Nature Reviews Immunology Contents July 2016 Volume 16 Number 7 pp 401-462

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TABLE OF CONTENTS
July 2016 Volume 16 Number 7
Impact Factor 39.416 *	In this issue Research Highlights Reviews Also this month  Featured article: Inflammasomes: mechanism of assembly, regulation and signalling Petr Broz & Vishva M. Dixit
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RESEARCH HIGHLIGHTS Top Cell death and immunity: Gasdermins: the hole picture emerges p401 | doi:10.1038/nri.2016.76 Gasdermins induce pyroptosis by forming pores in the cell membrane. PDF Tumour immunology: A checkpoint for NK cells p402 | doi:10.1038/nri.2016.68 The SOCS family member CIS is a crucial negative regulator of IL-15-induced signalling in NK cells. PDF T cells: Mitochondrial shape shifters p402 | doi:10.1038/nri.2016.79 Mitochondrial remodelling instructs metabolic adaptations in T cells. PDF JOURNAL CLUB Division of labour by CD4+ T helper cells p403 | doi:10.1038/nri.2016.53 Steven Ziegler describes a 1986 study by Mossmann et al. that defined two subsets of T helper cells on the basis of their activities. PDF Antiviral immunity: CD4+ T cells open the door for antibodies p404 | doi:10.1038/nri.2016.71 Memory CD4+ T cells promote vascular permeability, allowing protective antiviral antibodies to access neuronal tissue. PDF Inflammasome: To die or not to die p404 | doi:10.1038/nri.2016.73 Non-canonical inflammasome activation by self-derived oxidized phospholipid promotes both IL-1β release and cell survival. PDF Immune memory: Inflammasomes drive NK cell memory p405 | doi:10.1038/nri.2016.74 Contact hypersensitivity induces a memory NK cell response that requires the NLRP3 inflammasome in tissue-resident macrophages. PDF Immunology JOBS of the week Postdoctoral Position in Translational Bioinformatics / Computational Immunology German Cancer Research Center (DKFZ). More Science jobs from Immunology EVENT Systems Biology of Adaptive Immunity 14.05.17 Ascona, Switzerland More science events from
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REVIEWS		Top
Inflammasomes: mechanism of assembly, regulation and signalling Petr Broz & Vishva M. Dixit p407 | doi:10.1038/nri.2016.58 Dysregulated inflammasome activation is linked to numerous inflammatory disorders and is therefore tightly regulated. In this Review, the authors discuss the latest insights into the activation and assembly mechanisms of inflammasomes, the structure of distinct inflammasome complexes and the mechanisms that regulate inflammasome signalling. Abstract | Full Text | PDF
Origins of the cytolytic synapse Maike de la Roche, Yukako Asano & Gillian M. Griffiths p421 | doi:10.1038/nri.2016.54 Structural and functional similarities between the cytolytic synapses formed by CD8+ T cells and primary cilia are shedding new light on the mechanisms and order of events of synapse formation. Abstract | Full Text | PDF
C-type lectin receptors in the control of T helper cell differentiation Teunis B. H. Geijtenbeek & Sonja I. Gringhuis p433 | doi:10.1038/nri.2016.55 Here, the authors discuss the role of C-type lectin receptor signalling pathways in the control of T helper cell differentiation and examine how these receptors and pathways can be harnessed for vaccine strategies. Abstract | Full Text | PDF
Computational flow cytometry: helping to make sense of high-dimensional immunology data Yvan Saeys, Sofie Van Gassen & Bart N. Lambrecht p449 | doi:10.1038/nri.2016.56 A broad and practical overview for applying computational techniques to analyse, visualize and interpret high-dimensional data from flow cytometry. Computational flow cytometry improves reproducibility, allows automated identification of cell populations and biomarkers, as well as enables predictive modelling of clinical correlates and cell development pathways. Abstract | Full Text | PDF
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