite can be hypothetically derived from …             Orbital Reconstruction Enhanced Exchange Bias in La0.6Sr0.4MnO3/Orthorhombic YMnO3 Heterostructures ▶     Dongxing Zheng, Chao Jin, Peng Li et al.     The exchange bias in ferromagnetic/multiferroic heterostructures is usually considered to originate from interfacial coupling. In this work, an orbital reconstruction enhanced …             Predicting the epidemic threshold of the susceptible-infected-recovered model ▶     Wei Wang, Quan-Hui Liu, Lin-Feng Zhong et al.     Researchers have developed several theoretical methods for predicting epidemic thresholds, including the mean-field like (MFL) method, the quenched mean-field (QMF) method, and …             Superhydrophobic Ceramic Coatings by Solution Precursor Plasma Spray ▶     Yuxuan Cai, Thomas W. Coyle, Gisele Azimi et al.     This work presents a novel coating technique to manufacture ceramic superhydrophobic coatings rapidly and economically. A rare earth oxide (REO) was selected as the coating …             Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment ▶     Wenyi Wang, Elaine Wat, Patrick C. L. Hui et al.     The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been …             Refinement and growth enhancement of Al2Cu phase during magnetic field assisting directional solidification of hypereutectic Al-Cu alloy ▶     Jiang Wang, Sheng Yue, Yves Fautrelle et al.     Understanding how the magnetic fields affect the formation of reinforced phase during solidification is crucial to tailor the structure and therefor the performance of metal …             Unsteady stagnation-point flow and heat transfer of a special third grade fluid past a permeable stretching/shrinking sheet ▶     Kohilavani Naganthran, Roslinda Nazar, Ioan Pop     In this paper, the unsteady stagnation-point boundary layer flow and heat transfer of a special third grade fluid past a permeable stretching/shrinking sheet has been studied. …             Femtomagnetism in graphene induced by core level excitation of organic adsorbates ▶     Abhilash Ravikumar, Anu Baby, He Lin et al.     We predict the induction or suppression of magnetism in the valence shell of physisorbed and chemisorbed organic molecules on graphene occurring on the femtosecond time scale as …             Three-dimensional multiway power dividers based on transformation optics ▶     Yong-Le Wu, Zheng Zhuang, Li Deng et al.     The two-dimensional (2D) or three-dimensional (3D) multiway power dividers based on transformation optical theory are proposed in this paper. It comprises of several nonisotropic …             Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility ▶     H.F. Li, F.Y. Zhou, L. Li et al.     In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI …             Capacitive-coupled Series Spoof Surface Plasmon Polaritons ▶     Jia Yuan Yin, Jian Ren, Hao Chi Zhang et al.     A novel method to realize stopband within the operating frequency of spoof surface plasmon polaritons (SPPs) is presented. The stopband is introduced by a new kind of …             Steady-state mechanical squeezing in a hybrid atom-optomechanical system with a highly dissipative cavity ▶     Dong-Yang Wang, Cheng-Hua Bai, Hong-Fu Wang et al.     Quantum squeezing of mechanical resonator is important for studying the macroscopic quantum effects and the precision metrology of weak forces. Here we give a theoretical study …             Solution-Processed Donor-Acceptor Polymer Nanowire Network Semiconductors For High-Performance Field-Effect Transistors ▶     Yanlian Lei, Ping Deng, Jun Li et al.     Organic field-effect transistors (OFETs) represent a low-cost transistor technology for creating next-generation large-area, flexible and ultra-low-cost electronics. Conjugated …             Rate-dependent interface capture beyond the coffee-ring effect ▶     Yanan Li, Qiang Yang, Mingzhu Li et al.     The mechanism of droplet drying is a widely concerned fundamental issue since controlling the deposition morphology of droplet has significant influence on printing, biology …             Oscillatory penetration of near-fields in plasmonic excitation at metal-dielectric interfaces ▶     S. C. Lee, J. H. Kang, Q-H. Park et al.     The electric field immediately below an illuminated metal-film that is perforated with a hole array on a dielectric consists of direct transmission and scattering of the incident …             Dynamic and quantitative assessment of blood coagulation using optical coherence elastography ▶     Xiangqun Xu, Jiang Zhu, Zhongping Chen     Reliable clot diagnostic systems are needed for directing treatment in a broad spectrum of cardiovascular diseases and coagulopathy. Here, we report on non-contact measurement of …             N7-(carboxymethyl)guanine-Lithium Crystalline Complex: A Bioinspired Solid Electrolyte ▶     Dipak Dutta, N. Nagapradeep, Haijin Zhu et al.     Electrochemical device with components having direct significance to biological life processes is a potent futuristic strategy for the realization of all-round green and …             Facile preparation of salivary extracellular vesicles for cancer proteomics ▶     Yan Sun, Zhijun Xia, Zhi Shang et al.     Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent …             Predictability of uncontrollable multifocal seizures – towards new treatment options ▶     Klaus Lehnertz, Henning Dickten, Stephan Porz et al.     Drug-resistant, multifocal, non-resectable epilepsies are among the most difficult epileptic disorders to manage. An approach to control previously uncontrollable seizures in …             A reliable Raman-spectroscopy-based approach for diagnosis, classification and follow-up of B-cell acute lymphoblastic leukemia ▶     Stefano Managò, Carmen Valente, Peppino Mirabelli et al.     Acute lymphoblastic leukemia type B (B-ALL) is a neoplastic disorder that shows high mortality rates due to immature lymphocyte B-cell proliferation. B-ALL diagnosis requires …               Earth & Environmental Sciences ▲ top               North Atlantic forcing of moisture delivery to Europe throughout the Holocene ▶     Andrew C. Smith, Peter M. Wynn, Philip A. Barker et al.     Century-to-millennial scale fluctuations in precipitation and temperature are an established feature of European Holocene climates. Changes in moisture delivery are driven by …             Accelerated nucleation of the 2014 Iquique, Chile Mw 8.2 Earthquake ▶     Aitaro Kato, Jun’ichi Fukuda, Takao Kumazawa et al.     The earthquake nucleation process has been vigorously investigated based on geophysical observations, laboratory experiments, and theoretical studies; however, a general …             Role of oxidants in enhancing dewaterability of anaerobically digested sludge through Fe (II) activated oxidation processes: hydrogen peroxide versus persulfate ▶     Kang Song, Xu Zhou, Yiqi Liu et al.     Improving dewaterability of sludge is important for the disposal of sludge in wastewater treatment plants (WWTPs). This study, for the first time, investigated the Fe(II) …             Warming effects on photosynthesis of subtropical tree species: a translocation experiment along an altitudinal gradient ▶     Yiyong Li, Juxiu Liu, Guoyi Zhou et al.     Ongoing climate warming induced by human activities may have great impacts on trees, yet it remains unresolved how subtropical tree species respond to rising temperature in the …             Divergence of ecosystem services in U.S. National Forests and Grasslands under a changing climate ▶     Kai Duan, Ge Sun, Shanlei Sun et al.     The 170 National Forests and Grasslands (NFs) in the conterminous United States are public lands that provide important ecosystem services such as clean water and timber supply …             Centennial-scale solar forcing of the South American Monsoon System recorded in stalagmites ▶     Valdir F. Novello, Mathias Vuille, Francisco W. Cruz et al.     The South American Monsoon System (SAMS) is generally considered to be highly sensitive to Northern Hemisphere (NH) temperature variations on multi-centennial timescales. The …             Optical strain based pre-failure indication in failure process of geomaterials ▶     Sudipta Bhattacharjee, Debasis Deb     Multilevel extended digital image correlation (X-DIC) technique based on finite element method (FEM) is applied for measuring deformation of geomaterials under uni-axial loading …             Autonomous oscillation/separation of cell density artificially induced by optical interlink feedback as designed interaction between two isolated microalgae chips ▶     Kazunari Ozasa, June Won, Simon Song et al.     We demonstrate a designed interaction between two isolated cell populations of Euglena gracilis and Chlamydomonas reinhardtii, separately confined in two 25-square …             Response of AM fungi spore population to elevated temperature and nitrogen addition and their influence on the plant community composition and productivity ▶     Tao Zhang, Xue Yang, Rui Guo et al.     To examine the influence of elevated temperature and nitrogen (N) addition on species composition and development of arbuscular mycorrhizal fungi (AMF) and the effect of AMF on …             Physiological responses to daily light exposure ▶     Yefeng Yang, Yonghua Yu, Bo Yang et al.     Long daylength artificial light exposure associates with disorders, and a potential physiological mechanism has been proposed. However, previous studies have examined no more …             Self Calibrated Wireless Distributed Environmental Sensory Networks ▶     Barak Fishbain, Erick Moreno-Centeno     Recent advances in sensory and communication technologies have made Wireless Distributed Environmental Sensory Networks (WDESN) technically and economically feasible. WDESNs …             Emission of direct-gap band in germanium with Ge-GeSn layers on one-dimensional structure ▶     Zhong-Mei Huang, Wei-Qi Huang, Shi-Rong Liu et al.     In our experiment, it was observed that the emission of direct-gap band in germanium with Ge-GeSn layers on one-dimensional (1D) structure. The results of experiment and …             The influence of climate on peatland extent in Western Siberia since the Last Glacial Maximum ▶     G. A. Alexandrov, V. A. Brovkin, T. Kleinen     Boreal and subarctic peatlands are an important dynamical component of the earth system. They are sensitive to climate change, and could either continue to serve as a carbon sink …             Reactive Transport Modeling of the Enhancement of Density-Driven CO2 Convective Mixing in Carbonate Aquifers and its Potential Implication on Geological Carbon Sequestration ▶     Akand Islam, Alexander Y. Sun, Changbing Yang     We study the convection and mixing of CO2 in a brine aquifer, where the spread of dissolved CO2 is enhanced because of geochemical reactions with the host formations (calcite and …             Substantial dust loss of bioavailable phosphorus from agricultural soils ▶     Itzhak Katra, Avner Gross, Nitzan Swet et al.     Phosphorus (P) is an essential element in terrestrial ecosystems. Knowledge on the role of dust in the biogeochemical cycling of phosphorus is very limited with no quantitative …             Corrigendum: A universal mechanism of extreme events and critical phenomena ▶     J. H. Wu, Q. Jia                 Direct Synthesis of Novel and Reactive Sulfide-modified Nano Iron through Nanoparticle Seeding for Improved Cadmium-Contaminated Water Treatment ▶     Yiming Su, Adeyemi S. Adeleye, Yuxiong Huang et al.     Magnetic sulfide-modified nanoscale zerovalent iron (S-nZVI) is of great technical and scientific interest because of its promising application in groundwater remediation, …             The neglected nano-specific toxicity of ZnO nanoparticles in the yeast Saccharomyces cerevisiae ▶     Weicheng Zhang, Shaopan Bao, Tao Fang     Nanoparticles (NPs) with unique physicochemical properties induce nano-specific (excess) toxicity in organisms compared with their bulk counterparts. Evaluation and consideration …             Are viruses important in the plankton of highly turbid glacier-fed lakes? ▶     Fabian Drewes, Hannes Peter, Ruben Sommaruga     Viruses are ubiquitous in aquatic ecosystems where they significantly contribute to microbial mortality. In glacier-fed turbid lakes, however, viruses not only encounter low host …             Bi1−xLaxCuSeO as New Tunable Full Solar Light Active Photocatalysts ▶     Huanchun Wang, Shun Li, Yaochun Liu et al.     Photocatalysis is attracting enormous interest driven by the great promise of addressing current energy and environmental crises by converting solar light directly into chemical …             Molecular Structures of Al/Si and Fe/Si Coprecipitates and the Implication for Selenite Removal ▶     Ya-Ting Chan, Wen-Hui Kuan, Yu-Min Tzou et al.     Aluminum and iron oxides have been often used in the coagulation processes during water purification due to their unique surface properties toward anions. In the presence of …             Drought dominates the interannual variability in global terrestrial net primary production by controlling semi-arid ecosystems ▶     Ling Huang, Bin He, Aifang Chen et al.     Drought is a main driver of interannual variation in global terrestrial net primary production. However, how and to what extent drought impacts global NPP variability is unclear. …             Rapid climate fluctuations over the past millennium: evidence from a lacustrine record of Basomtso Lake, southeastern Tibetan Plateau ▶     Kai Li, Xingqi Liu, Ulrike Herzschuh et al.     Abrupt climate changes and fluctuations over short time scales are superimposed on long-term climate changes. Understanding rapid climate fluctuations at the decadal time scale …             Mitigating methane emission from paddy soil with rice-straw biochar amendment under projected climate change ▶     Xingguo Han, Xue Sun, Cheng Wang et al.     Elevated global temperatures and increased concentrations of carbon dioxide (CO2) in the atmosphere associated with climate change will exert profound effects on rice cropping …             Use of the lichen Xanthoria mandschurica in monitoring atmospheric elemental deposition in the Taihang Mountains, Hebei, China ▶     Hua-Jie Liu, Liang-Cheng Zhao, Shi-Bo Fang et al.     Air pollution is a major concern in China. Lichens are a useful biomonitor for atmospheric elemental deposition but have rarely been used in North China. The aim of this study …               Health Sciences ▲ top               Relationship between blood pressure reverse dipping and type 2 diabetes in hypertensive patients ▶     Lu Sun, Bin Yan, Ya Gao et al.     Recent studies suggested that nocturnal variations of blood pressure (BP) were closely related to type 2 diabetes. However, little information has been revealed about the …             TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis ▶     Fengqin Dong, Qi Ling, Dan Ye et al.     To evaluate the role of TCF7L2, a key regulator of glucose homeostasis, in estradiol (E2) and progesterone (P4)-modulated glucose metabolism, mouse insulinoma cells (MIN6) and …             Genetic polymorphisms of cell adhesion molecules in Behcet’s disease in a Chinese Han population ▶     Minming Zheng, Lijun Zhang, Hongsong Yu et al.     Cell adhesion molecules (CAMs) are involved in various immune-mediated diseases. This study was conducted to investigate the association of single nucleotide polymorphisms (SNPs) …             A genetic analysis of 23 Chinese patients with hemophilia B ▶     Qing-Yun Wang, Bei Hu, Hui Liu et al.     Hemophilia B (HB) is an X-linked recessive bleeding disorder caused by mutations in the coagulation factor IX (FIX) gene. Genotyping patients with HB is essential for genetic …             Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis ▶     Wen-Hua Wei, John Bowes, Darren Plant et al.     Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a …             Identifying Reproducible Molecular Biomarkers for Gastric Cancer Metastasis with the Aid of Recurrence Information ▶     Mengyao Li, Guini Hong, Jun Cheng et al.     To precisely diagnose metastasis state is important for tailoring treatments for gastric cancer patients. However, the routinely employed radiological and pathologic tests for …             NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell ▶     Zhi-Li Zhao, Lu Zhang, Cong-Fa Huang et al.     Cancer stem cells (CSCs) are considered responsible for tumor initiation and chemoresistance. This study was aimed to investigate the possibility of targeting head neck squamous …             Sleep Deprivation and Advice Taking ▶     Jan Alexander Häusser, Johannes Leder, Charlene Ketturat et al.     Judgements and decisions in many political, economic or medical contexts are often made while sleep deprived. Furthermore, in such contexts individuals are required to integrate …             Bioactivity Focus of α-Cyano-4-hydroxycinnamic acid (CHCA) Leads to Effective Multifunctional Aldose Reductase Inhibitors ▶     Laitao Zhang, Yi-Fang Li, Sheng Yuan et al.     Bioactivity focus on α-cyano-4-hydroxycinnamic acid (CHCA) scaffold results in a small library of novel multifunctional aldose reductase (ALR2) inhibitors. All the entities …             Hedgehog signaling activation induces stem cell proliferation and hormone release in the adult pituitary gland ▶     Joanna Pyczek, Rolf Buslei, David Schult et al.     Hedgehog (HH) signaling is known to be essential during the embryonal development of the pituitary gland but the knowledge about its role in the adult pituitary and in associated …             Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body ▶     Yasunari Seita, Tomoyuki Tsukiyama, Chizuru Iwatani et al.     Nonhuman primates are valuable for human disease modelling, because rodents poorly recapitulate some human diseases such as Parkinson’s disease and Alzheimer’s disease amongst …             Naringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone ▶     Xinlong Ma, Jianwei Lv, Xiaolei Sun et al.     Naringin maintains bone mass in various osteoporosis models, while its effect on bone in disuse osteoporosis has not been reported. The present study explores whether naringin …             Metabolomic Profiling of Infectious Parapneumonic Effusions Reveals Biomarkers for Guiding Management of Children with Streptococcus pneumoniae Pneumonia ▶     Chih-Yung Chiu, Gigin Lin, Mei-Ling Cheng et al.     Metabolic markers in biofluids represent an attractive tool for guiding clinical management. The aim of this study was to identify metabolic mechanisms during the progress of …             Tobacco control policies and perinatal health: a national quasi-experimental study ▶     Myrthe J. Peelen, Aziz Sheikh, Marjolein Kok et al.     We investigated whether changes in perinatal outcomes occurred following introduction of key tobacco control policies in the Netherlands: smoke-free legislation in workplaces …             Na+ Micro-Current Value Detection as a New Modality for Identification of Benign and Malignant Disease in Surgery ▶     Xu-Feng Zhang, Zhi-Da Long, Xue-Min Liu et al.     Increase of intracellular positive ions (mainly Na+) indicates greater possibility of cell malignancy. The present study investigated the correlation between the Na+ …             Aortic Arch Calcification Predicts Patency Loss of Arteriovenous Fistula in End-Stage Renal Disease Patients ▶     Yit-Sheung Yap, Kai-Ting Ting, Wen-Che Chi et al.     Aortic arch calcification (AAC) is recognized as an important cardiovascular risk factor in patients with end-stage renal disease (ESRD). The aim of the study was to evaluate the …             Circulating microRNAs in follicular fluid, powerful tools to explore in vitro fertilization process ▶     E. Scalici, S. Traver, T. Mullet et al.     Circulating or “extracellular” microRNAs (miRNAs) detected in biological fluids, could be used as potential diagnostic and prognostic biomarkers of several disease, such as …             Systematic Analysis of Adverse Event Reports for Sex Differences in Adverse Drug Events ▶     Yue Yu, Jun Chen, Dingcheng Li et al.     Increasing evidence has shown that sex differences exist in Adverse Drug Events (ADEs). Identifying those sex differences in ADEs could reduce the experience of ADEs for patients …             Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses ▶     Vilma Aho, Hanna M. Ollila, Erkki Kronholm et al.     Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were …             Lifecourse socioeconomic status and type 2 diabetes: the role of chronic inflammation in the English Longitudinal Study of Ageing ▶     Silvia Stringhini, Paola Zaninotto, Meena Kumari et al.     We examined the association between lifecourse socioeconomic status (SES) and the risk of type 2 diabetes at older ages, ascertaining the extent to which adult lifestyle factors …             Corrigendum: Panel-based NGS Reveals Novel Pathogenic Mutations in Autosomal Recessive Retinitis Pigmentosa ▶     Raquel Perez-Carro, Marta Corton, Iker Sánchez-Navarro et al.                 Low-intensity pulsed ultrasound treatment improved the rate of autograft peripheral nerve regeneration in rat ▶     Wenli Jiang, Yuexiang Wang, Jie Tang et al.     Low intensity pulsed ultrasound (LIPUS) has been widely used in clinic for the treatment of repairing pseudarthrosis, bone fractures and of healing in various soft tissues. Some …             Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist ▶     Tom Macleod, Rosella Doble, Dennis McGonagle et al.     The interleukin-36 receptor antagonist (IL-36Ra) which regulates IL-36α, -β and -γ is linked to psoriatic inflammation, especially loss-of-function mutations in pustular …             Evaluation of voltage-dependent calcium channel γ gene families identified several novel potential susceptible genes to schizophrenia ▶     Fanglin Guan, Tianxiao Zhang, Xinshe Liu et al.     Voltage-gated L-type calcium channels (VLCC) are distributed widely throughout the brain. Among the genes involved in schizophrenia (SCZ), genes encoding VLCC subunits have …             Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin ▶     A. Ian Smith, Niwanthi W. Rajapakse, Oded Kleifeld et al.                 Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis ▶     Jian Shen, Ning Song, Christopher J. Williams et al.     Atrophic vaginitis (AV) is common in postmenopausal women, but its causes are not well understood. The symptoms, which include vaginal itching, burning, dryness, irritation, and …             Interaction between IGFBP7 and insulin: a theoretical and experimental study ▶     Wenjing Ruan, Zhengzhong Kang, Youzhao Li et al.     Insulin-like growth factor binding protein 7 (IGFBP7) can bind to insulin with high affinity which inhibits the early steps of insulin action. Lack of recognition mechanism …             Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats ▶     Gerard Aragonès, Manuel Suárez, Andrea Ardid-Ruiz et al.     Proanthocyanidins (PACs) have been reported to modulate multiple targets by simultaneously controlling many pivotal metabolic pathways in the liver. However, the precise …             The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species ▶     Abdul A. Waheed, Scott MacDonald, Maisha Khan et al.     The HIV-1 accessory protein Vpu enhances virus release by counteracting the host restriction factor tetherin. To further understand the role of host cell proteins in Vpu …             Altered microRNA expression and pre-mRNA splicing events reveal new mechanisms associated with early stage Mycobacterium avium subspecies paratuberculosis infection ▶     Guanxiang Liang, Nilusha Malmuthuge, Yongjuan Guan et al.     The molecular regulatory mechanisms of host responses to Mycobacterium avium subsp. paratuberculosis (MAP) infection during the early subclinical stage are still not clear. In …             Regulation of aldosterone secretion by Cav1.3 ▶     Catherine B. Xie, Lalarukh Haris Shaikh, Sumedha Garg et al.     Aldosterone-producing adenomas (APAs) vary in phenotype and genotype. Zona glomerulosa (ZG)-like APAs frequently have mutations of an L-type calcium channel (LTCC) CaV1.3. Using …             HSP27 and 70 expression in thymic epithelial tumors and benign thymic alterations: diagnostic, prognostic and physiologic implications ▶     S. Janik, A. I. Schiefer, C. Bekos et al.     Thymic Epithelial Tumors (TETs), the most common tumors in the anterior mediastinum in adults, show a unique association with autoimmune Myasthenia Gravis (MG) and represent a …             Use of handheld X-ray fluorescence as a non-invasive method to distinguish between Asian and African elephant tusks ▶     Kittisak Buddhachat, Chatchote Thitaram, Janine L. Brown et al.     We describe the use of handheld X-ray fluorescence, for elephant tusk species identification. Asian (n = 72) and African (n = 85) elephant tusks were scanned and we utilized the …             Effectiveness of Multiple Blood-Cleansing Interventions in Sepsis, Characterized in Rats ▶     Ivan Stojkovic, Mohamed Ghalwash, Xi Hang Cao et al.     Sepsis is a serious, life-threatening condition that presents a growing problem in medicine, but there is still no satisfying solution for treating it. Several blood cleansing …             The Tumour Response to Induction Chemotherapy has Prognostic Value for Long-Term Survival Outcomes after Intensity-Modulated Radiation Therapy in Nasopharyngeal Carcinoma ▶     Hao Peng, Lei Chen, Yuan Zhang et al.     The prognostic value of the tumour response to induction chemotherapy (IC) for long-term survival outcomes after intensity-modulated radiation therapy in nasopharyngeal carcinoma …             Comparison of Vertebral Artery and Middle Cerebral Artery Monitoring for Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler ▶     Yu-Zhu Guo, Yong-Sheng Gao, Zhen-Ni Guo et al.     Contrast-enhanced transcranial Doppler (c-TCD) is a reliable and reproducible method for right-to-left shunt (RLS) detection, with high sensitivity. Monitoring the middle …             Physiological responses to daily light exposure ▶     Yefeng Yang, Yonghua Yu, Bo Yang et al.     Long daylength artificial light exposure associates with disorders, and a potential physiological mechanism has been proposed. However, previous studies have examined no more …             Field trial of medicinal plant, Bidens pilosa, against eimeriosis in broilers ▶     Cicero Lee-Tian Chang, Cheng-Ying Yang, Thangarasu Muthamilselvan et al.     Eimeriosis is a severe protozoan disease in poultry. Because of increasing concern about drug residue and drug resistance with the use of anticoccidial drugs, natural products …             Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human ▶     Amirah Amir, Bruce Russell, Jonathan Wee Kent Liew et al.     Plasmodium knowlesi is extensively used as an important malaria model and is now recognized as an important cause of human malaria in Malaysia. The strains of P. knowlesi …             In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures ▶     Xian-Zhen Yin, Ti-Qiao Xiao, Ashwini Nangia et al.     Polymorphism denotes the existence of more than one crystal structure of a substance, and great practical and theoretical interest for the chemical and pharmaceutical industries. …             A upconversion luminescene biosensor based on dual-signal amplification for the detection of short DNA species of c-erbB-2 oncogene ▶     Jianming Lan, Yingxin Liu, Li Li et al.     High-sensitivity detection of trace amounts of c-erbB-2 oncogene was reported to be equal to or surpass the ability of CA 15-3 for early diagnosis and/or follow-up recurrent …             Optogenetic control of human neurons in organotypic brain cultures ▶     My Andersson, Natalia Avaliani, Andreas Svensson et al.     Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including …             Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway ▶     Yixian Shi, Yongjun Li, Chenjie Huang et al.     The population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment …             Anxiety promotes memory for mood-congruent faces but does not alter loss aversion ▶     Caroline J. Charpentier, Chandni Hindocha, Jonathan P. Roiser et al.     Pathological anxiety is associated with disrupted cognitive processing, including working memory and decision-making. In healthy individuals, experimentally-induced state anxiety …             Generation of a monoclonal antibody recognizing the CEACAM glycan structure and inhibiting adhesion using cancer tissue-originated spheroid as an antigen ▶     Yumi Sato, Hiroaki Tateno, Jun Adachi et al.     Spheroids cultured directly from tumours can better reflect in vivo tumour characteristics than two-dimensional monolayer culture or three-dimensional culture of established cell …             Circulating microRNA profiles of Ebola virus infection ▶     Janice Duy, Jeffrey W. Koehler, Anna N. Honko et al.     Early detection of Ebola virus (EBOV) infection is essential to halting transmission and adjudicating appropriate treatment. However, current methods rely on viral …             Diarrhoea in the critically ill is common, associated with poor outcome, and rarely due to Clostridium difficile ▶     Nikhil Tirlapur, Zudin A. Puthucheary, Jackie A. Cooper et al.     Diarrhoea is common in Intensive Care Unit (ICU) patients, with a reported prevalence of 15–38%. Many factors may cause diarrhoea, including Clostridium difficile, drugs (e.g. …             Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals ▶     Hong Weng, Yan Yan, Ying-Hui Jin et al.     We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using …             Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study ▶     Katherine S. Ruth, John R. B. Perry, William E. Henley et al.     The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in …             Erratum: Scarce evidence of the causal role of germline mutations in UNC5C in hereditary colorectal cancer and polyposis ▶     Pilar Mur, Elena Sánchez-Cuartielles, Susanna Aussó et al.                 Corrigendum: ACEMg Diet Supplement Modifies Progression of Hereditary Deafness ▶     Kari L. Green, Donald L. Swiderski, Diane M. Prieskorn et al.                 Voxel-based analysis of grey and white matter degeneration in cervical spondylotic myelopathy ▶     Patrick Grabher, Siawoosh Mohammadi, Aaron Trachsler et al.     In this prospective study, we made an unbiased voxel-based analysis to investigate above-stenosis spinal degeneration and its relation to impairment in patients with cervical …             Microbiota-based Signature of Gingivitis Treatments: A Randomized Study ▶     Shi Huang, Zhen Li, Tao He et al.     Plaque-induced gingivitis can be alleviated by various treatment regimens. To probe the impacts of various anti-gingivitis treatments on plaque microflora, here a double blinded, …             Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer ▶     Dong-Xu He, Feng Gu, Fei Gao et al.     Cancer chemoresistance is regulated by complex genetic and epigenetic networks. In this study, the features of gene expression, methylation, and microRNA (miRNA) expression were …             Levels of human platelet-derived soluble CD40 ligand depend on haplotypes of CD40LG-CD40-ITGA2 ▶     Chaker Aloui, Antoine Prigent, Sofiane Tariket et al.     Increased circulating soluble CD40 ligand (sCD40L) is commonly associated with inflammatory disorders. We aimed to investigate whether gene polymorphisms in CD40LG, CD40 and ITGA2…             NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy ▶     Justin Chun, Hyunjae Chung, Xiangyu Wang et al.     Nod-like receptor pyrin domain-containing-3 (NLRP3) has been implicated in the pathogenesis of experimental renal injury, yet its characterization in human kidney disease remains …             A somatic reference standard for cancer genome sequencing ▶     David W. Craig, Sara Nasser, Richard Corbett et al.     Large-scale multiplexed identification of somatic alterations in cancer has become feasible with next generation sequencing (NGS). However, calibration of NGS somatic analysis …             Health Effects of PCBs in Residences and Schools (HESPERUS): PCB – health Cohort Profile ▶     Elvira Vaclavik Bräuner, Zorana Jovanovic Andersen, Marie Frederiksen et al.     Polychlorinated-biphenyls (PCBs) were introduced in the late 1920s and used until the 1970s when they were banned in most countries due to evidence of environmental build-up and …             Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD ▶     Elina M. Petäjä, You Zhou, Marika Havana et al.     Insulin-like growth factor binding protein 1 (IGFBP-1) is a potentially interesting marker for liver fat in NAFLD as it is exclusively produced by the liver, and insulin is its …             Properties of Two Enterovirus Antibodies that are Utilized in Diabetes Research ▶     Giuseppe Maccari, Angelo Genoni, Silvia Sansonno et al.     Human enteroviruses (EVs) comprise >100 different types. Research suggests a non-chance association between EV infections and type 1 diabetes. Immunohistochemical studies with …             The effects of a low-energy, high frequency liquid optic interface femtosecond laser system on lens capsulotomy ▶     Geraint P. Williams, Ben L. George, Yoke R. Wong et al.     The introduction of femtosecond laser assisted cataract surgery (FLACS) is a paradigm changing approach in cataract surgery, the most commonly performed surgical procedure. FLACS …             Circulating Fatty Acid Synthase in pregnant women: Relationship to blood pressure, maternal metabolism and newborn parameters ▶     Gemma Carreras-Badosa, Anna Prats-Puig, Teresa Puig et al.     The enzyme FASN (fatty acid synthase) is potentially related with hypertension and metabolic dysfunction. FASN is highly expressed in the human placenta. We aimed to investigate …             Sports Activity after Low-contact-stress Total Knee Arthroplasty – A long term follow-up study ▶     Ines Vielgut, Lukas Leitner, Norbert Kastner et al.     The purpose of this study was to provide comprehensive long-term data about sports activity levels in patients following total knee arthroplasty (TKA) and to determine the impact …             Hospitalization risk factors for children’s lower respiratory tract infection: A population-based, cross-sectional study in Mongolia ▶     Amarjargal Dagvadorj, Erika Ota, Sadequa Shahrook et al.     This study aimed to assess the potential risk factors for lower respiratory tract infection (LRTI)-related hospital admissions in Mongolian children. A population-based …             Phase 2 Randomised Controlled Trial and Feasibility Study of Future Care Planning in Patients with Advanced Heart Disease ▶     Martin A. Denvir, Sarah Cudmore, Gill Highet et al.     Future Care Planning (FCP) rarely occurs in patients with heart disease until close to death by which time the potential benefits are lost. We assessed the feasibility, …             Vibration from freight trains fragments sleep: A polysomnographic study ▶     Michael G. Smith, Ilona Croy, Oscar Hammar et al.     As the number of freight trains on railway networks increases, so does the potential for vibration exposure in dwellings nearby to freight railway lines. Nocturnal trains in …             Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts ▶     Hua-Yu Zhu, Wen-Dong Bai, Chao Li et al.     Abnormally high activation of transforming growth factor-β (TGF-β) signaling has been demonstrated to be involved in the initiation and progression of keloids. However, the …             Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis ▶     Nao Nishida, Jun Ohashi, Seik-Soon Khor et al.     Associations of variants located in the HLA class II region with chronic hepatitis B (CHB) infection have been identified in Asian populations. Here, HLA imputation method was …             Erythroleukemia cells acquire an alternative mitophagy capability ▶     Jian Wang, Yixuan Fang, Lili Yan et al.     Leukemia cells are superior to hematopoietic cells with a normal differentiation potential in buffering cellular stresses, but the underlying mechanisms for this leukemic …             Predictability of uncontrollable multifocal seizures – towards new treatment options ▶     Klaus Lehnertz, Henning Dickten, Stephan Porz et al.     Drug-resistant, multifocal, non-resectable epilepsies are among the most difficult epileptic disorders to manage. An approach to control previously uncontrollable seizures in …             Orthogonal NGS for High Throughput Clinical Diagnostics ▶     Niru Chennagiri, Eric J. White, Alexander Frieden et al.     Next generation sequencing is a transformative technology for discovering and diagnosing genetic disorders. However, high-throughput sequencing remains error-prone, necessitating …             Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells ▶     B. A. Krishna, B. Lau, S. E. Jackson et al.     Human cytomegalovirus (HCMV) latency in the myeloid lineage is maintained by repressive histone modifications around the major immediate early promoter (MIEP), which results in …             Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload ▶     Jie Ma, Qunfang Yang, Yuling Wei et al.     In the present study, the agonists and antagonists of DP receptor were used to examine whether the PGD2-DP signaling pathway affects neuronal function. Primary cultured …             Cardiac troponin T and echocardiographic dimensions after repeated sprint vs. moderate intensity continuous exercise in healthy young males ▶     Matthias Weippert, Dimitar Divchev, Paul Schmidt et al.     Regular physical exercise can positively influence cardiac function; however, investigations have shown an increase of myocardial damage biomarkers after acute prolonged …             Dynamic Changes of Functional Pain Connectome in Women with Primary Dysmenorrhea ▶     Ting-Hsuan Wu, Cheng-Hao Tu, Hsiang-Tai Chao et al.     Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and …             Feasibility of Leadless Cardiac Pacing Using Injectable Magnetic Microparticles ▶     Menahem Y. Rotenberg, Hovav Gabay, Yoram Etzion et al.     A noninvasive, effective approach for immediate and painless heart pacing would have invaluable implications in several clinical scenarios. Here we present a novel strategy that …             Clinicopathological Analysis and Multipronged Quantitative Proteomics Reveal Oxidative Stress and Cytoskeletal Proteins as Possible Markers for Severe Vivax Malaria ▶     Sandipan Ray, Sandip K. Patel, Apoorva Venkatesh et al.     In Plasmodium vivax malaria, mechanisms that trigger transition from uncomplicated to fatal severe infections are obscure. 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