Molecular Systems Biology - New articles published - 1 May 2016

April 2016 | Volume 12, Number 4 Submit Table of Contents Reviews Articles Corrigendum Articles Editorial Volume 12, Number 4 Reviews Transcriptomics resources of human tissues and organs Quantifying gene expression in human organs, tissues and cell types is vital to understand physiology and disease. Here we discuss publically available human transcriptome resources and their applications in combination with genome‐scale metabolic models. Mathias Uhlén, Björn M Hallström, Cecilia Lindskog, Adil Mardinoglu, Fredrik Pontén, and Jens Nielsen Published online 04.04.2016 Articles Predictive features of ligand‐specific signaling through the estrogen receptor Chemical biology profiling and X‐ray crystallography reveal specific structural perturbations that define how different types of ERα ligands use alternate signaling pathways to regulate proliferation of ERα+ breast cancer cells. Jerome C Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J Wright, René Houtman, Kathryn E Carlson, Jatinder S Josan, Olivier Elemento, John A Katzenellenbogen, Hai‐Bing Zhou, and Kendall W Nettles Published online 22.04.2016 Pooled‐matrix protein interaction screens using Barcode Fusion Genetics Barcode Fusion Genetics‐Yeast Two‐Hybrid, a new technology allowing many‐by‐many screening of protein interactions in a single pooled assay, is presented. High‐quality interactions are identified in search matrices up to ~2.5 million protein pairs in scale. Nozomu Yachie, Evangelia Petsalaki, Joseph C Mellor, Jochen Weile, Yves Jacob, Marta Verby, Sedide B Ozturk, Siyang Li, Atina G Cote, Roberto Mosca, Jennifer J Knapp, Minjeong Ko, Analyn Yu, Marinella Gebbia, Nidhi Sahni, Song Yi, Tanya Tyagi, Dayag Sheykhkarimli, Jonathan F Roth, Cassandra Wong, Louai Musa, Jamie Snider, Yi‐Chun Liu, Haiyuan Yu, Pascal Braun, Igor Stagljar, Tong Hao, Michael A Calderwood, Laurence Pelletier, Patrick Aloy, David E Hill, Marc Vidal, and Frederick P Roth Published online 22.04.2016 Corrigendum Frequency modulation of ERK activation dynamics rewires cell fate Hyunryul Ryu, Minhwan Chung, Maciej Dobrzyński, Dirk Fey, Yannick Blum, Sung Sik Lee, Matthias Peter, Boris N Kholodenko, Noo Li Jeon, and Olivier Pertz Published online 22.04.2016 Articles An inter‐species protein–protein interaction network across vast evolutionary distance An inter‐species “inter‐interactome” was generated by systematic mapping protein–protein interactions between human and yeast proteomes. Comparisons of the inter‐species interactome with the two “parent” intra‐species human and yeast networks reveal evolutionary constraints and plasticity of biological systems. Quan Zhong, Samuel J Pevzner, Tong Hao, Yang Wang, Roberto Mosca, Jörg Menche, Mikko Taipale, Murat Taşan, Changyu Fan, Xinping Yang, Patrick Haley, Ryan R Murray, Flora Mer, Fana Gebreab, Stanley Tam, Andrew MacWilliams, Amélie Dricot, Patrick Reichert, Balaji Santhanam, Lila Ghamsari, Michael A Cal derwood, Thomas Rolland, Benoit Charloteaux, Susan Lindquist, Albert‐László Barabási, David E Hill, Patrick Aloy, Michael E Cusick, Yu Xia, Frederick P Roth, and Marc Vidal Published online 22.04.2016 Editorial Sensing a revolution New fully integrated biosensors that monitor molecular and physiological parameters throughout our bodies are set to revolutionize medicine and personalized healthcare. Lars M Steinmetz and Allan Jones Published online 26.04.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.