Nature Cell Biology contents: July 2016 Volume 18 Number 7, pp 711 - 822

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Advertisement For essential cell health data you need on a routine basis, there isn't always time for the relaxed pace of the Western. Apoptosis. Oxidative stress. Cell cycle effects. Viability. Get quantitative, single-cell results in a fraction of the time needed for traditional immunoassays. Simple, rapid assessment of critical cell events on your benchtop with the Muse™ cell analyzer. See how it works — Watch video TABLE OF CONTENTS July 2016 Volume 18, Issue 7 Review News and Views Articles Letter Corrigendum Erratum Advertisement   White Papers: 3D Cell Culture for Tissue Modeling The RAFT™ 3D Cell Culture System is accompanied with protocols and a team of experts that assist researchers in setting up 3D cell cultures in their specific application. Learn more and download latest white paper: Co-culturing of bronchial epithelial and smooth muscle cells in 2D and 3D. The data shows the ability to perform more relevant modeling with 3D methods. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Special Issue on Dying Cell Recognition The studies collected in this special issue of Cell Death and Differentiation contribute to the understanding of the process of cell death and its effects by highlighting the importance of cell death for the health and function of neighbouring tissues and the organism as a whole. Access the special issue and watch the accompanying video summaries online.      Review Top Cilium assembly and disassembly   pp711 - 717 Irma Sánchez and Brian David Dynlacht doi:10.1038/ncb3370 News and Views Top Rewiring macrophages for anti-tumour immunity   pp718 - 720 Yunqin Lee and Subhra K. Biswas doi:10.1038/ncb3384 Tumour-associated macrophages facilitate cancer progression, but whether they can be reprogrammed to elicit an anti-tumour response remains unclear. Deletion of the microRNA-processing enzyme Dicer is now shown to rewire macrophages to an anti-tumour mode, leading to an enhanced response to immunotherapy and inhibition of tumour progression. See also: Article by Baer et al. Mapping the molecular steps of secretory-lysosome-driven tracheal tube fusion   pp720 - 722 Vahap Aydogan, Heinz-Georg Belting and Markus Affolter doi:10.1038/ncb3383 During development, tubular networks form through the joining of lumenized branches. Further insights into tracheal tube fusion in Drosophila melanogaster now reveal the molecular steps that promote the connection of two apical membrane compartments within a single cell through secretory lysosomes. See also: Article by Caviglia et al. p21 shapes cancer evolution   pp722 - 724 Vasily S. Romanov and K. Lenhard Rudolph doi:10.1038/ncb3382 Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A — the gene encoding p21 (also known as WAF1 or CIP1) — is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress. See also: Article by Galanos et al. New MAPS for misfolded proteins   pp724 - 726 Norbert Volkmar, Emma Fenech and John C. Christianson doi:10.1038/ncb3381 Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission. See also: Article by Lee et al. Cell Biology JOBS of the week Postdoc in Redox Cell Biology Helmholtz Association Two Postdoc Positions in Cell Biology Boston University Postdoctoral position Cell Biology Biophysics Centre National de la Recherche Scientifique (CNRS) Postdoctoral Fellow ? Tumor Microenvironment and Cancer Stem Cells Duke University Postdoctoral Research Scientist Cancer Research UK Beatson Institute in Glasgow More Science jobs from Cell Biology EVENT Physical Biology of the Cell 18.09.16 Woods Hole, USA More science events from Advertisement Japan is among the top producers of high quality research in the world, but new analysis using the Nature Index reveals this position is being challenged. Click here to see the efforts being made to reverse this decline and how international collaborations are playing a role in the strategies of Japan’s institutions. Nature.Index.com   Articles Top Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis   pp727 - 739 Sara Caviglia, Marko Brankatschk, Elisabeth J. Fischer, Suzanne Eaton and Stefan Luschnig doi:10.1038/ncb3374 Luschnig and colleagues present a model in which Staccato, in combination with Rab39, mediates the control of apical membrane fusion by interacting with components of the SNARE machinery in the formation of anastomoses in the tracheal tube. See also: News and Views by Aydogan et al. Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains   pp740 - 751 Bianca Schrul and Ron R. Kopito doi:10.1038/ncb3373 Kopito and Schrul show that the peroxisome proteins PEX19 and PEX3 mediate the correct insertion of the lipid droplet protein UBXD8 into ER subdomains. The polycystin complex mediates Wnt/Ca2+ signalling   pp752 - 764 Seokho Kim, Hongguang Nie, Vasyl Nesin, Uyen Tran, Patricia Outeda et al. doi:10.1038/ncb3363 Seokho et al. report that Wnt ligands bind the extracellular domain of polycystin 1 (PKD1) and induce Ca2+ influx through the Ca2+-permeable ion channel TRPP2. This activity is abrogated by PKD1 mutations linked to polycystic kidney disease. Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells   pp765 - 776 Jin-Gu Lee, Shokichi Takahama, Guofeng Zhang, Stanislav I. Tomarev and Yihong Ye doi:10.1038/ncb3372 Lee et al. report that aberrantly folded cytosolic proteins are recruited to the ER by the USP19 deubiquitylase, and are then encapsulated in late endosomes that fuse with the plasma membrane, leading to their secretion. See also: News and Views by Volkmar et al. Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing   pp777 - 789 Panagiotis Galanos, Konstantinos Vougas, David Walter, Alexander Polyzos, Apolinar Maya-Mendoza et al. doi:10.1038/ncb3378 Galanos and colleagues observe p21 accumulation in proliferating cancer cells, and show that in cultured p53-null cells, p21 can cause genomic instability by perturbing replication licensing through inhibition of the CRL4-CDT ubiquitin ligase. See also: News and Views by Romanov & Rudolph Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity   pp790 - 802 Caroline Baer, Mario Leonardo Squadrito, Damya Laoui, Danielle Thompson, Sarah K. Hansen et al. doi:10.1038/ncb3371 Baer et al. report that macrophage-specific DICER deletion abolishes TAM immunosuppressive activity and promotes anti-tumour immunity by recruitment and activation of cytotoxic T cells and increased IFN-γ production. See also: News and Views by Lee & Biswas PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia   pp803 - 813 Robert S. Banh, Caterina Iorio, Richard Marcotte, Yang Xu, Dan Cojocari et al. doi:10.1038/ncb3376 Banh et al. show that PTP1B decreases non-mitochondrial oxygen consumption by regulating the RNF213/α-KGDD pathway, thus promoting hypoxic survival of cancer cells. Letter Top Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes   pp814 - 821 Janine H. van Ree, Hyun-Ja Nam, Karthik B. Jeganathan, Arun Kanakkanthara and Jan M. van Deursen doi:10.1038/ncb3369 By engineering mice to express a version of the Pten tumour suppressor that lacks the three C-terminal amino acids, van Deursen and colleagues reveal a role for the protein in the generation of symmetric spindles through recruitment of Eg5 to centrosomes. Corrigendum Top Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis   p822 Sebastian R. Nielsen, Valeria Quaranta, Andrea Linford, Perpetua Emeagi, Carolyn Rainer et al. doi:10.1038/ncb3377 Erratum Top Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation   p822 Thomas Welte, Ik Sun Kim, Lin Tian, Xia Gao, Hai Wang et al. doi:10.1038/ncb3379 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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